Lista de obras - Akihito Ishigami - Dominio Público Uruguay

17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30

artículo científico publicado en 2011

A selective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice

scientific article published on 01 December 2006

Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.

artículo científico publicado en 2005

Absorption and excretion of ascorbic acid alone and in acerola (Malpighia emarginata) juice: comparison in healthy Japanese subjects

scientific article published on 01 January 2011

Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis

artículo científico publicado en 2008

Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice

artículo científico publicado en 2017

Age-associated changes in the transcriptomes of non-cultured adipose-derived stem cells from young and old mice assessed via single-cell transcriptome analysis

artículo científico publicado en 2020

Age-associated decrease of senescence marker protein-30/gluconolactonase in individual mouse liver cells: Immunohistochemistry and immunofluorescence

scientific article published on 14 October 2014

Age-related change in the degradation rate of ovalbumin microinjected into mouse liver parenchymal cells

artículo científico publicado en 1990

Age-related changes in DNA synthesis stimulated by epinephrine and isoproterenol in primary cultured rat hepatocytes

artículo científico publicado en 1994

Age-related changes of dopamine, noradrenaline and adrenaline in adrenal glands of mice

artículo científico publicado en 2012

Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm

artículo científico publicado en 2013

All-trans retinoic acid increases peptidylarginine deiminases in a newborn rat keratinocyte cell line.

artículo científico publicado en 1996

Anti-aging research using SMP30/GNL knockout mice

artículo científico publicado en 2010

Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance

artículo científico publicado en 2014

Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice

artículo científico publicado en 2014

Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice

scientific article published on 12 April 2012

Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice

artículo científico publicado en 2010

Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts.

artículo científico publicado en 2012

Ascorbic acid levels in various tissues, plasma and urine of mice during aging.

artículo científico publicado en 2012

Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice

artículo científico publicado en 2013

Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice.

artículo científico publicado en 2015

Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men.

artículo científico publicado en 2011

Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy

artículo científico publicado en 2005

Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels

artículo científico publicado en 2017

Coronary artery spasm related to thiol oxidation and senescence marker protein-30 in aging

artículo científico publicado en 2013

Detection of deiminated proteins in rat skin: probing with a monospecific antibody after modification of citrulline residues

scientific article published on 01 August 1995

Determination of dehydroascorbic acid in mouse tissues and plasma by using tris(2-carboxyethyl)phosphine hydrochloride as reductant in metaphosphoric acid/ethylenediaminetetraacetic acid solution

artículo científico publicado en 2010

Development of a new distyrylbenzene-derivative amyloid-β-aggregation and fibril formation inhibitor.

artículo científico publicado en 2012

Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain

artículo científico publicado en 2010

Dibutyl phthalate impairs neural progenitor cell proliferation and hippocampal neurogenesis

scientific article published on 25 April 2019

Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity

scientific article published on 01 March 2019

Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice.

artículo científico publicado en 2013

Effect of dietary restriction on the degradation of proteins in senescent mouse liver parenchymal cells in culture

scientific article published on 01 December 1990

Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice

scientific article published on 06 December 2011

Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice

artículo científico publicado en 2009

Effects of ascorbic acid deficiency on protein and lipid oxidation in livers from SMP30/GNL knockout mice

artículo científico publicado en 2013

Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse

artículo científico publicado en 2009

Effects of vitamin C on cytotherapy-mediated muscle regeneration

artículo científico publicado en 2012

Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease

artículo científico publicado en 2009

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.

artículo científico publicado en 2013

Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease

artículo científico publicado en 2009

Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice

artículo científico publicado en 2008

High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice

artículo científico publicado en 2015

Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin

artículo científico publicado en 2002

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.

artículo científico publicado en 2008

Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression.

artículo científico publicado en 2009

Importance of research on peptidylarginine deiminase and citrullinated proteins in age-related disease.

artículo científico publicado en 2010

Inactivation kinetics of horseradish peroxidase microinjected into hepatocytes from mice of various ages

scientific article published on 01 December 1988

Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain

artículo científico publicado en 2002

Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice

artículo científico publicado en 2013

Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease

artículo científico publicado en 2009

Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet

artículo científico publicado en 2013

Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain.

artículo científico publicado en 2007

Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process.

artículo científico publicado en 2004

Myasthenia gravis experimentally induced with muscle-specific kinase

artículo científico publicado en 2007

Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model

artículo científico publicado en 2021

Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase.

artículo científico publicado en 2003

Over-expression of Senescence Marker Protein-30 decreases reactive oxygen species in human hepatic carcinoma Hep G2 cells.

artículo científico publicado en 2009

Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.

artículo científico publicado en 2011

Pathophysiological significance of senescence marker protein-30.

scientific article published on July 2010

Pathophysiological significances of citrullinated proteins in geriatric diseases

artículo científico publicado en 2005

Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases

artículo científico publicado en 2012

Potato chip intake increases ascorbic acid levels and decreases reactive oxygen species in SMP30/GNL knockout mouse tissues

artículo científico publicado en 2014

Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage

artículo científico publicado en 2018

Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration.

artículo científico publicado en 2001

Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C-insufficient SMP30/GNL knockout mice

artículo científico publicado en 2020

Reduced aqueous humour ascorbic-acid concentration in women with smaller anterior chamber depth

artículo científico publicado en 2019

SMP30 deficiency causes increased oxidative stress in brain

artículo científico publicado en 2006

SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.

artículo científico publicado en 2004

Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.

artículo científico publicado en 2012

Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction

artículo científico publicado en 2013

Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction

artículo científico publicado en 2013

Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.

artículo científico publicado en 2009

Senescence marker protein-30 (SMP30) deficiency impairs myocardium-induced dilation of coronary arterioles associated with reactive oxygen species

artículo científico publicado en 2013

Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.

artículo científico publicado en 2005

Senescence marker protein-30 as a novel antiaging molecule.

artículo científico publicado en 2004

Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver

artículo científico publicado en 2004

Senescence marker protein-30 knockout mouse as a novel murine model of senile lung

artículo científico publicado en 2004

Senescence marker protein-30 knockout mouse as an aging model

artículo científico publicado en 2004

Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis

scientific journal article

Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking

scientific article published on 25 May 2006

Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes

artículo científico publicado en 2014

Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion.

artículo científico publicado en 2009

Senescence marker protein-30/gluconolactonase expression in the mouse ovary during gestation

artículo científico publicado en 2013

Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis

artículo científico publicado en 2014

Smad3 deficiency ameliorates hepatic fibrogenesis through the expression of senescence marker protein-30, an antioxidant-related protein

artículo científico publicado en 2013

Structural basis of the γ-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase

artículo científico publicado en 2013

Subcellular Localization of Peptidylarginine Deiminase 2 and Citrullinated Proteins in Brains of Scrapie-Infected Mice: Nuclear Localization of PAD2 and Membrane Fraction-Enriched Citrullinated Proteins ⬇️

artículo científico publicado el 1 de febrero de 2011

The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells

artículo científico publicado en 2017

The redox-sensitive DNA binding sites responsible for age-related downregulation of SMP30 by ERK pathway and reversal by calorie restriction

artículo científico publicado en 2006

Time course of vitamin C distribution and absorption after oral administration in SMP30/GNL knockout mice

artículo científico publicado en 2010

Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis

artículo científico publicado en 2012

Uric acid levels in tissues and plasma of mice during aging

artículo científico publicado en 2012

Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory

scientific article published on 08 January 2019

Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice

artículo científico publicado en 2010

Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance

artículo científico publicado en 2019

Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice

artículo científico publicado en 2010

Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice

artículo científico publicado en 2008

Vitamin C is not essential for carnitine biosynthesis in vivo: verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice

artículo científico publicado en 2008

Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration

artículo científico publicado en 2014

[Advanced approaches to anti-aging --use of aging model animals--]

scientific article published on 01 January 2010

cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I

artículo científico publicado en 2003

Lista de obras de Akihito Ishigami

17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30

A selective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice

Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.

Absorption and excretion of ascorbic acid alone and in acerola (Malpighia emarginata) juice: comparison in healthy Japanese subjects

Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis

Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice

Age-associated changes in the transcriptomes of non-cultured adipose-derived stem cells from young and old mice assessed via single-cell transcriptome analysis

Age-associated decrease of senescence marker protein-30/gluconolactonase in individual mouse liver cells: Immunohistochemistry and immunofluorescence

Age-related change in the degradation rate of ovalbumin microinjected into mouse liver parenchymal cells

Age-related changes in DNA synthesis stimulated by epinephrine and isoproterenol in primary cultured rat hepatocytes

Age-related changes of dopamine, noradrenaline and adrenaline in adrenal glands of mice

Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm

All-trans retinoic acid increases peptidylarginine deiminases in a newborn rat keratinocyte cell line.

Anti-aging research using SMP30/GNL knockout mice

Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance

Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice

Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice

Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice

Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts.

Ascorbic acid levels in various tissues, plasma and urine of mice during aging.

Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice

Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice.

Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men.

Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy

Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels

Coronary artery spasm related to thiol oxidation and senescence marker protein-30 in aging

Detection of deiminated proteins in rat skin: probing with a monospecific antibody after modification of citrulline residues

Determination of dehydroascorbic acid in mouse tissues and plasma by using tris(2-carboxyethyl)phosphine hydrochloride as reductant in metaphosphoric acid/ethylenediaminetetraacetic acid solution

Development of a new distyrylbenzene-derivative amyloid-β-aggregation and fibril formation inhibitor.

Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain

Dibutyl phthalate impairs neural progenitor cell proliferation and hippocampal neurogenesis

Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity

Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice.

Effect of dietary restriction on the degradation of proteins in senescent mouse liver parenchymal cells in culture

Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice

Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice

Effects of ascorbic acid deficiency on protein and lipid oxidation in livers from SMP30/GNL knockout mice

Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse

Effects of vitamin C on cytotherapy-mediated muscle regeneration

Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.

Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease

Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice

High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice

Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.

Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression.

Importance of research on peptidylarginine deiminase and citrullinated proteins in age-related disease.

Inactivation kinetics of horseradish peroxidase microinjected into hepatocytes from mice of various ages

Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain

Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice

Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease

Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet

Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain.

Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process.

Myasthenia gravis experimentally induced with muscle-specific kinase

Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model

Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase.

Over-expression of Senescence Marker Protein-30 decreases reactive oxygen species in human hepatic carcinoma Hep G2 cells.

Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.

Pathophysiological significance of senescence marker protein-30.

Pathophysiological significances of citrullinated proteins in geriatric diseases

Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases

Potato chip intake increases ascorbic acid levels and decreases reactive oxygen species in SMP30/GNL knockout mouse tissues

Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage

Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration.

Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C-insufficient SMP30/GNL knockout mice

Reduced aqueous humour ascorbic-acid concentration in women with smaller anterior chamber depth

SMP30 deficiency causes increased oxidative stress in brain

SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.

Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.

Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction

Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction

Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.

Senescence marker protein-30 (SMP30) deficiency impairs myocardium-induced dilation of coronary arterioles associated with reactive oxygen species

Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.

Senescence marker protein-30 as a novel antiaging molecule.

Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver

Senescence marker protein-30 knockout mouse as a novel murine model of senile lung