Lista de obras - Jeffrey N Johnston - Dominio Público Uruguay

1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis using Diverted Umpolung Amide Synthesis

artículo científico publicado en 2017

A Preparation of enantiomerically enriched axially chiral beta-diketimines: synthesis of (-)- and (+)-IAN amine

scientific article published on 14 May 2008

A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines

artículo científico publicado en 2015

A chiral N-phosphinyl phosphoramide: another offspring for the sage phosphoric acid progenitor ⬇️

artículo científico publicado el 15 de febrero de 2011

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions

artículo científico publicado en 2017

A diastereo- and enantioselective synthesis of alpha-substituted anti-alpha,beta-diaminophosphonic acid derivatives

artículo científico publicado en 2008

A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids

artículo científico publicado en 2008

A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids

scientific article published on 18 September 2008

A one-pot amidation of primary nitroalkanes

artículo científico publicado en 2016

Achiral Counterion Control of Enantioselectivity in a Brønsted Acid-Catalyzed Iodolactonization ⬇️

artículo científico publicado el 30 de marzo de 2012

Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis

artículo científico publicado en 2015

Alkene diamination using electron-rich amines: hypervalent iodine-promoted inter-/intramolecular C-N bond formation

artículo científico publicado en 2014

Application of an S --> O Allylic Transposition in the Context of a Bridgehead Olefinic System. New Opportunities for the Structural Modification of Bicyclo[6.2.1]undecanes via Transannular Ring Closure.

artículo científico publicado en 1998

Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

artículo científico publicado en 2010

Biomimetic Desymmetrization of a Carboxylic Acid

artículo científico publicado en 2018

Bronsted acid-promoted olefin aziridination and formal anti-aminohydroxylation

artículo científico publicado en 2005

Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction

artículo científico publicado en 2009

Brønsted acid catalyzed phosphoramidic acid additions to alkenes: diastereo- and enantioselective halogenative cyclizations for the synthesis of C- and P-chiral phosphoramidates

artículo científico publicado en 2014

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism

artículo científico publicado en 2018

Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor

artículo científico publicado en 2011

Chiral Brønsted Base-Promoted Nitroalkane Alkylation: Enantioselective Synthesis of sec-Alkyl-3-Substituted Indoles ⬇️

artículo científico publicado el 19 de noviembre de 2010

Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor

artículo científico publicado en 2012

Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

artículo científico publicado en 2004

Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents

scientific article published on 07 March 2007

Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

artículo científico publicado en 2018

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle

artículo científico publicado en 2016

Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution

artículo científico publicado en 2018

Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18 O-labeling ⬇️

artículo científico publicado el 19 de diciembre de 2011

Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.

artículo científico publicado en 2015

Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas

scientific article published on 19 November 2018

Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes

artículo científico publicado en 2015

Enantioselective Synthesis of α-Bromonitroalkanes for Umpolung Amide Synthesis: Preparation of tert-Butyl ((1R)-1-(4-(benzyloxy)phenyl)-2-bromo-2-nitroethyl)carbamate

artículo científico publicado en 2016

Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.

artículo científico publicado en 2016

Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes

artículo científico publicado en 2001

Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst.

artículo científico publicado en 2015

Enantioselective synthesis of α-oxy amides via Umpolung amide synthesis

artículo científico publicado en 2012

Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides

artículo científico publicado en 2018

Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis

artículo científico publicado en 2003

Free radical-mediated aryl amination: convergent two- and three-component couplings to chiral 2,3-disubstituted indolines

artículo científico publicado en 2008

Free radical-mediated vinyl amination: access to N,N-dialkyl enamines and their beta-stannyl and beta-thio derivatives

artículo científico publicado en 2002

Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate Reductase ⬇️

artículo científico publicado en 2011

IAN-amines: direct entry to a chiral C(2)-symmetric zirconium(IV) beta-diketimine complex

artículo científico publicado en 2002

MDM2 Antagonists Counteract Drug-Induced DNA Damage.

artículo científico publicado en 2017

Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells

artículo científico publicado en 2014

Nonconventional carbon additions to azomethines. aryl amination/indoline synthesis by direct aryl radical addition to azomethine nitrogen

artículo científico publicado en 2001

On the nature of rate acceleration in the synthesis and fragmentation of triazolines by Brønsted acid: secondary catalysis by water (hydronium triflate).

artículo científico publicado en 2008

On-Demand Complex Peptide Synthesis: An Aspirational (and Elusive?) Goal for Peptide Synthesis.

artículo científico publicado en 2016

Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition

artículo científico publicado en 2014

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

artículo científico publicado en 2012

Origins of selectivity in Brønsted acid-promoted diazoalkane-azomethine reactions (the aza-Darzens aziridine synthesis)

artículo científico publicado en 2011

Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines

artículo científico publicado en 2015

PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE

artículo científico publicado en 2011

Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.

scientific article published on 15 October 2013

Preparation of H,(4) PyrrolidineQuin-BAM (PBAM).

artículo científico publicado en 2012

Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy

scientific article published on 28 August 2006

Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control.

artículo científico publicado en 2016

Silyl imine electrophiles in enantioselective catalysis: a Rosetta Stone for peptide homologation, enabling diverse N-protected aryl glycines from aldehydes in three steps

artículo científico publicado en 2014

Stereoselective synthesis of complex polycyclic aziridines: use of the Brønsted acid-catalyzed aza-Darzens reaction to prepare an orthogonally protected mitomycin C intermediate with maximal convergency

artículo científico publicado en 2011

Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator

scientific article published on 15 October 2020

Synthesis of an advanced intermediate en route to the mitomycin natural products.

artículo científico publicado en 2006

The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements

artículo científico publicado en 2003

The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis.

artículo científico publicado en 2018

To protonate or alkylate? Stereoselective Brønsted acid catalysis of C-C bond formation using diazoalkanes.

artículo científico publicado en 2010

Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.

artículo científico publicado en 2012

Total synthesis of the chlorine-containing hapalindoles K, A, and G.

artículo científico publicado en 2011

Total synthesis of the lycopodium alkaloid (+)-serratezomine A.

artículo científico publicado en 2009

Umpolung amide synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen as a terminal oxidant

artículo científico publicado en 2014

Umpolung reactivity in amide and peptide synthesis

artículo científico publicado en 2010

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

scientific article published on 21 February 2019

Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N-->N proton transfer.

artículo científico publicado en 2009

Use of the vicinal element effect for regiochemical control of quinone substitutions and its implication for convergent mitomycin construction

artículo científico publicado en 2001

VNI cures acute and chronic experimental Chagas disease

artículo científico publicado en 2013

Lista de obras de Jeffrey N Johnston

1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis using Diverted Umpolung Amide Synthesis

A Preparation of enantiomerically enriched axially chiral beta-diketimines: synthesis of (-)- and (+)-IAN amine

A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines

A chiral N-phosphinyl phosphoramide: another offspring for the sage phosphoric acid progenitor ⬇️

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions

A diastereo- and enantioselective synthesis of alpha-substituted anti-alpha,beta-diaminophosphonic acid derivatives

A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids

A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids

A one-pot amidation of primary nitroalkanes

Achiral Counterion Control of Enantioselectivity in a Brønsted Acid-Catalyzed Iodolactonization ⬇️

Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis

Alkene diamination using electron-rich amines: hypervalent iodine-promoted inter-/intramolecular C-N bond formation

Application of an S --> O Allylic Transposition in the Context of a Bridgehead Olefinic System. New Opportunities for the Structural Modification of Bicyclo[6.2.1]undecanes via Transannular Ring Closure.

Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

Biomimetic Desymmetrization of a Carboxylic Acid

Bronsted acid-promoted olefin aziridination and formal anti-aminohydroxylation

Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction

Brønsted acid catalyzed phosphoramidic acid additions to alkenes: diastereo- and enantioselective halogenative cyclizations for the synthesis of C- and P-chiral phosphoramidates

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism

Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor

Chiral Brønsted Base-Promoted Nitroalkane Alkylation: Enantioselective Synthesis of sec-Alkyl-3-Substituted Indoles ⬇️

Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor

Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents

Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle

Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution

Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18 O-labeling ⬇️

Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.

Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas

Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes

Enantioselective Synthesis of α-Bromonitroalkanes for Umpolung Amide Synthesis: Preparation of tert-Butyl ((1R)-1-(4-(benzyloxy)phenyl)-2-bromo-2-nitroethyl)carbamate

Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.

Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes

Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst.

Enantioselective synthesis of α-oxy amides via Umpolung amide synthesis

Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides

Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis

Free radical-mediated aryl amination: convergent two- and three-component couplings to chiral 2,3-disubstituted indolines

Free radical-mediated vinyl amination: access to N,N-dialkyl enamines and their beta-stannyl and beta-thio derivatives

Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate Reductase ⬇️

IAN-amines: direct entry to a chiral C(2)-symmetric zirconium(IV) beta-diketimine complex

MDM2 Antagonists Counteract Drug-Induced DNA Damage.

Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells

Nonconventional carbon additions to azomethines. aryl amination/indoline synthesis by direct aryl radical addition to azomethine nitrogen

On the nature of rate acceleration in the synthesis and fragmentation of triazolines by Brønsted acid: secondary catalysis by water (hydronium triflate).

On-Demand Complex Peptide Synthesis: An Aspirational (and Elusive?) Goal for Peptide Synthesis.

Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

Origins of selectivity in Brønsted acid-promoted diazoalkane-azomethine reactions (the aza-Darzens aziridine synthesis)

Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines

PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE

Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.

Preparation of H,(4) PyrrolidineQuin-BAM (PBAM).

Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy

Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control.

Silyl imine electrophiles in enantioselective catalysis: a Rosetta Stone for peptide homologation, enabling diverse N-protected aryl glycines from aldehydes in three steps

Stereoselective synthesis of complex polycyclic aziridines: use of the Brønsted acid-catalyzed aza-Darzens reaction to prepare an orthogonally protected mitomycin C intermediate with maximal convergency

Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator

Synthesis of an advanced intermediate en route to the mitomycin natural products.

The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements

The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis.

To protonate or alkylate? Stereoselective Brønsted acid catalysis of C-C bond formation using diazoalkanes.

Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.

Total synthesis of the chlorine-containing hapalindoles K, A, and G.

Total synthesis of the lycopodium alkaloid (+)-serratezomine A.

Umpolung amide synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen as a terminal oxidant

Umpolung reactivity in amide and peptide synthesis

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N-->N proton transfer.

Use of the vicinal element effect for regiochemical control of quinone substitutions and its implication for convergent mitomycin construction

VNI cures acute and chronic experimental Chagas disease