Lista de obras - Robbert H Cool - Dominio Público Uruguay

A highly active adipyl-cephalosporin acylase obtained via rational randomization

artículo científico publicado en 2007

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

artículo científico publicado en 2008

Activation of the small GTPase Ral in platelets.

artículo científico publicado en 1998

Altering the substrate specificity of cephalosporin acylase by directed evolution of the Beta -subunit.

artículo científico publicado en 2002

An ABC-type multidrug transporter of Lactococcus lactis possesses an exceptionally broad substrate specificity

artículo científico publicado en 2000

Analysis of a substrate specificity switch residue of cephalosporin acylase

artículo científico publicado en 2003

Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

artículo científico publicado en 1995

Assessing Pseudomonas virulence with nonmammalian host: Galleria mellonella.

artículo científico publicado en 2014

Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides.

artículo científico publicado en 1996

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).

artículo científico publicado en 1997

Characterization of the interaction between human complement protein C4 and a single-chain variable fragment antibody by capillary electrophoresis and surface plasmon resonance

artículo científico publicado en 2004

Creation of RANKL mutants with low affinity for decoy receptor OPG and their potential anti-fibrosis activity

scientific article published on 25 May 2019

Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs

scientific article published on 06 December 2019

DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

artículo científico publicado en 2014

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design

artículo científico publicado en 2008

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

artículo científico publicado en 2015

Deinococcus radiodurans can interfere with quorum sensing by producing an AHL-acylase and an AHL-lactonase

artículo científico publicado en 2014

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

artículo científico publicado en 2006

Discriminatory residues in Ras and Rap for guanine nucleotide exchange factor recognition

artículo científico publicado en 1999

Effector recognition by the small GTP-binding proteins Ras and Ral

scientific article published on 01 June 1999

Effects of ions on the intrinsic activities of c-H-ras protein p21. A comparison with elongation factor Tu

scientific article published on 01 February 1992

Elongation factor Tu: a molecular switch in protein biosynthesis

artículo científico publicado el 1 de marzo de 1992

Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome.

artículo científico publicado en 1996

Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model.

artículo científico publicado en 2009

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

artículo científico publicado en 2009

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

artículo científico publicado en 1998

Functional Role of the Noncatalytic Domains of Elongation Factor Tu in the Interactions with Ligands†

artículo científico publicado en 1998

Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models

scientific article published on 26 June 2019

Heterologous production of Escherichia coli penicillin G acylase in Pseudomonas aeruginosa

artículo científico publicado en 2009

High yield production of human invariant chain CD74 constructs fused to solubility-enhancing peptides and characterization of their MIF-binding capacities.

artículo científico publicado en 2018

Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

scientific article published on 01 May 1998

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL ⬇️

artículo científico publicado el 2 de enero de 2012

Lipase A gene transcription in Pseudomonas alcaligenes is under control of RNA polymerase σ54 and response regulator LipR.

artículo científico publicado en 2012

Lipase expression in Pseudomonas alcaligenes is under the control of a two-component regulatory system

artículo científico publicado en 2008

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

artículo científico publicado en 2000

Minimum requirements for specific binding of RNA and coat protein of alfalfa mosaic virus

artículo científico publicado en 1984

Mutagenesis of the NH2-terminal domain of elongation factor Tu.

artículo científico publicado en 1990

Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase

artículo científico publicado en 2004

Mutations at position 1122 in the catalytic domain of the mouse ras-specific guanine nucleotide exchange factor CDC25Mm originate both loss-of-function and gain-of-function proteins.

artículo científico publicado en 1998

NMR study of the phosphate-binding elements of Escherichia coli elongation factor Tu catalytic domain.

artículo científico publicado en 1991

Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis

artículo científico publicado en 2017

PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2

artículo científico publicado en 1999

Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade.

artículo científico publicado en 1999

PvdP is a tyrosinase that drives maturation of the pyoverdine chromophore in Pseudomonas aeruginosa

scientific journal article

Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1.

artículo científico publicado en 2006

Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells

artículo científico publicado en 1998

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

artículo científico publicado en 1996

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

artículo científico publicado en 2010

Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells

artículo científico publicado en 2016

Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ

artículo científico publicado en 2014

S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1).

artículo científico publicado en 2002

Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders

artículo científico publicado en 2018

Specific Inhibition of Phorbol Ester-stimulated Phospholipase D by Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B-1470 in HEK-293 Cells ⬇️

artículo científico publicado el 27 de marzo de 1998

Stimulation of gene induction and cell growth by the Ras effector Rlf

artículo científico publicado en 1997

Structure Determination of the Ras-Binding Domain of the Ral-Specific Guanine Nucleotide Exchange Factor Rlf, ⬇️

artículo científico publicado el 29 de septiembre de 1998

Structure-function relationships of elongation factor Tu as studied by mutagenesis

artículo científico publicado en 1991

Structure-function relationships of elongation factor Tu. Isolation and activity of the guanine-nucleotide-binding domain

artículo científico publicado en 1989

Substitution of histidine-84 and the GTPase mechanism of elongation factor Tu.

artículo científico publicado en 1991

Targeting AML through DR4 with a novel variant of rhTRAIL

artículo científico publicado en 2011

The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp.

artículo científico publicado en 2010

The functional and structural roles of residues Gln114 and Glu117 in elongation factor Tu.

artículo científico publicado en 1990

The multiple signaling systems regulating virulence in Pseudomonas aeruginosa

artículo científico publicado en 2012

Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors

artículo científico publicado en 2010

Lista de obras de Robbert H Cool

A highly active adipyl-cephalosporin acylase obtained via rational randomization

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

Activation of the small GTPase Ral in platelets.

Altering the substrate specificity of cephalosporin acylase by directed evolution of the Beta -subunit.

An ABC-type multidrug transporter of Lactococcus lactis possesses an exceptionally broad substrate specificity

Analysis of a substrate specificity switch residue of cephalosporin acylase

Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

Assessing Pseudomonas virulence with nonmammalian host: Galleria mellonella.

Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides.

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).

Characterization of the interaction between human complement protein C4 and a single-chain variable fragment antibody by capillary electrophoresis and surface plasmon resonance

Creation of RANKL mutants with low affinity for decoy receptor OPG and their potential anti-fibrosis activity

Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs

DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

Deinococcus radiodurans can interfere with quorum sensing by producing an AHL-acylase and an AHL-lactonase

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

Discriminatory residues in Ras and Rap for guanine nucleotide exchange factor recognition

Effector recognition by the small GTP-binding proteins Ras and Ral

Effects of ions on the intrinsic activities of c-H-ras protein p21. A comparison with elongation factor Tu

Elongation factor Tu: a molecular switch in protein biosynthesis

Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome.

Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model.

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

Functional Role of the Noncatalytic Domains of Elongation Factor Tu in the Interactions with Ligands†

Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models

Heterologous production of Escherichia coli penicillin G acylase in Pseudomonas aeruginosa

High yield production of human invariant chain CD74 constructs fused to solubility-enhancing peptides and characterization of their MIF-binding capacities.

Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL ⬇️

Lipase A gene transcription in Pseudomonas alcaligenes is under control of RNA polymerase σ54 and response regulator LipR.

Lipase expression in Pseudomonas alcaligenes is under the control of a two-component regulatory system

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

Minimum requirements for specific binding of RNA and coat protein of alfalfa mosaic virus

Mutagenesis of the NH2-terminal domain of elongation factor Tu.

Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase

Mutations at position 1122 in the catalytic domain of the mouse ras-specific guanine nucleotide exchange factor CDC25Mm originate both loss-of-function and gain-of-function proteins.

NMR study of the phosphate-binding elements of Escherichia coli elongation factor Tu catalytic domain.

Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis

PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2

Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade.

PvdP is a tyrosinase that drives maturation of the pyoverdine chromophore in Pseudomonas aeruginosa

Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1.

Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells

Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ

S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1).

Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders

Specific Inhibition of Phorbol Ester-stimulated Phospholipase D by Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B-1470 in HEK-293 Cells ⬇️

Stimulation of gene induction and cell growth by the Ras effector Rlf

Structure Determination of the Ras-Binding Domain of the Ral-Specific Guanine Nucleotide Exchange Factor Rlf, ⬇️

Structure-function relationships of elongation factor Tu as studied by mutagenesis

Structure-function relationships of elongation factor Tu. Isolation and activity of the guanine-nucleotide-binding domain

Substitution of histidine-84 and the GTPase mechanism of elongation factor Tu.

Targeting AML through DR4 with a novel variant of rhTRAIL

The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp.

The functional and structural roles of residues Gln114 and Glu117 in elongation factor Tu.

The multiple signaling systems regulating virulence in Pseudomonas aeruginosa

Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors