Lista de obras - Layton H Smith - Dominio Público Uruguay

A Systematic Approach to Identify Biased Agonists of the Apelin Receptor through High-Throughput Screening

artículo científico publicado en 2017

A chemical biology approach identified PI3K as a potential therapeutic target for neurofibromatosis type 2

artículo científico publicado en 2014

APJ acts as a dual receptor in cardiac hypertrophy ⬇️

artículo científico publicado el 16 de agosto de 2012

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

scholarly article

Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.

artículo científico publicado en 2011

Assessment of drug-induced arrhythmic risk using limit cycle and autocorrelation analysis of human iPSC-cardiomyocyte contractility

artículo científico publicado en 2016

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

artículo científico publicado en 2017

Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C

artículo científico publicado en 2010

Computational tools and resources for metabolism-related property predictions. 2. Application to prediction of half-life time in human liver microsomes

artículo científico publicado en 2012

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.

artículo científico publicado en 2014

Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus

artículo científico publicado en 2014

Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells

artículo científico publicado en 2004

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

artículo científico publicado en 2009

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor

artículo científico publicado en 2012

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

artículo científico publicado en 2013

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

artículo científico publicado en 2015

Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress

artículo científico publicado en 2017

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

artículo científico publicado en 2012

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

artículo científico publicado en 2014

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

artículo científico publicado en 2017

Exendin-4 improves cardiac function in mice overexpressing monocyte chemoattractant protein-1 in cardiomyocytes.

artículo científico publicado en 2014

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter

artículo científico publicado en 2012

High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

artículo científico publicado en 2012

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation ⬇️

artículo científico publicado el 5 de agosto de 2011

Identification of Inhibitors of Triacylglyceride Accumulation in Muscle Cells: Comparing HTS Results from 1536-Well Plate-Based and High-Content Platforms ⬇️

artículo científico publicado el 29 de agosto de 2013

Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections

artículo científico publicado en 2009

Imidazole-derived agonists for the neurotensin 1 receptor.

artículo científico publicado en 2013

In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes

artículo científico publicado en 2012

Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules

artículo científico publicado en 2010

Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence ⬇️

artículo científico publicado el 23 de octubre de 2012

Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis

artículo científico publicado en 2005

Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence

artículo científico publicado en 2013

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.

artículo científico publicado en 2011

Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

artículo científico publicado en 2003

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

artículo científico publicado en 2018

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma

artículo científico publicado en 2014

Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.

artículo científico publicado en 2013

Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies

artículo científico publicado en 2015

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans‐inhibition ⬇️

artículo científico publicado el 1 de marzo de 2013

Lista de obras de Layton H Smith

A Systematic Approach to Identify Biased Agonists of the Apelin Receptor through High-Throughput Screening

A chemical biology approach identified PI3K as a potential therapeutic target for neurofibromatosis type 2

APJ acts as a dual receptor in cardiac hypertrophy ⬇️

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.

Assessment of drug-induced arrhythmic risk using limit cycle and autocorrelation analysis of human iPSC-cardiomyocyte contractility

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C

Computational tools and resources for metabolism-related property predictions. 2. Application to prediction of half-life time in human liver microsomes

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.

Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus

Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

Exendin-4 improves cardiac function in mice overexpressing monocyte chemoattractant protein-1 in cardiomyocytes.

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter

High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation ⬇️

Identification of Inhibitors of Triacylglyceride Accumulation in Muscle Cells: Comparing HTS Results from 1536-Well Plate-Based and High-Content Platforms ⬇️

Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections

Imidazole-derived agonists for the neurotensin 1 receptor.

In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes

Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules

Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence ⬇️

Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis

Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.

Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma

Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.

Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans‐inhibition ⬇️