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Lista de obras de Eisuke Mekada

A crucial role of tetraspanin, CD9 in fertilization

artículo científico publicado en 2000

A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor

artículo científico publicado en 2001

A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

artículo científico publicado en 1998

A novel anti-human HB-EGF monoclonal antibody with multiple antitumor mechanisms against ovarian cancer cells

artículo científico publicado en 2011

Amino-terminal processing of cell surface heparin-binding epidermal growth factor-like growth factor up-regulates its juxtacrine but not its paracrine growth factor activity

scientific article published on 01 November 1996

An attempt to separate mononuclear cells fused with human red blood cell-ghosts from a cell mixture treated with HVJ (Sendai virus) using a fluorescence activated cell sorter (FACS II) ⬇️

artículo científico publicado el 1 de enero de 1978

Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals

artículo científico publicado en 1993

Antibodies introduced into living cells by red cell ghosts are functionally stable in the cytoplasm of the cells ⬇️

artículo científico publicado el 1 de diciembre de 1979

Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF

artículo científico publicado en 2014

Assessment of HB-EGF levels in peritoneal fluid and serum of ovarian cancer patients using ELISA

artículo científico publicado en 2011

Binding properties of diphtheria toxin to cells are altered by mutation in the fragment A domain

scientific article published in 1985

Biological behavior of ovarian cancer

artículo científico publicado en 2004

CD9 Amino Acids Critical for Upregulation of Diphtheria Toxin Binding ⬇️

artículo científico publicado el 14 de diciembre de 2001

CD9 and the family of four transmembrane domain proteins

artículo científico publicado el 1 de marzo de 1995

CD9 expression in solid non-neuroepithelial tumors and infiltrative astrocytic tumors

artículo científico publicado en 2002

Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers.

artículo científico publicado en 2016

Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane

artículo científico publicado en 2000

Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer

artículo científico publicado en 2005

Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer

artículo científico publicado en 2005

Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes

artículo científico publicado en 2013

Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice

scientific article published on 09 August 2012

Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice

artículo científico publicado en 2013

Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.

artículo científico publicado en 2006

Degradation of a nuclear-localized protein in mammalian COS cells, using Escherichia coli beta-galactosidase as a model protein ⬇️

artículo científico publicado el 5 de mayo de 1992

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.

artículo científico publicado en 2011

Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

artículo científico publicado en 1995

Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice

artículo científico publicado en 2001

Diphtheria toxin translocation across endosome membranes. A novel cell permeabilization assay reveals new diphtheria toxin fragments in endocytic vesicles

artículo científico publicado en 1998

Domain analysis of the tetraspanins: studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding

scientific article published on 01 October 2000

Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.

artículo científico publicado en 2008

Elevated levels of anti-CD9 antibodies in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis

artículo científico publicado en 2002

Enhanced CD9 expression in the mouse and human brains infected with transmissible spongiform encephalopathies

scientific article published on 01 September 2000

Entry of diphtheria toxin into cells: possible existence of cellular factor(s) for entry of diphtheria toxin into cells was studied in somatic cell hybrids and hybrid toxins.

artículo científico publicado en 1984

ErbB and HB-EGF signaling in heart development and function.

artículo científico publicado en 2006

ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.

artículo científico publicado en 2017

Expression and distribution of CD9 in myelin of the central and peripheral nervous systems.

artículo científico publicado en 1996

Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer

artículo científico publicado en 2003

FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts

artículo científico publicado en 2006

HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers

artículo científico publicado en 2011

HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development

artículo científico publicado en 2008

HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans

artículo científico publicado en 2010

HB-EGF promotes epithelial cell migration in eyelid development

artículo científico publicado en 2005

Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

scientific journal article

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

scientific journal article

Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy.

artículo científico publicado en 2004

Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity

scientific journal article

Heparin-binding EGF-like growth factor: a juxtacrine growth factor

artículo científico publicado en 2000

Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy.

artículo científico publicado en 2006

Heparin-like molecules on the cell surface potentiate binding of diphtheria toxin to the diphtheria toxin receptor/membrane-anchored heparin-binding epidermal growth factor-like growth factor

scientific article published on 01 December 1995

Hybrid toxin of the A chain of ricin toxin and a subunit of Wistaria floribunda lectin. Possible importance of the hydrophobic region for entry of toxin into the cell

scientific article published on 01 July 1980

Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.

artículo científico publicado en 2014

Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane

artículo científico publicado en 2000

Immune system-related CD9 is expressed in mouse central nervous system myelin at a very late stage of myelination

artículo científico publicado en 1997

Immunohistochemical distribution of CD9, heparin binding epidermal growth factor-like growth factor, and integrin alpha3beta1 in normal human tissues

artículo científico publicado en 2001

Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity

scientific journal article

Improved methods using HVJ(Sendai virus) for introducing substances into cells ⬇️

artículo científico publicado el 30 de marzo de 1979

Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites.

artículo científico publicado en 2000

Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures

artículo científico publicado en 2009

Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells.

artículo científico publicado en 2000

Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation

scientific article published on 22 September 2006

Loss of motility-related protein 1 (MRP1/CD9) and integrin alpha3 expression in endometrial cancers

artículo científico publicado en 2001

MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.

artículo científico publicado en 2012

Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.

artículo científico publicado en 2007

Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor.

artículo científico publicado en 2010

Methylamine facilitates demonstration of specific uptake of diphtheria toxin by CHO cell and toxin-resistant CHO cell mutants

scientific article published on 01 December 1982

Methylamine stimulates the action of ricin toxin but inhibits that of diphtheria toxin

scientific article published on 01 February 1981

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

artículo científico publicado en 2003

Modification of the cell surface with neuraminidase increases the sensitivities of cells to diphtheria toxin and Pseudomonas aeruginosa exotoxin ⬇️

artículo científico publicado el 1 de octubre de 1979

Monoclonal antibodies against diphtheria toxin fragment A. Characterization and introduction into living cells

artículo científico publicado en 1984

Monoclonal antibody against diphtheria toxin. Effect on toxin binding and entry into cells

scientific article published on 01 April 1983

Mutant with diphtheria toxin receptor and acidification function but defective in entry of toxin

artículo científico publicado en 1987

N-myc transactivates RCC1 gene expression in rat fibroblast cells transformed by N-myc and v-ras.

artículo científico publicado en 1998

New approach to cancer therapy: heparin binding-epidermal growth factor-like growth factor as a novel targeting molecule.

artículo científico publicado en 2007

One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell

artículo científico publicado en 1978

Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells

scientific article published on 04 January 2007

Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis.

artículo científico publicado en 2005

Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity

artículo científico publicado en 1995

Possible involvement of CD81 in acrosome reaction of sperm in mice

artículo científico publicado en 2008

Pre-clinical study of BK-UM, a novel inhibitor of HB-EGF, for ovarian cancer therapy

artículo científico publicado en 2014

Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.

artículo científico publicado en 2010

Purification of diphtheria toxin receptor from Vero cells

artículo científico publicado en 1991

Quantitative introduction of a given macromolecule into cells by fusion with erythrocyte ghosts using a fluorescence activated cell sorter

artículo científico publicado en 1978

Reconstitution of hybrid toxin from Fragment A of diphtheria toxin and a subunit of Wistaria floribunda lectin

artículo científico publicado en 1978

Reduced expression of CD9 in oral squamous cell carcinoma: CD9 expression inversely related to high prevalence of lymph node metastasis

scientific article published on 01 February 2001

Requirement of CD9 on the egg plasma membrane for fertilization

artículo científico publicado en 2000

Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia

artículo científico publicado en 2005

Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer

artículo científico publicado en 2012

Structure-function analysis of the diphtheria toxin receptor toxin binding site by site-directed mutagenesis

scientific article published on 01 October 1997

Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo

artículo científico publicado en 2007

Suppression of the biological activities of the epidermal growth factor (EGF)-like domain by the heparin-binding domain of heparin-binding EGF-like Growth Factor

artículo científico publicado en 2004

Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer.

artículo científico publicado en 2009

Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans

artículo científico publicado en 2012

Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans.

artículo científico publicado en 2004

Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation

scientific journal article

Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes

artículo científico publicado en 2003

The 27-kD diphtheria toxin receptor-associated protein (DRAP27) from vero cells is the monkey homologue of human CD9 antigen: expression of DRAP27 elevates the number of diphtheria toxin receptors on toxin-sensitive cells

artículo científico publicado en 1992

The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase

artículo científico publicado en 1990

The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signal

artículo científico publicado en 2003

Treatment of FL cells with neuraminidase stimulating the sensitivities to diphtheria toxin and ricin toxin [proceedings]

scientific article published on 01 April 1978

Validation of HB-EGF and amphiregulin as targets for human cancer therapy.

artículo científico publicado en 2007

[Diphtheria toxin receptor complex]

artículo científico publicado en 1996

[Diphtheria toxin receptor]

artículo científico publicado en 1993

[Diphtheria toxin receptor]

artículo científico publicado en 2001

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