Lista de obras - Alex von Kriegsheim - Dominio Público Uruguay

-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--

artículo científico publicado en 2021

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells

artículo científico publicado en 2018

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

artículo científico publicado en 2018

An Integrated Global Analysis of Compartmentalized HRAS Signaling

artículo científico publicado en 2019

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein.

artículo científico publicado en 2018

Asparagine hydroxylation is a reversible post-translational modification

artículo científico publicado en 2020

BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome

artículo científico publicado en 2018

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

artículo científico publicado en 2016

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

artículo científico publicado en 2017

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

artículo científico publicado en 2017

Cell fate decisions are specified by the dynamic ERK interactome

artículo científico publicado en 2009

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

artículo científico publicado en 2018

Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.

artículo científico publicado en 2018

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

artículo científico publicado en 2024

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

artículo científico publicado en 2017

Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.

artículo científico publicado en 2015

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

artículo científico publicado en 2016

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

scientific article published on 02 August 2019

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity

artículo científico publicado en 2013

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

scientific journal article

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

artículo científico publicado en 2011

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

artículo científico publicado en 2015

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus ⬇️

artículo científico publicado en 2014

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

artículo científico publicado en 2014

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

scientific article published on 21 December 2016

Hypoxia Reduces the Pathogenicity of Pseudomonas aeruginosa by Decreasing the Expression of Multiple Virulence Factors.

artículo científico publicado en 2017

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy

artículo científico publicado en 2019

Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.

artículo científico publicado en 2018

In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells.

artículo científico publicado en 2014

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species

artículo científico publicado en 2010

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability

artículo científico publicado en 2017

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

artículo científico publicado en 2012

Mapping of signaling pathways by functional interaction proteomics

artículo científico publicado en 2008

Mass Spectrometry and Bioinformatic Analysis of Hydroxylation-Dependent Protein-Protein Interactions

artículo científico publicado en 2018

Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK.

artículo científico publicado en 2014

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

artículo científico publicado en 2017

NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

artículo científico publicado en 2016

Network-based identification of feedback modules that control RhoA activity and cell migration

artículo científico publicado en 2015

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

artículo científico publicado en 2014

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

artículo científico publicado en 2015

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

artículo científico publicado en 2018

On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics

artículo científico publicado en 2014

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

scientific article published on 01 July 2018

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins ⬇️

artículo científico publicado en 2017

Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

artículo científico publicado en 2020

Phosphatase and feedback regulation of Raf-1 signaling

artículo científico publicado en 2007

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

artículo científico publicado en 2017

Potential mechanisms of calcium dependent regulation of the mammalian cell cycle revealed by comprehensive unbiased label-free nLC-MS/MS quantitative proteomics

artículo científico publicado en 2017

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.

artículo científico publicado en 2016

Protein-Protein Interaction Detection Via Mass Spectrometry-Based Proteomics

artículo científico publicado en 2016

Proteomics and phosphoproteomics for the mapping of cellular signalling networks

artículo científico publicado en 2008

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

artículo científico publicado en 2021

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

artículo científico publicado en 2018

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis

artículo científico publicado en 2021

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

artículo científico publicado en 2013

Rac1 and RhoA: Networks, loops and bistability

artículo científico publicado en 2016

Raf family kinases: old dogs have learned new tricks

artículo científico publicado en 2011

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.

artículo científico publicado en 2016

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

artículo científico publicado en 2013

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

scientific journal article

Signalling by protein phosphatases and drug development: a systems-centred view.

artículo científico publicado en 2012

Signalling mechanisms regulating phenotypic changes in breast cancer cells

artículo científico publicado en 2015

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

artículo científico publicado en 2011

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

scientific journal article

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

artículo científico publicado en 2017

The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins

artículo científico publicado en 2022

Towards complete analysis of the platelet proteome

artículo científico publicado en 2002

Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.

artículo científico publicado en 2017

Uncovering Bistability in the Rac1/RhoA Signaling Network Through Integrating Computational Modeling and Experimentation

artículo científico publicado en 2018

WT1-Associated Protein-Protein Interaction Networks

artículo científico publicado en 2016

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

artículo científico publicado en 2018

Lista de obras de Alex von Kriegsheim

-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

An Integrated Global Analysis of Compartmentalized HRAS Signaling

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein.

Asparagine hydroxylation is a reversible post-translational modification

BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

Cell fate decisions are specified by the dynamic ERK interactome

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus ⬇️

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

Hypoxia Reduces the Pathogenicity of Pseudomonas aeruginosa by Decreasing the Expression of Multiple Virulence Factors.

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy

Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.

In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells.

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

Mapping of signaling pathways by functional interaction proteomics

Mass Spectrometry and Bioinformatic Analysis of Hydroxylation-Dependent Protein-Protein Interactions

Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK.

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

Network-based identification of feedback modules that control RhoA activity and cell migration

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins ⬇️

Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

Phosphatase and feedback regulation of Raf-1 signaling

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

Potential mechanisms of calcium dependent regulation of the mammalian cell cycle revealed by comprehensive unbiased label-free nLC-MS/MS quantitative proteomics

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.

Protein-Protein Interaction Detection Via Mass Spectrometry-Based Proteomics

Proteomics and phosphoproteomics for the mapping of cellular signalling networks

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

Rac1 and RhoA: Networks, loops and bistability

Raf family kinases: old dogs have learned new tricks

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

Signalling by protein phosphatases and drug development: a systems-centred view.

Signalling mechanisms regulating phenotypic changes in breast cancer cells

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins

Towards complete analysis of the platelet proteome

Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.

Uncovering Bistability in the Rac1/RhoA Signaling Network Through Integrating Computational Modeling and Experimentation

WT1-Associated Protein-Protein Interaction Networks

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.