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Lista de obras de John R. Falck

(Z)-alpha-haloacrylates: an exceptionally stereoselective preparation via Cr(II)-mediated olefination of aldehydes with trihaloacetates

scientific article published on 01 March 2003

11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta

artículo científico publicado en 2008

11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression

artículo científico publicado en 2003

11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells

artículo científico publicado en 2006

14,15-Dihydroxy-eicosa-5(Z)-enoic Acid Selectively Inhibits 14,15-Epoxyeicosatrienoic Acid-Induced Relaxations in Bovine Coronary Arteries ⬇️

artículo científico publicado el 29 de septiembre de 2010

14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.

artículo científico publicado en 2004

14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries

artículo científico publicado en 2002

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

artículo científico publicado en 2009

14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries

artículo científico publicado en 2003

14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries

artículo científico publicado en 2005

16(R)-hydroxy-5,8,11,14-eicosatetraenoic acid, a new arachidonate metabolite in human polymorphonuclear leukocytes

scientific article published on 01 August 2000

17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues

artículo científico publicado en 2011

19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension

scientific article published on 13 August 2019

2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion.

artículo científico publicado en 2004

20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction

artículo científico publicado en 2008

20-HETE can act as a nonhypoxic regulator of HIF-1alpha in human microvascular endothelial cells.

artículo científico publicado en 2009

20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats

artículo científico publicado en 2001

20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.

artículo científico publicado en 2008

20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells

artículo científico publicado en 2009

20-HETE mediates the effect of parathyroid hormone and protein kinase C on renal phosphate transport.

artículo científico publicado en 1998

20-HETE pathway antagonists inhibit rat small mesenteric artery tone

artículo científico publicado en 2002

20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.

artículo científico publicado en 2010

20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase

artículo científico publicado en 2006

20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: Photoaffinity Labeling of a 14,15-Epoxyeicosatrienoic Acid Receptor ⬇️

artículo científico publicado el 15 de abril de 2011

20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma

scientific article published on 15 June 2006

20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling

artículo científico publicado en 2009

20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells.

artículo científico publicado en 2003

20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction

artículo científico publicado en 2003

20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.

artículo científico publicado en 2007

3(S)-hydroxy-leukotriene B4 is a potent granulocyte chemotaxin in the guinea pig dermis

scientific article published on 01 August 1995

5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.

artículo científico publicado en 2013

5,6-epoxyeicosatrienoic acid mediates the enhanced renal vasodilation to arachidonic acid in the SHR.

artículo científico publicado en 2003

8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.

artículo científico publicado en 2009

9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A.

artículo científico publicado en 2005

A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.

artículo científico publicado en 2008

A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3-NLRP3 Pathway

artículo científico publicado en 2020

A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes

artículo científico publicado en 2005

A convenient preparation of 3-substituted furans: synthesis of perillene and dendrolasin

artículo científico publicado en 2002

A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid

artículo científico publicado en 2012

A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones

artículo científico publicado en 2003

A role for heterocellular coupling and EETs in dilation of rat cremaster arteries

artículo científico publicado en 2006

A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels.

artículo científico publicado en 2011

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins

artículo científico publicado en 2004

A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins

artículo científico publicado en 2006

Abdominal Surgical Incision Induces Remote Preconditioning of Trauma (RPCT) via Activation of Bradykinin Receptors (BK2R) and the Cytochrome P450 Epoxygenase Pathway in Canine Hearts ⬇️

artículo científico publicado el 1 de diciembre de 2011

Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.

artículo científico publicado en 2007

Acylation of glucosaminyl phosphatidylinositol revisited. Palmitoyl-CoA dependent palmitoylation of the inositol residue of a synthetic dioctanoyl glucosaminyl phosphatidylinositol by hamster membranes permits efficient mannosylation of the glucosam

scientific article published on 01 October 1996

Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ

artículo científico publicado en 2013

Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway

scientific journal article

Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.

artículo científico publicado en 2008

Aging increases cytochrome P450 4A modulation of alpha1-adrenergic vasoconstriction in mesenteric arteries

artículo científico publicado en 2008

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

artículo científico publicado en 2001

Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats

artículo científico publicado en 2001

Alternative pathways for Heck intermediates: palladium-catalyzed oxyarylation of homoallylic alcohols

artículo científico publicado en 2011

Amide-directed tandem C-C/C-N bond formation through C-H activation.

artículo científico

An Economic and Practical Synthesis of the 2-Tetrahydrofuranyl Ether Protective Group

artículo científico publicado en 2006

An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase

scientific article published on 01 January 1997

An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.

artículo científico publicado en 2002

Analysis of oxidized glycerophosphocholine lipids using electrospray ionization mass spectrometry and microderivatization techniques

scientific article published on 01 February 2000

Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs.

artículo científico publicado en 2011

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.

artículo científico publicado en 2008

Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells

artículo científico publicado en 2001

Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways.

artículo científico publicado en 2008

Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding

artículo científico publicado en 1999

Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and adenophostin A

scientific article published on 01 March 2000

Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator

artículo científico publicado en 2004

Asymmetric total synthesis of (+)-fostriecin

artículo científico publicado en 2002

Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases.

artículo científico publicado en 2002

Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids

artículo científico publicado en 2005

Bromo-boronolactonization of olefins

artículo científico publicado en 2001

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy

artículo científico publicado en 2013

CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)

artículo científico publicado en 2011

CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension.

artículo científico publicado en 2009

CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent

artículo científico publicado en 2010

Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity

artículo científico publicado en 2000

Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid

artículo científico publicado en 1999

Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes

artículo científico publicado en 2006

Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells

artículo científico publicado en 2005

Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury

artículo científico publicado en 2011

Cascade synthesis of (E)-2-alkylidenecyclobutanols

scientific article published on October 2009

Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization.

artículo científico publicado en 2017

Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes

scientific journal article

Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases

artículo científico publicado en 2004

Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding

artículo científico publicado en 2007

Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids

artículo científico publicado en 2005

Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid

artículo científico publicado en 2008

Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).

artículo científico publicado en 2005

Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling

scientific article published on 01 December 2003

Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites

artículo científico publicado en 2006

Chromium vinylidene carbenoids: generation, characterization, and reactivity. First evidence for an internal proton return phenomenon with vinylidene carbenoids

artículo científico publicado en 2001

Chromium vinylidene carbenoids: stereospecific synthesis of (Z)-2-chloroalk-2-en-1-ols

artículo científico publicado en 2001

Chromium-carbyne complexes: intermediates for organic synthesis

artículo científico publicado en 2007

Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD

artículo científico publicado en 2009

Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.

artículo científico publicado en 2010

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock

artículo científico publicado en 2013

Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.

artículo científico publicado en 2010

Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles

artículo científico publicado en 2003

Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

artículo científico publicado en 2000

Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid

artículo científico publicado en 2006

Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes.

artículo científico publicado en 2011

Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination

scientific article published on 01 March 2019

Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.

artículo científico publicado en 2005

Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling

artículo científico publicado en 2006

Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.

artículo científico publicado en 2005

Cytochrome P450 epoxygenases provide a novel mechanism for penile erection

artículo científico publicado en 2006

Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer

artículo científico publicado en 2010

Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells

artículo científico publicado en 2004

Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats

artículo científico publicado en 2004

Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay

scientific article published on 01 March 1997

Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs

artículo científico publicado en 2001

Determination of trans-arachidonic acid isomers in human blood plasma

artículo científico publicado en 2004

Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents

scientific article published on 19 November 2019

Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions

artículo científico publicado en 2010

Differential Cleavage of Arylmethyl Ethers: Reactivity of 2,6-Dimethoxybenzyl Ethers Financial support was provided by the Robert A. Welch Foundation, NIH (GM31278, DK38226), CNRS, Instituts de Recherche Pierre Fabre (to R.B.), and an unrestricted g

Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension

artículo científico publicado en 2001

Dimethylthiocarbamate (DMTC): an alcohol protecting group

scientific article published on 01 December 2003

Diphospho-myo-inositol phosphates in Dictyostelium and Polysphondylium: identification of a new bisdiphospho-myo-inositol tetrakisphosphate

scientific article published on 01 April 1998

Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism.

artículo científico publicado en 2009

Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.

artículo científico publicado en 2007

EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels

artículo científico publicado en 2011

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

artículo científico publicado en 2012

Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts.

artículo científico publicado en 2013

Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle

article

Effects of a 20-HETE antagonist and agonists on cerebral vascular tone

artículo científico publicado en 2004

Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries

artículo científico publicado en 2004

Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection

artículo científico publicado en 2005

Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

artículo científico publicado en 2008

Efficient iridium-catalyzed C-H functionalization/silylation of heteroarenes

artículo científico publicado en 2008

Eicosanoid Regulation of Vascular Endothelial Growth Factor Expression and Angiogenesis in Microvessel Endothelial Cells

artículo científico publicado en 2002

Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats.

scientific article published on 24 October 2008

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

artículo científico publicado en 2006

Enalapril treatment alters the contribution of epoxyeicosatrienoic acids but not gap junctions to endothelium-derived hyperpolarizing factor activity in mesenteric arteries of spontaneously hypertensive rats

artículo científico publicado en 2009

Endogenously produced 20-HETE modulates myogenic and TGF response in microperfused afferent arterioles.

artículo científico publicado en 2013

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice

artículo científico publicado en 2011

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

artículo científico publicado en 2010

Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries

artículo científico publicado en 2006

Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries

artículo científico publicado en 2004

Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid

artículo científico publicado en 2001

Epoxyeicosanoids promote organ and tissue regeneration.

artículo científico publicado en 2013

Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ

artículo científico publicado en 2010

Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model

artículo científico publicado en 2008

Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo.

artículo científico publicado en 2011

Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.

artículo científico publicado en 2008

Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury

artículo científico publicado en 2006

Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

artículo científico publicado en 2009

Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors.

artículo científico publicado en 2004

Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response

artículo científico publicado en 2013

Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells

artículo científico publicado en 2007

Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition

artículo científico publicado en 2005

Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin

artículo científico publicado en 2001

Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions

artículo científico publicado en 1984

Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation.

artículo científico publicado en 2003

Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells

artículo científico publicado en 2005

Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation

artículo científico publicado en 2004

Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.

artículo científico publicado en 2010

Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids

artículo científico publicado en 2005

Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction

artículo científico publicado en 2012

Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats.

artículo científico publicado en 2008

Fe(0)-mediated synthesis of tri- and tetra-substituted olefins from carbonyls: an environmentally friendly alternative to Cr(II).

artículo científico publicado en 2006

Functional coupling of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate receptor

artículo científico publicado en 1998

Generation of Nucleophilic Chromium Acetylides from gem-Trichloroalkanes and Chromium Chloride: Synthesis of Propargyl Alcohols

artículo científico publicado en 2010

Global identification of O-GlcNAc-modified proteins

artículo científico publicado en 2006

Glomerular autacoids stimulated by bradykinin regulate efferent arteriole tone

artículo científico publicado en 2003

Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance

artículo científico publicado en 2005

Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin

artículo científico publicado en 2012

Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo ⬇️

artículo científico publicado el 14 de enero de 2011

Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes

artículo científico publicado en 2008

Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.

artículo científico publicado en 2012

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

artículo científico publicado en 1997

High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle

artículo científico publicado en 2006

Highly stereoselective synthesis of (Z,E)-1-halo-1,3-dienol esters via rearrangement of Fischer chromium chloro-carbenes using microwave irradiation

artículo científico publicado en 2009

Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta

artículo científico publicado en 2008

Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells

artículo científico publicado en 2004

Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue

scientific journal article

Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta

artículo científico publicado en 1998

Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats: effects of tempol.

artículo científico publicado en 2010

Impairment of flow-induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive and hypertensive rats

artículo científico publicado en 2000

Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.

artículo científico publicado en 2012

Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats.

artículo científico publicado en 2011

Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats

artículo científico publicado en 2007

Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction.

artículo científico publicado en 2012

Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation

artículo científico publicado en 2005

Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury

artículo científico publicado en 2010

Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists.

artículo científico publicado en 2010

Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.

artículo científico publicado en 2006

Inhibition of telomerase by BIBR 1532 and related analogues

scientific article published on 01 April 2003

Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex

artículo científico publicado en 2008

Intramolecular N-Me and N-H aminoetherification for the synthesis of <i>N</i>-unprotected 3-amino-O-heterocycles

artículo científico publicado en 2021

Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.

artículo científico publicado en 2010

Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats

artículo científico publicado en 2013

Iridium-catalyzed (Z)-trialkylsilylation of terminal olefins.

artículo científico publicado en 2010

Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid

artículo científico publicado en 2001

Lysine propionylation and butyrylation are novel post-translational modifications in histones

artículo científico publicado en 2007

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides

artículo científico publicado en 2011

Measurement of 20-hydroxyeicosatetraenoic acid in human urine by gas chromatography-mass spectrometry

artículo científico publicado en 2004

Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes

scientific article published on 01 October 2000

Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid

artículo científico publicado en 2006

Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells.

artículo científico publicado en 2006

Mechanisms of carbon monoxide attenuation of tubuloglomerular feedback.

artículo científico publicado en 2012

Metabolism of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE) in corneal tissues: formation of novel metabolites

scientific article published on 01 November 1991

Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes

artículo científico publicado en 1992

Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta

artículo científico publicado en 2003

Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites.

artículo científico publicado en 1996

Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis

artículo científico publicado en 1993

Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.

artículo científico publicado en 1995

Microsomal cytochrome P450 and eicosanoid metabolism

scientific article published on 01 May 2002

Mild and rapid hydroxylation of aryl/heteroaryl boronic acids and boronate esters with N-oxides

artículo científico publicado en 2012

Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats

artículo científico publicado en 2010

Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.

artículo científico publicado en 2010

Modulation of V1-receptor-mediated renal vasoconstriction by epoxyeicosatrienoic acids.

artículo científico publicado en 2004

Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats

artículo científico publicado en 2009

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform

artículo científico publicado en 1995

Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.

artículo científico publicado en 1997

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.

artículo científico publicado en 2007

N-acylsulfonamide assisted tandem C-H olefination/annulation: synthesis of isoindolinones

artículo científico publicado en 2011

NO and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat.

artículo científico publicado en 2004

Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries

artículo científico publicado en 2004

Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat.

artículo científico publicado en 2005

Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity.

artículo científico publicado en 2013

Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-tr

artículo científico publicado en 2003

Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.

artículo científico publicado en 2005

Orally active epoxyeicosatrienoic acid analog attenuates kidney injury in hypertensive Dahl salt-sensitive rat.

artículo científico publicado en 2013

Ovariectomy, but not estrogen deficiency, increases CYP4A modulation of alpha(1)-adrenergic vasoconstriction in aging female rats.

artículo científico publicado en 2008

Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production

artículo científico publicado en 2006

P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid

artículo científico publicado en 2004

P450BM-3: absolute configuration of the primary metabolites of palmitic acid

scientific article published on 01 June 1999

Pd-catalyzed cross-coupling of α-(acyloxy)-tri-n-butylstannanes with alkenyl, aryl, and heteroaryl electrophiles

artículo científico publicado en 2010

Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.

artículo científico publicado en 2007

Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets

artículo científico publicado en 1995

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

artículo científico publicado en 2003

Phosphorylation of a synaptic vesicle-associated protein by an inositol hexakisphosphate-regulated protein kinase

artículo científico publicado en 2001

Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase

scientific article published on 01 December 1995

Picolinate-Directed Arene meta-C-H Amination via FeCl3 Catalysis

artículo científico publicado en 2020

Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells ⬇️

artículo científico publicado el 1 de julio de 1997

Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

artículo científico publicado en 2003

Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2)

artículo científico publicado en 2000

Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks

artículo científico publicado en 2006

Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats.

artículo científico publicado en 2011

Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels

artículo científico publicado en 2009

Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury

artículo científico publicado en 2008

Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures.

artículo científico publicado en 2012

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation

artículo científico publicado en 2006

Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

artículo científico publicado en 2007

ROS-sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice.

artículo científico publicado en 2006

Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry

artículo científico publicado en 2009

Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog

artículo científico publicado en 2007

Recombinant p42IP4, a brain-specific 42-kDa high-affinity Ins(1,3,4,5)P4 receptor protein, specifically interacts with lipid membranes containing Ptd-Ins(3,4,5)P3.

artículo científico publicado en 1999

Red blood cells: reservoirs of cis- and trans-epoxyeicosatrienoic acids

artículo científico publicado en 2005

Reductive olefination of aldehydes via chromium Brook rearrangement

artículo científico publicado en 2006

Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase

artículo científico publicado en 2005

Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor.

artículo científico publicado en 2006

Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.

artículo científico publicado en 2011

Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries

artículo científico publicado en 2001

Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats

artículo científico publicado en 2005

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells

artículo científico publicado en 2007

Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats

artículo científico publicado en 2005

Rhodium catalyzed C-H olefination of N-benzoylsulfonamides with internal alkenes

artículo científico publicado en 2011

Rhodium catalyzed synthesis of isoindolinones via C-H activation of N-benzoylsulfonamides

artículo científico publicado en 2012

Rhodium(I)-catalyzed N-CN bond cleavage: intramolecular β-cyanation of styrenes

artículo científico publicado en 2013

Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation

artículo científico publicado en 2011

Ring expansion/homologation--aldehyde condensation cascade using tert-trihalomethylcarbinols

artículo científico publicado en 2006

Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.

artículo científico publicado en 2009

Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery

artículo científico publicado en 2005

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav ⬇️

artículo científico publicado el 23 de enero de 1998

Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries ⬇️

artículo científico publicado el 30 de diciembre de 2010

Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.

artículo científico publicado en 2008

Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier.

artículo científico publicado en 2007

Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes

artículo científico publicado en 2010

Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta

artículo científico publicado en 2005

Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries

artículo científico publicado en 2001

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function

artículo científico publicado en 2006

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.

artículo científico publicado en 2007

Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.

artículo científico publicado en 2010

Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels

artículo científico publicado en 2003

Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.

artículo científico publicado en 2011

Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension

artículo científico publicado en 2008

Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation

artículo científico publicado en 2005

Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs

artículo científico publicado en 2011

Stereocontrolled synthesis of α-amino-α'-alkoxy ketones by a copper-catalyzed cross-coupling of peptidic thiol esters and α-alkoxyalkylstannanes.

artículo científico publicado en 2011

Stereoselective transformations of trihalomethylcarbinols induced by chromous chloride

artículo científico publicado en 2005

Stereospecific Stille Cross-Couplings Using Mn(II)Cl2.

artículo científico publicado en 2018

Stereospecific Suzuki cross-coupling of alkyl alpha-cyanohydrin triflates.

artículo científico publicado en 2010

Stereospecific cross-coupling of alpha-(thiocarbamoyl)organostannanes with alkenyl, aryl, and heteroaryl iodides

artículo científico publicado en 2007

Stereospecific synthesis of trans-arachidonic acids

artículo científico publicado en 2001

Steroid-producing cells regulate arterial tone of adrenal cortical arteries.

artículo científico publicado en 2007

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding

artículo científico publicado en 2011

Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR.

artículo científico publicado en 2008

Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3.

artículo científico publicado en 2001

Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase

artículo científico publicado en 2007

Synthesis and stereochemical assignment of FR252921, a promising immunosuppressant

artículo científico publicado en 2007

Synthesis of enantioenriched alpha-(hydroxyalkyl)-tri-n-butylstannanes

artículo científico publicado en 2008

Synthesis, structural identification and biological activity of 11,12-dihydroxyeicosatetraenoic acids formed in human platelets

artículo científico publicado en 1991

Tagging-via-substrate strategy for probing O-GlcNAc modified proteins.

artículo científico publicado en 2005

Targeting QseC signaling and virulence for antibiotic development

artículo científico publicado en 2008

The Cytochrome P450 Inhibitor Ketoconazole Potentiates 5-Hydroxytryptamine-Induced Contraction in Rat Aorta

artículo científico publicado en 2007

The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production

scientific article published on 16 July 2018

The Roles of Intrarenal 20-Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acids in the Regulation of Renal Function in Hypertensive Ren-2 Transgenic Rats

artículo científico publicado en 2007

The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury

scientific article published on 06 July 2018

The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood

artículo científico publicado en 2011

The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase

artículo científico publicado en 2003

The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3

scientific article published in 1996

The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.

artículo científico publicado en 1997

The mechanism of oleic acid nitration by *NO(2).

artículo científico publicado en 2008

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

artículo científico publicado en 2004

The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation

artículo científico publicado en 2005

The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents.

artículo científico publicado en 2007

Total Synthesis of (±)-Halomon by a Johnson-Claisen Rearrangement

artículo científico publicado en 1998

Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration

artículo científico publicado en 2005

Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor.

artículo científico publicado en 1999

Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels

artículo científico publicado en 2005

Two distinct pathways account for EDHF-dependent dilatation in the gracilis artery of dyslipidaemic hApoB+/+ mice.

artículo científico publicado en 2005

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