Lista de obras - Carleen Cullinane - Dominio Público Uruguay

18F-FLT PET as a surrogate marker of drug efficacy during mTOR inhibition by everolimus in a preclinical cisplatin-resistant ovarian tumor model

artículo científico publicado en 2010

A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper-64 with High Tumor Uptake and Retention

scientific article published on 05 September 2019

A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

artículo científico publicado en 2016

A dual radiologic contrast agent protocol for 18F-FDG and 18F-FLT PET/CT imaging of mice bearing abdominal tumors.

artículo científico publicado en 2011

A microwave-assisted stereoselective synthesis of polyandrocarpamines A and B

AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo

artículo científico publicado en 2013

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

artículo científico publicado en 2015

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF<sup>V600</sup> melanoma

artículo científico publicado en 2022

Adriamycin-induced inhibition of mitochondrial-encoded polypeptides as a model system for the identification of hotspots for DNA-damaging agents

article

Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer

artículo científico publicado en 2010

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

artículo científico publicado en 2012

An in vitro transcription assay for probing drug-DNA interactions at individual drug sites

artículo científico publicado en 1998

An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development

artículo científico publicado en 2005

Applications of positron emission tomography in the development of molecular targeted cancer therapeutics

artículo científico publicado en 2003

Applying Advanced Imaging Techniques to a Murine Model of Orthotopic Osteosarcoma

artículo científico publicado en 2015

Barminomycin forms GC-specific adducts and virtual interstrand crosslinks with DNA

artículo científico publicado en 1999

Bifunctional (64)Cu-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography

artículo científico publicado en 2015

Botryllamides K and L, new tyrosine derivatives from the Australian ascidian Aplidium altarium ⬇️

article

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

scientific article published on 26 May 2020

Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells

artículo científico publicado en 2014

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

artículo científico publicado en 2015

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

artículo científico publicado en 2013

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

artículo científico publicado en 2015

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151.

artículo científico publicado en 2014

DNA damage by nitrogen mustard in a gene containing multiple Sp1-binding sites

article

DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria

artículo científico publicado en 1998

DNA sequence-specific adducts of adriamycin and mitomycin C

artículo científico publicado en 1989

DNA targeted platinum complexes: synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum(II) complexes tethered to phenazine-1-carboxamides

artículo científico publicado en 2000

Detection of Apoptotic Cells Using Immunohistochemistry

artículo científico publicado en 2014

Detection of Apoptotic Cells Using Propidium Iodide Staining

artículo científico publicado en 2014

Diagnostic imaging agents for Alzheimer's disease: copper radiopharmaceuticals that target Aβ plaques

artículo científico publicado en 2013

Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models

artículo científico publicado en 2011

Dipyridophenazine Complexes of Cobalt(III): DNA Photocleavage and Photobiology

scholarly article by Alison M. Funston et al published 2005 in Australian Journal of Chemistry

Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C14-erythromycin breath test and the antipyrine clearance test

Does Adriamycin Induce Interstrand Cross-Links in DNA?

artículo científico publicado en 1994

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models

artículo científico publicado en 2012

EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. Epidermal growth factor receptor

artículo científico publicado en 2003

Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of αvβ3 Integrin Expression with Gallium-68.

artículo científico publicado en 2016

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in hematological tumors

artículo científico publicado en 2014

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in solid tumors

artículo científico publicado en 2014

Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts

artículo científico publicado en 2000

Formation of DNA adducts by formaldehyde-activated mitoxantrone.

artículo científico publicado en 1999

Formation of adriamycin--DNA adducts in vitro.

artículo científico publicado en 1994

Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in ovarian cancer cell lines

artículo científico publicado en 2003

High-resolution transcription assay for probing drug-DNA interactions at individual drug sites

artículo científico publicado en 2001

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

scientific article published on 26 March 2018

Imaging of molecular target modulation in oncology: challenges of early clinical trials

Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results.

artículo científico publicado en 2007

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

artículo científico publicado en 2013

In vitro transcription analysis of DNA adducts induced by cyanomorpholinoadriamycin

artículo científico publicado en 1992

In vitro transcription analysis of DNA alkylation by nitrogen mustard

scientific article published on 01 August 1991

In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer

artículo científico publicado en 2011

Inclusion complexes of the antitumour metallocenes Cp(2)MCl(2) (M = Mo, Ti) with cucurbit[n]urils

artículo científico publicado en 2008

Induction of stable transcriptional blockage sites by Adriamycin: GpC specificity of apparent Adriamycin-DNA adducts and dependence on iron(III) ions

scientific article published on 01 June 1990

Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

artículo científico publicado en 2017

Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells

artículo científico publicado en 2011

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

artículo científico publicado en 2017

Inhibition of RNA Polymerase II Transcription in Human Cell Extracts by Cisplatin DNA Damage

article

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

scientific journal article

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

artículo científico publicado en 2016

Interstrand cross-linking by adriamycin in nuclear and mitochondrial DNA of MCF-7 cells

artículo científico publicado en 2000

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

artículo científico publicado en 2015

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

artículo científico publicado en 2012

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model

artículo científico publicado en 2016

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

artículo científico publicado en 2014

Measuring apoptosis in mammals in vivo

artículo científico publicado en 2014

Mitochondrial and nuclear DNA damage induced by sulphur mustard in keratinocytes

scientific article published on 01 December 2001

Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging

artículo científico publicado en 2005

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities

artículo científico publicado en 2013

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

artículo científico publicado en 2004

Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033.

artículo científico publicado en 2006

New Tris(hydroxypyridinone) Bifunctional Chelators Containing Isothiocyanate Groups Provide a Versatile Platform for Rapid One-Step Labeling and PET Imaging with (68)Ga(3.).

artículo científico publicado en 2015

New insight into drug-DNA interactions at individual drug binding sites probed by RNA polymerase during active transcription of the DNA

artículo científico publicado en 1990

Nuclear and mitochondrial distribution of organoamidoplatinum(II) lesions in cisplatin-sensitive and -resistant adenocarcinoma cells.

artículo científico publicado en 2001

PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

artículo científico publicado en 2013

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

artículo científico publicado en 2017

Peptide receptor chemoradionuclide therapy in small cell carcinoma: from bench to bedside

artículo científico publicado en 2014

Preclinical FLT-PET and FDG-PET imaging of tumor response to the multi-targeted Aurora B kinase inhibitor, TAK-901.

artículo científico publicado en 2013

Preclinical evaluation of nilotinib efficacy in an imatinib-resistant KIT-driven tumor model

artículo científico publicado en 2010

Preparation and cell growth inhibitory activity of [PtR(2)L(2)] (R=polyfluorophenyl, L(2)=diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)(2)) and the X-ray crystal structure of [Pt(C(6)F(5))(2)(cis-chxn)].

artículo científico publicado en 2002

RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition

artículo científico publicado en 2011

Rapid kit-based (68)Ga-labelling and PET imaging with THP-Tyr(3)-octreotate: a preliminary comparison with DOTA-Tyr(3)-octreotate

artículo científico publicado en 2015

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

scientific article published on 18 September 2020

Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer

artículo científico publicado en 2013

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis

artículo científico publicado en 2014

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.

artículo científico publicado en 2013

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.

artículo científico publicado en 2016

Sequence Specificity of (Cyanomorpholino)adriamycin Adducts in Human Cells

artículo científico publicado en 1994

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

artículo científico publicado en 2017

Strand breakage by decay of DNA-bound 124I provides a basis for combined PET imaging and Auger endoradiotherapy

artículo científico publicado en 2016

Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: the importance of pKa matching

artículo científico publicado en 2012

Studies of a Cobalt(III) Complex of the MMP Inhibitor Marimastat: A Potential Hypoxia-Activated Prodrug

scientific article published on 01 January 2007

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

artículo científico publicado en 2013

Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes

artículo científico publicado en 2018

Synthesis, cytotoxicity and cucurbituril binding of triamine linked dinuclear platinum complexes

artículo científico publicado en 2009

Synthesis, cytotoxicity, cell uptake and DNA interstrand cross-linking of 4,4'-dipyrazolylmethane-linked multinuclear platinum anti-cancer complexes.

artículo científico publicado en 2001

Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl].

artículo científico publicado en 2012

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

artículo científico publicado en 2015

The DNA sequence specificity of cyanomorpholinoadriamycin

scientific article published on 01 November 1991

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

scientific article published on 11 November 2020

The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells.

artículo científico publicado en 2014

Thermal stability of DNA adducts induced by cyanomorpholinoadriamycin in vitro.

artículo científico publicado en 1993

Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study

artículo científico publicado en 2010

Transcriptional footprinting of drug-DNA interactions.

artículo científico publicado en 1997

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

artículo científico publicado en 2015

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

artículo científico publicado en 2014

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

artículo científico publicado en 2012

[(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells

artículo científico

β -[¹⁸F]Fluoro Azomycin Arabinoside (β -[¹⁸F]FAZA): Synthesis, Radiofluorination and Preliminary PET Imaging of Murine A431 Tumors

artículo científico publicado en 2017

Lista de obras de Carleen Cullinane

18F-FLT PET as a surrogate marker of drug efficacy during mTOR inhibition by everolimus in a preclinical cisplatin-resistant ovarian tumor model

A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper-64 with High Tumor Uptake and Retention

A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

A dual radiologic contrast agent protocol for 18F-FDG and 18F-FLT PET/CT imaging of mice bearing abdominal tumors.

A microwave-assisted stereoselective synthesis of polyandrocarpamines A and B

AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF<sup>V600</sup> melanoma

Adriamycin-induced inhibition of mitochondrial-encoded polypeptides as a model system for the identification of hotspots for DNA-damaging agents

Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

An in vitro transcription assay for probing drug-DNA interactions at individual drug sites

An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development

Applications of positron emission tomography in the development of molecular targeted cancer therapeutics

Applying Advanced Imaging Techniques to a Murine Model of Orthotopic Osteosarcoma

Barminomycin forms GC-specific adducts and virtual interstrand crosslinks with DNA

Bifunctional (64)Cu-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography

Botryllamides K and L, new tyrosine derivatives from the Australian ascidian Aplidium altarium ⬇️

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151.

DNA damage by nitrogen mustard in a gene containing multiple Sp1-binding sites

DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria

DNA sequence-specific adducts of adriamycin and mitomycin C

DNA targeted platinum complexes: synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum(II) complexes tethered to phenazine-1-carboxamides

Detection of Apoptotic Cells Using Immunohistochemistry

Detection of Apoptotic Cells Using Propidium Iodide Staining

Diagnostic imaging agents for Alzheimer's disease: copper radiopharmaceuticals that target Aβ plaques

Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models

Dipyridophenazine Complexes of Cobalt(III): DNA Photocleavage and Photobiology

Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C14-erythromycin breath test and the antipyrine clearance test

Does Adriamycin Induce Interstrand Cross-Links in DNA?

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models

EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. Epidermal growth factor receptor

Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of αvβ3 Integrin Expression with Gallium-68.

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in hematological tumors

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in solid tumors

Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts

Formation of DNA adducts by formaldehyde-activated mitoxantrone.

Formation of adriamycin--DNA adducts in vitro.

Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in ovarian cancer cell lines

High-resolution transcription assay for probing drug-DNA interactions at individual drug sites

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

Imaging of molecular target modulation in oncology: challenges of early clinical trials

Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results.

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

In vitro transcription analysis of DNA adducts induced by cyanomorpholinoadriamycin

In vitro transcription analysis of DNA alkylation by nitrogen mustard

In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer

Inclusion complexes of the antitumour metallocenes Cp(2)MCl(2) (M = Mo, Ti) with cucurbit[n]urils

Induction of stable transcriptional blockage sites by Adriamycin: GpC specificity of apparent Adriamycin-DNA adducts and dependence on iron(III) ions

Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Inhibition of RNA Polymerase II Transcription in Human Cell Extracts by Cisplatin DNA Damage

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Interstrand cross-linking by adriamycin in nuclear and mitochondrial DNA of MCF-7 cells

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

Measuring apoptosis in mammals in vivo

Mitochondrial and nuclear DNA damage induced by sulphur mustard in keratinocytes

Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033.

New Tris(hydroxypyridinone) Bifunctional Chelators Containing Isothiocyanate Groups Provide a Versatile Platform for Rapid One-Step Labeling and PET Imaging with (68)Ga(3.).

New insight into drug-DNA interactions at individual drug binding sites probed by RNA polymerase during active transcription of the DNA

Nuclear and mitochondrial distribution of organoamidoplatinum(II) lesions in cisplatin-sensitive and -resistant adenocarcinoma cells.

PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

Peptide receptor chemoradionuclide therapy in small cell carcinoma: from bench to bedside

Preclinical FLT-PET and FDG-PET imaging of tumor response to the multi-targeted Aurora B kinase inhibitor, TAK-901.

Preclinical evaluation of nilotinib efficacy in an imatinib-resistant KIT-driven tumor model