Lista de obras - Dirk Fasshauer - Dominio Público Uruguay

A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function

artículo científico publicado en 2000

A Structural Change Occurs upon Binding of Syntaxin to SNAP-25

scientific article published in Journal of Biological Chemistry

A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex

artículo científico publicado en 2010

A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.

artículo científico publicado en 2009

A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion

artículo científico publicado en 2007

A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly

artículo científico publicado en 2003

ADP ribosylation factor and a 14-kD polypeptide are associated with heparan sulfate-carrying post-trans-Golgi network secretory vesicles in rat hepatocytes.

artículo científico publicado en 1994

ARF and VAPP14: two proteins involved in the delivery of heparan sulfate proteoglycan from the trans-Golgi network to the plasma membrane

artículo científico publicado en 1994

Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain.

artículo científico publicado en 2005

An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system

artículo científico publicado en 2007

BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy

artículo científico publicado en 2021

Budding insights on cell polarity

article published in 2007

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

artículo científico publicado en 1998

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

artículo científico publicado en 1998

Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide

artículo científico publicado en 2003

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs

artículo científico publicado en 2002

Determinants of synaptobrevin regulation in membranes

artículo científico publicado en 2007

Differences in the SNARE evolution of fungi and metazoa.

artículo científico publicado en 2009

Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies

artículo científico publicado en 2007

Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals.

artículo científico publicado en 2017

Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies.

artículo científico publicado en 2017

Getting Nervous: An Evolutionary Overhaul for Communication

artículo científico publicado en 2017

High Cell Diversity and Complex Peptidergic Signaling Underlie Placozoan Behavior

scientific article published on 18 October 2018

Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling

artículo científico publicado en 2001

Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression

scientific journal article

Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly

scientific journal article

Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes

artículo científico publicado en 2008

Is assembly of the SNARE complex enough to fuel membrane fusion?

artículo científico publicado en 2009

Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

artículo científico publicado en 1999

Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties

artículo científico publicado en 1999

Molecular machines governing exocytosis of synaptic vesicles

artículo científico publicado en 2012

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

artículo científico publicado en 2012

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

artículo científico publicado en 2008

N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane Fusion

artículo científico publicado en 2006

Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.

artículo científico publicado en 2014

PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2

artículo científico publicado en 2020

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

artículo científico publicado en 2013

Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi

artículo científico publicado en 2009

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

artículo científico publicado en 2011

Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis

artículo científico publicado en 2002

SNARE assembly and disassembly exhibit a pronounced hysteresis

artículo científico publicado en 2002

SNAREing the basis of multicellularity: consequences of protein family expansion during evolution

artículo científico publicado en 2008

Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions

artículo científico publicado en 2000

Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles

artículo científico publicado en 2006

Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.

artículo científico publicado en 2016

Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion

artículo científico publicado en 2009

Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion

scientific article published in 2010

Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1.

artículo científico publicado en 2003

Structural Changes Are Associated with SolubleN-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

artículo científico publicado en 1997

Structural basis for the inhibitory role of tomosyn in exocytosis

scientific journal article

Structural insights into the SNARE mechanism

artículo científico publicado en 2003

Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis

artículo científico publicado en 2010

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

artículo científico publicado en 2007

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation

artículo científico publicado en 2013

The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate

artículo científico publicado en 2009

The Habc domain and the SNARE core complex are connected by a highly flexible linker

scientific journal article

The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis

artículo científico publicado en 2003

The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex

artículo científico publicado en 2014

Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis

artículo científico publicado en 2012

Lista de obras de Dirk Fasshauer

A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function

A Structural Change Occurs upon Binding of Syntaxin to SNAP-25

A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex

A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.

A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion

A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly

ADP ribosylation factor and a 14-kD polypeptide are associated with heparan sulfate-carrying post-trans-Golgi network secretory vesicles in rat hepatocytes.

ARF and VAPP14: two proteins involved in the delivery of heparan sulfate proteoglycan from the trans-Golgi network to the plasma membrane

Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain.

An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system

BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy

Budding insights on cell polarity

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs

Determinants of synaptobrevin regulation in membranes

Differences in the SNARE evolution of fungi and metazoa.

Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies

Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals.

Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies.

Getting Nervous: An Evolutionary Overhaul for Communication

High Cell Diversity and Complex Peptidergic Signaling Underlie Placozoan Behavior

Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling

Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression

Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly

Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes

Is assembly of the SNARE complex enough to fuel membrane fusion?

Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties

Molecular machines governing exocytosis of synaptic vesicles

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane Fusion

Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.

PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis

SNARE assembly and disassembly exhibit a pronounced hysteresis

SNAREing the basis of multicellularity: consequences of protein family expansion during evolution

Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions

Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles

Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.

Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion

Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion

Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1.

Structural Changes Are Associated with SolubleN-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

Structural basis for the inhibitory role of tomosyn in exocytosis

Structural insights into the SNARE mechanism

Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation

The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate

The Habc domain and the SNARE core complex are connected by a highly flexible linker

The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis

The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex

Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis