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Lista de obras de Aurora Martinez

A Kinetic and Conformational Study on the Interaction of Tetrahydropteridines with Tyrosine Hydroxylase†

artículo científico publicado en 2000

A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria

scientific article published on 04 December 2019

A dynamic model of long-range conformational adaptations triggered by nucleotide binding in GroEL-GroES.

artículo científico publicado en 2012

A scavenger receptor B (CD36)-like protein is a potential mediator of intestinal heme absorption in the hematophagous ectoparasite Lepeophtheirus salmonis

artículo científico publicado en 2019

Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237.

artículo científico publicado en 2003

Adsorption and bioactivity of tyrosine hydroxylase on gold surfaces and nanoparticles.

artículo científico publicado en 2010

Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR

artículo científico publicado en 2010

Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism.

artículo científico publicado en 2005

Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans

artículo científico publicado en 2008

Arc is a flexible modular protein capable of reversible self-oligomerization

artículo científico publicado en 2015

Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif

artículo científico publicado en 2020

Avidity of onconeural antibodies is of clinical relevance

artículo científico publicado en 2013

Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability.

artículo científico publicado en 2017

Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients

artículo científico publicado en 2008

Blood phenylalanine reduction corrects CNS dopamine and serotonin deficiencies and partially improves behavioral performance in adult phenylketonuric mice

artículo científico publicado en 2017

Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low s

artículo científico publicado en 2012

Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency

artículo científico publicado en 2015

Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR

artículo científico publicado en 1993

Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity.

artículo científico publicado en 2005

Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations

artículo científico publicado en 2011

Conformational stability and activity analysis of two hydroxymethylbilane synthase mutants, K132N and V215E, with different phenotypic association with acute intermittent porphyria

artículo científico publicado en 2013

Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia

artículo científico publicado en 2017

Cooperative homotropic interaction of l-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase

artículo científico publicado en 1990

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations

artículo científico publicado en 2004

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

artículo científico publicado en 1997

Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase

artículo científico publicado en 1997

Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4).

artículo científico publicado en 2015

DNAJC12 deficiency: A new strategy in the diagnosis of hyperphenylalaninemias

artículo científico publicado en 2017

Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila

article

Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms

artículo científico publicado en 2015

Dissection of binding between a phosphorylated tyrosine hydroxylase peptide and 14-3-3zeta: A complex story elucidated by NMR.

artículo científico publicado en 2014

Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine

artículo científico publicado en 2011

Domain structure and stability of human phenylalanine hydroxylase inferred from infrared spectroscopy

artículo científico publicado en 1998

Dynamics, Flexibility and Ligand-Induced Conformational Changes in Biological Macromolecules: A Computational Approach ⬇️

artículo científico publicado el 1 de diciembre de 2011

Dynamics, flexibility, and allostery in molecular chaperonins

artículo científico publicado en 2015

EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors

artículo científico publicado en 1991

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

artículo científico publicado en 2019

Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases

artículo científico publicado en 2019

Effect of mutations at Cys237 on the activation state and activity of human phenylalanine hydroxylase

artículo científico publicado en 1997

Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice

artículo científico publicado en 2017

Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2.

artículo científico publicado en 2010

Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets.

artículo científico publicado en 2013

Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

artículo científico publicado en 2006

Evidence for a functionally important histidine residue in human tyrosine hydroxylase

artículo científico publicado en 1995

Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris

artículo científico publicado en 2004

Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases.

artículo científico publicado en 2011

Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in Dopa-responsive dystonia

artículo científico publicado en 2014

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury

scientific article published on 17 February 2020

HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers ⬇️

artículo científico publicado el 16 de febrero de 2012

HAMLET interacts with lipid membranes and perturbs their structure and integrity

artículo científico publicado en 2010

Identification of a novel lytic peptide for the treatment of solid tumours.

artículo científico publicado en 2014

Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

artículo científico publicado en 2008

Inactivation of purified phenylalanine hydroxylase by dithiothreitol

artículo científico publicado en 1992

Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus

artículo científico publicado en 2009

L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.

artículo científico publicado en 2002

Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics

artículo científico publicado en 2008

Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria

artículo científico publicado en 2014

Long Noncoding RNA SChLAP1 Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling

artículo científico publicado en 2019

Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations

artículo científico publicado en 2004

Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins

artículo científico publicado en 2013

Overview of computational methods employed in early-stage drug discovery.

artículo científico publicado en 2009

Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.

artículo científico publicado en 1998

Pathogenic variants of DNAJC12 and evaluation of the encoded co-chaperone as a genetic modifier of hyperphenylalaninemia

scientific article published on 25 April 2020

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms

artículo científico publicado en 2016

Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG.

artículo científico publicado en 2016

Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type ⬇️

artículo científico publicado el 13 de mayo de 2013

Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis ⬇️

artículo científico publicado el 26 de septiembre de 2012

Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration

artículo científico publicado en 2010

Phenylalanine hydroxylase misfolding and pharmacological chaperones.

artículo científico publicado en 2012

Phenylalanine hydroxylase variants interact with the co-chaperone DNAJC12

artículo científico publicado en 2019

Phenylalanine hydroxylase: function, structure, and regulation.

artículo científico publicado en 2013

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects

artículo científico publicado en 2002

Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules

artículo científico publicado en 2017

Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ.

artículo científico publicado en 2014

Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure.

artículo científico publicado en 2003

Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases

artículo científico publicado en 2007

Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit

artículo científico publicado en 2011

Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations

artículo científico publicado en 2003

Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus

artículo científico publicado en 1988

Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry.

artículo científico publicado en 2012

Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions

artículo científico publicado en 1991

Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles

scientific article published on 08 January 2021

Rescue of misfolded proteins and stabilization by small molecules.

artículo científico publicado en 2010

Rescuing proteins of low kinetic stability by chaperones and natural ligands phenylketonuria, a case study

artículo científico publicado en 2008

Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials

artículo científico publicado en 2013

Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase

artículo científico publicado en 2008

Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases

artículo científico publicado en 2007

Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo

article

Stabilization of human tyrosine hydroxylase in maltodextrin nanoparticles for delivery to neuronal cells and tissue

artículo científico publicado en 2018

Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme.

artículo científico publicado en 2016

Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice

artículo científico publicado en 2005

Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability

artículo científico publicado en 2007

Structural and stability effects of phosphorylation: Localized structural changes in phenylalanine hydroxylase

artículo científico publicado en 2004

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophila

artículo científico publicado en 2013

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

artículo científico publicado en 2022

Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin

artículo científico publicado en 2019

Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.

artículo científico publicado en 1996

Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications

artículo científico publicado en 2010

Surface-Mediated Priming DuringIn VitroGeneration of Monocyte-Derived Dendritic Cells

artículo científico publicado en 2014

Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity

artículo científico publicado en 2004

Tetrahydrobiopterin for patients with phenylketonuria

artículo científico publicado en 2007

Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: implications for tetrahydrobiopterin-responsive hyperphenylalaninemia

artículo científico publicado en 2004

Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase

artículo científico publicado en 2008

Tetrahydrobiopterin treatment reduces brain L-Phe but only partially improves serotonin in hyperphenylalaninemic ENU1/2 mice.

artículo científico publicado en 2018

The 14-3-3 proteins in regulation of cellular metabolism.

artículo científico publicado en 2011

The Benefit of Large Neutral Amino Acid Supplementation to a Liberalized Phenylalanine-Restricted Diet in Adult Phenylketonuria Patients: Evidence from Adult Pah-Enu2 Mice

scientific article published on 19 September 2019

The N-Terminal Sequence of Tyrosine Hydroxylase Is a Conformationally Versatile Motif That Binds 14-3-3 Proteins and Membranes

artículo científico publicado en 2014

The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase

artículo científico publicado en 2021

The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase.

artículo científico publicado en 2005

The activity of wild-type and mutant phenylalanine hydroxylase and its regulation by phenylalanine and tetrahydrobiopterin at physiological and pathological concentrations: an isothermal titration calorimetry study

artículo científico publicado en 2005

The binding of 14-3-3γ to membranes studied by intrinsic fluorescence spectroscopy

artículo científico publicado en 2011

The binding of tyrosine hydroxylase to negatively charged lipid bilayers involves the N-terminal region of the enzyme

artículo científico publicado en 2002

The effect of substrate, dihydrobiopterin, and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase

artículo científico publicado en 2001

The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy

artículo científico publicado en 1992

The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions

artículo científico publicado en 2003

The mechanism of BH4-responsive hyperphenylalaninemia-As it occurs in the ENU1/2 genetic mouse model

artículo científico publicado en 2012

The peripheral binding of 14-3-3γ to membranes involves isoform-specific histidine residues

artículo científico publicado en 2012

The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum

artículo científico publicado en 2008

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation

artículo científico publicado en 2011

Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase

artículo científico publicado en 2004

Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes

artículo científico publicado en 2009

Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity.

artículo científico publicado en 2016

Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease

artículo científico publicado en 2016

Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity, as shown by kinetic analyses and surface plasmon resonance detection.

artículo científico publicado en 1999

alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids

artículo científico publicado en 2005

pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40

artículo científico publicado en 1990

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