Lista de obras - Luc Brunsveld - Dominio Público Uruguay

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.

artículo científico publicado en 2017

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

artículo científico publicado en 2021

A multi-gram-scale stereoselective synthesis of Z -endoxifen

scholarly article by Lech-Gustav Milroy published in May 2018

A natural-product switch for a dynamic protein interface

artículo científico publicado en 2014

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

scientific article published on 01 December 2019

A supramolecular polymer as a self-assembling polyvalent scaffold

artículo científico publicado en 2009

A thermodynamic model for multivalency in 14-3-3 protein-protein interactions

article

Allosteric small molecule modulators of nuclear receptors

artículo científico publicado en 2019

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach

artículo científico publicado en 2021

An on-bead assay for the identification of non-natural peptides targeting the androgen receptor-cofactor interaction.

artículo científico publicado en 2010

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

artículo científico publicado en 2005

Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2 Photocatalysis

artículo científico publicado en 2016

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

artículo científico publicado en 2013

Bioactivity-guided mapping and navigation of chemical space.

artículo científico publicado en 2009

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

artículo científico publicado en 2015

Bright Bioluminescent BRET Sensor Proteins for Measuring Intracellular Caspase Activity

artículo científico publicado en 2017

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

artículo científico publicado en 2014

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

artículo científico publicado en 2016

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

artículo científico publicado en 2005

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery

artículo científico publicado en 2012

Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation

artículo científico publicado en 2016

Combining supramolecular chemistry with biology.

artículo científico publicado en 2010

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

artículo científico publicado en 2008

Competitive protein recruitment in artificial cells

artículo científico publicado en 2024

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

artículo científico publicado en 2009

Conformational ordering of apolar, chiral m-phenylene ethynylene oligomers

artículo científico publicado en 2000

Conjugated protein domains as engineered scaffold proteins

artículo científico publicado en 2020

Cooperativity basis for small-molecule stabilization of protein-protein interactions

scientific article published on 25 January 2019

Cooperativity in the folding of helical m-phenylene ethynylene oligomers based upon the 'sergeants-and-soldiers' principle

artículo científico publicado en 2001

Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

artículo científico publicado en 2011

Cucurbit[8]uril reactivation of an inactivated caspase-8 mutant reveals differentiated enzymatic substrate processing

scientific article published on 05 November 2018

Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation

artículo científico publicado en 2015

Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt

scientific article published on 20 May 2020

Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach

artículo científico publicado en 2011

Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants.

artículo científico publicado en 2014

Directed supramolecular surface assembly of SNAP-tag fusion proteins

artículo científico publicado en 2012

Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires

artículo científico publicado en 2018

Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

scientific article published on 22 April 2020

Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

scientific article published on 12 March 2020

Estrogen Receptor Folding Modulates cSrc Kinase SH2 Interaction via a Helical Binding Mode

artículo científico publicado en 2015

Evaluation of fluorophores to label SNAP-tag fused proteins for multicolor single-molecule tracking microscopy in live cells

artículo científico publicado en 2014

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

artículo científico publicado en 2021

Finite-size effects on bacterial population expansion under controlled flow conditions.

artículo científico publicado en 2017

Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers

artículo científico publicado en 2020

Fragment-based Differential Targeting of PPI Stabilizer Interfaces

scientific article published on 05 June 2020

Fragment-based exploration of the 14-3-3/Amot-p130 interface

artículo científico publicado en 2021

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

artículo científico publicado en 2021

Helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs

scientific article published in Nature

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

artículo científico publicado en 2017

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

artículo científico publicado en 2017

Identification of an allosteric binding site for RORγt inhibition

artículo científico publicado en 2015

Immobilization of Ferrocene-Modified SNAP-Fusion Proteins

artículo científico publicado en 2013

Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy.

artículo científico publicado en 2017

Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains

artículo científico publicado en 2009

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

artículo científico publicado en 2018

Integrin-Targeting Fluorescent Proteins: Exploration of RGD Insertion Sites.

artículo científico publicado en 2016

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

artículo científico publicado en 2011

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

artículo científico

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

scientific article published on 24 December 2019

Lipidated Ras and Rab Peptides and Proteins — Synthesis, Structure, and Function

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

artículo científico publicado en 2006

Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion

Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein

artículo científico publicado en 2009

Membrane binding of lipidated Ras peptides and proteins--the structural point of view

artículo científico publicado en 2008

Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation

scientific article published on 12 May 2020

Modular columnar supramolecular polymers as scaffolds for biomedical applications.

artículo científico publicado en 2013

Modulation of Protein Dimerization by a Supramolecular Host-Guest System

artículo científico publicado en 2009

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

artículo científico publicado en 2017

Modulators of protein-protein interactions

artículo científico publicado en 2014

Molecular interference in antibody-antigen interaction studied with magnetic force immunoassay.

artículo científico publicado en 2015

Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms

scientific article published on 31 October 2019

Multivalent protein assembly using monovalent self-assembling building blocks

artículo científico publicado en 2013

Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers

artículo científico publicado en 2018

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation

scientific article published on 17 April 2020

Optimizing charge state distribution is a prerequisite for accurate protein biomarker quantification with LC-MS/MS, as illustrated by hepcidin measurement

artículo científico publicado en 2018

PNA-induced assembly of fluorescent proteins using DNA as a framework.

artículo científico publicado en 2013

Perturbation of Estrogen Receptor α Localization with Synthetic Nona-Arginine LXXLL-Peptide Coactivator Binding Inhibitors

artículo científico publicado en 2009

Pharmaceutical implications of helix length control in helix-mediated protein-protein interactions.

artículo científico

Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides

artículo científico publicado en 2011

Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks

artículo científico publicado en 2018

Protein Dimerization Induced by Supramolecular Interactions with Cucurbit[8]uril

artículo científico publicado en 2010

Proteinassembly along a supramolecular wire

artículo científico publicado en 2010

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome ⬇️

artículo científico publicado en 2020

Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction

artículo científico publicado en 2008

Rapid phenotype hemoglobin screening by high-resolution mass spectrometry on intact proteins

artículo científico publicado en 2016

Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions

scientific article published on 17 September 2018

Real life dabigatran and metabolite concentrations, focused on inter-patient variability and assay differences in patients with atrial fibrillation

artículo científico publicado en 2017

Relationship between Side-Chain Polarity and the Self-Assembly Characteristics of Perylene Diimide Derivatives in Aqueous Solution

artículo científico publicado en 2017

Reversible Polymers Formed from Self-Complementary Monomers Using Quadruple Hydrogen Bonding

scientific article published in Science

Reversible and Oriented Immobilization of Ferrocene-Modified Proteins

artículo científico publicado en 2012

SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins

artículo científico publicado en 2013

Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 interaction with Semi-Synthetic Natural Products

scientific article published on 05 June 2020

Self-Assembled Fluorescent Nanoparticles from π-Conjugated Small Molecules: En Route to Biological Applications.

artículo científico publicado en 2015

Self-assembled fluorescent organic nanoparticles for live-cell imaging

artículo científico publicado en 2013

Self-assembly of folded m-phenylene ethynylene oligomers into helical columns

artículo científico publicado en 2001

Semiconductive, One-Dimensional, Self-Assembled Nanostructures Based on Oligopeptides with π-Conjugated Segments

scientific article published on 14 March 2011

Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits

artículo científico publicado en 2015

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

artículo científico publicado en 2019

Site-specific protection and dual labeling of human epidermal growth factor (hEGF) for targeting, imaging, and cargo delivery.

artículo científico publicado en 2014

Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold

artículo científico publicado en 2016

Small-molecule inhibition of APT1 affects Ras localization and signaling

artículo científico publicado en 2010

Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.

artículo científico publicado en 2017

Solid-Phase Synthesis of Lipidated Ras Peptides Employing the Ellman Sulfonamide Linker

Solution structure of a cucurbit[8]uril induced compact supramolecular protein dimer.

artículo científico publicado en 2014

Stabilization of protein-protein interactions in drug discovery

artículo científico publicado en 2017

Stabilizer-Guided Inhibition of Protein-Protein Interactions

artículo científico publicado en 2015

Stable helical beta 3-peptides in water via covalent bridging of side chains

artículo científico publicado en 2006

Stable helical peptoids via covalent side chain to side chain cyclization

artículo científico publicado en 2008

Strong and reversible monovalent supramolecular protein immobilization

artículo científico publicado en 2010

Structural interface between LRRK2 and 14-3-3 protein.

artículo científico publicado en 2017

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

artículo científico publicado en 2003

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

artículo científico publicado en 2006

Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions

scientific article published on 07 August 2020

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation

artículo científico publicado en 2008

Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin

scientific journal article

Subtype-specific modulation of estrogen receptor-coactivator interaction by phosphorylation.

artículo científico publicado en 2014

Supramolecular Chemistry Targeting Proteins.

artículo científico publicado en 2017

Supramolecular Control over Split-Luciferase Complementation

artículo científico publicado en 2016

Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs

artículo científico publicado en 2020

Supramolecular Polymers as Dynamic Multicomponent Cellular Uptake Carriers

artículo científico publicado en 2012

Supramolecular Protein Immobilization on Lipid Bilayers

artículo científico publicado en 2015

Supramolecular chemical biology; bioactive synthetic self-assemblies.

artículo científico publicado en 2012

Supramolecular control of cell adhesion via ferrocene–cucurbit[7]uril host–guest binding on gold surfaces

scientific article published on 01 May 2013

Supramolecular control over donor-acceptor photoinduced charge separation

artículo científico publicado en 2004

Supramolecularly Oriented Immobilization of Proteins Using Cucurbit[8]uril

scientific article published on 12 November 2012

Switching from infliximab innovator to biosimilar in patients with inflammatory bowel disease: a 12-month multicentre observational prospective cohort study.

artículo científico publicado en 2017

Synthesis and Self-Assembly of Bay-Substituted Perylene Diimide Gemini-Type Surfactants as Off-On Fluorescent Probes for Lipid Bilayers.

artículo científico publicado en 2018

Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain

artículo científico publicado en 2010

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

scientific article published on 01 April 2005

Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase

artículo científico publicado en 2007

Synthesis of the Rheb and K-Ras4B GTPases

Tetrazine- trans-Cyclooctene Chemistry Applied to Fabricate Self-Assembled Fluorescent and Radioactive Nanoparticles for in Vivo Dual Mode Imaging

artículo científico publicado en 2019

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.

artículo científico publicado en 2017

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

artículo científico publicado en 2010

Therapeutic drug monitoring of infliximab: performance evaluation of three commercial ELISA kits

artículo científico publicado en 2015

Therapeutic intervention based on protein prenylation and associated modifications

artículo científico publicado en 2006

Twist Sense Bias Induced by Chiral Side Chains in Helically Folded Oligomers

artículo científico publicado en 2000

Using the IPTG-Inducible Pgrac212 Promoter for Overexpression of Human Rhinovirus 3C Protease Fusions in the Cytoplasm of Bacillus subtilis Cells

artículo científico publicado en 2019

Lista de obras de Luc Brunsveld

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

A multi-gram-scale stereoselective synthesis of Z -endoxifen

A natural-product switch for a dynamic protein interface

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

A supramolecular polymer as a self-assembling polyvalent scaffold

A thermodynamic model for multivalency in 14-3-3 protein-protein interactions

Allosteric small molecule modulators of nuclear receptors

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach

An on-bead assay for the identification of non-natural peptides targeting the androgen receptor-cofactor interaction.

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2 Photocatalysis

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

Bioactivity-guided mapping and navigation of chemical space.

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

Bright Bioluminescent BRET Sensor Proteins for Measuring Intracellular Caspase Activity

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery

Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation

Combining supramolecular chemistry with biology.

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

Competitive protein recruitment in artificial cells

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

Conformational ordering of apolar, chiral m-phenylene ethynylene oligomers

Conjugated protein domains as engineered scaffold proteins

Cooperativity basis for small-molecule stabilization of protein-protein interactions

Cooperativity in the folding of helical m-phenylene ethynylene oligomers based upon the 'sergeants-and-soldiers' principle

Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

Cucurbit[8]uril reactivation of an inactivated caspase-8 mutant reveals differentiated enzymatic substrate processing

Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation

Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt

Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach

Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants.

Directed supramolecular surface assembly of SNAP-tag fusion proteins

Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires

Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

Estrogen Receptor Folding Modulates cSrc Kinase SH2 Interaction via a Helical Binding Mode

Evaluation of fluorophores to label SNAP-tag fused proteins for multicolor single-molecule tracking microscopy in live cells

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

Finite-size effects on bacterial population expansion under controlled flow conditions.

Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers

Fragment-based Differential Targeting of PPI Stabilizer Interfaces

Fragment-based exploration of the 14-3-3/Amot-p130 interface

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

Identification of an allosteric binding site for RORγt inhibition

Immobilization of Ferrocene-Modified SNAP-Fusion Proteins

Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy.

Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

Integrin-Targeting Fluorescent Proteins: Exploration of RGD Insertion Sites.

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

Lipidated Ras and Rab Peptides and Proteins — Synthesis, Structure, and Function

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion

Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein

Membrane binding of lipidated Ras peptides and proteins--the structural point of view

Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation

Modular columnar supramolecular polymers as scaffolds for biomedical applications.

Modulation of Protein Dimerization by a Supramolecular Host-Guest System

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

Modulators of protein-protein interactions

Molecular interference in antibody-antigen interaction studied with magnetic force immunoassay.

Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms

Multivalent protein assembly using monovalent self-assembling building blocks

Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation

Optimizing charge state distribution is a prerequisite for accurate protein biomarker quantification with LC-MS/MS, as illustrated by hepcidin measurement

PNA-induced assembly of fluorescent proteins using DNA as a framework.

Perturbation of Estrogen Receptor α Localization with Synthetic Nona-Arginine LXXLL-Peptide Coactivator Binding Inhibitors

Pharmaceutical implications of helix length control in helix-mediated protein-protein interactions.

Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides