Lista de obras - Mitchell R McGill - Dominio Público Uruguay

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen

artículo científico publicado en 2016

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide

artículo científico publicado en 2015

Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways

artículo científico publicado en 2019

Acetaminophen-induced Liver Injury: from Animal Models to Humans

artículo científico publicado en 2014

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

artículo científico publicado en 2012

Animal models of drug-induced liver injury

scientific article published on 03 September 2018

Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.

artículo científico publicado en 2013

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

artículo científico publicado en 2014

Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses

artículo científico publicado en 2015

Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

artículo científico publicado en 2015

Biomarkers of drug-induced liver injury

scientific article published on 06 March 2019

Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation

artículo científico publicado en 2018

Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro

artículo científico publicado en 2016

Caveats of using acetaminophen hepatotoxicity models for natural product testing

scientific article published on 04 October 2012

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

artículo científico publicado en 2013

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

artículo científico publicado en 2014

Connexin32: a mediator of acetaminophen-induced liver injury?

artículo científico publicado en 2016

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

scientific article published on 02 June 2020

Critical review of resveratrol in xenobiotic-induced hepatotoxicity.

artículo científico publicado en 2015

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products ⬇️

artículo científico publicado el 4 de febrero de 2011

Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity

artículo científico publicado en 2015

Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F₁ Mice

scientific article published on 03 April 2019

Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

artículo científico publicado en 2016

Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats

scientific article published on 01 January 2019

Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

artículo científico publicado en 2017

Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity

artículo científico publicado en 2019

Falsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein

artículo científico publicado en 2016

Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients

artículo científico publicado en 2014

Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children

artículo científico publicado en 2020

Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study

artículo científico publicado en 2016

HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity Δσ ⬇️

artículo científico publicado el 11 de febrero de 2011

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

artículo científico publicado en 2019

Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity

artículo científico publicado en 2010

Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations

scientific article published on 01 February 2020

Increased C-Reactive Protein in Healthy Controls.

artículo científico publicado en 2018

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

artículo científico publicado en 2017

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

artículo científico publicado en 2016

Involvement of connexin43 in acetaminophen-induced liver injury.

artículo científico publicado en 2016

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity

artículo científico publicado en 2015

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity

artículo científico publicado en 2015

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration

scientific article published on 11 March 2018

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury ⬇️

artículo científico publicado el 5 de abril de 2012

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

artículo científico publicado en 2015

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.

artículo científico publicado en 2014

Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.

artículo científico publicado en 2012

Mechanisms and biomarkers of liver regeneration after drug-induced liver injury

scientific article published on 21 March 2019

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

artículo científico publicado en 2014

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

artículo científico

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.

artículo científico publicado en 2015

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

artículo científico publicado en 2015

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.

artículo científico publicado en 2013

Modulation of O-GlcNAc levels in the liver impacts acetaminophen-induced liver injury by affecting protein adduct formation and glutathione synthesis.

artículo científico publicado en 2018

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

artículo científico publicado en 2012

Monoacylglycerol acyltransferase 1 knockdown exacerbates hepatic ischemia-reperfusion injury in mice with hepatic steatosis

scientific article published on 11 September 2020

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.

scientific article published on 15 January 2014

Oxidant Stress, Antioxidant Defense, and Liver Injury

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity

artículo científico publicado en 2012

Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration

scientific article published on 17 June 2019

Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

artículo científico publicado en 2011

Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity

scientific article published on 01 January 2013

Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity

artículo científico publicado en 2015

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

artículo científico publicado en 2013

Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis

artículo científico publicado en 2016

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

artículo científico publicado en 2015

Professionalism in Residency Training: A Compilation of Desirable Behaviors and a Case-Based Comparison Between Pathologists in Training and Practice.

artículo científico publicado en 2016

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange

scientific article published on 01 May 2019

Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning

artículo científico publicado en 2013

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation

artículo científico publicado en 2012

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

artículo científico publicado en 2013

Redrawing the Map to Novel DILI Biomarkers in Circulation: Where Are We, Where Should We Go, and How Can We Get There?

artículo científico publicado en 2021

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

artículo científico publicado en 2016

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

artículo científico publicado en 2015

Serum Glutamate Dehydrogenase—Biomarker for Liver Cell Death or Mitochondrial Dysfunction?

artículo científico publicado en 2013

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

artículo científico publicado en 2014

Strategies for folding of affinity tagged proteins using GroEL and osmolytes.

artículo científico publicado en 2008

The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review

artículo científico publicado en 2023

The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity?

artículo científico publicado en 2018

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation

artículo científico publicado en 2013

The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling

scientific article published on 14 January 2019

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

artículo científico publicado en 2012

The past and present of serum aminotransferases and the future of liver injury biomarkers.

artículo científico publicado en 2016

The role of cytochrome P450 3A4-mediated metabolism in sorafenib and lapatinib hepatotoxicity

artículo científico publicado en 2023

The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury

artículo científico publicado en 2014

Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.

artículo científico publicado en 2015

Lista de obras de Mitchell R McGill

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide

Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways

Acetaminophen-induced Liver Injury: from Animal Models to Humans

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

Animal models of drug-induced liver injury

Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses

Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

Biomarkers of drug-induced liver injury

Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation

Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro

Caveats of using acetaminophen hepatotoxicity models for natural product testing

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

Connexin32: a mediator of acetaminophen-induced liver injury?

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

Critical review of resveratrol in xenobiotic-induced hepatotoxicity.

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products ⬇️

Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity

Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F₁ Mice

Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats

Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity

Falsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein

Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients

Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children

Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study

HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity Δσ ⬇️

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity

Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations

Increased C-Reactive Protein in Healthy Controls.

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

Involvement of connexin43 in acetaminophen-induced liver injury.

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury ⬇️

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.

Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.

Mechanisms and biomarkers of liver regeneration after drug-induced liver injury

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.

Modulation of O-GlcNAc levels in the liver impacts acetaminophen-induced liver injury by affecting protein adduct formation and glutathione synthesis.

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Monoacylglycerol acyltransferase 1 knockdown exacerbates hepatic ischemia-reperfusion injury in mice with hepatic steatosis

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.

Oxidant Stress, Antioxidant Defense, and Liver Injury

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity

Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration

Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity

Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

Professionalism in Residency Training: A Compilation of Desirable Behaviors and a Case-Based Comparison Between Pathologists in Training and Practice.

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange

Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

Redrawing the Map to Novel DILI Biomarkers in Circulation: Where Are We, Where Should We Go, and How Can We Get There?

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

Serum Glutamate Dehydrogenase—Biomarker for Liver Cell Death or Mitochondrial Dysfunction?

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

Strategies for folding of affinity tagged proteins using GroEL and osmolytes.

The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review

The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity?

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation

The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling