Lista de obras - Michael P. Brown - Dominio Público Uruguay

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

artículo científico publicado en 2013

A phase 2 study of tasisulam sodium (LY573636 sodium) as second-line treatment for patients with unresectable or metastatic melanoma

artículo científico publicado en 2011

A phase I study of the GM-CSF antagonist E21R

artículo científico publicado en 2002

A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

scientific article published on 22 September 2020

A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.

artículo científico

A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution

artículo científico publicado en 2009

APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy

artículo científico publicado en 2009

Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells. A model for immunotherapy.

artículo científico publicado en 2001

An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant

artículo científico publicado en 2013

An open-label, multicentre safety study of vemurafenib in patients with BRAFV600-mutant metastatic melanoma: final analysis and a validated prognostic scoring system

artículo científico publicado en 2018

Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition

artículo científico publicado en 2011

Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy.

artículo científico publicado en 2017

Autoradiography imaging in targeted alpha therapy with Timepix detector

artículo científico publicado en 2015

Breast cancer stem cells: treatment resistance and therapeutic opportunities

scientific article published on 10 February 2011

CD40 is not detected on human prostate cancer cells by immunohistologic techniques

artículo científico publicado en 2001

CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice

artículo científico publicado en 2003

Can cancer registries show whether treatment is contributing to survival increases for melanoma of the skin at a population level?

artículo científico publicado en 2013

Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors

artículo científico publicado en 2009

Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study

artículo científico publicado en 2018

Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man.

artículo científico publicado en 2003

Could bystander killing contribute significantly to the antitumor activity of brentuximab vedotin given with standard first-line chemotherapy for Hodgkin lymphoma?

artículo científico publicado en 2014

Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy

artículo científico publicado en 2009

Current and emerging immunotherapeutic approaches to treat and prevent peanut allergy

artículo científico publicado en 2012

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.

artículo científico publicado en 2012

Dasatinib alters the metastatic phenotype of B16-OVA melanoma in vivo

artículo científico publicado en 2010

Dasatinib inhibits recombinant viral antigen-specific murine CD4+ and CD8+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo

artículo científico publicado en 2008

Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

artículo científico publicado en 2016

Detection of TNF alpha and Fas ligand mRNA within synovial mononuclear cells by fluorescence in-cell labeling PCR (FICL-PCR).

artículo científico publicado en 1998

Development of a transmission alpha particle dosimetry technique using A549 cells and a Ra-223 source for targeted alpha therapy.

artículo científico publicado en 2016

Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2.

artículo científico publicado en 2015

Do Human Lymphocyte Antigens Play a Role in the Clinical Antimelanoma Activity of Ipilimumab? ⬇️

artículo científico publicado el 1 de mayo de 2011

Dose selection, pharmacokinetics, and pharmacodynamics of BRAF inhibitor dabrafenib (GSK2118436).

artículo científico publicado en 2014

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

artículo científico publicado en 2021

Eosinophilic fasciitis as a paraneoplastic phenomenon associated with metastatic colorectal carcinoma

artículo científico publicado en 2008

Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care

artículo científico publicado en 2008

Expression of Drosophila Ca2+ permeable transient receptor potential-like channel protein in a prostate cancer cell line decreases cell survival.

artículo científico publicado en 2003

Feasibility and kinetics of CD34+ hematopoietic progenitor cell mobilization in response to a single administration of docetaxel chemotherapy and pegfilgrastim in a contemporary cohort of patients with metastatic breast cancer

artículo científico publicado en 2016

Feasibility of adding everolimus to carboplatin and paclitaxel, with or without bevacizumab, for treatment-naive, advanced non-small cell lung cancer

artículo científico publicado en 2013

First-in-Man Dose-Escalation Study of the Selective BRAF Inhibitor RG7256 in Patients with BRAF V600-Mutated Advanced Solid Tumors.

artículo científico

Flt3 ligand expands dendritic cell numbers in normal and malignant murine prostate

artículo científico publicado en 2002

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade

artículo científico publicado en 2016

Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma

artículo científico publicado en 2014

Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy

artículo científico publicado en 2003

Human Flt-3 ligand-mobilized dendritic cells require additional activation to drive effective immune responses

article

Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells

artículo científico publicado en 2009

Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation.

artículo científico publicado en 2005

Improving vaccines by incorporating immunological coadjuvants

artículo científico publicado en 2007

In vivo targeting of dead tumor cells in a murine tumor model using a monoclonal antibody specific for the La autoantigen

artículo científico publicado en 2007

Induction of both cellular and humoral immunity following a rational prime-boost immunization regimen that incorporates recombinant ovine atadenovirus and fowlpox virus

artículo científico publicado en 2010

Innate immune recognition of poxviral vaccine vectors

artículo científico publicado en 2011

Is the Induction of Tumor Cell Senescence the Key to a Good Irradiated Tumor Vaccine? ⬇️

artículo científico publicado el 1 de mayo de 2012

Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy

artículo científico publicado en 2014

Multifunctional core-shell magnetic cisplatin nanocarriers

artículo científico publicado en 2009

Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling

artículo científico publicado en 2013

Nutlin-3a is a potential therapeutic for ewing sarcoma

artículo científico publicado en 2010

Open-label, multicentre safety study of vemurafenib in 3219 patients with BRAFV600 mutation-positive metastatic melanoma: 2-year follow-up data and long-term responders' analysis.

artículo científico publicado en 2017

Phase I study evaluating the safety and efficacy of oral panobinostat in combination with radiotherapy or chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer

artículo científico publicado en 2015

Phase II study evaluating efficacy and safety of everolimus with letrozole for management of advanced (unresectable or metastatic) non-small cell lung cancer after failure of platinum-based treatment: a preliminary analysis of toxicity.

artículo científico publicado en 2014

Phase II trial of continuous once-daily dosing of sunitinib as first-line treatment in patients with metastatic renal cell carcinoma.

artículo científico publicado en 2011

Postchemotherapy and Tumor-Selective Targeting with the La-Specific DAB4 Monoclonal Antibody Relates to Apoptotic Cell Clearance

artículo científico publicado en 2014

Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to drozitumab therapy

artículo científico publicado en 2013

Prolonged and severe myelosuppression in two patients after low-dose temozolomide treatment- case study and review of literature.

artículo científico publicado en 2007

Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases.

artículo científico publicado en 2012

Recombinant fowlpox virus elicits transient cytotoxic T cell responses due to suboptimal innate recognition and recruitment of T cell help

artículo científico publicado en 2008

Risk of cumulative toxicity after complete melanoma response with pembrolizumab

artículo científico publicado en 2017

Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus.

artículo científico publicado en 2015

Sentinel node biopsy for melanoma: The medical oncology perspective

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

scientific journal article

Suppression of androgen receptor signaling in prostate cancer cells by an inhibitory receptor variant.

artículo científico publicado en 2006

T-cell recognition of a prostate specific antigen is not sufficient to induce prostate tissue destruction

article

Targeted α-therapy using 227Th-APOMAB and cross-fire antitumour effects: preliminary in-vivo evaluation.

artículo científico publicado en 2014

The La Autoantigen Is a Malignancy-Associated Cell Death Target That Is Induced by DNA-Damaging Drugs

artículo científico publicado en 2007

The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®.

artículo científico publicado en 2014

The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT.

artículo científico publicado en 2014

The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells.

artículo científico publicado en 2014

The potential role of fowlpox virus in rational vaccine design

artículo científico publicado en 2006

The use of vemurafenib in Australian patients with unresectable or metastatic melanoma containing the V600 BRAF gene mutation

artículo científico publicado en 2014

Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice

artículo científico publicado en 1998

Transforming growth factor-β-mediated signaling in T lymphocytes impacts on prostate-specific immunity and early prostate tumor progression

Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

artículo científico publicado en 2013

Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436).

artículo científico publicado en 2013

Unravelling the complexity of cancer-immune system interplay

artículo científico publicado en 2010

Vedolizumab: a novel treatment for ipilimumab-induced colitis

artículo científico publicado en 2016

Vemurafenib in patients with BRAF(V600) mutated metastatic melanoma: an open-label, multicentre, safety study.

artículo científico publicado en 2014

Lista de obras de Michael P. Brown

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

A phase 2 study of tasisulam sodium (LY573636 sodium) as second-line treatment for patients with unresectable or metastatic melanoma

A phase I study of the GM-CSF antagonist E21R

A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.

A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution

APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy

Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells. A model for immunotherapy.

An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant

An open-label, multicentre safety study of vemurafenib in patients with BRAFV600-mutant metastatic melanoma: final analysis and a validated prognostic scoring system

Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition

Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy.

Autoradiography imaging in targeted alpha therapy with Timepix detector

Breast cancer stem cells: treatment resistance and therapeutic opportunities

CD40 is not detected on human prostate cancer cells by immunohistologic techniques

CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice

Can cancer registries show whether treatment is contributing to survival increases for melanoma of the skin at a population level?

Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors

Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study

Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man.

Could bystander killing contribute significantly to the antitumor activity of brentuximab vedotin given with standard first-line chemotherapy for Hodgkin lymphoma?

Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy

Current and emerging immunotherapeutic approaches to treat and prevent peanut allergy

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.

Dasatinib alters the metastatic phenotype of B16-OVA melanoma in vivo

Dasatinib inhibits recombinant viral antigen-specific murine CD4+ and CD8+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo

Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

Detection of TNF alpha and Fas ligand mRNA within synovial mononuclear cells by fluorescence in-cell labeling PCR (FICL-PCR).

Development of a transmission alpha particle dosimetry technique using A549 cells and a Ra-223 source for targeted alpha therapy.

Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2.

Do Human Lymphocyte Antigens Play a Role in the Clinical Antimelanoma Activity of Ipilimumab? ⬇️

Dose selection, pharmacokinetics, and pharmacodynamics of BRAF inhibitor dabrafenib (GSK2118436).

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

Eosinophilic fasciitis as a paraneoplastic phenomenon associated with metastatic colorectal carcinoma

Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care

Expression of Drosophila Ca2+ permeable transient receptor potential-like channel protein in a prostate cancer cell line decreases cell survival.

Feasibility and kinetics of CD34+ hematopoietic progenitor cell mobilization in response to a single administration of docetaxel chemotherapy and pegfilgrastim in a contemporary cohort of patients with metastatic breast cancer

Feasibility of adding everolimus to carboplatin and paclitaxel, with or without bevacizumab, for treatment-naive, advanced non-small cell lung cancer

First-in-Man Dose-Escalation Study of the Selective BRAF Inhibitor RG7256 in Patients with BRAF V600-Mutated Advanced Solid Tumors.

Flt3 ligand expands dendritic cell numbers in normal and malignant murine prostate

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade

Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma

Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy

Human Flt-3 ligand-mobilized dendritic cells require additional activation to drive effective immune responses

Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells

Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation.

Improving vaccines by incorporating immunological coadjuvants

In vivo targeting of dead tumor cells in a murine tumor model using a monoclonal antibody specific for the La autoantigen

Induction of both cellular and humoral immunity following a rational prime-boost immunization regimen that incorporates recombinant ovine atadenovirus and fowlpox virus

Innate immune recognition of poxviral vaccine vectors

Is the Induction of Tumor Cell Senescence the Key to a Good Irradiated Tumor Vaccine? ⬇️

Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy

Multifunctional core-shell magnetic cisplatin nanocarriers

Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling

Nutlin-3a is a potential therapeutic for ewing sarcoma

Open-label, multicentre safety study of vemurafenib in 3219 patients with BRAFV600 mutation-positive metastatic melanoma: 2-year follow-up data and long-term responders' analysis.

Phase I study evaluating the safety and efficacy of oral panobinostat in combination with radiotherapy or chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer

Phase II study evaluating efficacy and safety of everolimus with letrozole for management of advanced (unresectable or metastatic) non-small cell lung cancer after failure of platinum-based treatment: a preliminary analysis of toxicity.

Phase II trial of continuous once-daily dosing of sunitinib as first-line treatment in patients with metastatic renal cell carcinoma.

Postchemotherapy and Tumor-Selective Targeting with the La-Specific DAB4 Monoclonal Antibody Relates to Apoptotic Cell Clearance

Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to drozitumab therapy

Prolonged and severe myelosuppression in two patients after low-dose temozolomide treatment- case study and review of literature.

Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases.

Recombinant fowlpox virus elicits transient cytotoxic T cell responses due to suboptimal innate recognition and recruitment of T cell help

Risk of cumulative toxicity after complete melanoma response with pembrolizumab

Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus.

Sentinel node biopsy for melanoma: The medical oncology perspective

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

Suppression of androgen receptor signaling in prostate cancer cells by an inhibitory receptor variant.

T-cell recognition of a prostate specific antigen is not sufficient to induce prostate tissue destruction

Targeted α-therapy using 227Th-APOMAB and cross-fire antitumour effects: preliminary in-vivo evaluation.

The La Autoantigen Is a Malignancy-Associated Cell Death Target That Is Induced by DNA-Damaging Drugs

The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®.

The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT.

The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells.

The potential role of fowlpox virus in rational vaccine design

The use of vemurafenib in Australian patients with unresectable or metastatic melanoma containing the V600 BRAF gene mutation

Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice

Transforming growth factor-β-mediated signaling in T lymphocytes impacts on prostate-specific immunity and early prostate tumor progression