Lista de obras - Heping Xu - Dominio Público Uruguay

A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis.

artículo científico publicado en 2017

Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.

artículo científico publicado en 2013

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

artículo científico publicado en 2007

Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration

artículo científico publicado en 2015

Analysis of retinal circulation using an image-based network model of retinal vasculature

artículo científico publicado en 2010

Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.

artículo científico publicado en 2018

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

article

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7 ⬇️

artículo científico publicado en 2019

CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation.

artículo científico publicado en 2012

Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion.

artículo científico publicado en 2011

Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration

artículo científico publicado en 2011

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

artículo científico publicado en 2018

Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07.

artículo científico publicado en 2008

Cholesterol homeostasis, macrophage malfunction and age-related macular degeneration

scientific article published on 01 November 2018

Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients - A Pilot Study

artículo científico publicado en 2020

Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production.

artículo científico publicado en 2017

Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

artículo científico publicado en 2013

Complement factor B in retinal pigment epithelial cell is up-regulated by inflammatory cytokine TNF-α and INF-γ

Comprehensive analysis of mouse retinal mononuclear phagocytes.

artículo científico publicado en 2017

Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation

artículo científico publicado en 2008

Culture and characterization of microglia from the adult murine retina.

artículo científico publicado en 2014

Dendritic cell physiology and function in the eye.

artículo científico publicado en 2010

Development of an image-based model for capillary vasculature of retina

artículo científico publicado en 2011

Development of an image-based network model of retinal vasculature.

artículo científico publicado en 2010

Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2.

artículo científico publicado en 2009

Diabetic retinopathy and dysregulated innate immunity

artículo científico publicado en 2017

Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators.

artículo científico publicado en 2005

Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice.

artículo científico publicado en 2011

Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72.

artículo científico publicado en 2002

Experimental autoimmune uveoretinitis (EAU)-related tissue damage and angiogenesis is reduced in CCL2⁻/⁻CX₃CR1gfp/gfp mice

artículo científico publicado en 2014

Expression of Complement Components and Regulators by Different Subtypes of Bone Marrow-Derived Macrophages

artículo científico publicado en 2012

Extremely complex populations of small RNAs in the mouse retina and RPE/choroid.

artículo científico publicado en 2013

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

article published in 2019

Good news-bad news: the Yin and Yang of immune privilege in the eye.

artículo científico publicado en 2012

Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy

artículo científico publicado en 2019

Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells.

artículo científico publicado en 2017

Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.

artículo científico publicado en 2016

Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy

artículo científico publicado en 2020

IL-33 attenuates the development of experimental autoimmune uveitis.

artículo científico publicado en 2014

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

scientific article published on 03 December 2019

Imaging ocular immune responses by intravital microscopy.

artículo científico publicado en 2002

Immune activation in retinal aging: a gene expression study

artículo científico publicado en 2010

Immune regulation in the aging retina

scientific article published on 20 October 2018

Improved leukocyte tracking in mouse retinal and choroidal circulation.

artículo científico publicado en 2002

Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis

artículo científico publicado en 2010

Intravitreal Injection of Normal Saline Induces Retinal Degeneration in the C57BL/6J Mouse.

artículo científico publicado en 2014

Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis

artículo científico publicado en 2005

Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier.

artículo científico publicado en 2002

LYVE-1-positive macrophages are present in normal murine eyes

artículo científico publicado en 2007

Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.

artículo científico publicado en 2005

Leukocyte trafficking in experimental autoimmune uveitis: breakdown of blood-retinal barrier and upregulation of cellular adhesion molecules

artículo científico publicado en 2003

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

article

Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse

artículo científico publicado en 2014

Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis

artículo científico publicado en 2022

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration

artículo científico publicado en 2020

Mechanistical retinal drug targets and challenges

artículo científico publicado en 2018

Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

scientific article published on 17 June 2019

Modelling of pulsatile blood flow in arterial trees of retinal vasculature.

artículo científico publicado en 2010

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

artículo científico publicado en 2018

Molecular Mechanisms Underlying Age-Related Ocular Diseases.

artículo científico publicado en 2018

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice

artículo científico publicado en 2013

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

artículo científico publicado en 2017

Para-inflammation in the aging retina.

artículo científico publicado en 2009

Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent

artículo científico publicado en 2012

Parainflammation, chronic inflammation, and age-related macular degeneration

artículo científico publicado en 2015

Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation

artículo científico publicado en 2013

Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8).

artículo científico publicado en 2017

Persistent Inflammation Subverts Thrombospondin-1–Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation

article

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis

scientific article published on 14 November 2020

Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology

scientific article published on 30 August 2018

Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate.

artículo científico publicado en 2011

Quantitative In Situ Analysis of Claudin Expression at the Blood–Retinal Barrier

artículo científico publicado en 2011

RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

artículo científico publicado en 2014

Requirements for passage of T lymphocytes across non-inflamed retinal microvessels ⬇️

artículo científico publicado el 1 de septiembre de 2003

Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

artículo científico publicado en 2008

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis.

artículo científico publicado en 2016

SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis.

artículo científico publicado en 2018

STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration

artículo científico publicado en 2016

STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes

artículo científico publicado en 2019

Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors-Implications in subretinal immune regulation

scientific article published on 12 March 2020

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

scientific article published on 11 July 2018

Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2(Akita) diabetic mouse

artículo científico publicado en 2015

Sustained intraocular vascular endothelial growth factor neutralisation does not affect retinal and choroidal vasculature in Ins2Akita diabetic mice

scientific article published on 26 April 2019

Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis.

artículo científico publicado en 2009

Targeting the complement system for the management of retinal inflammatory and degenerative diseases.

artículo científico publicado en 2016

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.

artículo científico publicado en 2015

The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye.

artículo científico publicado en 2018

The keratan sulfate disaccharide Gal(6S03) beta1,4-GlcNAc(6S03) modulates interleukin 12 production by macrophages in murine Thy-1 type autoimmune disease

artículo científico publicado en 2005

The soluble isoform of CTLA‐4 as a regulator of T‐cell responses ⬇️

artículo científico publicado el 6 de marzo de 2013

The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic

scientific article published on 12 March 2019

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

artículo científico publicado en 2017

Turnover of resident retinal microglia in the normal adult mouse

artículo científico publicado en 2007

Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy

scientific article published on 05 December 2019

Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina

artículo científico publicado en 2008

Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture

artículo científico publicado en 2017

Lista de obras de Heping Xu

A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis.

Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration

Analysis of retinal circulation using an image-based network model of retinal vasculature

Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7 ⬇️

CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation.

Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion.

Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07.

Cholesterol homeostasis, macrophage malfunction and age-related macular degeneration

Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients - A Pilot Study

Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production.

Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

Complement factor B in retinal pigment epithelial cell is up-regulated by inflammatory cytokine TNF-α and INF-γ

Comprehensive analysis of mouse retinal mononuclear phagocytes.

Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation

Culture and characterization of microglia from the adult murine retina.

Dendritic cell physiology and function in the eye.

Development of an image-based model for capillary vasculature of retina

Development of an image-based network model of retinal vasculature.

Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2.

Diabetic retinopathy and dysregulated innate immunity

Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators.

Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice.

Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72.

Experimental autoimmune uveoretinitis (EAU)-related tissue damage and angiogenesis is reduced in CCL2⁻/⁻CX₃CR1gfp/gfp mice

Expression of Complement Components and Regulators by Different Subtypes of Bone Marrow-Derived Macrophages

Extremely complex populations of small RNAs in the mouse retina and RPE/choroid.

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

Good news-bad news: the Yin and Yang of immune privilege in the eye.

Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy

Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells.

Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.

Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy

IL-33 attenuates the development of experimental autoimmune uveitis.

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

Imaging ocular immune responses by intravital microscopy.

Immune activation in retinal aging: a gene expression study

Immune regulation in the aging retina

Improved leukocyte tracking in mouse retinal and choroidal circulation.

Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis

Intravitreal Injection of Normal Saline Induces Retinal Degeneration in the C57BL/6J Mouse.

Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis

Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier.

LYVE-1-positive macrophages are present in normal murine eyes

Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.

Leukocyte trafficking in experimental autoimmune uveitis: breakdown of blood-retinal barrier and upregulation of cellular adhesion molecules

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse

Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration

Mechanistical retinal drug targets and challenges

Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

Modelling of pulsatile blood flow in arterial trees of retinal vasculature.

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

Molecular Mechanisms Underlying Age-Related Ocular Diseases.

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

Para-inflammation in the aging retina.

Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent

Parainflammation, chronic inflammation, and age-related macular degeneration

Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation

Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8).

Persistent Inflammation Subverts Thrombospondin-1–Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis

Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology

Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate.

Quantitative In Situ Analysis of Claudin Expression at the Blood–Retinal Barrier

RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

Requirements for passage of T lymphocytes across non-inflamed retinal microvessels ⬇️

Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis.

SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis.

STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration