Lista de obras - Ivan Votruba - Dominio Público Uruguay

3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic

artículo científico publicado en 2010

6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents

artículo científico publicado en 2010

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

artículo científico publicado en 2002

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

artículo científico publicado en 2011

Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro

artículo científico publicado en 1990

Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants ⬇️

artículo científico publicado el 26 de agosto de 2011

CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases

artículo científico publicado en 2010

Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides

artículo científico publicado en 2005

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.

artículo científico publicado en 2010

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis

artículo científico publicado en 1993

Evaluation of the impact of S‐adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome ⬇️

artículo científico publicado el 15 de marzo de 1998

Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines

artículo científico publicado en 2004

Genotoxicity of purine acyclic nucleotide analogs

artículo científico publicado el 1 de enero de 1997

In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl- 2,5-dihydrofuran-2-ones against common and emerging yeasts and molds

artículo científico publicado en 2004

Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues

artículo científico publicado en 1990

Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes

artículo científico publicado en 2000

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

artículo científico publicado en 2008

Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates

artículo científico publicado el 1 de febrero de 2012

Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).

artículo científico publicado en 2009

Mechanism of inhibitory effects of 2,3-dihydro-1,3-6h-oxazine-2,6-dione (3-oxauracil). Biosynthesis of 3-oxauridine phosphates in intact cells and cell-free extracts of Escherichia coli

artículo científico publicado en 1979

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

artículo científico publicado en 2013

PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.

artículo científico publicado en 2003

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase

artículo científico publicado en 2008

Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells

artículo científico publicado el 1 de julio de 2010

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma

artículo científico publicado en 2007

Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds

artículo científico publicado en 2004

Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7.

artículo científico publicado en 2008

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines

artículo científico publicado en 2011

Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations

artículo científico publicado en 2008

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides

artículo científico publicado en 2007

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides

artículo científico publicado en 2007

Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*

scientific journal article

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization

artículo científico publicado en 2010

Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated ⬇️

artículo científico publicado el 1 de enero de 1995

Lista de obras de Ivan Votruba

3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic

6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro

Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants ⬇️

CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases

Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis

Evaluation of the impact of S‐adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome ⬇️

Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines

Genotoxicity of purine acyclic nucleotide analogs

In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl- 2,5-dihydrofuran-2-ones against common and emerging yeasts and molds

Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues

Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates

Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).

Mechanism of inhibitory effects of 2,3-dihydro-1,3-6h-oxazine-2,6-dione (3-oxauracil). Biosynthesis of 3-oxauridine phosphates in intact cells and cell-free extracts of Escherichia coli

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase

Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma

Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds

Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7.

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines

Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides

Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization

Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated ⬇️