Lista de obras - Carl R Walkley - Dominio Público Uruguay

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency

artículo científico publicado en 2007

ADAR1, inosine and the immune sensing system: distinguishing self from non-self

artículo científico publicado en 2016

ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity

artículo científico publicado en 2018

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

scientific article published on 05 July 2019

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.

artículo científico publicado en 2016

Adar3 Is Involved in Learning and Memory in Mice

artículo científico publicado en 2018

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

artículo científico publicado en 2016

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

artículo científico publicado en 2015

Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation

artículo científico publicado en 2015

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

scientific article published on 04 December 2019

Cell division and hematopoietic stem cells: not always exhausting

artículo científico publicado en 2005

Cells of origin in osteosarcoma: mesenchymal stem cells or osteoblast committed cells?

artículo científico

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.

artículo científico publicado en 2015

Control of self-renewal and differentiation of hematopoietic stem cells by negative cell-cycle regulators

artículo científico publicado en 2007

Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment

artículo científico publicado en 2012

Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies.

artículo científico publicado en 2013

Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

artículo científico publicado en 2016

Defining the functions of adenosine-to-inosine RNA editing through hematology

scientific article published on 01 July 2019

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum.

artículo científico publicado en 2011

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

artículo científico publicado en 2017

Dynamic landscape and regulation of RNA editing in mammals.

artículo científico publicado en 2017

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.

artículo científico publicado en 2013

Erythropoiesis, anemia and the bone marrow microenvironment.

scientific article published on 12 January 2011

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

artículo científico publicado en 2011

Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion

artículo científico publicado en 2011

Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms

artículo científico publicado en 2014

Generation and analysis of Siah2 mutant mice.

artículo científico publicado en 2003

Genetically engineered mouse models and human osteosarcoma

artículo científico publicado en 2012

Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells

artículo científico publicado en 2007

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α.

artículo científico publicado en 2015

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

artículo científico publicado en 2011

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

artículo científico publicado en 2020

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

artículo científico publicado en 2019

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

artículo científico publicado en 2016

Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation.

artículo científico publicado en 2003

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

artículo científico publicado en 2013

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death.

artículo científico publicado en 2016

Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo

artículo científico publicado en 2014

Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development

artículo científico publicado en 2016

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

artículo científico publicado en 2004

MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity

artículo científico publicado en 2002

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

artículo científico publicado en 2013

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

scientific article published on 06 November 2018

Murine Models of Bone Sarcomas

scientific article published on 01 January 2019

Murine models of osteosarcoma: A piece of the translational puzzle

artículo científico publicado en 2017

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

artículo científico publicado en 2005

Osteopenia in Siah1a mutant mice.

artículo científico publicado en 2004

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

artículo científico publicado en 2016

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

artículo científico publicado en 2014

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

artículo científico publicado en 2007

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.

artículo científico publicado en 2017

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

artículo científico publicado en 2006

RARγ is a negative regulator of osteoclastogenesis

artículo científico publicado en 2015

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

artículo científico publicado en 2015

Rb and hematopoiesis: stem cells to anemia

artículo científico publicado en 2008

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

artículo científico publicado en 2008

Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells

artículo científico publicado en 2006

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

artículo científico publicado en 2007

Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis.

artículo científico publicado en 2002

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs

artículo científico publicado en 2017

Role of ADARs in mouse development

artículo científico publicado en 2012

Rothmund-Thomson Syndrome-like RECQL4 truncating mutations cause a haploinsufficient low bone mass phenotype in mice

scientific article published on 23 December 2020

Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations

artículo científico publicado en 2018

Src family kinases and their role in hematological malignancies

artículo científico publicado en 2015

Srsf2P95Hinitiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells

article

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

artículo científico publicado en 2017

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

artículo científico publicado en 2015

Taking HSCs down a Notch in leukemia.

artículo científico publicado en 2011

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

artículo científico publicado en 2004

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

artículo científico publicado en 2017

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation

artículo científico publicado en 2015

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

artículo científico publicado en 2014

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

artículo científico

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

artículo científico publicado en 2016

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

artículo científico publicado en 2012

The majority of A-to-I RNA editing is not required for mammalian homeostasis

scientific article published on 09 December 2019

The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA.

artículo científico publicado en 2016

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

scholarly article by Mannu K Walia et al published 28 August 2018 in Cell Death and Disease

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma

artículo científico publicado en 2015

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation

artículo científico publicado en 2017

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

artículo científico publicado en 2018

Lista de obras de Carl R Walkley

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency

ADAR1, inosine and the immune sensing system: distinguishing self from non-self

ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.

Adar3 Is Involved in Learning and Memory in Mice

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

Cell division and hematopoietic stem cells: not always exhausting

Cells of origin in osteosarcoma: mesenchymal stem cells or osteoblast committed cells?

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.

Control of self-renewal and differentiation of hematopoietic stem cells by negative cell-cycle regulators

Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment

Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies.

Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

Defining the functions of adenosine-to-inosine RNA editing through hematology

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum.

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Dynamic landscape and regulation of RNA editing in mammals.

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.

Erythropoiesis, anemia and the bone marrow microenvironment.

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion

Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms

Generation and analysis of Siah2 mutant mice.

Genetically engineered mouse models and human osteosarcoma

Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α.

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation.

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death.

Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo

Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

Murine Models of Bone Sarcomas

Murine models of osteosarcoma: A piece of the translational puzzle

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

Osteopenia in Siah1a mutant mice.

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

RARγ is a negative regulator of osteoclastogenesis

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Rb and hematopoiesis: stem cells to anemia

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis.

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs

Role of ADARs in mouse development

Rothmund-Thomson Syndrome-like RECQL4 truncating mutations cause a haploinsufficient low bone mass phenotype in mice

Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations

Src family kinases and their role in hematological malignancies

Srsf2P95Hinitiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

Taking HSCs down a Notch in leukemia.

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

The majority of A-to-I RNA editing is not required for mammalian homeostasis

The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA.

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma