Lista de obras - Shozeb Haider - Dominio Público Uruguay

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

artículo científico publicado en 2015

A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands

artículo científico publicado en 2010

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

artículo científico publicado en 2010

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome

artículo científico publicado en 2005

A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes

artículo científico publicado en 2009

A novel mutation in HSD11B2 causes apparent mineralocorticoid excess in an Omani kindred.

artículo científico publicado en 2016

A novel small-molecule inhibitor of IL-6 signalling.

artículo científico publicado en 2010

A rare CYP21A2 mutation in a congenital adrenal hyperplasia kindred displaying genotype-phenotype nonconcordance

artículo científico publicado en 2015

A structural analysis of G-quadruplex/ligand interactions.

artículo científico publicado en 2011

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

artículo científico publicado en 2017

Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages

artículo científico publicado en 2013

Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

artículo científico publicado en 2009

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif

artículo científico publicado en 2010

Bisphosphonates inactivate human EGFRs to exert antitumor actions

artículo científico publicado en 2014

Blocking FSH induces thermogenic adipose tissue and reduces body fat.

artículo científico publicado en 2017

Boronic acid inhibitors of the class A β-lactamase KPC-2

artículo científico publicado en 2018

Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?

artículo científico publicado en 2016

Carbazole Derivatives' Binding to c-KIT G-Quadruplex DNA

Carbazole ligands as c-myc G-quadruplex binders

artículo científico publicado en 2018

Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency

artículo científico publicado en 2017

Clinical, genetic, and structural basis of congenital adrenal hyperplasia due to 11β-hydroxylase deficiency

artículo científico publicado en 2017

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale.

artículo científico publicado en 2013

Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.

artículo científico publicado en 2005

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

artículo científico publicado en 2017

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus

artículo científico publicado en 2018

Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance

scientific article published in Scientific Reports

Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

artículo científico publicado en 2014

Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor

scientific article published on 07 October 2019

Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.

artículo científico publicado en 2015

Dynamic Profiling of β-Coronavirus 3CL M<sup>pro</sup> Protease Ligand-Binding Sites

artículo científico publicado en 2021

Electrostatic Switching Controls Channel Dynamics of the Sensor Protein VirB10 in A. tumefaciens Type IV Secretion System

artículo científico publicado en 2020

Enhancement of antiviral immunity by small molecule antagonist of suppressor of cytokine signaling

artículo científico publicado en 2010

Epitope-specific monoclonal antibodies to FSHβ increase bone mass

artículo científico publicado en 2018

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.

artículo científico publicado en 2004

Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment

artículo científico publicado en 2018

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus

artículo científico publicado en 2020

Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.

artículo científico publicado en 2017

Extended molecular dynamics of a c-kit promoter quadruplex

artículo científico publicado en 2015

First-in-class humanized FSH blocking antibody targets bone and fat

scientific article published on 30 October 2020

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

artículo científico publicado en 2005

Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel

artículo científico publicado en 2015

Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.

artículo científico publicado en 2005

G-Quadruplexes (GQU).

artículo científico publicado en 2018

HSV-1-induced SOCS-1 expression in keratinocytes: use of a SOCS-1 antagonist to block a novel mechanism of viral immune evasion

artículo científico publicado en 2009

Holliday Junctions Formed from Human Telomeric DNA

artículo científico publicado en 2018

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

artículo científico publicado en 2007

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops.

artículo científico publicado en 2018

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

artículo científico publicado en 2019

Ion channel gates: comparative analysis of energy barriers.

artículo científico publicado en 2008

Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes

artículo científico publicado en 2019

Mechanism of glucocerebrosidase activation and dysfunction in Gaucher disease unraveled by molecular dynamics and deep learning

artículo científico publicado en 2019

Molecular dynamics of HIV1-integrase in complex with 93del - a structural perspective on the mechanism of inhibition.

artículo científico publicado en 2012

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.

artículo científico publicado en 2005

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study

artículo científico publicado en 2007

Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition

artículo científico publicado en 2012

Mutations disrupting neuritogenesis genes confer risk for cerebral palsy

artículo científico publicado en 2020

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation

artículo científico publicado en 2018

Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis

scientific article published on 10 July 2019

N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.

artículo científico publicado en 2013

Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths

scientific article published on 26 May 2020

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity

artículo científico publicado en 2012

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

artículo científico publicado en 2011

Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant

artículo científico publicado en 2019

Recessive Inheritance of Congenital Hydrocephalus With Other Structural Brain Abnormalities Caused by Compound Heterozygous Mutations in ATP1A3

scientific article published on 26 September 2019

Regioselective glycosylation of novobiocin alters activity.

artículo científico publicado en 2017

Reply to Graham et al.: In silico atomistic coordinates and molecular dynamics simulation trajectories of the glucocerebrosidase-saposin C complex

scientific article published on 01 June 2019

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

artículo científico publicado en 2020

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway

scientific article published on 10 July 2019

Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer

artículo científico publicado en 2014

SET domain-mediated lysine methylation in lower organisms regulates growth and transcription in hosts.

artículo científico publicado en 2016

Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe

scientific article published on 01 March 2019

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

scientific article published on 13 November 2009

Signal transduction mechanism of a peptide mimetic of interferon-gamma.

artículo científico publicado en 2004

Simulations of a protein translocation pore: SecY

scientific article published on 01 October 2006

Structural Dynamics of Lateral and Diagonal Loops of Human Telomeric G-Quadruplexes in Extended MD Simulations

artículo científico publicado en 2018

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

artículo científico publicado en 2010

Structure–phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia ⬇️

artículo científico publicado el 28 de enero de 2013

Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes

artículo científico publicado en 2011

Synergistic Effect of Chlorogenic Acid and Caffeic Acid with Fosfomycin on Growth Inhibition of a Resistant Listeria monocytogenes Strain

artículo científico publicado en 2020

Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

artículo científico publicado en 2009

Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.

artículo científico publicado en 2018

Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands

artículo científico publicado en 2008

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

article

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

artículo científico publicado en 2019

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies

artículo científico publicado en 2011

The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines

artículo científico publicado en 2017

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

artículo científico publicado en 2008

Lista de obras de Shozeb Haider

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome

A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes

A novel mutation in HSD11B2 causes apparent mineralocorticoid excess in an Omani kindred.

A novel small-molecule inhibitor of IL-6 signalling.

A rare CYP21A2 mutation in a congenital adrenal hyperplasia kindred displaying genotype-phenotype nonconcordance

A structural analysis of G-quadruplex/ligand interactions.

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages

Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif

Bisphosphonates inactivate human EGFRs to exert antitumor actions

Blocking FSH induces thermogenic adipose tissue and reduces body fat.

Boronic acid inhibitors of the class A β-lactamase KPC-2

Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?

Carbazole Derivatives' Binding to c-KIT G-Quadruplex DNA

Carbazole ligands as c-myc G-quadruplex binders

Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency

Clinical, genetic, and structural basis of congenital adrenal hyperplasia due to 11β-hydroxylase deficiency

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale.

Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus

Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance

Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor

Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.

Dynamic Profiling of β-Coronavirus 3CL M<sup>pro</sup> Protease Ligand-Binding Sites

Electrostatic Switching Controls Channel Dynamics of the Sensor Protein VirB10 in A. tumefaciens Type IV Secretion System

Enhancement of antiviral immunity by small molecule antagonist of suppressor of cytokine signaling

Epitope-specific monoclonal antibodies to FSHβ increase bone mass

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.

Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus

Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.

Extended molecular dynamics of a c-kit promoter quadruplex

First-in-class humanized FSH blocking antibody targets bone and fat

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel

Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.

G-Quadruplexes (GQU).

HSV-1-induced SOCS-1 expression in keratinocytes: use of a SOCS-1 antagonist to block a novel mechanism of viral immune evasion

Holliday Junctions Formed from Human Telomeric DNA

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops.

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

Ion channel gates: comparative analysis of energy barriers.

Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes

Mechanism of glucocerebrosidase activation and dysfunction in Gaucher disease unraveled by molecular dynamics and deep learning

Molecular dynamics of HIV1-integrase in complex with 93del - a structural perspective on the mechanism of inhibition.

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study

Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition

Mutations disrupting neuritogenesis genes confer risk for cerebral palsy

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation

Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis

N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.

Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant

Recessive Inheritance of Congenital Hydrocephalus With Other Structural Brain Abnormalities Caused by Compound Heterozygous Mutations in ATP1A3

Regioselective glycosylation of novobiocin alters activity.

Reply to Graham et al.: In silico atomistic coordinates and molecular dynamics simulation trajectories of the glucocerebrosidase-saposin C complex

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway

Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer

SET domain-mediated lysine methylation in lower organisms regulates growth and transcription in hosts.

Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

Signal transduction mechanism of a peptide mimetic of interferon-gamma.

Simulations of a protein translocation pore: SecY

Structural Dynamics of Lateral and Diagonal Loops of Human Telomeric G-Quadruplexes in Extended MD Simulations

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

Structure–phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia ⬇️

Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes

Synergistic Effect of Chlorogenic Acid and Caffeic Acid with Fosfomycin on Growth Inhibition of a Resistant Listeria monocytogenes Strain