Lista de obras - Sam Hay - Dominio Público Uruguay

1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol

artículo científico publicado en 2016

A common mechanism for coenzyme cobalamin-dependent reductive dehalogenases

artículo científico publicado en 2017

A perspective on conformational control of electron transfer in nitric oxide synthases

artículo científico publicado en 2016

A quantitative fluorescence-based steady-state assay of DNA polymerase

artículo científico publicado en 2014

An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

artículo científico publicado en 2016

Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

scientific article published on 01 January 2008

Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?

artículo científico publicado en 2009

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

artículo científico publicado en 2008

Barrier compression and its contribution to both classical and quantum mechanical aspects of enzyme catalysis.

artículo científico publicado en 2010

Barrier compression enhances an enzymatic hydrogen-transfer reaction.

artículo científico publicado en 2009

Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase

artículo científico publicado en 2009

Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays

artículo científico publicado en 2015

Chelator-Based Parameterization of the 12-6-4 Lennard-Jones Molecular Mechanics Potential for More Realistic Metal Ion–Protein Interactions

artículo científico publicado en 2022

Conformational and Thermodynamic Control of Electron Transfer in Neuronal Nitric Oxide Synthase†

scientific article published on 06 April 2007

Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy.

artículo científico publicado en 2007

Convergence of theory and experiment on the role of preorganization, quantum tunneling and enzyme motions into flavoenzyme-catalyzed hydride transfer.

artículo científico publicado en 2017

Conversion of the Escherichia coli cytochrome b562 to an archetype cytochrome b: a mutant with bis-histidine ligation of heme iron

artículo científico publicado en 2005

Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation

artículo científico publicado en 2008

Correlating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic Trap

artículo científico publicado en 2016

DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis

artículo científico publicado en 2007

Decoupled Associative and Dissociative Processes in Strong yet Highly Dynamic Host-Guest Complexes.

artículo científico publicado en 2017

Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase

artículo científico publicado en 2008

Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases

artículo científico publicado en 2009

Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions

artículo científico publicado en 2010

Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?

artículo científico publicado en 2015

Donor-Acceptor Distance Sampling Enhances the Performance of "Better than Nature" Nicotinamide Coenzyme Biomimetics.

artículo científico publicado en 2016

Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex.

artículo científico publicado en 2008

Dual transcriptional-translational cascade permits cellular level tuneable expression control.

artículo científico

Dynamic, electrostatic model for the generation and control of high-energy radical intermediates by a coenzyme B₁₂-dependent enzyme.

artículo científico publicado en 2013

Electrochemical and structural properties of a protein system designed to generate tyrosine Pourbaix diagrams

artículo científico publicado en 2011

Energy landscapes and catalysis in nitric-oxide synthase

artículo científico publicado en 2014

Enzymatic C-H activation of aromatic compounds through CO2 fixation

artículo científico publicado en 2020

Enzymatic Single-Molecule Kinetic Isotope Effects

scientific article published on 19 February 2013

Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase

artículo científico publicado en 2019

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification.

artículo científico publicado en 2015

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol--methyltransferase

Evaluating spectral overlap with the degree of quenching in UCP luminescence energy transfer systems

artículo científico publicado en 2019

Evidence of preorganization in quinonoid intermediate formation from L-Trp in H463F mutant Escherichia coli tryptophan indole-lyase from effects of pressure and pH.

artículo científico publicado en 2012

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction

artículo científico publicado en 2009

Examining the importance of dynamics, barrier compression and hydrogen tunnelling in enzyme catalysed reactions

article published in 2011

Excited state dynamics can be used to probe donor-acceptor distances for H-tunneling reactions catalyzed by flavoproteins

artículo científico publicado en 2013

Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors

Fast protein motions are coupled to enzyme H-transfer reactions

artículo científico publicado en 2013

Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.

artículo científico publicado en 2011

Good vibrations in enzyme-catalysed reactions

artículo científico publicado en 2012

Graphene-aramid nanocomposite fibres via superacid co-processing

artículo científico publicado en 2019

Ground-State Destabilization by Phe-448 and Phe-449 Contributes to Tyrosine Phenol-Lyase Catalysis

H-transfers in Photosystem II: what can we learn from recent lessons in the enzyme community?

artículo científico publicado en 2008

Incorporation of hydrostatic pressure into models of hydrogen tunneling highlights a role for pressure-modulated promoting vibrations

artículo científico publicado en 2008

Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism.

artículo científico publicado en 2008

Is There a Dynamic Protein Contribution to the Substrate Trigger in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase?

scientific article published on 22 September 2011

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

artículo científico

Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase

artículo científico publicado en 2007

Making a single-chain four-helix bundle for redox chemistry studies

artículo científico publicado en 2008

MhuD from Mycobacterium tuberculosis: Probing a Dual Role in Heme Storage and Degradation

scientific article published on 11 September 2019

Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.

artículo científico publicado en 2013

Moving a phenol hydroxyl group from the surface to the interior of a protein: effects on the phenol potential and pK(A).

artículo científico publicado en 2005

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

artículo científico publicado en 2007

Nature of the Energy Landscape for Gated Electron Transfer in a Dynamic Redox Protein

artículo científico publicado en 2010

New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition. ⬇️

artículo científico publicado en 2015

Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

artículo científico publicado en 2018

Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

scientific article published on 01 December 2015

O21. Ca2+-calmodulin exerts thermodynamic and conformational regulation over electron transport in nNOS

Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure

artículo científico publicado en 2009

Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin

scientific article published on 23 May 2019

Practical aspects on the use of kinetic isotope effects as probes of flavoprotein enzyme mechanisms

artículo científico publicado en 2014

Preparation and photophysical properties of a caged kynurenine

artículo científico publicado en 2012

Pressure Effects on Enzyme-Catalyzed Quantum Tunneling Events Arise from Protein-Specific Structural and Dynamic Changes

artículo científico publicado en 2012

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol.

artículo científico publicado en 2018

Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed 'deep' H-tunnelling reaction

artículo científico publicado en 2010

Probing reversible chemistry in coenzyme B12 -dependent ethanolamine ammonia lyase with kinetic isotope effects

artículo científico publicado en 2015

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects

artículo científico publicado en 2007

Protein engineering of cytochrome b562 for quinone binding and light-induced electron transfer

artículo científico publicado en 2004

Protein motions are coupled to the reaction chemistry in coenzyme B12-dependent ethanolamine ammonia lyase

artículo científico publicado en 2012

Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment

artículo científico publicado en 2007

Proton tunnelling and promoting vibrations during the oxidation of ascorbate by ferricyanide?

article

Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors

artículo científico publicado en 2014

Real-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome c

artículo científico publicado en 2015

Redox characteristics of a de novo quinone protein

artículo científico publicado en 2007

Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation

artículo científico publicado en 2014

Relating localized protein motions to the reaction coordinate in coenzyme B₁₂-dependent enzymes

artículo científico publicado en 2013

Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions

artículo científico publicado en 2008

Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase.

artículo científico publicado en 2008

Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling

artículo científico publicado en 2009

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

artículo científico publicado en 2015

Time Course Analysis of Enzyme-Catalyzed DNA Polymerization

artículo científico publicado en 2016

Towards the free energy landscape for catalysis in mammalian nitric oxide synthases.

artículo científico

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

scientific journal article

Ultrafast infrared spectral fingerprints of vitamin B12 and related cobalamins

artículo científico publicado en 2012

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis

artículo científico publicado en 2019

Untangling heavy protein and cofactor isotope effects on enzyme- catalyzed hydride transfer.

artículo científico publicado en 2016

What are the signatures of tunnelling in enzyme-catalysed reactions?

artículo científico publicado en 2019

Zero-point energy and tunnelling: general discussion

artículo científico publicado en 2019

α-Secondary Isotope Effects as Probes of “Tunneling-Ready” Configurations in Enzymatic H-Tunneling: Insight from Environmentally Coupled Tunneling Models

article

Lista de obras de Sam Hay

1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol

A common mechanism for coenzyme cobalamin-dependent reductive dehalogenases

A perspective on conformational control of electron transfer in nitric oxide synthases

A quantitative fluorescence-based steady-state assay of DNA polymerase

An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

Barrier compression and its contribution to both classical and quantum mechanical aspects of enzyme catalysis.

Barrier compression enhances an enzymatic hydrogen-transfer reaction.

Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase

Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays

Chelator-Based Parameterization of the 12-6-4 Lennard-Jones Molecular Mechanics Potential for More Realistic Metal Ion–Protein Interactions

Conformational and Thermodynamic Control of Electron Transfer in Neuronal Nitric Oxide Synthase†

Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy.

Convergence of theory and experiment on the role of preorganization, quantum tunneling and enzyme motions into flavoenzyme-catalyzed hydride transfer.

Conversion of the Escherichia coli cytochrome b562 to an archetype cytochrome b: a mutant with bis-histidine ligation of heme iron

Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation

Correlating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic Trap

DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis

Decoupled Associative and Dissociative Processes in Strong yet Highly Dynamic Host-Guest Complexes.

Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase

Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases

Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions

Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?

Donor-Acceptor Distance Sampling Enhances the Performance of "Better than Nature" Nicotinamide Coenzyme Biomimetics.

Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex.

Dual transcriptional-translational cascade permits cellular level tuneable expression control.

Dynamic, electrostatic model for the generation and control of high-energy radical intermediates by a coenzyme B₁₂-dependent enzyme.

Electrochemical and structural properties of a protein system designed to generate tyrosine Pourbaix diagrams

Energy landscapes and catalysis in nitric-oxide synthase

Enzymatic C-H activation of aromatic compounds through CO2 fixation

Enzymatic Single-Molecule Kinetic Isotope Effects

Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification.

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol--methyltransferase

Evaluating spectral overlap with the degree of quenching in UCP luminescence energy transfer systems

Evidence of preorganization in quinonoid intermediate formation from L-Trp in H463F mutant Escherichia coli tryptophan indole-lyase from effects of pressure and pH.

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction

Examining the importance of dynamics, barrier compression and hydrogen tunnelling in enzyme catalysed reactions

Excited state dynamics can be used to probe donor-acceptor distances for H-tunneling reactions catalyzed by flavoproteins

Expanding the Scope of Biomolecule Monitoring with Ratiometric Signaling from Rare-Earth Upconverting Phosphors

Fast protein motions are coupled to enzyme H-transfer reactions

Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.

Good vibrations in enzyme-catalysed reactions

Graphene-aramid nanocomposite fibres via superacid co-processing

Ground-State Destabilization by Phe-448 and Phe-449 Contributes to Tyrosine Phenol-Lyase Catalysis

H-transfers in Photosystem II: what can we learn from recent lessons in the enzyme community?

Incorporation of hydrostatic pressure into models of hydrogen tunneling highlights a role for pressure-modulated promoting vibrations

Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism.

Is There a Dynamic Protein Contribution to the Substrate Trigger in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase?

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase

Making a single-chain four-helix bundle for redox chemistry studies

MhuD from Mycobacterium tuberculosis: Probing a Dual Role in Heme Storage and Degradation

Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.

Moving a phenol hydroxyl group from the surface to the interior of a protein: effects on the phenol potential and pK(A).

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

Nature of the Energy Landscape for Gated Electron Transfer in a Dynamic Redox Protein

New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition. ⬇️

Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

Nuclear quantum tunnelling in enzymatic reactions – an enzymologist's perspective

O21. Ca2+-calmodulin exerts thermodynamic and conformational regulation over electron transport in nNOS

Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure

Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin

Practical aspects on the use of kinetic isotope effects as probes of flavoprotein enzyme mechanisms

Preparation and photophysical properties of a caged kynurenine

Pressure Effects on Enzyme-Catalyzed Quantum Tunneling Events Arise from Protein-Specific Structural and Dynamic Changes

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol.

Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed 'deep' H-tunnelling reaction

Probing reversible chemistry in coenzyme B12 -dependent ethanolamine ammonia lyase with kinetic isotope effects

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects

Protein engineering of cytochrome b562 for quinone binding and light-induced electron transfer

Protein motions are coupled to the reaction chemistry in coenzyme B12-dependent ethanolamine ammonia lyase

Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment

Proton tunnelling and promoting vibrations during the oxidation of ascorbate by ferricyanide?

Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors

Real-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome c

Redox characteristics of a de novo quinone protein