Lista de obras - Carlo Ballatore - Dominio Público Uruguay

1,2,4-Triazolo[1,5-a]pyrimidines in drug design

artículo científico publicado en 2019

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

artículo científico publicado en 2018

A facile route to paclitaxel C-10 carbamates

artículo científico publicado en 2005

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.

artículo científico publicado en 2015

Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.

artículo científico publicado en 2012

Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497.

artículo científico publicado en 2014

Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D

artículo científico publicado en 2016

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis

artículo científico publicado en 2018

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies

artículo científico publicado en 2014

Carboxylic acid (bio)isosteres in drug design

artículo científico publicado en 2013

Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro

scientific article published on 31 October 2020

Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists

artículo científico publicado en 2011

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

artículo científico publicado en 1999

Design, Synthesis, and Evaluation of An Anti‐trypanosomal [1,2,4]Triazolo[1,5‐<i>a</i>]pyrimidine Probe for Photoaffinity Labeling Studies

artículo científico publicado en 2024

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines

scientific article published on 05 May 2018

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors

artículo científico publicado en 2013

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

scientific article published on 01 February 2000

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy ⬇️

artículo científico publicado el 13 de octubre de 2010

Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-<i>a</i>]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies

artículo científico publicado en 2021

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group

artículo científico publicado en 2014

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

artículo científico publicado en 2007

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

artículo científico publicado en 2009

Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells.

artículo científico publicado en 2006

Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.

artículo científico publicado en 1998

Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies

artículo científico publicado en 2012

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

artículo científico publicado en 2014

Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies

artículo científico publicado en 2011

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

artículo científico publicado en 2016

Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies

artículo científico publicado en 2007

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine

artículo científico publicado en 2015

Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists

artículo científico publicado en 2014

Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

scientific article published on 04 February 2020

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

artículo científico publicado en 2015

Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.

artículo científico publicado en 1999

Solid phase synthesis of 2-aminobenzothiazoles

artículo científico publicado en 2009

Structure Property Relationships of Carboxylic Acid Isosteres

artículo científico publicado en 2016

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

artículo científico publicado en 2001

Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand

artículo científico publicado en 2006

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

artículo científico publicado en 2007

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies ⬇️

artículo científico publicado el 14 de diciembre de 2010

The design, synthesis, and evaluation of two universal doxorubicin-linkers: preparation of conjugates that retain topoisomerase II activity

scientific article published on 18 October 2005

The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.

artículo científico publicado en 1999

Lista de obras de Carlo Ballatore

1,2,4-Triazolo[1,5-a]pyrimidines in drug design

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

A facile route to paclitaxel C-10 carbamates

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.

Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.

Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497.

Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies

Carboxylic acid (bio)isosteres in drug design

Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro

Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

Design, Synthesis, and Evaluation of An Anti‐trypanosomal [1,2,4]Triazolo[1,5‐<i>a</i>]pyrimidine Probe for Photoaffinity Labeling Studies

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy ⬇️

Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-<i>a</i>]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells.

Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.

Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine

Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists

Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.

Solid phase synthesis of 2-aminobenzothiazoles

Structure Property Relationships of Carboxylic Acid Isosteres

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies ⬇️

The design, synthesis, and evaluation of two universal doxorubicin-linkers: preparation of conjugates that retain topoisomerase II activity

The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.