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Lista de obras de Jeffrey Aubé

(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection

artículo científico publicado en 2012

1,3-allylic strain as a strategic diversification element for constructing libraries of substituted 2-arylpiperidines.

artículo científico publicado en 2011

3-Substituted Biquinolinium Inhibitors of AraC Family Transcriptional Activator VirF from S. flexneri Obtained Through In Situ Chemical Ionization of 3,4-Disubstituted Dihydroquinolines

artículo científico publicado en 2014

A Combined Intramolecular Diels–Alder/Intramolecular Schmidt Reaction: Formal Synthesis of (±)-Stenine

artículo científico publicado en 2002

A New Twist on Amide Solvolysis ⬇️

artículo científico publicado el 22 de febrero de 2012

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition

artículo científico publicado en 2012

A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence

artículo científico publicado en 2014

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

artículo científico publicado en 2001

A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry

artículo científico publicado en 2012

A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C

artículo científico publicado en 2010

Ab initio approach to understanding the stereoselectivity of reactions between hydroxyalkyl azides and ketones

artículo científico publicado en 2004

An Interrupted Schmidt Reaction: C-C Bond Formation Arising from Nitrilium Ion Capture

artículo científico publicado en 2018

An RNA-binding protein, Hu-antigen R, in pancreatic cancer epithelial to mesenchymal transition, metastasis, and cancer stem cells

scientific article published on 02 September 2020

An efficient computational model to predict protonation at the amide nitrogen and reactivity along the C-N rotational pathway

artículo científico publicado en 2015

An expeditious total synthesis of (+/-)-stenine

artículo científico publicado en 2005

Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A

artículo científico publicado en 2018

Asymmetric Schmidt reaction of hydroxyalkyl azides with ketones.

artículo científico publicado en 2003

Asymmetric Total Synthesis of Dendrobatid Alkaloids:  Preparation of Indolizidine 251F and Its 3-Desmethyl Analogue Using an Intramolecular Schmidt Reaction Strategy

artículo científico publicado en 2004

Asymmetric total synthesis of alkaloids 223A and 6-epi-223A

artículo científico publicado en 2009

Asymmetric total synthesis of dendrobatid alkaloid 251F.

artículo científico publicado en 2002

Automated three-component synthesis of a library of γ-lactams.

artículo científico publicado en 2012

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

scientific article published on 09 July 2019

Base-promoted reactions of bridged ketones and 1,3- and 1,4-haloalkyl azides: competitive alkylation vs azidation reactions of ketone enolates

artículo científico publicado en 2004

Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users

artículo científico publicado en 2013

Butitaxel analogues: synthesis and structure-activity relationships

scientific article published on 01 January 1997

Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates

scientific article published on 09 September 2019

Cation-n control of regiochemistry of intramolecular Schmidt reactions en route to bridged bicyclic lactams

artículo científico publicado en 2009

Cation-pi control of regiochemistry of intramolecular schmidt reactions en route to bridged bicyclic lactams

artículo científico publicado en 2007

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

artículo científico publicado en 2013

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

artículo científico publicado en 2014

Chemistry of bridged lactams and related heterocycles

artículo científico publicado en 2013

Chemotype-selective modes of action of κ-opioid receptor agonists

scientific article published on 11 October 2013

Copper-catalyzed oxaziridine-mediated oxidation of C-H bonds.

artículo científico publicado en 2012

Corey-Chaykovsky epoxidation of twisted amides: synthesis and reactivity of bridged spiro-epoxyamines.

scientific article published on September 2009

Correction to "Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis"

artículo científico publicado en 2019

Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease

artículo científico publicado en 1999

Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus

artículo científico publicado en 2014

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

artículo científico publicado en 2017

Development of functionally selective, small molecule agonists at kappa opioid receptors

artículo científico publicado en 2013

Discovery and Development of Small Molecules That Reduce PNC Prevalence

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

artículo científico publicado en 2012

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

artículo científico publicado en 2014

Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

scientific article published on 28 April 2020

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

Domino reactions that combine an azido-Schmidt ring expansion with the Diels-Alder reaction

scientific article published on 01 December 2004

Double conjugate addition of a nitropropionate ester to a quinone monoketal: synthesis of an advanced intermediate to (+/-)-gelsemine.

artículo científico publicado en 2007

Drug repurposing and the medicinal chemist.

artículo científico publicado en 2012

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis

scientific article published on 11 June 2019

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

artículo científico publicado en 2019

Effect of progressive benzyl substitution on the conformations of aminocaproic acid-cyclized dipeptides.

artículo científico publicado en 2001

Effect of stereochemistry on the transport of Aca-linked β-turn peptidomimetics across a human intestinal cell line ⬇️

artículo científico publicado el 1 de septiembre de 1997

Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence

artículo científico publicado en 2008

Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification

artículo científico publicado en 2008

Facile C−N Cleavage in a Series of Bridged Lactams

scientific article published in 2005

First asymmetric total synthesis of (+)-sparteine

artículo científico publicado en 2002

G protein signaling–biased agonism at the κ-opioid receptor is maintained in striatal neurons

article

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors

artículo científico publicado en 2015

High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity

artículo científico publicado en 2011

Highly stereoselective ring expansion reactions mediated by attractive cation-n interactions

artículo científico publicado en 2008

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A

artículo científico publicado en 2019

Hydrolysis of Iminium Ethers Derived from the Reaction of Ketones with Hydroxy Azides: Synthesis of Macrocyclic Lactams and Lactones

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

artículo científico publicado en 2012

Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol

scientific article published on 29 December 2015

In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave‐Assisted Flow Format ⬇️

artículo científico publicado el 27 de julio de 2011

Intramolecular and Intermolecular Schmidt Reactions of Alkyl Azides with Aldehydes.

artículo científico publicado en 2007

Intramolecular reactions of benzylic azides with ketones: competition between Schmidt and Mannich pathways

scientific article published on 01 February 2001

Lewis acid-mediated reactions of alkyl azides with alpha,beta-unsaturated ketones.

artículo científico publicado en 2003

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

artículo científico publicado en 2019

Mechanism of the acid-promoted intramolecular schmidt reaction: theoretical assessment of the importance of lone pair-cation, cation-π, and steric effects in controlling regioselectivity

artículo científico publicado en 2011

Medium-bridged lactams: a new class of non-planar amides

artículo científico publicado en 2010

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

artículo científico publicado en 2018

Minor withanolides of Physalis longifolia: structure and cytotoxicity.

artículo científico publicado en 2012

Modular synthesis of cyclic peptidomimetics inspired by gamma-turns

artículo científico publicado en 2005

Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection

artículo científico publicado en 2018

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands

artículo científico publicado en 2010

Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.

artículo científico publicado en 2015

Nonbonded, attractive cation-pi interactions in azide-mediated asymmetric ring expansion reactions

artículo científico publicado en 2008

Nucleophilic addition to iminium ethers in the preparation of functionalized N-alkyl heterocycles

artículo científico publicado en 2007

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

artículo científico publicado en 2019

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity

artículo científico publicado en 2014

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline

artículo científico publicado en 2012

Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif

artículo científico publicado en 2014

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.

artículo científico publicado en 2014

Probing chemical space with alkaloid-inspired libraries

artículo científico publicado en 2014

Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers

artículo científico publicado en 2010

Reactions of cyclopropanone acetals with alkyl azides: carbonyl addition versus ring-opening pathways

artículo científico publicado en 2007

Reactivity toward deamidation of asparagine residues in beta-turn structures.

artículo científico publicado en 2000

Reagent-controlled regiodivergent ring expansions of steroids.

artículo científico publicado en 2018

Rearrangements of bicyclic nitrones to lactams: comparison of photochemical and modified Barton conditions

artículo científico publicado en 2003

Regiochemical studies of the ring expansion reactions of hydroxy azides with cyclic ketones

scientific article published on 01 June 2000

Regioselective single and double conjugate additions to substituted cyclohexa-2,5-dienone monoacetals

artículo científico publicado en 2005

Remote control of diastereoselectivity in intramolecular reactions of chiral allylsilanes.

artículo científico publicado en 2006

Resolution of Carboxylic Acids Using Copper(I)-Promoted Removal of Propargylic Esters under Neutral Conditions ⬇️

artículo científico publicado el 14 de abril de 2011

Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine.

artículo científico publicado en 2005

Ring expansive routes to quinolizidine alkaloids: formal synthesis of (-)-lasubine II

scientific article published on 01 December 2003

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor

artículo científico publicado en 2017

Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation

artículo científico publicado en 2022

Small-molecule libraries: naturally inspired oligomers

scientific article published on 24 January 2012

Solution-phase parallel synthesis of a library of delta(2)-pyrazolines

artículo científico publicado en 2007

Stability of medium-bridged twisted amides in aqueous solutions

artículo científico publicado en 2009

Stereocontrol in a combined allylic azide rearrangement and intramolecular Schmidt reaction

artículo científico publicado en 2012

Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones

artículo científico publicado en 2013

Stereoselective Synthesis of Freidinger Lactams Using Oxaziridines Derived from Amino Acids

scientific article published on 01 February 1997

Stereoselectivity in nucleophilic additions to 3-azidoalkanals.

artículo científico publicado en 2011

Structural characterization of N-protonated amides: regioselective N-activation of medium-bridged twisted lactams

artículo científico publicado en 2010

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

artículo científico publicado en 2018

Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction

artículo científico publicado en 2008

Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues.

artículo científico publicado en 2013

Synthesis and conformational studies of dipeptides constrained by disubstituted 3-(aminoethoxy)propionic acid linkers

artículo científico publicado en 2004

Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication.

artículo científico publicado en 1998

Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes

artículo científico publicado en 2011

Synthesis and rearrangement of a bridged thioamide

artículo científico publicado en 2009

Synthesis and structural study of cyclic 5-aminovaleric acid-linked beta-Ala-beta-Ala dipeptides

artículo científico publicado en 2008

Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence

artículo científico publicado en 2007

Synthesis of a small library of diketopiperazines as potential inhibitors of calpain.

artículo científico publicado en 2005

Synthesis of enantiomerically enriched (R)-5-tert-butylazepan-2-one using a hydroxyalkyl azide mediated ring-expansion reaction

artículo científico publicado en 2008

Synthesis of the Nonribosomal Peptide Phevalin and Analogs

scientific article published on 01 March 2019

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).

artículo científico publicado en 2018

Synthetic probes for the study of biological function

artículo científico publicado en 2013

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype

scientific article published on 08 August 2019

Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

artículo científico publicado en 2020

Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction.

artículo científico publicado en 2015

Three-component synthesis of 1,4-diazepin-5-ones and the construction of gamma-turn-like peptidomimetic libraries

artículo científico publicado en 2008

Transport characteristics of peptides and peptidomimetics: I. N-methylated peptides as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa.

artículo científico publicado en 2001

Transport characteristics of peptides and peptidomimetics: II. Hydroxyethylamine bioisostere-containing peptidomimetics as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa.

artículo científico publicado en 2001

Unusual tethering effects in the Schmidt reaction of hydroxyalkyl azides with ketones: cation-pi and steric stabilization of a pseudoaxial phenyl group

artículo científico publicado en 2003

Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A.

artículo científico publicado en 2011

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