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Lista de obras de Thavendran Govender

(1R,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

artículo científico publicado en 2009

(1R,3S)-Methyl 6,7-dimeth-oxy-1-(4-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate

artículo científico publicado en 2010

(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carbothio-amide

artículo científico publicado en 2011

(1S,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

artículo científico publicado en 2011

(1S,3S)-Methyl 6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate

artículo científico publicado en 2011

(2-(Benzo[d]thia-zol-2yl-meth-oxy)-5-chloro-phen-yl)(phen-yl)methanone.

artículo científico publicado en 2012

(3S)-2-Benzyl-3-carb-oxy-1,2,3,4-tetra-hydro-isoquinolinium chloride monohydrate.

artículo científico publicado en 2010

(68)Ga-NOTA-functionalized Ubiquicidin: Cytotoxicity, Biodistribution, Radiation Dosimetry and First-in-Human Positron Emission Tomography/Computed Tomography Imaging of Infections.

artículo científico publicado en 2017

(S)-2-Benzyl-N-(2,6-diisopropyl-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.

artículo científico publicado en 2011

(S)-Benzyl 3-phenyl-carbamoyl-1,2,3,4-tetra-hydro-isoquinoline-2-carboxyl-ate.

artículo científico publicado en 2012

(S)-Methyl 2-benzamido-3-(3,4-dimeth-oxy-phen-yl)propano-ate.

artículo científico publicado en 2011

(S)-Methyl 3-(3,4-dimethoxyphenyl)-2-[2-(diphenylphosphanyl)benzamido]propanoate ⬇️

artículo científico publicado el 12 de noviembre de 2011

1,7-Dimethyl-penta-cyclo-[5.4.0.0.0.0]undecane-8,11-dione.

artículo científico publicado en 2010

2-(3,5-Dimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoic acid.

artículo científico publicado en 2012

2-(4-Chloro-3-nitro-phen-yl)-4-(4-chloro-phen-yl)-1,3-thia-zole.

artículo científico publicado en 2009

2-(Tricyclo[3.3.1.1]dec-2-ylamino)ethanol hemihydrate.

artículo científico publicado en 2008

2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis

artículo científico publicado en 2015

2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole.

artículo científico publicado en 2011

3-(2-Amino-1,3-thia-zol-4-yl)-6-bromo-2H-chromen-2-one

artículo científico publicado en 2009

6,7-Dimeth-oxy-3-meth-oxy-carbonyl-1-(2-meth-oxy-phen-yl)-3,4-dihydro-isoquinoline 2-oxide.

artículo científico publicado en 2011

6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms

artículo científico publicado en 2015

A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis.

artículo científico publicado en 2015

A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli)

scientific article published on 10 March 2020

A sensitive WST-8-based bioassay for PEGylated granulocyte colony stimulating factor using the NFS-60 cell line

artículo científico publicado en 2014

An efficient solid-phase strategy for total synthesis of naturally occurring amphiphilic marine siderophores: amphibactin-T and moanachelin ala-B.

artículo científico publicado en 2015

An improved synthesis of Fmoc-N-methyl-alpha-amino acids

artículo científico publicado en 2005

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant

artículo científico publicado en 2018

Analysis of Current Pulses in HeLa-Cell Permeabilization Due to High Voltage DC Corona Discharge.

artículo científico publicado en 2016

Applied Enantioselective Aminocatalysis: α-Heteroatom Functionalization Reactions on the Carbapenem (β-Lactam Antibiotic) Core

Artificial Intelligence vs. Statistical Modeling and Optimization of Continuous Bead Milling Process for Bacterial Cell Lysis

artículo científico publicado en 2016

Asymmetric conjugate addition of thioglycolate to a range of chalcones using tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands

article

Binding Free Energy Calculations of Nine FDA-approved Protease Inhibitors Against HIV-1 Subtype C I36T↑T Containing 100 Amino Acids Per Monomer

artículo científico publicado en 2015

Brain penetration of ketamine: Intranasal delivery VS parenteral routes of administraion

artículo científico publicado en 2019

Chemical Platforms for Peptide Vaccine Constructs

artículo científico publicado en 2015

Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane--a potential anti-inflammatory agent

artículo científico publicado en 2007

Chiral Hetero- and Carbocyclic Compounds from the Asymmetric Hydrogenation of Cyclic Alkenes

artículo científico publicado en 2012

Clofazimine protects against mycobacterium tuberculosis dissemination in the CNS following an aerosol challenge in a murine model.

artículo científico publicado en 2017

Comparison of the molecular dynamics and calculated binding free energies for nine FDA-approved HIV-1 PR drugs against subtype B and C-SA HIV PR.

artículo científico publicado en 2012

Complete NMR elucidation of a novel trishomocubane hydantoin and its mono- and bis-t-Boc protected derivatives

artículo científico publicado en 2004

Concerted hydrolysis mechanism of HIV-1 natural substrate against subtypes B and C-SA PR: insight through molecular dynamics and hybrid QM/MM studies

scientific article published on 16 January 2020

Cu(OAc)2-Catalysed Oxidative Dual C-H/N-H Activation of Terminal Alkynes andN-Deprotected Sulfonimidamides: An Easy Access toN-Alkynylated Sulfonimidamides

article by Ganesh Chandra Nandi et al published 17 March 2015 in European Journal of Organic Chemistry

Design and study of peptide-based inhibitors of amylin cytotoxicity

artículo científico publicado en 2010

Design, synthesis, characterization, and antibacterial activity of {5-chloro-2-[(3-substitutedphenyl-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones

artículo científico publicado en 2010

Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

artículo científico publicado en 2015

Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of tigecycline in rat brain tissues.

artículo científico publicado en 2015

Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics.

artículo científico publicado en 2017

Efficient Purification of rhG-CSF and its PEGylated Forms and Evaluation for In Vitro Activities

artículo científico publicado en 2015

Enantioselective Organocatalyzed Transformations of β-Ketoesters.

artículo científico publicado en 2016

Enantioselective Synthesis of Chiral Sulfones by Ir-Catalyzed Asymmetric Hydrogenation: A Facile Approach to the Preparation of Chiral Allylic and Homoallylic Compounds

artículo científico publicado en 2012

Enhanced brain penetration of pretomanid by intranasal administration of an oil-in-water nanoemulsion

scientific article published on 23 May 2018

Erratum: Tetra-kis-μ-l-alanine-κO:O'-bis-[tetra-aqua-terbium(III)] hexa-perchlorate. Corrigendum.

artículo científico publicado en 2010

Ethyl 2-(3,5-dimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoate

artículo científico publicado en 2012

Ethyl 4-(1,3-benzodioxol-5-yl)-6-methyl-2-sulfanylidene-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate

artículo científico publicado en 2011

Ethyl 4-(4-hydroxy-phen-yl)-6-methyl-2-oxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate monohydrate

artículo científico publicado en 2009

Ethyl 6-methyl-2-sulfanyl-idene-4-[4-(trifluoro-meth-yl)phen-yl]-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

artículo científico publicado en 2011

Evaluation of MALDI Biotyping for Rapid Subspecies Identification of Carbapenemase-Producing Bacteria via Protein Profiling

Evidence for the presence of clofazimine and its distribution in the healthy mouse brain.

artículo científico publicado en 2015

Exploring the concerted mechanistic pathway for HIV-1 PR-substrate revealed by umbrella sampling simulation

artículo científico publicado en 2020

Exploring the flap dynamics of the South African HIV subtype C protease in presence of FDA-approved inhibitors: MD study

scientific article published on 24 September 2018

Facile synthesis of Fmoc-N-methylated α- and β-amino acids

Fast and efficient detection of tuberculosis antigens using liposome encapsulated secretory proteins of Mycobacterium tuberculosis.

artículo científico publicado en 2015

Highly chemoselective ligation of thiol- and amino-peptides on a bromomaleimide core

artículo científico publicado en 2016

I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions

artículo científico publicado en 2017

Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads: virtual screening and molecular dynamics simulations

artículo científico publicado en 2019

Immobilized coupling reagents: synthesis of amides/peptides.

artículo científico publicado en 2014

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation

artículo científico publicado en 2010

In vitro evaluation of metal chelators as potential metallo- β -lactamase inhibitors

artículo científico publicado en 2016

Inhibition mechanism of L,D-transpeptidase 5 in presence of the β-lactams using ONIOM method

artículo científico publicado en 2018

Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity

artículo científico

Interaction of beta-amyloid interactions with peptide functionalized gold nanoparticles.

artículo científico publicado en 2012

Investigating time dependent brain distribution of nevirapine via mass spectrometric imaging

scientific article published on 04 November 2019

Investigation of the binding free energies of FDA approved drugs against subtype B and C-SA HIV PR: ONIOM approach.

artículo científico publicado en 2017

Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease

artículo científico publicado en 2019

Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent.

artículo científico publicado en 2017

Linear and cyclic glycopeptide as HIV protease inhibitors

artículo científico publicado en 2012

MALDI MSI and LC-MS/MS: Towards preclinical determination of the neurotoxic potential of fluoroquinolones.

artículo científico publicado en 2015

Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs

artículo científico publicado en 2019

Mass spectrometric investigations into the brain delivery of abacavir, stavudine and didanosine in a rodent model

artículo científico publicado en 2019

Mechanistic investigation of the uncatalyzed esterification reaction of acetic acid and acid halides with methanol: a DFT study.

artículo científico publicado en 2016

Metabolic Imaging of Infection.

artículo científico publicado en 2017

Methyl 1-cyclo-hexyl-6,7-dimeth-oxy-3,4-dihydro-isoquinoline-3-carboxyl-ate. ⬇️

artículo científico publicado en 2011

Methyl 2-(2,3,5-trimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoate

artículo científico publicado en 2012

Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

artículo científico

Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells

artículo científico publicado en 2010

Microwave-Assisted Synthesis of Antimicrobial Peptides.

artículo científico publicado en 2017

Microwave-Assisted Synthesis of Guanidine Organocatalysts Bearing a Tetrahydroisoquinoline Framework and Their Evaluation in Michael Addition Reactions

article

Microwave-assisted synthesis of meso-carboxyalkyl-BODIPYs and an application to fluorescence imaging

scientific article published on 28 September 2020

Molecular Modeling of T. rangeli, T. brucei gambiense, and T. evansi Sialidases in Complex with the DANA Inhibitor

artículo científico publicado en 2012

Molecular insight on the non-covalent interactions between carbapenems and l,d-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study

artículo científico publicado en 2018

N-(2-Hydroxy-ethyl)-N-(tricyclo-[3.3.1.1]dec-2-yl)benzamide.

artículo científico publicado en 2008

N-(Adamantan-1-yl)-2-chloro-acetamide

artículo científico publicado en 2011

N-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity

artículo científico publicado en 2019

NMR elucidation of a novel (S)-pentacyclo-undecane bis-(4-phenyloxazoline) ligand and related derivatives

artículo científico publicado en 2008

NOTA: a potent metallo-β-lactamase inhibitor.

artículo científico publicado en 2015

Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

artículo científico publicado en 2016

Novel PCU cage diol peptides as potential targets against wild-type CSA HIV-1 protease: synthesis, biological screening and molecular modelling studies

article

Novel polycyclic 'cage'-1,2-diamines as potential anti-tuberculosis agents.

artículo científico publicado en 2012

Novel tetrahydroisoquinoline based organocatalysts for asymmetric Diels–Alder reactions: insight into the catalytic mode using ROESY NMR and DFT studies

On-Water Synthesis of Biaryl Sulfonyl Fluorides

artículo científico publicado en 2016

Optically active diaryl tetrahydroisoquinoline derivatives

scientific article published on 08 February 2011

Optimized Microwave Assisted Synthesis of LL37, a Cathelicidin Human Antimicrobial Peptide

Organocatalytic Mannich Reactions on a Carbapenem Core - Synthesis of Mannich Bases and Bicyclic Diazanonanes

Organocatalytic synthesis of chiral benzopyrans

Organocatalyzed stereospecific C-C bond formation of β-lactams

artículo científico publicado en 2013

Oxyma-B, an excellent racemization suppressor for peptide synthesis

artículo científico publicado en 2014

Pd-catalyzed C–N coupling of vinylbromides and sulfonimidamides: a facile synthesis of N′-vinylsulfonimidamides

scholarly article in RSC Advances, vol. 5 no. 76, 2015

Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors

artículo científico publicado en 2011

Pentacycloundecane lactam vs lactone norstatine type protease HIV inhibitors: binding energy calculations and DFT study

artículo científico publicado en 2015

Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease

artículo científico publicado en 2011

Pentacycloundecane-diol-based HIV-1 protease inhibitors: biological screening, 2D NMR, and molecular simulation studies

artículo científico publicado en 2012

Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

artículo científico publicado en 2015

Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein-protein binding

artículo científico publicado en 2015

Poly-N-methylated Aβ-Peptide C-Terminal fragments (MEPTIDES) reverse the deleterious effects of amyloid-β in rats

artículo científico publicado en 2017

Poly-N-methylated amyloid beta-peptide (Abeta) C-terminal fragments reduce Abeta toxicity in vitro and in Drosophila melanogaster

artículo científico publicado en 2009

Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs ⬇️

artículo científico publicado el 3 de febrero de 2012

Pore formation in phospholipid bilayers by amphiphilic cavitands

scientific article published on 20 April 2011

Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging

artículo científico publicado en 2017

Potential inhibition of HIV-1 encapsidation by oligoribonucleotide-dendrimer nanoparticle complexes.

artículo científico publicado en 2017

Preclinical evaluation of 68Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-ubiquicidin as a radioligand for PET infection imaging

artículo científico publicado en 2014

Proline N-oxides: modulators of the 3D conformation of linear peptides through "NO-turns".

artículo científico publicado en 2014

Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.

artículo científico publicado en 2016

Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study.

artículo científico publicado en 2015

Rilpivirine as a potential candidate for the treatment of HIV-associated neurocognitive disorders (HAND)

artículo científico publicado en 2019

Short AntiMicrobial Peptides (SAMPs) as a class of extraordinary promising therapeutic agents.

artículo científico publicado en 2016

Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems.

artículo científico publicado en 2015

Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI.

artículo científico publicado en 2016

Solid-Phase Synthesis of Pyrrole Derivatives through a Multicomponent Reaction Involving Lys-Containing Peptides.

artículo científico publicado en 2018

Solid-phase peptide synthesis (SPPS), C-terminal vs. side-chain anchoring: a reality or a myth.

artículo científico

Spatial distribution of elvitegravir and tenofovir in rat brain tissue: Application of matrix-assisted laser desorption/ionization mass spectrometry imaging and liquid chromatography/tandem mass spectrometry

scientific article published on 01 November 2019

Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.

artículo científico publicado en 2015

Sulfonimidamide in medizinischer Chemie und Agrochemie

Sulfonimidamides in Medicinal and Agricultural Chemistry

artículo científico publicado en 2016

Synthesis and Biological Evaluation of a Teixobactin Analogue

artículo científico publicado en 2015

Synthesis and NMR elucidation of novel penta-cycloundecane amine derivatives as potential antituberculosis agents

artículo científico publicado en 2008

Synthesis and NMR elucidation of novel pentacycloundecane-based peptides

artículo científico publicado en 2010

Synthesis and NMR elucidation of novel tetrapeptides

artículo científico publicado en 2011

Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates

artículo científico publicado en 2010

Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach

artículo científico publicado en 2011

Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction

scholarly article in RSC Advances, vol. 8 no. 65, 2018

Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors

artículo científico publicado en 2012

Synthesis, 68Ga-radiolabeling, and preliminary in vivo assessment of a depsipeptide-derived compound as a potential PET/CT infection imaging agent

artículo científico publicado en 2015

Synthesis, in vitro evaluation, and 68 Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection.

artículo científico publicado en 2017

Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors

article

Synthetic approaches to radiochemical probes for imaging of bacterial infections.

artículo científico publicado en 2017

TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

artículo científico publicado en 2014

Targeting the cell wall of Mycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.

artículo científico publicado en 2015

Tetra-kis-μ-l-alanine-κO:O'-bis-[tetra-aqua-terbium(III)] hexa-perchlorate.

artículo científico publicado en 2010

Tetrahydroisoquinoline-Based N-Oxides as Chiral Organocatalysts for the Asymmetric Allylation of Aldehydes

The Driving Force for the Acylation of β-Lactam Antibiotics by L,D-Transpeptidase 2: Quantum Mechanics/Molecular Mechanics (QM/MM) Study

scientific article published on 10 April 2019

The catalytic role of water in the binding site of l,d-transpeptidase 2 within acylation mechanism: A QM/MM (ONIOM) modelling

artículo científico publicado en 2018

The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.

artículo científico publicado en 2017

The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study.

artículo científico publicado en 2015

The impact of active site mutations of South African HIV PR on drug resistance: Insight from molecular dynamics simulations, binding free energy and per-residue footprints

artículo científico publicado en 2014

Theoretical Model for HIV-1 PR That Accounts for Substrate Recognition and Preferential Cleavage of Natural Substrates

scientific article published on 22 July 2019

Time-dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction.

artículo científico publicado en 2018

Tissue distribution of pretomanid in rat brain via mass spectrometry imaging

artículo científico publicado en 2015

Total synthesis of a depsidomycin analogue by convergent solid-phase peptide synthesis and macrolactonization strategy for antitubercular activity.

artículo científico publicado en 2011

Towards a stereoselective synthesis of α,α-disubstituted proline analogues

Trishomocubane Amino Acid as a β-turn scaffold

Visualization of Time-Dependent Distribution of Rifampicin in Rat Brain Using MALDI MSI and Quantitative LCMS/MS.

artículo científico publicado en 2015

Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder

scientific article published on 01 October 2019

l-Proline organocatalyzed Michael synthesis of monobactam and carbapenem β-lactam cores

{(1R,3S)-2-Benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl}diphenyl-methanol.

artículo científico publicado en 2010

{2-[(1,3-Benzo-thia-zol-2-yl)meth-oxy]-5-fluoro-phen-yl}(4-chloro-phen-yl)methanone

scientific article published on 08 June 2013

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