Lista de obras - Stylianos Michalakis - Dominio Público Uruguay

A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation

artículo científico publicado en 2020

A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.

artículo científico publicado en 2010

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

scientific journal article

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting

artículo científico publicado en 2021

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network

artículo científico

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments

artículo científico publicado en 2016

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects

artículo científico publicado en 2017

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

artículo científico publicado en 2017

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy

scientific article published on 12 November 2018

Advancing Gene Therapy for PDE6A Retinitis Pigmentosa

artículo científico publicado en 2019

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues

artículo científico publicado en 2015

Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation

artículo científico publicado en 2016

CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration

artículo científico publicado en 2012

CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity

artículo científico publicado en 2011

COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic

scientific article published on 06 May 2020

Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice

artículo científico publicado en 2016

Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction

scientific article published on 27 December 2012

Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.

artículo científico publicado en 2007

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

artículo científico publicado en 2015

Cyclic nucleotide-gated channels

artículo científico publicado en 2009

Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

artículo científico publicado en 2018

Detection of cGMP in the degenerating retina

artículo científico publicado en 2013

Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial

artículo científico publicado en 2018

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice

artículo científico publicado en 2017

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

artículo científico publicado en 2017

Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.

artículo científico publicado en 2017

Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency

artículo científico publicado en 2012

Function and dysfunction of CNG channels: insights from channelopathies and mouse models

artículo científico publicado en 2007

Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis

artículo científico publicado en 2018

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa

artículo científico publicado en 2017

Gene replacement therapy for retinal CNG channelopathies

artículo científico

Gene therapy for achromatopsia.

artículo científico publicado en 2017

Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia

artículo científico publicado en 2012

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

artículo científico publicado en 2014

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

artículo científico publicado en 2012

Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

artículo científico publicado en 2017

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

artículo científico publicado en 2016

HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path

artículo científico publicado en 2010

HCN3 contributes to the ventricular action potential waveform in the murine heart

artículo científico publicado en 2011

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

scientific article published on 17 April 2018

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.

artículo científico publicado en 2018

Hyperpolarization-activated cation channels: from genes to function

artículo científico publicado en 2009

Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration

artículo científico publicado en 2014

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

scientific journal article

Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.

artículo científico publicado en 2005

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy

article

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

artículo científico publicado en 2016

In vivo analysis of cone survival in mice

artículo científico publicado en 2009

In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.

artículo científico publicado en 2016

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes

artículo científico publicado en 2019

Investigation of the immunogenicity of different types of aggregates of a murine monoclonal antibody in mice

artículo científico publicado en 2014

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency

artículo científico publicado en 2012

Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping

scientific journal article

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia

artículo científico publicado en 2016

Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study

artículo científico publicado en 2013

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

artículo científico publicado en 2021

Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry

artículo científico publicado en 2019

Morphological characterization of the retina of the CNGA3(-/-)Rho(-/-) mutant mouse lacking functional cones and rods

artículo científico publicado en 2004

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

artículo científico publicado en 2013

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

artículo científico publicado en 2017

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

scientific article published on 27 December 2019

Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1

scientific article published on 06 April 2020

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders

artículo científico publicado en 2021

Optimized Subretinal Injection Technique for Gene Therapy Approaches

article

Optimized technique for subretinal injections in mice

artículo científico publicado en 2013

Optogenetic Control of Neural Circuits in the Mongolian Gerbil.

artículo científico publicado en 2018

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

artículo científico publicado en 2014

Patients and animal models of CNGβ1-deficient retinitis pigmentosa support gene augmentation approach

artículo científico publicado en 2017

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

artículo científico publicado en 2017

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.

artículo científico publicado en 2014

Photopharmacological control of bipolar cells restores visual function in blind mice

artículo científico publicado en 2017

Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies.

artículo científico publicado en 2009

Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis

article

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

artículo científico publicado en 2010

Quantitative LC-MS Provides No Evidence for m6 dA or m4 dC in the Genome of Mouse Embryonic Stem Cells and Tissues

artículo científico publicado en 2017

Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice.

artículo científico publicado en 2015

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

artículo científico publicado en 2021

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization

artículo científico publicado en 2016

Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function

artículo científico publicado en 2010

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.

artículo científico publicado en 2018

Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications

artículo científico publicado en 2015

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

artículo científico publicado en 2015

Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial

scientific article published on 30 April 2020

Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy.

artículo científico publicado en 2016

Structural and functional phenotyping in the cone-specific photoreceptor function loss 1 (cpfl1) mouse mutant - a model of cone dystrophies

artículo científico publicado en 2010

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

artículo científico publicado en 2017

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.

artículo científico publicado en 2017

Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs

artículo científico publicado en 2022

Synaptic plasticity in CNGA3(-/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods.

artículo científico publicado en 2006

Synthesis of galactosyl-queuosine and distribution of hypermodified Q-nucleosides in mouse tissues

artículo científico publicado en 2020

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

scientific article published in 2022

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

article

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.

artículo científico publicado en 2014

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the <i>Cnga3</i>-Deficient Mouse Model of Achromatopsia

artículo científico publicado en 2020

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel

artículo científico publicado en 2011

The cyclic nucleotide-gated ion channel CNGA3 contributes to coolness-induced responses of Grueneberg ganglion neurons

artículo científico publicado en 2010

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

artículo científico publicado en 2011

The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides

scientific journal article

The retinitis pigmentosa mutation c.3444+1G>A in CNGB1 results in skipping of exon 32

artículo científico publicado en 2010

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

artículo científico publicado en 2010

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).

artículo científico publicado en 2013

Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia

artículo científico publicado en 2015

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function

artículo científico publicado en 2013

cGMP-dependent cone photoreceptor degeneration in the cpfl1 mouse retina.

artículo científico publicado en 2010

cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

artículo científico publicado en 2015

Lista de obras de Stylianos Michalakis

A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation

A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy

Advancing Gene Therapy for PDE6A Retinitis Pigmentosa

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues

Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation

CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration

CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity

COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic

Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice

Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction

Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

Cyclic nucleotide-gated channels

Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

Detection of cGMP in the degenerating retina

Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.

Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency

Function and dysfunction of CNG channels: insights from channelopathies and mouse models

Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa

Gene replacement therapy for retinal CNG channelopathies

Gene therapy for achromatopsia.

Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path

HCN3 contributes to the ventricular action potential waveform in the murine heart

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.

Hyperpolarization-activated cation channels: from genes to function

Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

In vivo analysis of cone survival in mice

In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes

Investigation of the immunogenicity of different types of aggregates of a murine monoclonal antibody in mice

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency

Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia

Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry

Morphological characterization of the retina of the CNGA3(-/-)Rho(-/-) mutant mouse lacking functional cones and rods

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders

Optimized Subretinal Injection Technique for Gene Therapy Approaches

Optimized technique for subretinal injections in mice

Optogenetic Control of Neural Circuits in the Mongolian Gerbil.

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

Patients and animal models of CNGβ1-deficient retinitis pigmentosa support gene augmentation approach

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.

Photopharmacological control of bipolar cells restores visual function in blind mice

Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies.

Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

Quantitative LC-MS Provides No Evidence for m6 dA or m4 dC in the Genome of Mouse Embryonic Stem Cells and Tissues

Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice.

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization