Lista de obras - Dimitar Efremov - Dominio Público Uruguay

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

article

Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia.

artículo científico publicado en 2013

Autoimmune hemolytic anemia during bendamustine plus rituximab treatment in CLL patients: multicenter experience

artículo científico publicado en 2016

B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia

artículo científico publicado en 2006

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

artículo científico publicado en 2014

B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage

artículo científico publicado en 2011

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

scientific article published on 28 August 2019

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199.

artículo científico publicado en 2016

Bendamustine in combination with rituximab for elderly patients with previously untreated B-cell chronic lymphocytic leukemia: A retrospective analysis of real-life practice in Italian hematology departments

artículo científico publicado en 2015

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL).

artículo científico publicado en 2013

CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential

scientific article published on 15 August 2007

CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders

artículo científico publicado en 2003

Characterization of a second secreted IgE isoform and identification of an asymmetric pathway of IgE assembly.

scientific article published on April 1996

Chic adaptor regulates apoptosis in CLL

artículo científico publicado en 2010

Chlorambucil plus Rituximab as Front-Line Therapy in Elderly/Unfit Patients Affected by B-Cell Chronic Lymphocytic Leukemia: Results of a Single-Centre Experience

artículo científico publicado en 2013

Chlorambucil plus rituximab as front-line therapy for elderly and/or unfit chronic lymphocytic leukemia patients: correlation with biologically-based risk stratification

artículo científico publicado en 2017

Chronic Lymphocytic Leukemia With Eyelid Involvement Responding to Alemtuzumab

artículo científico publicado en 2008

Chronic lymphocytic leukemia patients with a V1-69 gene rearrangement do not have inferior survival with respect to patients that express other unmutated VH genes

article

Chronic lymphocytic leukemia: a tale of one or two signals?

artículo científico publicado en 2012

Clonal B-cell expansions in peripheral blood of HCV-infected patients

artículo científico publicado en 1995

Comparison between oral and intravenous fludarabine plus cyclophosphamide regime as front-line therapy in patients affected by chronic lymphocytic leukaemia: influence of biological parameters on the clinical outcome

artículo científico publicado en 2010

Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia

artículo científico publicado en 2005

Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study

article

Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2

scientific article published on 13 June 2018

Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir

artículo científico publicado en 2004

Efficacy and safety of low-dose alemtuzumab as treatment of autoimmune hemolytic anemia in pretreated B-cell chronic lymphocytic leukemia

artículo científico publicado en 2007

Ethnic difference in the prevalence of monoclonal B-cell proliferation in patients affected by hepatitis C virus chronic liver disease

artículo científico publicado en 1999

Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

article

FOXO discriminates tonic from chronic in DLBCL.

artículo científico publicado en 2016

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy.

artículo científico publicado en 2018

Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia--author's response to Hebbring.

artículo científico publicado en 2013

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

artículo científico publicado en 2017

Hepatitis C virus, mixed cryoglobulinaemia and non-Hodgkin's lymphoma.

artículo científico publicado en 1998

IGHD3-3fails to behave as unfavourable prognostic marker in chronic lymphocytic leukaemia

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

artículo científico publicado en 2012

IL-4 regulates B-cell receptor signaling in CLL.

artículo científico publicado en 2016

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

artículo científico publicado en 1996

Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL).

artículo científico publicado en 2006

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

artículo científico publicado en 2008

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

artículo científico publicado en 2014

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

artículo científico publicado en 2009

Lamivudine treatment for acute hepatitis B virus infection during allogeneic peripheral blood stem cell transplantation

artículo científico publicado en 2003

Long-term follow up of frontline therapy with fludarabine and cyclophosphamide in chronic lymphocytic leukemia: impact of biological parameters on clinical outcome.

artículo científico publicado en 2013

Low prevalence of chronic hepatitis C virus infection in B-cell non-Hodgkin's lymphoma patients from a population with a high prevalence of healthy hepatitis c virus carriers.

artículo científico publicado en 2000

Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience.

artículo científico publicado en 2005

Low-dose thalidomide in combination with oral fludarabine and cyclophosphamide is ineffective in heavily pre-treated patients with chronic lymphocytic leukemia

artículo científico publicado en 2006

Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies

artículo científico publicado en 2020

Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy

artículo científico

Mild and severe beta-thalassemia among homozygotes from Turkey: identification of the types by hybridization of amplified DNA with synthetic probes.

artículo científico publicado en 1988

Molecular analysis of IgE H-chain transcripts expressed in vivo by peripheral blood lymphocytes from normal and atopic individuals

artículo científico publicado en 1993

Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study

article

Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort.

artículo científico publicado en 2010

Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia

artículo científico publicado en 2010

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

artículo científico publicado en 2004

Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites

artículo científico publicado en 1997

New and Old Monoclonal Antibodies for the Treatment of Chronic Lymphocytic Leukemia

artículo científico publicado en 2011

New developments in the management of chronic lymphocytic leukemia: role of ofatumumab

artículo científico publicado en 2016

Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLL

artículo científico publicado en 2012

Oral fludarabine and cyclophosphamide as front-line chemotherapy in patients with chronic lymphocytic leukemia. The impact of biological parameters in the response duration

artículo científico publicado en 2008

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

artículo científico publicado en 2012

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens

artículo científico publicado en 2017

Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation

artículo científico publicado en 2009

Prevalence, characteristics and management of occult hepatitis B virus infection in patients with chronic lymphocytic leukemia: a single center experience

artículo científico publicado en 2015

Prognostic value of immunoglobulin variable heavy chain gene mutation status: long term follow-up in a series of chronic lymphocytic leukemia patients.

artículo científico publicado en 2006

Rare hemoglobin variants: Hb G-Szuhu (HBB: c.243C>G), Hb G-Coushatta (HBB: c.68A>C) and Hb Mizuho (HBB: c.206T>C) in Sri Lankan families

artículo científico publicado en 2015

Recent advances in the pathogenesis and treatment of chronic lymphocytic leukemia

artículo científico

Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.

artículo científico publicado en 2010

Regression of monoclonal B-cell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy

artículo científico publicado en 1996

Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

artículo científico publicado en 1996

Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type

artículo científico publicado en 2020

Signal-dependent and signal-independent functions of the B-cell receptor in chronic lymphocytic leukemia

artículo científico publicado en 2014

Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells

artículo científico publicado en 2007

Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas.

artículo científico publicado en 1998

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

artículo científico publicado en 2005

Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype.

artículo científico publicado en 2009

TLR9 signaling defines distinct prognostic subsets in CLL.

artículo científico

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia.

artículo científico publicado en 2016

The -158 (C-->T) promoter mutation is responsible for the increased transcription of the 3' gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin.

artículo científico publicado en 1994

The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease.

artículo científico publicado en 2006

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

artículo científico publicado en 2007

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

artículo científico publicado en 2012

The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells.

artículo científico publicado en 2015

The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

artículo científico publicado en 2010

The Syk kinase as a therapeutic target in leukemia and lymphoma

artículo científico publicado en 2011

The detection of β-globin gene mutations in β-thalassemia using oligonucleotide probes and amplified DNA

article

The leukemic cells of chronic lymphocytic leukemia patients with autoimmune hemolytic anemia produce isotype-switched immunoglobulins that are preferentially encoded by the 51p1 and DP-50 VH genes

artículo científico publicado en 1997

The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes.

artículo científico publicado en 2012

The pathologic significance of the immunoglobulins expressed by chronic lymphocytic leukemia B-cells in the development of autoimmune hemolytic anemia

artículo científico publicado en 1998

The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

artículo científico publicado en 2010

The relative levels of βAand βSmRNAs in Hb S heterozygotes and in patients with Hb S-β+-thalassaemia or Hb S-β+-HPFH combinations

artículo científico publicado en 1994

The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors

artículo científico publicado en 1996

The use of low-dose alemtuzumab in pretreated B-cell chronic lymphocytic leukemia

artículo científico publicado en 2010

The use of monoclonal antibodies in the treatment of autoimmune complications of chronic lymphocytic leukemia

artículo científico publicado en 2013

Therapeutic Targets in Chronic Lymphocytic Leukemia

artículo científico publicado en 2020

Treatment approach for elderly and unfit patients with chronic lymphocytic leukemia

artículo científico publicado en 2017

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.

artículo científico publicado en 2015

ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells

artículo científico publicado en 2006

Lista de obras de Dimitar Efremov

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia.

Autoimmune hemolytic anemia during bendamustine plus rituximab treatment in CLL patients: multicenter experience

B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199.

Bendamustine in combination with rituximab for elderly patients with previously untreated B-cell chronic lymphocytic leukemia: A retrospective analysis of real-life practice in Italian hematology departments

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL).

CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential

CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders

Characterization of a second secreted IgE isoform and identification of an asymmetric pathway of IgE assembly.

Chic adaptor regulates apoptosis in CLL

Chlorambucil plus Rituximab as Front-Line Therapy in Elderly/Unfit Patients Affected by B-Cell Chronic Lymphocytic Leukemia: Results of a Single-Centre Experience

Chlorambucil plus rituximab as front-line therapy for elderly and/or unfit chronic lymphocytic leukemia patients: correlation with biologically-based risk stratification

Chronic Lymphocytic Leukemia With Eyelid Involvement Responding to Alemtuzumab

Chronic lymphocytic leukemia patients with a V1-69 gene rearrangement do not have inferior survival with respect to patients that express other unmutated VH genes

Chronic lymphocytic leukemia: a tale of one or two signals?

Clonal B-cell expansions in peripheral blood of HCV-infected patients

Comparison between oral and intravenous fludarabine plus cyclophosphamide regime as front-line therapy in patients affected by chronic lymphocytic leukaemia: influence of biological parameters on the clinical outcome

Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia

Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study

Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2

Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir

Efficacy and safety of low-dose alemtuzumab as treatment of autoimmune hemolytic anemia in pretreated B-cell chronic lymphocytic leukemia

Ethnic difference in the prevalence of monoclonal B-cell proliferation in patients affected by hepatitis C virus chronic liver disease

Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

FOXO discriminates tonic from chronic in DLBCL.

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy.

Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia--author's response to Hebbring.

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Hepatitis C virus, mixed cryoglobulinaemia and non-Hodgkin's lymphoma.

IGHD3-3fails to behave as unfavourable prognostic marker in chronic lymphocytic leukaemia

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

IL-4 regulates B-cell receptor signaling in CLL.

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL).

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

Lamivudine treatment for acute hepatitis B virus infection during allogeneic peripheral blood stem cell transplantation

Long-term follow up of frontline therapy with fludarabine and cyclophosphamide in chronic lymphocytic leukemia: impact of biological parameters on clinical outcome.

Low prevalence of chronic hepatitis C virus infection in B-cell non-Hodgkin's lymphoma patients from a population with a high prevalence of healthy hepatitis c virus carriers.

Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience.

Low-dose thalidomide in combination with oral fludarabine and cyclophosphamide is ineffective in heavily pre-treated patients with chronic lymphocytic leukemia

Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies

Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy

Mild and severe beta-thalassemia among homozygotes from Turkey: identification of the types by hybridization of amplified DNA with synthetic probes.

Molecular analysis of IgE H-chain transcripts expressed in vivo by peripheral blood lymphocytes from normal and atopic individuals

Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study

Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort.

Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites

New and Old Monoclonal Antibodies for the Treatment of Chronic Lymphocytic Leukemia

New developments in the management of chronic lymphocytic leukemia: role of ofatumumab

Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLL

Oral fludarabine and cyclophosphamide as front-line chemotherapy in patients with chronic lymphocytic leukemia. The impact of biological parameters in the response duration

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens

Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation

Prevalence, characteristics and management of occult hepatitis B virus infection in patients with chronic lymphocytic leukemia: a single center experience

Prognostic value of immunoglobulin variable heavy chain gene mutation status: long term follow-up in a series of chronic lymphocytic leukemia patients.

Rare hemoglobin variants: Hb G-Szuhu (HBB: c.243C>G), Hb G-Coushatta (HBB: c.68A>C) and Hb Mizuho (HBB: c.206T>C) in Sri Lankan families

Recent advances in the pathogenesis and treatment of chronic lymphocytic leukemia

Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.

Regression of monoclonal B-cell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy

Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type

Signal-dependent and signal-independent functions of the B-cell receptor in chronic lymphocytic leukemia

Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells

Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas.

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype.

TLR9 signaling defines distinct prognostic subsets in CLL.

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia.

The -158 (C-->T) promoter mutation is responsible for the increased transcription of the 3' gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin.

The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease.