Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade

Author response: A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

Author response: Cytokine ranking via mutual information algorithm correlates cytokine profiles with presenting disease severity in patients infected with SARS-CoV-2

Editor's evaluation: A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

Editor's evaluation: Arbidol inhibits human esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

Editor's evaluation: Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma

Editor's evaluation: Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

Editor's evaluation: Selective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer

Editor's evaluation: The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion

Faculty Opinions recommendation of A FISH-based method for assessment of HER-2 amplification status in breast cancer circulating tumor cells following CellSearch isolation.

Faculty Opinions recommendation of A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1.

Faculty Opinions recommendation of A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.

Faculty Opinions recommendation of A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer.

Faculty Opinions recommendation of A novel microfluidic platform for size and deformability based separation and the subsequent molecular characterization of viable circulating tumor cells.

Faculty Opinions recommendation of A novel retinoblastoma therapy from genomic and epigenetic analyses.

Faculty Opinions recommendation of A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.

Faculty Opinions recommendation of Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes.

Faculty Opinions recommendation of Advances in adenovirus-mediated p53 cancer gene therapy.

Faculty Opinions recommendation of Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Faculty Opinions recommendation of Androgen receptor activity in T cells limits checkpoint blockade efficacy.

Faculty Opinions recommendation of Association of dietary inflammatory potential with colorectal cancer risk in men and women.

Faculty Opinions recommendation of BET inhibitors potentiate chemotherapy and killing of SPOP-mutant colon cancer cells via induction of DR5.

Faculty Opinions recommendation of BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

Faculty Opinions recommendation of CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.

Faculty Opinions recommendation of CDK4/6 inhibition triggers anti-tumour immunity.

Faculty Opinions recommendation of Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Faculty Opinions recommendation of Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

Faculty Opinions recommendation of Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.

Faculty Opinions recommendation of Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer.

Faculty Opinions recommendation of Circulating tumor cells and circulating tumor DNA: challenges and opportunities on the path to clinical utility.

Faculty Opinions recommendation of Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy.

Faculty Opinions recommendation of Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.

Faculty Opinions recommendation of Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.

Faculty Opinions recommendation of Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Faculty Opinions recommendation of Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy.

Faculty Opinions recommendation of Direct Lipido-Metabolomics of Single Floating Cells for Analysis of Circulating Tumor Cells by Live Single-cell Mass Spectrometry.

Faculty Opinions recommendation of Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.

Faculty Opinions recommendation of Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy.

Faculty Opinions recommendation of Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.

Faculty Opinions recommendation of Eradication of spontaneous malignancy by local immunotherapy.

Faculty Opinions recommendation of Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Faculty Opinions recommendation of Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.

Faculty Opinions recommendation of Genetic and transcriptional evolution alters cancer cell line drug response.

Faculty Opinions recommendation of Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors.

Faculty Opinions recommendation of Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver.

Faculty Opinions recommendation of High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining.

Faculty Opinions recommendation of Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.

Faculty Opinions recommendation of Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.

Faculty Opinions recommendation of Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer.

Faculty Opinions recommendation of Identification of novel RAS signaling therapeutic vulnerabilities in Diffuse Intrinsic Pontine Gliomas.

Faculty Opinions recommendation of Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

Faculty Opinions recommendation of Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.

Faculty Opinions recommendation of LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway.

Faculty Opinions recommendation of Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer.

Faculty Opinions recommendation of Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis.

Faculty Opinions recommendation of Macrophages orchestrate breast cancer early dissemination and metastasis.

Faculty Opinions recommendation of Mannose impairs tumour growth and enhances chemotherapy.

Faculty Opinions recommendation of Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

Faculty Opinions recommendation of Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Faculty Opinions recommendation of Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers.

Faculty Opinions recommendation of Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer.

Faculty Opinions recommendation of Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source.

Faculty Opinions recommendation of Mutational analysis of circulating tumor cells from colorectal cancer patients and correlation with primary tumor tissue.

Faculty Opinions recommendation of Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment.

Faculty Opinions recommendation of Personalized oncology through integrative high-throughput sequencing: a pilot study.

Faculty Opinions recommendation of Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity.

Faculty Opinions recommendation of Predicting drug response and synergy using a deep learning model of human cancer cells.

Faculty Opinions recommendation of Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Faculty Opinions recommendation of Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations.

Faculty Opinions recommendation of RB constrains lineage fidelity and multiple stages of tumour progression and metastasis.

Faculty Opinions recommendation of Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.

Faculty Opinions recommendation of Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front Mutations.

Faculty Opinions recommendation of Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma.

Faculty Opinions recommendation of Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.

Faculty Opinions recommendation of Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

Faculty Opinions recommendation of Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

Faculty Opinions recommendation of Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.

Faculty Opinions recommendation of Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.

Faculty Opinions recommendation of Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition.

Faculty Opinions recommendation of TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.

Faculty Opinions recommendation of Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels.

Faculty Opinions recommendation of Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors.

Faculty Opinions recommendation of Targeting p53-dependent stem cell loss for intestinal chemoprotection.

Faculty Opinions recommendation of The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.

Faculty Opinions recommendation of The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma.

Faculty Opinions recommendation of The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.

Faculty Opinions recommendation of The evolutionary history of 2,658 cancers.

Faculty Opinions recommendation of The proposal to lower P value thresholds to .005.

Faculty Opinions recommendation of Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.

Faculty Opinions recommendation of VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.

Faculty Opinions recommendation of Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation.

Faculty Opinions recommendation of c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.

Faculty Opinions recommendation of eRNAs are required for p53-dependent enhancer activity and gene transcription.

Faculty Opinions recommendation of p53 modulates acquired resistance to EGFR inhibitors and radiation.

GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer

HIF1α inhibition by dual targeting of CDK4/6 and HSP90 reduces cancer cell viability including Rb-deficient cells

ITGB6 inhibition stimulates anti-tumor responses in immunocompetent mouse models of head & neck squamous cell carcinoma and pancreatic adenocarcinoma

Immunotherapy for Colorectal Cancer: Mechanisms and Predictive Biomarkers

Integrin/TGF-β1 inhibitor GLPG-0187 blocks SARS-CoV-2 Delta and Omicron pseudovirus infection of airway epithelial cells which could attenuate disease severity

Neuroendocrine Prostate Cancer Drivers SOX2 and BRN2 Confer Differential Responses to Imipridones ONC201, ONC206, and ONC212 in Prostate Cancer Cell Lines

Neuroendocrine differentiation (ND) in sensitivity of neuroendocrine tumor (NET) cells to ONC201/TIC10 cancer therapeutic

P53-independent restoration of p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9

SARS-CoV-2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells

Supplementary Figure S1 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Supplementary Figure S2 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Supplementary Figure S3 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Supplementary Figure S4 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Supplementary Figure S5 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Supplementary Figure S6 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Supplementary Table S2 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Supplementary Table S3 from <i>XPO1</i><sup><i>R749Q</i></sup> Mutations Co-occur with <i>POLE</i> Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Synergistic anti-tumor activity, reduced pERK, and immuno-stimulatory cytokine profiles with 5-FU or ONC212 plus KRAS G12D inhibitor MRTX1133 in CRC and pancreatic cancer cells independent of G12D mutation

Synergistic combination therapy with ONC201 or ONC206, Enzalutamide and Darolutamide in preclinical studies of castration-resistant prostate cancer

TRAIL agonists rescue mice from radiation-induced lung injury

TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

miR-6883 downregulates HIF1α in colorectal and breast cancer cells