Lista de obras - Lutz Heide - Dominio Público Uruguay

4-Coumaroyl coenzyme A 3-hydroxylase activity from cell cultures of Lithospermum erythrorhizon and its relationship to polyphenol oxidase

scientific article published on 01 November 1997

4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon : purification of a plant membrane-bound prenyltransferase ⬇️

artículo científico publicado el 1 de julio de 1998

A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation

artículo científico publicado en 2012

A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.

artículo científico publicado en 2006

A membrane-bound prenyltransferase catalyzes the O-prenylation of 1,6-dihydroxyphenazine in the marine bacterium Streptomyces sp. CNQ-509

artículo científico publicado en 2014

Active expression of the ubiA gene from E. coli in tobacco: influence of plant ER-specific signal peptides on the expression of a membrane-bound prenyltransferase in plant cells

artículo científico publicado en 2000

Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar

artículo científico publicado en 2005

Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains

artículo científico publicado en 2011

An artificial pathway to 3,4-dihydroxybenzoic acid allows generation of new aminocoumarin antibiotic recognized by catechol transporters of E. coli.

artículo científico publicado en 2011

An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. ⬇️

artículo científico publicado en 2003

Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis.

artículo científico publicado en 2004

Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus

artículo científico publicado en 2009

Artemisinin in traditional tea preparations of Artemisia annua

artículo científico publicado en 2006

Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering

artículo científico publicado en 2008

Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.

artículo científico publicado en 2004

Availability and affordability of antimalarial and antibiotic medicines in Malawi.

artículo científico publicado en 2017

Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo

artículo científico publicado en 2020

Biosynthesis of clorobiocin: investigation of the transfer and methylation of the pyrrolyl-2-carboxyl moiety

scientific article published on 25 November 2006

Biosynthesis of p-Hydroxybenzoate from p-Coumarate and p-Coumaroyl-Coenzyme A in Cell-Free Extracts of Lithospermum erythrorhizon Cell Cultures

scientific article published on 01 September 1994

Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042

artículo científico publicado en 2007

Clarification of the Escherichia coli genetic map in the 92-minute region containing the ubiCA operon and the plsB, dgk, lexA, and dinF genes.

artículo científico publicado en 1993

CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin

artículo científico publicado en 2003

CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin

artículo científico publicado en 2003

CloQ, a prenyltransferase involved in clorobiocin biosynthesis

artículo científico publicado en 2003

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis

artículo científico publicado en 2003

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. ⬇️

artículo científico publicado en 2000

Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. ⬇️

artículo científico publicado en 2003

Colour coding of labels for essential drugs

Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry.

artículo científico publicado en 2015

Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes

artículo científico publicado en 2006

Diversity and evolution of the phenazine biosynthesis pathway

artículo científico publicado en 2009

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds

artículo científico publicado en 2015

Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the Aminocoumarin Antibiotic Novobiocin

artículo científico publicado en 2014

Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin

artículo científico publicado en 2014

Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor

artículo científico publicado en 2007

Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials.

artículo científico publicado en 2004

Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial

artículo científico publicado en 2001

Enzymatic synthesis of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis

artículo científico publicado en 1981

Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis.

artículo científico publicado en 1982

Enzymic synthesis of o-succinylbenzoyl-CoA in cell-free extracts of anthraquinone producing Galium mollugo L. cell suspension cultures

artículo científico publicado en 1982

Evolutionary relationships of microbial aromatic prenyltransferases

artículo científico publicado en 2011

Expression of bacterial chorismate pyruvate-lyase in tobacco: evidence for the presence of chorismate in the plant cytosol

artículo científico publicado en 1998

Five gene products are required for assembly of the central pyrrole moiety of coumermycin A1.

artículo científico publicado en 2013

Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin

artículo científico publicado en 2002

Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.

artículo científico publicado en 2009

Genetic engineering of plant secondary metabolism. Accumulation of 4-hydroxybenzoate glucosides as a result of the expression of the bacterial ubiC gene in tobacco.

artículo científico publicado en 1996

Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene.

artículo científico publicado en 1999

Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete

artículo científico publicado en 2014

Geranylhydroquinone 3"-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures.

artículo científico publicado en 2000

HPLC-MS/MS analysis of willow bark extracts contained in pharmaceutical preparations

artículo científico publicado en 2005

Herba Artemisiae annuae tea preparation compared to sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria in adults: a randomized double-blind clinical trial

artículo científico publicado en 2008

Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

artículo científico publicado en 2005

Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains

artículo científico publicado en 2010

High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon

artículo científico publicado en 2002

Identification and structural elucidation of new caprazamycins from Streptomyces sp. MK730-62F2 by liquid chromatography/electrospray ionization tandem mass spectrometry

artículo científico publicado en 2011

Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489.

artículo científico publicado en 2004

Immobilization of isochorismate hydroxymutase. Comparison of native versus immobilized enzyme

artículo científico publicado en 1993

Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics

scientific article published on 01 August 2007

In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach

artículo científico publicado en 2004

Influence of willow bark extract on cyclooxygenase activity and on tumor necrosis factor alpha or interleukin 1 beta release in vitro and ex vivo

artículo científico publicado en 2003

Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.

artículo científico publicado en 2011

Mass spectrometric pathway monitoring of secondary metabolites: systematic analysis of culture extracts of Streptomyces species

artículo científico publicado en 2004

Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host

artículo científico publicado en 2005

Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

artículo científico publicado en 2006

Molecular replacement in the 'twilight zone': structure determination of the non-haem iron oxygenase NovR from Streptomyces spheroides through repeated density modification of a poor molecular-replacement solution

artículo científico publicado en 2006

New Aminocoumarins from the Rare Actinomycete Catenulispora acidiphila DSM 44928: Identification, Structure Elucidation, and Heterologous Production

artículo científico publicado en 2014

New Aspects of Shikonin Biosynthesis: Geranyl Pyrophosphate Synthase and Origin of p-Hydroxybenzoic Acid

scientific article published on 01 December 1988

New aminocoumarin antibiotics as gyrase inhibitors.

artículo científico

New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster

artículo científico publicado en 2007

New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN.

artículo científico publicado en 2004

New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976.

artículo científico publicado en 2004

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

artículo científico publicado en 2005

NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis.

artículo científico publicado en 2005

Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.

artículo científico publicado en 2003

Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesis

artículo científico publicado en 2005

Partial purification and properties of geranyl pyrophosphate synthase from Lithospermum erythrorhizon cell cultures

artículo científico publicado en 1989

Partial purification, properties, and kinetic studies of UDP-glucose:p-hydroxybenzoate glucosyltransferase from cell cultures of Lithospermum erythrorhizon

artículo científico publicado en 1991

Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster

artículo científico publicado en 2013

Pharmacokinetics of salicin after oral administration of a standardised willow bark extract

artículo científico publicado en 2001

Prenyl transfer to aromatic substrates: genetics and enzymology.

scientific article published on 18 March 2009

Prices, availability and affordability of medicines in Rwanda

artículo científico publicado en 2020

Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains. ⬇️

artículo científico publicado en 2004

Properties of isochorismate hydroxymutase from Flavobacterium K3-15.

artículo científico publicado en 1993

Purification and characterization of an alcohol dehydrogenase from Lithospermum erythrorhizon cell cultures

artículo científico publicado en 1996

Quality assurance in anti-tuberculosis drug procurement by the Stop TB Partnership-Global Drug Facility: Procedures, costs, time requirements, and comparison of assay and dissolution results by manufacturers and by external analysis

artículo científico publicado en 2020

Quality of medicines in southern Togo: Investigation of antibiotics and of medicines for non-communicable diseases from pharmacies and informal vendors

scientific article published in PLoS ONE

Quality of oxytocin and misoprostol in health facilities of Rwanda

artículo científico publicado en 2021

Quality, availability and storage conditions of oxytocin and misoprostol in Malawi

scientific article published on 29 March 2020

Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria

artículo científico publicado en 2004

Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates

artículo científico publicado en 2009

Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase for shikonin biosynthesis in Lithospermum erythrorhizon cell suspension cultures

artículo científico publicado en 1998

Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis.

artículo científico publicado en 2011

S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces

artículo científico publicado en 2010

Salicin and treatment of rheumatic diseases.

artículo científico publicado en 2003

Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action

artículo científico publicado en 2005

Stability of misoprostol tablets collected in Malawi and Rwanda: Importance of intact primary packaging

artículo científico publicado en 2020

Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase CloQ from the Clorobiocin Biosynthetic Pathway ⬇️

artículo científico publicado el 12 de octubre de 2010

Structure-Based Engineering Increased the Catalytic Turnover Rate of a Novel Phenazine Prenyltransferase

artículo científico publicado en 2012

Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis

artículo científico publicado en 2006

Surveillance for falsified and substandard medicines in Africa and Asia by local organizations using the low-cost GPHF Minilab.

artículo científico publicado en 2017

The ABBA family of aromatic prenyltransferases: broadening natural product diversity

artículo científico publicado en 2008

The aminocoumarins: biosynthesis and biology.

scientific article published on 10 August 2009

The biosynthetic gene clusters of aminocoumarin antibiotics.

artículo científico publicado en 2006

The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042 ⬇️

artículo científico publicado el 8 de diciembre de 2010

Transcriptional regulation of the novobiocin biosynthetic gene cluster.

artículo científico publicado en 2009

Two pathways for pyrrole formation in coumermycin A(1) biosynthesis: the central pyrrole moiety is formed from L-threonine

scientific article published on 27 September 2011

Ubiquinone biosynthesis. Cloning of the genes coding for chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyl transferase from Escherichia coli

artículo científico publicado en 1992

Unusual N-prenylation in diazepinomicin biosynthesis: the farnesylation of a benzodiazepine substrate is catalyzed by a new member of the ABBA prenyltransferase superfamily

artículo científico publicado en 2013

Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties

artículo científico publicado en 2008

Use of an inducible promoter for antibiotic production in a heterologous host.

artículo científico publicado en 2010

Use of thin-layer chromatography to detect counterfeit sulfadoxine/pyrimethamine tablets with the wrong active ingredient in Malawi

artículo científico publicado en 2016

Wirksamkeit und Verträglichkeit eines standardisierten Weidenrindenextraktes bei Arthrose-Patienten: Randomisierte, Placebo-kontrollierte Doppelblindstudie

artículo científico publicado en 2000

[Pharmaceutical biology in the spotlight]

artículo científico publicado en 1994

[Untersuchungen zur Biosynthese des Vitamin K2. Isolierung des aktivierten Derivates der o-Succinylbenzoesäure aus zellfreien Extrakten von Mycobacterium phlei.].

artículo científico publicado en 1981

cDNA cloning and gene expression of phenylalanine ammonia-lyase in Lithospermum erythrorhizon ⬇️

artículo científico publicado en 1997

novE and novG act as positive regulators of novobiocin biosynthesis.

artículo científico publicado en 2008

Lista de obras de Lutz Heide

4-Coumaroyl coenzyme A 3-hydroxylase activity from cell cultures of Lithospermum erythrorhizon and its relationship to polyphenol oxidase

4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon : purification of a plant membrane-bound prenyltransferase ⬇️

A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation

A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.

A membrane-bound prenyltransferase catalyzes the O-prenylation of 1,6-dihydroxyphenazine in the marine bacterium Streptomyces sp. CNQ-509

Active expression of the ubiA gene from E. coli in tobacco: influence of plant ER-specific signal peptides on the expression of a membrane-bound prenyltransferase in plant cells

Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar

Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains

An artificial pathway to 3,4-dihydroxybenzoic acid allows generation of new aminocoumarin antibiotic recognized by catechol transporters of E. coli.

An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. ⬇️

Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis.

Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus

Artemisinin in traditional tea preparations of Artemisia annua

Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering

Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.

Availability and affordability of antimalarial and antibiotic medicines in Malawi.

Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo

Biosynthesis of clorobiocin: investigation of the transfer and methylation of the pyrrolyl-2-carboxyl moiety

Biosynthesis of p-Hydroxybenzoate from p-Coumarate and p-Coumaroyl-Coenzyme A in Cell-Free Extracts of Lithospermum erythrorhizon Cell Cultures

Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042

Clarification of the Escherichia coli genetic map in the 92-minute region containing the ubiCA operon and the plsB, dgk, lexA, and dinF genes.

CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin

CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin

CloQ, a prenyltransferase involved in clorobiocin biosynthesis

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. ⬇️

Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. ⬇️

Colour coding of labels for essential drugs

Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry.

Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes

Diversity and evolution of the phenazine biosynthesis pathway

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds

Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the Aminocoumarin Antibiotic Novobiocin

Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin

Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor

Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials.

Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial

Enzymatic synthesis of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis

Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis.

Enzymic synthesis of o-succinylbenzoyl-CoA in cell-free extracts of anthraquinone producing Galium mollugo L. cell suspension cultures

Evolutionary relationships of microbial aromatic prenyltransferases

Expression of bacterial chorismate pyruvate-lyase in tobacco: evidence for the presence of chorismate in the plant cytosol

Five gene products are required for assembly of the central pyrrole moiety of coumermycin A1.

Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin

Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.

Genetic engineering of plant secondary metabolism. Accumulation of 4-hydroxybenzoate glucosides as a result of the expression of the bacterial ubiC gene in tobacco.

Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene.

Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete

Geranylhydroquinone 3"-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures.

HPLC-MS/MS analysis of willow bark extracts contained in pharmaceutical preparations

Herba Artemisiae annuae tea preparation compared to sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria in adults: a randomized double-blind clinical trial

Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains

High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon

Identification and structural elucidation of new caprazamycins from Streptomyces sp. MK730-62F2 by liquid chromatography/electrospray ionization tandem mass spectrometry

Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489.

Immobilization of isochorismate hydroxymutase. Comparison of native versus immobilized enzyme

Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics

In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach

Influence of willow bark extract on cyclooxygenase activity and on tumor necrosis factor alpha or interleukin 1 beta release in vitro and ex vivo

Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.

Mass spectrometric pathway monitoring of secondary metabolites: systematic analysis of culture extracts of Streptomyces species

Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host

Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

Molecular replacement in the 'twilight zone': structure determination of the non-haem iron oxygenase NovR from Streptomyces spheroides through repeated density modification of a poor molecular-replacement solution

New Aminocoumarins from the Rare Actinomycete Catenulispora acidiphila DSM 44928: Identification, Structure Elucidation, and Heterologous Production

New Aspects of Shikonin Biosynthesis: Geranyl Pyrophosphate Synthase and Origin of p-Hydroxybenzoic Acid

New aminocoumarin antibiotics as gyrase inhibitors.

New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster

New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN.

New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976.

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis.

Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.

Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesis

Partial purification and properties of geranyl pyrophosphate synthase from Lithospermum erythrorhizon cell cultures

Partial purification, properties, and kinetic studies of UDP-glucose:p-hydroxybenzoate glucosyltransferase from cell cultures of Lithospermum erythrorhizon

Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster

Pharmacokinetics of salicin after oral administration of a standardised willow bark extract