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Lista de obras de Sabine Flitsch

'One-pot' sequential enzymatic modification of synthetic glycolipids in vesicle membranes.

artículo científico publicado en 2018

2-Pyridylfuran: A New Fluorescent Tag for the Analysis of Carbohydrates

article

A Bifunctional Spin Label for Ligand Recognition on Surfaces

artículo científico publicado en 2017

A Careful Consideration of the Influence of Structure, Partial charges and Basis Sets on Collision Cross Sections of Monosaccharides when Comparing Values from DFT Calculated Conformers to those Obtained Experimentally

article published in 2017

A novel method for the specific glycosylation of proteins

A promiscuous glycosyltransferase generates poly-β-1,4-glucan derivatives that facilitate mass spectrometry-based detection of cellulolytic enzymes

artículo científico publicado en 2021

A recycling pathway for cyanogenic glycosides evidenced by the comparative metabolic profiling in three cyanogenic plant species

artículo científico publicado en 2015

A self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center

artículo científico publicado en 2003

A versatile gold surface approach for fabrication and interrogation of glycoarrays

artículo científico publicado en 2008

A versatile route to edge-specific modifications to pristine graphene by electrophilic aromatic substitution

artículo científico publicado en 2020

Accelerated Enzymatic Galactosylation of N-Acetylglucosaminolipids in Lipid Microdomains

artículo científico publicado en 2012

Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

artículo científico publicado en 2015

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides

artículo científico publicado en 2017

Advancing Solutions to the Carbohydrate Sequencing Challenge

scientific article published on 21 August 2019

An Asymmetric Enzyme-Catalyzed Retro-Claisen Reaction for the Desymmetrization of Cyclic beta-Diketones This work was supported by the BBSRC (grants to N.J.T. and S.L.F.) and the European Commission (grant to J.G.). We also thank Mr. J. Millar and D

scientific article published on 01 March 2001

An Asymmetric Enzyme-Catalyzed Retro-Claisen Reaction for the Desymmetrization of Cyclicβ-Diketones

artículo científico publicado en 2001

An Efficient Synthetic Route to Glycoamino Acid Building Blocks for Glycopeptide Synthesis

artículo científico publicado en 2004

An Enzymatic N-Acylation Step Enables the Biocatalytic Synthesis of Unnatural Sialosides

artículo científico publicado en 2020

Analysis of the domain properties of the novel cytochrome P450 RhF.

artículo científico publicado en 2005

Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis.

artículo científico publicado en 2017

Application of carbohydrate arrays coupled with mass spectrometry to detect activity of plant-polysaccharide degradative enzymes from the fungus Aspergillus niger

artículo científico publicado en 2017

Applications of a highly α2,6-selective pseudosialidase.

artículo científico publicado en 2018

Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis.

artículo científico publicado en 2016

Assessing the cluster glycoside effect during the binding of concanavalin A to mannosylated artificial lipid rafts

artículo científico publicado en 2009

Automated glycan assembly of type 14 capsular polysaccharide fragments

artículo científico publicado en 2020

Baeyer-Villiger Oxidations

Biocatalysis

artículo científico publicado en 2021

Biocatalysis in Asia and the Pacific

artículo científico publicado en 2024

Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases

artículo científico publicado en 2023

Biocatalytic Oxidation in Continuous Flow for the Generation of Carbohydrate Dialdehydes ⬇️

scholarly article

Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides

artículo científico publicado en 2020

Biochemical characterisation of the neuraminidase pool of the human gut symbiont Akkermansia muciniphila

artículo científico publicado en 2015

Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease.

artículo científico publicado en 2011

Biocompatible functionalisation of starch

artículo científico publicado en 2010

Biological and biochemical properties of two Xenopus laevis N-acetylgalactosaminyltransferases with contrasting roles in embryogenesis.

artículo científico publicado en 2014

Bi‐enzymatic Conversion of Cinnamic Acids to 2‐Arylethylamines

artículo científico publicado en 2020

Bottom-Up Elucidation of Glycosidic Bond Stereochemistry.

artículo científico publicado en 2017

COS-1 cell expression and one-step affinity protein purification and activity of epitope-tagged human erythropoietin and of site-directed mutants

artículo científico publicado en 1997

Cell-specific bioorthogonal tagging of glycoproteins

artículo científico publicado en 2022

Characterisation of CYP102A25 from B. marmarensis and CYP102A26 from P. halophilus: P450 homologues of BM3 with preference towards hydroxylation of medium chain fatty acids

artículo científico publicado en 2017

Characterisation of a Bacterial Galactokinase with High Activity and Broad Substrate Tolerance for Chemoenzymatic Synthesis of 6-Aminogalactose-1-Phosphate and Analogues

artículo científico publicado en 2017

ChemInform Abstract: An Asymmetric Enzyme-Catalyzed Retro-Claisen Reaction for the Desymmetrization of Cyclic β-Diketones

ChemInform Abstract: Copper-Catalyzed Double Additions and Radical Cyclization Cascades in the Re-Engineering of the Antibacterial Pleuromutilin

article

ChemInform Abstract: Cytochromes P450 as Useful Biocatalysts: Addressing the Limitations

ChemInform Abstract: Enzymatic Reactions on Immobilized Substrates

ChemInform Abstract: Enzyme Cleavable Linker Units

ChemInform Abstract: Straightforward Synthesis of 2-Acetamido-2-deoxy-β-D-glucopyranosyl Esters under Microwave Conditions

Chemo-enzymatic synthesis of a β-mannosyl-containing trisaccharide

Chemoenzymatic Synthesis of Optically Pure l- and d-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation

scholarly article by Syed T. Ahmed et al published 13 August 2015 in ACS Catalysis

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

artículo científico publicado en 2020

Chemoenzymatic synthesis of O-mannosylpeptides in solution and on solid phase

artículo científico publicado en 2012

Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion

artículo científico publicado en 2011

Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope

artículo científico publicado en 2011

Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope.

artículo científico publicado en 2018

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

article

Controlling protein retention on enzyme-responsive surfaces

artículo científico publicado en 2006

Copper-Catalyzed Double Additions and Radical Cyclization Cascades in the Re-Engineering of the Antibacterial Pleuromutilin

artículo científico publicado en 2015

Cytochromes P450 as useful biocatalysts: addressing the limitations

artículo científico publicado en 2011

Design, synthesis and assaying of potential aquaporin inhibitors.

scientific article published on January 2009

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

artículo científico publicado en 2012

Development and application of a highly α2,6-selective pseudosialidase

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades

artículo científico publicado en 2021

Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors.

artículo científico publicado en 2017

Development of recombinant, immobilised β-1,4-mannosyltransferase for use as an efficient tool in the chemoenzymatic synthesis of N-linked oligosaccharides

article

Discovery and Biochemical Characterization of a Thermostable Glucose-1-phosphate Nucleotidyltransferase from Thermodesulfatator indicus.

artículo científico publicado en 2017

Discovery of novel human aquaporin-1 blockers

artículo científico publicado en 2012

Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing.

artículo científico publicado en 2013

Drug Discovery and Development

artículo científico publicado en 2024

Dual purpose S-trityl-linkers for glycoarray fabrication on both polystyrene and gold.

artículo científico publicado en 2012

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways

artículo científico publicado en 2011

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

artículo científico publicado en 2009

Effect of microwave radiation on enzymatic and chemical Peptide bond synthesis on solid phase

artículo científico publicado en 2009

Efficient terpene hydroxylation catalysts based upon P450 enzymes derived from actinomycetes

artículo científico publicado en 2005

Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling

artículo científico publicado en 2015

Engineered Ammonia Lyases for the Production of Challenging Electron-Rich l-Phenylalanines

article published in 2018

Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme.

artículo científico publicado en 2009

Enzymatic Building Block Synthesis for Automated Solid Phase Glycan Assembly

artículo científico publicado en 2020

Enzymatic Late-Stage Modifications: Better Late Than Never

artículo científico publicado en 2021

Enzymatic Synthesis of Trideuterated Sialosides

artículo científico publicado en 2019

Enzymatic amine acyl exchange in peptides on gold surfaces

artículo científico publicado en 2012

Enzymatic elaboration of oxime-linked glycoconjugates in solution and on liposomes

Enzymatic generation and in situ screening of a dynamic combinatorial library of sialic acid analogues

artículo científico publicado en 2002

Enzymatic glycosylation of peptide arrays on gold surfaces

artículo científico publicado en 2008

Enzymatic glycosylations on arrays

artículo científico publicado en 2010

Enzymatic optical resolution via acylation–hydrolysis on a solid support

artículo científico publicado en 2003

Enzymatic reactions on immobilised substrates

artículo científico publicado en 2013

Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases

scientific article published on 01 June 2019

Enzymatic synthesis of a new type of penicillin

article

Enzymatic synthesis of colorimetric substrates to determine α-2,3- and α-2,6-specific neuraminidase activity

scholarly article in RSC Advances, vol. 3 no. 44, 2013

Enzymatic synthesis of peptides on a solid support

artículo científico publicado en 2008

Enzymatischer Amin-Acyl-Austausch in Peptiden auf Gold-Oberflächen

article published in 2012

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

article

Enzyme catalysis on solid surfaces

artículo científico publicado en 2008

Enzyme-catalyzed formation of glycosidic linkages

artículo científico publicado en 1997

Enzyme-cleavable linkers for peptide and glycopeptide synthesis

artículo científico publicado en 2005

Enzymkatalysierte späte Modifizierungen: Besser spät als nie

artículo científico publicado en 2021

Evidence That Bilayer Bending Rigidity Affects Membrane Protein Folding†

article

Exploiting the Disialyl Galactose Activity of α2,6-Sialyltransferase from Photobacterium damselae To Generate a Highly Sialylated Recombinant α-1-Antitrypsin

scientific article published on 11 October 2019

Expression and mutagenesis of recombinant human and murine erythropoietins in Escherichia coli

article

Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS.

artículo científico publicado en 2012

Galactose Oxidase Enables Modular Assembly of Conjugates from Native Antibodies with High Drug-to-Antibody Ratios

Ganzzellen-Biokatalysator für stereoselektive C-H-Aminierungen

Generation of a dynamic combinatorial library using sialic acid aldolase and in situ screening against wheat germ agglutinin

Glycoarrays—tools for determining protein–carbohydrate interactions and glycoenzyme specificity

artículo científico publicado en 2008

Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution

artículo científico publicado en 2011

Glycosylation characterization of human and porcine fibrinogen proteins by lectin-binding biophotonic microarray imaging.

artículo científico publicado en 2013

Glycosylation with a twist

scientific article published in Nature

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

artículo científico publicado en 2011

High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI

artículo científico publicado en 2019

Highly site-selective stability increases by glycosylation of dihydrofolate reductase

artículo científico publicado en 2010

IRMPD Spectroscopy Sheds New (Infrared) Light on the Sulfate Pattern of Carbohydrates

artículo científico publicado en 2017

Identification of a new class of cytochrome P450 from a Rhodococcus sp.

artículo científico publicado en 2002

Improved biotransformations on charged PEGA supports

artículo científico publicado en 2003

In Vitro Sialylation of Recombinant Alpha-1-Antitrypsin using α2,6 Sialyltransferase from Photobacterium Damselae Produces Di-sialyl Galactose Motifs in N-Glycans

In vivo anti-malarial effect of the beta-amino alcohol 1t on Plasmodium berghei.

artículo científico publicado en 2009

Increased thermal stability of site-selectively glycosylated dihydrofolate reductase

artículo científico publicado en 2005

Increasing the diversity of biocatalytic reactions

scientific article published on 19 February 2011

Inexpensive and fast pathogenic bacteria screening using field-effect transistors

artículo científico publicado en 2016

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

artículo científico publicado en 2012

Innentitelbild: Ganzzellen-Biokatalysator für stereoselektive C-H-Aminierungen (Angew. Chem. 4/2016)

Inside Cover: Whole-Cell Biocatalysts for Stereoselective C−H Amination Reactions (Angew. Chem. Int. Ed. 4/2016)

Intermediates in the folding of the membrane protein bacteriorhodopsin

artículo científico publicado en 1995

Introduction of permanently charged groups into PEGA resins leads to improved biotransformations on solid support

Introduction to Glycosylation: new methodologies and applications

scientific article published on 10 September 2020

Kinetics of enzyme attack on substrates covalently attached to solid surfaces: influence of spacer chain length, immobilized substrate surface concentration and surface charge

artículo científico publicado en 2008

LICRED: a versatile drop-in vector for rapid generation of redox-self-sufficient cytochrome P450s

artículo científico publicado en 2010

Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins.

artículo científico publicado en 2017

Lipase-catalysed acylation of starch and determination of the degree of substitution by methanolysis and GC.

artículo científico publicado en 2010

Lipase-catalyzed kinetic resolution on solid-phase via a "capture and release" strategy

artículo científico publicado en 2003

MALDI-ToF MS analysis of glycosyltransferase activities on gold surface arrays

artículo científico publicado en 2012

Microwave-assisted ring opening of epoxides: a general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities

artículo científico publicado en 2007

Natural heterogeneous catalysis with immobilised oxidase biocatalysts

artículo científico publicado en 2020

New Chemical Tools for Diagnosis and Treatment of Cancer

artículo científico publicado en 2022

Novel Mechanism of Inhibition of Elastase by β-Lactams Is Defined by Two Inhibitor Crystal Complexes

artículo científico publicado en 1999

Nucleotide sequence of a portion of the camphor-degrading gene cluster from Rhodococcus sp. NCIMB 9784.

artículo científico publicado en 2004

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

article

One-Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation

artículo científico publicado en 2022

Optimized polymer-enzyme electrostatic interactions significantly improve penicillin G amidase efficiency in charged PEGA polymers

artículo científico publicado en 2005

Organically modified xerogels as supports for solid-phase chemistry

Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

artículo científico publicado en 2012

Oxygenation of CH and CC Bonds

P450(camr), a cytochrome P450 catalysing the stereospecific 6- endo-hydroxylation of (1 R)-(+)-camphor.

artículo científico publicado en 2002

Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope

Penicillin biosynthesis: active site mapping with aminoadipoylcysteinylvaline variants

article

Penicillin biosynthesis: structure–reactivity profile of unsaturated substrates for isopenicillin N synthetase

Penicillin biosynthesis: the origin of hydroxy groups in β-lactams derived from unsaturated substrates

Phytanyl-pyrophosphate-linked substrate for a bacterial alpha-mannosyltransferase.

artículo científico publicado en 2000

Preparation of aminoethyl glycosides for glycoconjugation

artículo científico publicado en 2010

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp

article

Profiling Glycosyltransferase Activities by Tritium Imaging of Glycan Microarrays

artículo científico publicado en 2013

Profiling Primary Protease Specificity by Peptide Synthesis on a Solid Support

artículo científico publicado en 2004

Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-Fluorinated Monosaccharides

scholarly article published 9 March 2020

Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides

artículo científico publicado en 2020

Protease-catalyzed peptide synthesis on solid support

artículo científico publicado en 2002

Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action

artículo científico publicado en 2006

Rapid Screening of Diverse Biotransformations for Enzyme Evolution

artículo científico publicado en 2021

Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

artículo científico publicado en 2016

Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering

scientific article published on 08 August 2004

Real-Time Imaging of Protease Action on Substrates Covalently Immobilised to Polymer Supports

artículo científico publicado en 2007

Real-Time Screening of Biocatalysts in Live Bacterial Colonies.

artículo científico publicado en 2017

Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S )-δ-Decalactone

artículo científico publicado en 2019

Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous

artículo científico publicado en 2012

Regio‐ and Enantio‐selective Chemo‐enzymatic C−H‐Lactonization of Decanoic Acid to ( S )‐δ‐Decalactone

Retinal Binding during Folding and Assembly of the Membrane Protein Bacteriorhodopsin†

artículo científico publicado en 1996

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

artículo científico publicado en 2021

S-linked sugars lost and found

article

SPOT synthesis of peptide arrays on self-assembled monolayers and their evaluation as enzyme substrates

artículo científico publicado en 2008

Selective Oxidation of N -Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant

artículo científico publicado en 2019

Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin

artículo científico publicado en 2001

Sialylation of lactosyl lipids in membrane microdomains by T. cruzi trans-sialidase

artículo científico

Slow α Helix Formation during Folding of a Membrane Protein†

artículo científico publicado en 1997

Solid-phase synthesis of thioether-linked glycopeptide mimics for application to glycoprotein semisynthesis

artículo científico publicado en 2002

Straightforward Synthesis of 2-Acetamido-2-deoxy-β-d-glucopyranosyl Esters under Microwave Conditions

Substrate promiscuity of cytochrome P450 RhF

Sugars tied to the spot.

artículo científico publicado en 2003

Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays

article

Synthesis and modifications of carbohydrates, using biotransformations

artículo científico publicado en 2004

Synthesis and screening of a library of Lewis deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

artículo científico publicado en 2024

Synthesis of Enantiomerically Pure Ring-Substituted l-Pyridylalanines by Biocatalytic Hydroamination

artículo científico publicado en 2016

Synthesis of N-linked glycopeptides on solid support and their evaluation as protease substrates

artículo científico publicado en 2005

Synthesis of a novel acceptor substrate for a mannosyl transferase

Synthesis of homogenous site-selectively glycosylated proteins

artículo científico publicado en 2004

Synthesis of novel acceptor substrates for the dolichyl phosphate mannose synthase from yeast

artículo científico publicado en 2003

Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades

artículo científico publicado en 2020

The Time and Place for Nature in Drug Discovery

artículo científico publicado en 2022

The characterisation of a galactokinase from Streptomyces coelicolor

artículo científico publicado en 2019

The chemoenzymatic synthesis of neoglycolipids and lipid-linked oligosaccharides using glycosyltransferases

artículo científico publicado en 1994

The chemoenzymatic synthesis of the core trisaccharide of N-linked oligosaccharides using a recombinant beta-mannosyltransferase.

artículo científico publicado en 1997

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

scholarly article by Michele Tavanti published in July 2018

The preparation of deoxy derivatives of mannose-1-phosphate and their substrate specificity towards recombinant GDP-mannose pyrophosphorylase from Salmonella enterica, group B

The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac

artículo científico publicado en 2017

Three-Component Stereoselective Enzymatic Synthesis of Amino-Diols and Amino-Polyols

artículo científico publicado en 2022

Two-Photon Microscopy to Spatially Resolve and Quantify Fluorophores in Single-Bead Chemistry

artículo científico publicado en 2003

UDP-Glucose 4-Epimerase and β-1,4-Galactosyltransferase from the Oyster Magallana gigas as Valuable Biocatalysts for the Production of Galactosylated Products.

artículo científico publicado en 2018

Understanding enzyme action on immobilised substrates

artículo científico publicado en 2005

Understanding protease catalysed solid phase peptide synthesis

artículo científico publicado en 2003

Using two photon microscopy to quantify enzymatic reaction rates on polymer beads

artículo científico publicado en 2003

Utility of Ion-Mobility Spectrometry for Deducing Branching of Multiply Charged Glycans and Glycopeptides in a High-Throughput Positive ion LC-FLR-IMS-MS Workflow

artículo científico publicado en 2020

Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions

artículo científico publicado en 2015

Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s

artículo científico publicado en 2016

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