Lista de obras - Keigo Machida - Dominio Público Uruguay

"Second hit" models of alcoholic liver disease.

artículo científico publicado en 2009

A super TLR agonist to improve efficacy of dendritic cell vaccine in induction of anti-HCV immunity

artículo científico publicado en 2012

Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage

artículo científico publicado en 2010

Alcohol, TLR4-TGF-β antagonism, and liver cancer.

artículo científico publicado en 2013

Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A

artículo científico publicado en 2008

HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice

artículo científico publicado en 2006

HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases

artículo científico publicado en 2014

Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein

artículo científico publicado en 2008

Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway

artículo científico publicado en 2009

Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes ⬇️

artículo científico publicado el 25 de octubre de 2010

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

artículo científico publicado en 2006

Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells

artículo científico publicado en 2005

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.

artículo científico publicado en 2007

Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins

artículo científico publicado en 2009

Hepatitis C virus egress and release depend on endosomal trafficking of core protein

artículo científico publicado en 2010

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2.

artículo científico publicado en 2017

Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes

scholarly article

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6

artículo científico publicado en 2006

Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes

artículo científico publicado en 2004

Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.

artículo científico publicado en 2009

Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines

artículo científico publicado en 2006

Hepatitis C virus translation preferentially depends on active RNA replication

artículo científico publicado en 2012

Hepatitis C virus-related lymphomagenesis in a mouse model.

artículo científico publicado en 2011

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.

artículo científico publicado en 1997

Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity.

artículo científico publicado en 2010

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

artículo científico publicado en 2012

Morphogens and hepatic stellate cell fate regulation in chronic liver disease.

artículo científico publicado en 2012

Mouse intragastric infusion (iG) model.

artículo científico publicado en 2012

NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.

artículo científico publicado en 2015

Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.

artículo científico

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice.

artículo científico publicado en 2014

PPARs and Liver Disease

artículo científico publicado en 2013

Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A

artículo científico publicado en 2010

SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication

artículo científico publicado en 2009

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma

artículo científico publicado en 2015

TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis

artículo científico publicado en 2015

TLRs, Alcohol, HCV, and Tumorigenesis ⬇️

artículo científico publicado el 1 de enero de 2010

The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex

artículo científico publicado en 2013

Toll-like receptor signaling in liver diseases

artículo científico publicado en 2010

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry

artículo científico publicado en 2012

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

artículo científico publicado en 2015

Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus.

artículo científico publicado en 2013

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.

artículo científico publicado en 2010

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

scientific article published on 17 June 2020

Lista de obras de Keigo Machida

"Second hit" models of alcoholic liver disease.

A super TLR agonist to improve efficacy of dendritic cell vaccine in induction of anti-HCV immunity

Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage

Alcohol, TLR4-TGF-β antagonism, and liver cancer.

Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A

HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice

HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases

Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein

Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway

Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes ⬇️

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.

Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins

Hepatitis C virus egress and release depend on endosomal trafficking of core protein

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2.

Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6

Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes

Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.

Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines

Hepatitis C virus translation preferentially depends on active RNA replication

Hepatitis C virus-related lymphomagenesis in a mouse model.

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.

Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity.

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

Morphogens and hepatic stellate cell fate regulation in chronic liver disease.

Mouse intragastric infusion (iG) model.

NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.

Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice.

PPARs and Liver Disease

Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A

SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma

TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis

TLRs, Alcohol, HCV, and Tumorigenesis ⬇️

The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex

Toll-like receptor signaling in liver diseases

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus.

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs