Lista de obras -

A Combined Ligand‐ and Structure‐Based Virtual Screening Protocol Identifies Submicromolar PPARγ Partial Agonists ⬇️

artículo científico publicado el 3 de enero de 2011

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses

artículo científico publicado en 2022

An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines

artículo científico publicado en 2014

An extension of the BioAssay Ontology to include pharmacokinetic/pharmacodynamic terminology for the enrichment of scientific workflows

artículo científico publicado en 2023

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

artículo científico publicado en 2011

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

artículo científico

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

artículo científico

BioAssay Ontology (BAO): a semantic description of bioassays and high-throughput screening results

artículo científico publicado en 2011

BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets

artículo científico publicado en 2011

CLO: The cell line ontology

artículo científico publicado en 2014

Chemical interrogation of the neuronal kinome using a primary cell-based screening assay

artículo científico publicado en 2013

Chroman-3-amides as potent Rho kinase inhibitors

artículo científico

Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

artículo científico publicado en 2008

Connecting omics signatures of diseases, drugs, and mechanisms of actions with iLINCS

artículo científico publicado en 2019

DD-01LIGAND- AND STRUCTURE-BASED VIRTUAL SCREENING TO DISCOVER POLYPHARMACOLOGICAL DUAL EGFR AND BRD4 INHIBITORS

artículo científico publicado en 2014

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data

artículo científico publicado en 2017

Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop

artículo científico publicado en 2017

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

artículo científico

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

artículo científico

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.

artículo científico publicado en 2008

Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.

artículo científico publicado en 2008

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

artículo científico publicado en 2008

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

artículo científico

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype

artículo científico publicado en 2011

Drug Repositioning in Glioblastoma: A Pathway Perspective.

artículo científico publicado en 2018

Drug and disease signature integration identifies synergistic combinations in glioblastoma

scientific article published in Nature Communications

Drug target ontology to classify and integrate drug discovery data

artículo científico publicado en 2017

DrugCentral 2018: an update

artículo científico publicado en 2019

Epigenetic pathways and glioblastoma treatment: insights from signaling cascades

artículo científico

Evolving BioAssay Ontology (BAO): modularization, integration and applications

artículo científico publicado en 2014

FAIRshake: Toolkit to Evaluate the FAIRness of Research Digital Resources

scientific article published on 30 October 2019

FAIRsharing, a cohesive community approach to the growth in standards, repositories and policies

Far away from the lamppost

artículo científico publicado en 2018

Formalization, annotation and analysis of diverse drug and probe screening assay datasets using the BioAssay Ontology (BAO)

artículo científico publicado en 2012

GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework

scientific article published on 29 September 2013

How to Develop a Drug Target Ontology: KNowledge Acquisition and Representation Methodology (KNARM)

artículo científico publicado en 2019

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation

artículo científico publicado en 2007

Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput Screening ⬇️

artículo científico publicado el 1 de septiembre de 2011

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.

artículo científico publicado en 2017

Improving the Utility of the Tox21 Dataset by Deep Metadata Annotations and Constructing Reusable Benchmarked Chemical Reference Signatures

artículo científico publicado en 2019

Inhibition of Lymphoid Tyrosine Phosphatase by Benzofuran Salicylic Acids ⬇️

artículo científico publicado el 29 de diciembre de 2010

Kinome-wide activity classification of small molecules by deep learning

scholarly article published 4 January 2019

Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design

artículo científico publicado en 2009

LINCS Data Portal 2.0: next generation access point for perturbation-response signatures

artículo científico publicado en 2020

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

artículo científico publicado en 2015

Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action

artículo científico publicado en 2014

Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS).

artículo científico publicado en 2014

Novel Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

artículo científico publicado en 2019

Novel kinase inhibitors by reshuffling ligand functionalities across the human kinome

article

OSCI: standardized stem cell ontology representation and use cases for stem cell investigation.

artículo científico publicado en 2019

Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses.

artículo científico publicado en 2017

Pharos: Collating protein information to shed light on the druggable genome

artículo científico publicado en 2016

Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets

scholarly article by Uzma Saqib et al published 2018 in Frontiers in Pharmacology

Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay

artículo científico publicado en 2009

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

artículo científico publicado en 2015

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

artículo científico publicado en 2011

Sustainable data and metadata management at the BD2K-LINCS Data Coordination and Integration Center.

artículo científico publicado en 2018

TCRD and Pharos 2021: mining the human proteome for disease biology

artículo científico publicado en 2020

TIN-X: target importance and novelty explorer

artículo científico

Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors ⬇️

artículo científico publicado el 12 de agosto de 2010

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

artículo científico publicado en 2017

The SmartAPI Ecosystem for Making Web APIs FAIR

artículo científico publicado en 2017

Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity

artículo científico publicado en 2024

Unexplored therapeutic opportunities in the human genome

scientific article published on 23 March 2018

Unexplored therapeutic opportunities in the human genome.

artículo científico publicado en 2018

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit

artículo científico publicado en 2019

Using the BioAssay Ontology for analyzing high-throughput screening data

artículo científico publicado en 2014

piNET: a versatile web platform for downstream analysis and visualization of proteomics data

artículo científico publicado en 2020

Lista de obras de

A Combined Ligand‐ and Structure‐Based Virtual Screening Protocol Identifies Submicromolar PPARγ Partial Agonists ⬇️

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses

An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines

An extension of the BioAssay Ontology to include pharmacokinetic/pharmacodynamic terminology for the enrichment of scientific workflows

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

BioAssay Ontology (BAO): a semantic description of bioassays and high-throughput screening results

BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets

CLO: The cell line ontology

Chemical interrogation of the neuronal kinome using a primary cell-based screening assay

Chroman-3-amides as potent Rho kinase inhibitors

Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

Connecting omics signatures of diseases, drugs, and mechanisms of actions with iLINCS

DD-01LIGAND- AND STRUCTURE-BASED VIRTUAL SCREENING TO DISCOVER POLYPHARMACOLOGICAL DUAL EGFR AND BRD4 INHIBITORS

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data

Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.

Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype

Drug Repositioning in Glioblastoma: A Pathway Perspective.

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Drug target ontology to classify and integrate drug discovery data

DrugCentral 2018: an update

Epigenetic pathways and glioblastoma treatment: insights from signaling cascades

Evolving BioAssay Ontology (BAO): modularization, integration and applications

FAIRshake: Toolkit to Evaluate the FAIRness of Research Digital Resources

FAIRsharing, a cohesive community approach to the growth in standards, repositories and policies

Far away from the lamppost

Formalization, annotation and analysis of diverse drug and probe screening assay datasets using the BioAssay Ontology (BAO)

GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework

How to Develop a Drug Target Ontology: KNowledge Acquisition and Representation Methodology (KNARM)

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation

Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput Screening ⬇️

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.

Improving the Utility of the Tox21 Dataset by Deep Metadata Annotations and Constructing Reusable Benchmarked Chemical Reference Signatures

Inhibition of Lymphoid Tyrosine Phosphatase by Benzofuran Salicylic Acids ⬇️

Kinome-wide activity classification of small molecules by deep learning

Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design

LINCS Data Portal 2.0: next generation access point for perturbation-response signatures

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action

Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS).

Novel Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

Novel kinase inhibitors by reshuffling ligand functionalities across the human kinome

OSCI: standardized stem cell ontology representation and use cases for stem cell investigation.

Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses.

Pharos: Collating protein information to shed light on the druggable genome

Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets

Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

Sustainable data and metadata management at the BD2K-LINCS Data Coordination and Integration Center.

TCRD and Pharos 2021: mining the human proteome for disease biology

TIN-X: target importance and novelty explorer

Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors ⬇️

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

The SmartAPI Ecosystem for Making Web APIs FAIR

Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity

Unexplored therapeutic opportunities in the human genome

Unexplored therapeutic opportunities in the human genome.

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit

Using the BioAssay Ontology for analyzing high-throughput screening data

piNET: a versatile web platform for downstream analysis and visualization of proteomics data