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Lista de obras de Tomàs Pumarola Suñé

A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study

artículo científico publicado en 2003

A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain.

artículo científico publicado en 2016

A monoclonal antibody that induces T cell aggregation reacts with vascular endothelial cells and placental trophoblasts.

artículo científico publicado en 1986

A pilot case-control study of zidovudine compared with zidovudine plus didanosine in patients with advanced HIV-1 disease and no previous experience with antiretrovirals

article

A prospective survey of human herpesvirus-6 primary infection in solid organ transplant recipients.

artículo científico publicado en 2006

A randomized study comparing triple versus double antiretroviral therapy or no treatment in HIV-1-infected patients in very early stage disease: the Spanish Earth-1 study.

artículo científico publicado en 1999

A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain)

artículo científico publicado en 2022

Acute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: clinical description and follow-up

artículo científico publicado en 2008

Analysis of Human Metapneumovirus and Human Bocavirus Viral Load

article

Antiretroviral activity of didanosine in patients with different clusters of reverse transcriptase mutations

artículo científico publicado en 2006

Antiviral activity of maca (Lepidium meyenii) against human influenza virus.

artículo científico publicado en 2014

Assessing the burden of paediatric influenza in Europe: the European Paediatric Influenza Analysis (EPIA) project

artículo científico publicado en 2010

Assessment of a Novel Automatic Real-Time PCR Assay on the Cobas 4800 Analyzer as a Screening Platform for Hepatitis C Virus Genotyping in Clinical Practice: Comparison with Massive Sequencing.

artículo científico publicado en 2016

Benefit of conjugate pneumococcal vaccination in preventing influenza hospitalization in children: a case-control study.

artículo científico publicado en 2013

Cerebrospinal fluid HIV-1 RNA levels in asymptomatic patients with early stage chronic HIV-1 infection: support for the hypothesis of local virus replication

artículo científico publicado en 1999

Changes in HIV-1 RNA Viral Load Following Tuberculin Skin Test

article

Changes in epidemiology, clinical features and severity of influenza A (H1N1) 2009 pneumonia in the first post-pandemic influenza season

artículo científico publicado en 2012

Circulation of a novel human respiratory syncytial virus Group B genotype during the 2014-2015 season in Catalonia (Spain).

artículo científico publicado en 2015

Clinical impact and efficacy of lamivudine therapy in de novo hepatitis B infection after liver transplantation

artículo científico publicado en 2002

Clinical relevance of mixed respiratory viral infections in adults with influenza A H1N1.

artículo científico publicado en 2011

Comparative analysis of methods for detecting resistance

artículo científico publicado en 2001

Comparison of immunologic restoration and virologic response in plasma, tonsillar tissue, and cerebrospinal fluid in HIV-1-infected patients treated with double versus triple antiretroviral therapy in very early stages: The Spanish EARTH-2 Study. Ea

artículo científico publicado en 2000

Comparison of twice-daily stavudine plus once- or twice-daily didanosine and nevirapine in early stages of HIV infection: the Scan Study

article

Conclusions of the workshop "Results and lessons learned during the pandemic flu (H1N1) 2009 from the research and the public health surveillance"

artículo científico publicado en 2011

Confirmation of HTLV-III virus in cornea

artículo científico publicado en 1986

Correction: No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.

artículo científico publicado en 2015

Creatine phosphokinase in leptospirosis

artículo científico publicado el 1 de noviembre de 1991

D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

artículo científico publicado en 2010

Determination of French influenza outbreaks periods between 1985 and 2011 through a web-based Delphi method

artículo científico publicado en 2013

Diagnóstico microbiológico de las infecciones virales respiratorias en el paciente adulto

artículo científico publicado en 2014

Dicrocoelium dendriticum: An Unusual Parasitological Diagnosis in a Reference International Health Unit

artículo científico publicado en 2016

Differences in sentinel influenza confirmed incidence rates and clinical presentation of influenza virus: 2008-09 seasonal vs 2009-10 pandemic influenza.

artículo científico publicado en 2011

Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain.

artículo científico publicado en 2013

Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza

artículo científico publicado en 2011

Dose-Finding Study of Once-Daily Indinavir/Ritonavir Plus Zidovudine and Lamivudine in HIV-Infected Patients

article

Double (V27A/S31N) mutant 2009 pandemic influenza A (H1N1) virus isolated from adamantane non-treated inmunocompetent child.

artículo científico publicado en 2010

Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy

artículo científico publicado en 1999

Early virological failure in treatment-naive HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine

artículo científico publicado en 2005

Economic Evaluation of Health Services Costs During Pandemic Influenza A (H1N1) Pdm09 Infection in Pregnant and Non-Pregnant Women in Spain

artículo científico publicado en 2016

Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia.

artículo científico publicado en 2011

Effect of mycophenolate mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection: a randomized pilot study.

artículo científico publicado en 2004

Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization

artículo científico publicado en 2012

Effectiveness of non-pharmaceutical measures in preventing pediatric influenza: a case-control study.

artículo científico publicado en 2015

Effectiveness of pandemic and seasonal influenza vaccines in preventing pandemic influenza-associated hospitalization

artículo científico publicado en 2012

Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons.

artículo científico publicado en 2013

Effectiveness of virosomal subunit influenza vaccine in preventing influenza-related illnesses and its social and economic consequences in children aged 3-14 years: a prospective cohort study.

artículo científico publicado en 2006

Effects of different antigenic stimuli on thymic function and interleukin-7/CD127 system in patients with chronic HIV infection

artículo científico publicado en 2014

El laboratorio de microbiología en el trasplante

scientific article published on 01 April 2007

Epidemiology and risk factors for late infection in solid organ transplant recipients.

artículo científico publicado en 2011

Erratum: Evaluation of a new, rapid, simple test for the detection of influenza virus

artículo científico publicado en 2015

Evaluation of a new, rapid, simple test for the detection of influenza virus

artículo científico publicado en 2015

Evaluation of the Roche COBAS® TaqMan® HIV-1 test for quantifying HIV-1 RNA in infected cells and lymphoid tissue

article

Evaluation of the usefulness of a quantitative blood culture in the diagnosis of catheter-related bloodstream infection: Comparative analysis of two periods (2002 and 2012).

artículo científico publicado en 2016

Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor

artículo científico publicado en 2005

First Enterovirus D68 (EV-D68) cases detected in hospitalised patients in a tertiary care university hospital in Spain, October 2014.

artículo científico publicado en 2015

First recurrence of Clostridium difficile infection: clinical relevance, risk factors, and prognosis.

artículo científico publicado en 2016

Frequency of apnea and respiratory viruses in infants with bronchiolitis

artículo científico publicado en 2014

GESIDA Consensus document on the use of resistance studies in clinical practice

artículo científico publicado en 2001

Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain

artículo científico publicado en 2011

Genotype and phenotype at baseline and at failure in human immunodeficiency virus-infected antiretroviral-naive patients in a randomized trial comparing zidovudine and lamivudine plus nelfinavir or nevirapine

artículo científico publicado en 2003

Genotypic and phenotypic resistance patterns in early-stage HIV-1-infected patients failing initial therapy with stavudine, didanosine and nevirapine.

artículo científico publicado en 2002

Gripe 2014

artículo científico publicado en 2014

HIV antigen in the brains of patients with the AIDS dementia complex

artículo científico publicado en 1987

HIV-1 DNA predicts disease progression and post-treatment virological control

artículo científico publicado en 2014

HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations

article

High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir

artículo científico publicado en 2005

Higher vaccine effectiveness in seasons with predominant circulation of seasonal influenza A(H1N1) than in A(H3N2) seasons: test-negative case-control studies using surveillance data, Spain, 2003-2011.

artículo científico publicado en 2014

Host adaptive immunity deficiency in severe pandemic influenza.

artículo científico publicado en 2010

Host-dependent editing of SARS-CoV-2 in COVID-19 patients

artículo científico publicado en 2021

Human herpesvirus 7 primary infection in kidney transplant recipients.

artículo científico publicado en 2008

Human herpesvirus type 6 and type 7 in transplant recipients

artículo científico publicado en 2003

Human immunodeficiency virus-infected patients with community-acquired pneumonia: implication of respiratory viruses

artículo científico publicado en 2008

Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence.

artículo científico publicado en 2005

Immunogenicity and acceptance of influenza A (H1N1) vaccine in a cohort of chronic hepatitis C patients receiving pegylated-interferon treatment

artículo científico publicado en 2012

Immunohistochemically proven cytomegalovirus end-organ disease in solid organ transplant patients: clinical features and usefulness of conventional diagnostic tests.

artículo científico publicado en 2007

Immunologic reconstitution after 1 year of highly active antiretroviral therapy, with or without protease inhibitors.

artículo científico publicado en 2002

Immunological and virological factors at baseline may predict response to structured therapy interruption in early stage chronic HIV-1 infection

artículo científico publicado en 2002

Immunosuppressed patients with pandemic influenza A 2009 (H1N1) virus infection

artículo científico publicado en 2011

Impact of influenza season and environmental factors on the clinical presentation and outcome of invasive pneumococcal disease

artículo científico publicado en 2014

Impact of valganciclovir prophylaxis on the development of severe late-cytomegalovirus disease in high-risk solid organ transplant recipients

artículo científico publicado en 2007

Incidence of respiratory viruses among travelers with a febrile syndrome returning from tropical and subtropical areas.

artículo científico publicado en 2008

Incidence of respiratory viruses in Peruvian children with acute respiratory infections.

artículo científico publicado en 2015

Infection with human herpesvirus 6 after kidney-pancreas transplant.

artículo científico publicado en 2004

Inflammatory responses in blood samples of human immunodeficiency virus-infected patients with pulmonary infections

artículo científico publicado en 2004

Influence of Age in Renal Transplant Infections: Cases and Controls Study

artículo científico publicado en 2005

Influence of Mannose-Binding Lectin Gene Polymorphisms on The Invasiveness of Cytomegalovirus Disease After Solid Organ Transplantation

article

Influence of a Vaccination Schedule on Viral Load Rebound and Immune Responses in Successfully Treated HIV-Infected Patients

article

Influence of cytomegalovirus disease in outcome of solid organ transplant patients.

artículo científico publicado en 2011

Influence of episodes of intermittent viremia ("blips") on immune responses and viral load rebound in successfully treated HIV-infected patients.

artículo científico publicado en 2012

Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine

artículo científico publicado en 2012

Influencia de las nuevas tecnologías en la microbiología moderna

artículo científico publicado en 2010

Influenza A(H1N1)pdm09 virus: viral characteristics and genetic evolution.

artículo científico publicado en 2012

Influenza A(H1N1)pdm09: beyond the pandemic.

artículo científico publicado en 2012

Influenza C virus surveillance during the first influenza A (H1N1) 2009 pandemic wave in Catalonia, Spain

artículo científico publicado en 2011

Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza

article

Influenza infection in the intensive care unit: Four years after the 2009 pandemic.

artículo científico publicado en 2015

Inhibitory quotient as a prognostic factor of response to a salvage antiretroviral therapy containing ritonavir-boosted saquinavir. The CIVSA Study

article

Lack of evidence of a stable viral load set-point in early stage asymptomatic patients with chronic HIV-1 infection

article

Leptospirosis. Review of 11 cases

artículo científico publicado en 1997

Long-term CD4+ T-cell response to highly active antiretroviral therapy according to baseline CD4+ T-cell count

artículo científico publicado en 2004

Long-term Clinical Follow-up, without Antiretroviral Therapy, of Patients with Chronic HIV-1 Infection with Good Virological Response to Structured Treatment Interruption

article

Lymphocyte subpopulations in Spanish parenteral drug addicts

artículo científico publicado en 1986

Lymphoid tissue viral burden and duration of viral suppression in plasma

artículo científico publicado en 2001

Manejo clínico de la infección aguda y crónica por el virus de la inmunodeficiencia humana antes del inicio del tratamiento antirretroviral

artículo científico publicado en 2011

Metaneumovirus humano

article

Microbiologic features and outcome of pneumonia in transplanted patients

artículo científico publicado en 2006

Microbiology of transplants

artículo científico publicado en 2011

Modelling the evolution and spread of HIV immune escape mutants

artículo científico publicado en 2010

Molecular epidemiology and molecular characterization of respiratory syncytial viruses at a tertiary care university hospital in Catalonia (Spain) during the 2013-2014 season.

artículo científico publicado en 2015

Monitoring anti-retroviral treatment

artículo científico publicado en 1996

Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.

artículo científico publicado en 2007

No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity

artículo científico publicado en 2015

Occupational risk of infection by human immunodeficiency virus

artículo científico publicado en 1988

Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain

artículo científico publicado en 2011

P18-07. Ex vivo production of autologous HIV-1 to be used as immunogen in autologous dendritic cell-based therapeutic vaccine (clinical trial DCV02).

artículo científico publicado en 2009

P20-06. Study of viral variability evolution in patients submitted to a therapeutic vaccine based on autologous dendritic cells pulsed with autologous HIV-1

article

Pandemic 2009 A(H1N1) infection requiring hospitalization of elderly Spanish adults

artículo científico publicado en 2012

Pandemic A/H1N1 influenza: transmission of the first cases in Spain

artículo científico publicado en 2011

Pandemic influenza A (H1N1) infection in pregnant and nonpregnant women in Spain (2009-2010).

artículo científico publicado en 2014

Pandemic influenza A(H1N1) outbreak among a group of medical students who traveled to the Dominican Republic.

artículo científico publicado en 2011

Performance evaluation of the ADVIA Centaur® HIV Ag/Ab Combo assay

article

Persistence of yellow fever vaccine RNA in urine.

artículo científico publicado en 2011

Pharmacokinetics and pharmacodynamics of low dose mycophenolate mofetil in HIV-infected patients treated with abacavir, efavirenz and nelfinavir.

artículo científico publicado en 2005

Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants

artículo científico publicado en 2011

Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection

artículo científico publicado en 2012

Population dynamics and antigenic drift of Bordetella pertussis following whole cell vaccine replacement, Barcelona, Spain, 1986-2015

scientific article published on 01 January 2019

Predictive factors influencing peak viral load drop in response to nucleoside reverse transcriptase inhibitors in antiretroviral-naive HIV-1-infected patients

artículo científico publicado en 1998

Predictive factors of severe multilobar pneumonia and shock in patients with influenza.

artículo científico publicado en 2013

Predictors of progression in chronically infected naive patients with plasma viraemia below 5000 copies/ml and CD4 T lymphocytes greater than 500 × 106/l

artículo científico publicado en 2001

Predictors of tonsillar tissue HIV-1 viral burden at baseline and after 1 year of antiretroviral therapy

article

Prevalence of antitetanus antibodies in pregnant women from Catalonia

artículo científico publicado en 1989

Prevalence of hepatitis B markers in the population of Catalonia (Spain). Rationale for universal vaccination of adolescents

artículo científico publicado el 1 de septiembre de 1992

Prevalence of human immunodeficiency virus in an infertile population.

artículo científico publicado en 1991

Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy

artículo científico publicado en 2011

Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors.

artículo científico publicado en 2012

Prognostic factors of non-HIV immunocompromised patients with pulmonary infiltrates

artículo científico publicado en 2002

Prolonged Zika Virus Viremia during Pregnancy

artículo científico publicado en 2016

Prospective serological study of leptospirosis in Southern Spain

article

Pulmonary Infiltrates in HIV-Infected Patients in the Highly Active Antiretroviral Therapy Era in Spain

artículo científico publicado en 2001

Pulmonary infiltrates in immunosuppressed patients: analysis of a diagnostic protocol.

artículo científico publicado en 2002

Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic procedures.

artículo científico publicado en 2001

Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3.

artículo científico publicado en 2004

Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy

artículo científico publicado en 2000

Restoration of T Cell Responses to Toxoplasma gondii after Successful Combined Antiretroviral Therapy in Patients with AIDS with Previous Toxoplasmic Encephalitis

article

Results of routine syphilitic and human immunodeficiency virus (HIV) serology in infertility

artículo científico publicado en 1992

Risk factors and effectiveness of preventive measures against influenza in the community

artículo científico publicado en 2012

Risk of selecting de novo drug-resistance mutations during structured treatment interruptions in patients with chronic HIV infection

artículo científico

Selection and viral load kinetics of an oseltamivir-resistant pandemic influenza A (H1N1) virus in an immunocompromised patient during treatment with neuraminidase inhibitors

artículo científico publicado en 2010

Serodiscordance in chronic Chagas disease diagnosis: a real problem in non-endemic countries.

artículo científico publicado en 2016

Seroepidemiology of measles in Catalonia (Spain) 1985–1986

article

Severe acute respiratory syndrome epidemics: the end or a hiatus of the epidemic?

artículo científico publicado en 2003

Severe leptospirosis. Description of a series of 10 cases

artículo científico publicado en 1990

Short-course antiretroviral therapy in primary HIV infection

artículo científico publicado en 2013

Significant Improvement in Diagnosis of Hepatitis C Virus Infection by a One-Step Strategy in a Central Laboratory: an Optimal Tool for Hepatitis C Elimination?

artículo científico publicado en 2019

Similar HIV-1 evolution and immunological responses at 10 years despite several therapeutic strategies and host HLA Types

artículo científico publicado en 2004

Smoking may increase the risk of hospitalization due to influenza.

artículo científico publicado en 2016

Social factors related to the clinical severity of influenza cases in Spain during the A (H1N1) 2009 virus pandemic

artículo científico publicado en 2013

Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010.

artículo científico publicado en 2012

Structured Treatment Interruptions and Low Doses of IL-2 in Patients with Primary HIV Infection. Inflammatory, Virological and Immunological Outcomes

artículo científico publicado en julio de 2015

Structured observations reveal slow HIV-1 CTL escape

artículo científico publicado en 2015

Substitutions in position 222 of haemagglutinin of pandemic influenza A (H1N1) 2009 viruses in Spain

artículo científico publicado en 2011

Surveillance of the pandemic influenza (H1N1) 2009 in Catalonia: results and implications

artículo científico publicado en 2011

Síndrome respiratorio agudo grave

scientific article published on 01 May 2003

Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza.

artículo científico publicado en 2009

Th1/Th2 Cytokine Release Pattern During In Vivo Cytomegalovirus Disease in Solid Organ Transplantation

artículo científico publicado en 2007

The Influence of Innate Immunity Gene Receptors Polymorphisms in Renal Transplant Infections

article

The role of the clinical microbiology laboratory in solid organ transplantation programs

artículo científico publicado el 1 de marzo de 2012

The role of viruses in the aetiology of community-acquired pneumonia in adults.

artículo científico publicado en 2006

The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection

artículo científico publicado en 2001

The virology laboratory in cytomegalovirus infection. Current possibilities

artículo científico publicado en 1997

Therapeutic Immunization with Dendritic Cells Loaded with Heat‐Inactivated Autologous HIV‐1 in Patients with Chronic HIV‐1 Infection

article

Thrombotic cerebral vasculopathy associated with herpes zoster

artículo científico publicado en 1986

Timing of oseltamivir administration and outcomes in hospitalized adults with pandemic 2009 influenza A(H1N1) virus infection.

artículo científico publicado en 2011

Transmission of HIV-1 from an obstetrician to a patient during a caesarean section

article

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

artículo científico publicado en 2008

Trends in Transmission of Drug Resistance and Prevalence of Non-B Subtypes in Patients with Acute or Recent HIV-1 Infection in Barcelona in the Last 16 Years (1997-2012)

artículo científico publicado en 2015

Updated European recommendations for the clinical use of HIV drug resistance testing

artículo científico publicado en 2004

Viral load in asymptomatic patients with CD4+ lymphocyte counts above 500 × 106/l

artículo científico publicado en 1997

Viriasis nosocomiales. Virus de la hepatitis, herpesvirus y virus de la gripe

artículo científico publicado en 2013

Virological diagnosis in community-acquired pneumonia in immunocompromised patients

artículo científico publicado en 2007

Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain.

artículo científico publicado en 2016

Zika virus infection in pregnant women in Barcelona, Spain

artículo científico publicado en 2016

[A 52-year-old man with gait instability].

artículo científico publicado en 2010

[Characteristics of cases hospitalized for severe pandemic (H1N1) 2009 in Catalonia].

artículo científico publicado en 2011

[Clinical and epidemiological characteristics of influenza A virus infection in children aged less than 7 years old in primary care]

artículo científico publicado en 2006

[Homosexuality and viral infection]

artículo científico publicado en 1989

[Infection by the human immunodeficiency virus type 1 in the population of prisoners of Catalonia]

scientific article published on 01 February 1994

[Infections in immunosuppressed patients].

artículo científico publicado en 2008

[Leptospirosis. Considerations on its microbiologic diagnosis in a clinical case]

artículo científico publicado en 2000

[Parvovirus B19]

artículo científico publicado en 1995

[Risk factors of influenza (H1N1) 2009 hospitalization and effectiveness of pharmaceutical and nonpharmaceutical interventions in its prevention: a case-control study].

artículo científico publicado en 2011

[Selection criteria of organ donors with respect to infectious disease transmission. Study Group on Infections in Transplantation (GESITRA). Spanish Society of Infectious Diseases and and Clinical Microbiology (SEIMS). National Organization of Trans

scientific article published on 01 May 1999

[The virus of human immunodeficiency: virological characteristics, natural history and physiopathology of the nervous system infection]

scientific article published on 01 December 1996