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Lista de obras de Michael W Parker

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

scientific article published on 01 September 2019

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

artículo científico publicado en 2015

A common channel-forming motif in evolutionarily distant porins.

artículo científico publicado en 1991

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

artículo científico publicado en 2018

A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.

artículo científico publicado en 2016

A homology model for the human theta-class glutathione transferase T1-1.

artículo científico publicado en 1998

A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications

artículo científico publicado en 1998

A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore

article

A rivet model for channel formation by aerolysin-like pore-forming toxins

artículo científico publicado en 2006

A single amino acid substitution can restore the solubility of aggregated colicin A mutants in Escherichia coli

scientific article published on 01 December 1994

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

scientific article published on 20 June 2019

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

artículo científico publicado en 2014

AMP and adenosine are both ligands for adenosine 2B receptor signaling.

artículo científico publicado en 2017

AMPK beta subunit targets metabolic stress sensing to glycogen

artículo científico publicado en 2003

Ab initio calculations on hidden modulators of theta class glutathione transferase activity

artículo científico publicado en 2000

Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N‑truncated Abeta in sporadic Alzheimer disease cases and mouse models.

artículo científico publicado en 2015

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

artículo científico publicado en 2018

Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.

artículo científico publicado en 2014

Aerolysin--a paradigm for membrane insertion of beta-sheet protein toxins?

artículo científico publicado en 1998

Aerolysin--the ins and outs of a model channel-forming toxin.

artículo científico publicado en 1996

Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.

artículo científico publicado en 2002

Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase

artículo científico publicado en 2011

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope

artículo científico publicado en 2008

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

artículo científico publicado en 2021

An Activation-Specific Platelet Inhibitor That Can Be Turned On/Off by Medically Used Hypothermia

artículo científico publicado en 2011

An Escherichia coli cell-free system for recombinant protein synthesis on a milligram scale.

artículo científico publicado en 2011

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin

scientific article published on 02 July 2019

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

artículo científico publicado en 2012

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin

artículo científico publicado en 2015

Anxiety over GABA(A) receptor structure relieved by AChBP.

artículo científico publicado en 2002

Application of molecular dynamics in the crystallographic refinement of colicin A

artículo científico publicado en 1989

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation

artículo científico publicado en 2013

Binding and kinetic mechanisms of the Zeta class glutathione transferase

artículo científico publicado en 2004

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

scientific article published on 19 August 2019

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

artículo científico publicado en 2015

Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1

artículo científico publicado en 2006

Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione S-transferases. Investigation of Ser-9 and Tyr-113 in a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.

artículo científico publicado en 1997

Characterization of pathogenic human monoclonal autoantibodies against GM-CSF.

artículo científico publicado en 2013

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation

scientific article published on 17 June 2019

Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique

artículo científico publicado en 2003

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

artículo científico publicado en 2009

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica

artículo científico publicado en 2010

Conformational Changes in Aerolysin during the Transition from the Water-Soluble Protoxin to the Membrane Channel ⬇️

artículo científico publicado el 9 de diciembre de 1997

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

artículo científico publicado en 2016

Conformational States of Human Placental Glutathione Transferase as Probed by Limited Proteolysis

artículo científico publicado en 1993

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407.

artículo científico publicado en 2017

Conversion of a transmembrane to a water-soluble protein complex by a single point mutation

artículo científico publicado en 2002

Copper binding to the Alzheimer's disease amyloid precursor protein

artículo científico publicado en 2007

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

artículo científico publicado en 2007

Cryptic clues as to how water-soluble protein toxins form pores in membranes

artículo científico publicado en 2003

Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis

artículo científico publicado en 2003

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

artículo científico publicado en 2015

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

artículo científico publicado en 2014

Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity

artículo científico publicado en 2001

Crystal structure of manganese superoxide dismutase from Bacillus stearothermophilus at 2.4 Å resolution

artículo científico publicado en 1988

Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site

artículo científico publicado en 2010

Crystal structure of theLeishmania majorMIX protein: A scaffold protein that mediates protein-protein interactions

artículo científico publicado en 2011

Crystallization and preliminary X-ray analysis of a bacterial glutathione transferase

artículo científico publicado en 1996

Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin

artículo científico publicado en 1996

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate

artículo científico publicado en 2009

Crystallization and preliminary X-ray analysis of glutathione transferases from cyanobacteria

artículo científico publicado en 2009

Crystallization and preliminary X-ray analysis of phosphoporin from the outer membrane of Escherichia coli

artículo científico publicado en 1991

Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin

artículo científico publicado en 2004

Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2.

artículo científico publicado en 2012

Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β

artículo científico publicado en 2014

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

scientific article published on 19 February 2014

Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex

artículo científico publicado en 2008

Crystallization and preliminary X-ray diffraction analysis of the unliganded human growth hormone receptor

artículo científico publicado en 2004

Crystallization and preliminary X-ray diffraction studies of a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.

artículo científico publicado en 1994

Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease

artículo científico publicado en 2004

Crystallization and preliminary x-ray analysis of the auto-inhibited twitchin kinase

scientific article published on 01 March 1994

Crystallization of a proform of aerolysin, a hole-forming toxin from Aeromonas hydrophila

artículo científico publicado en 1990

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae

artículo científico publicado en 2009

Crystallization of glutathione S-transferase from human placenta

artículo científico publicado en 1990

Crystallization of the glycogen-binding domain of the AMP-activated protein kinase beta subunit and preliminary X-ray analysis

artículo científico publicado en 2004

Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment

artículo científico publicado en 2009

Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase

artículo científico publicado en 1997

Crystallographic phases through genetic engineering: experiences with colicin A

artículo científico publicado en 1989

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

article

Cytokine receptor activation at the cell surface

artículo científico

Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels

artículo científico publicado en 2005

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

artículo científico publicado en 2015

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

artículo científico publicado en 2008

Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition

artículo científico publicado en 2008

Direct involvement of the TEN domain at the active site of human telomerase

artículo científico publicado en 2010

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

artículo científico publicado en 2013

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9.

artículo científico publicado en 2015

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

scientific article published on 17 July 2019

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

artículo científico publicado en 2014

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

artículo científico publicado en 2021

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

scientific article published on 09 September 2019

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody

artículo científico publicado en 2014

EPO does not promote interaction between the erythropoietin and beta-common receptors

artículo científico publicado en 2018

Elucidation of the substrate binding site of Siah ubiquitin ligase

scientific journal article

Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences

artículo científico publicado en 2003

Evaluation of the role of two conserved active-site residues in beta class glutathione S-transferases

artículo científico publicado en 2000

Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency

artículo científico publicado en 2015

Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

artículo científico publicado en 2017

Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).

artículo científico publicado en 2007

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate

artículo científico publicado en 2009

Federated repositories of X-ray diffraction images

artículo científico publicado en 2008

Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1

artículo científico publicado en 2011

From glutathione transferase to pore in a CLIC.

artículo científico publicado en 2002

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

artículo científico publicado en 2013

Functional analysis of the evolutionarily conserved proline 53 residue in Proteus mirabilis glutathione transferase B1-1.

artículo científico publicado en 1999

GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme

artículo científico publicado en 2002

GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase

artículo científico publicado en 2001

Glutamic acid-65 is an essential residue for catalysis in Proteus mirabilis glutathione S-transferase B1-1.

artículo científico publicado en 2002

Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme.

artículo científico publicado en 2016

Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme

artículo científico publicado en 2003

Homology model for the human GSTT2 Theta class glutathione transferase

artículo científico publicado en 1997

Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

artículo científico publicado en 2006

Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases

artículo científico publicado en 2000

Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases.

artículo científico publicado en 2000

Identification and Characterization of a Misfolded Monomeric Serpin Formed at Physiological Temperature ⬇️

artículo científico publicado el 17 de septiembre de 2010

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

artículo científico publicado en 2008

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

artículo científico publicado en 2011

Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming ToxinClostridium perfringensPerfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy†

artículo científico publicado en 1998

Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens

artículo científico publicado en 2002

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

artículo científico publicado en 2008

Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

artículo científico publicado en 2009

Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP.

artículo científico publicado en 2007

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

artículo científico publicado en 2018

Insights into autoregulation from the crystal structure of twitchin kinase

scientific article published in Nature

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

artículo científico publicado en 2005

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin

artículo científico publicado en 2005

Insights into the structural basis for zinc inhibition of the glycine receptor

artículo científico publicado en 2003

Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel

artículo científico publicado en 2012

Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site

artículo científico publicado en 2004

Iron- and manganese-containing superoxide dismutases can be distinguished by analysis of their primary structures

article

Kinetic properties of missense mutations in patients with glutathione synthetase deficiency

artículo científico publicado en 2000

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis.

artículo científico publicado en 2018

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

artículo científico publicado en 2020

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

artículo científico publicado en 2013

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9

artículo científico publicado en 2011

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

artículo científico publicado en 2014

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

artículo científico publicado en 2015

Membrane insertion of the pore-forming domain of colicin A. A spectroscopic study

artículo científico publicado en 1991

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

artículo científico publicado en 2005

Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34

scientific article published on 08 May 2013

Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies

artículo científico publicado en 2015

Molecular basis of cytokine receptor activation

artículo científico publicado en 2010

Molecular basis of glutathione synthetase deficiency and a rare gene permutation event

artículo científico publicado en 1999

Molecular determinants of common gating of a ClC chloride channel

artículo científico publicado en 2013

Molecular determinants of ginkgolide binding in the glycine receptor pore

artículo científico publicado en 2006

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

artículo científico publicado en 2006

Molecular evolution of glutathione S-transferases in the genus Drosophila.

artículo científico publicado en 2007

Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins

artículo científico publicado en 2012

Monoubiquitination by the human Fanconi Anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

artículo científico publicado en 2020

More than one way to make a hole

artículo científico publicado en 1997

Movement of a Loop in Domain 3 of Aerolysin Is Required for Channel Formation†

artículo científico publicado en 1998

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme

artículo científico publicado en 1997

Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus

artículo científico publicado en 2005

Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.

artículo científico publicado en 2003

Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo

artículo científico publicado en 2005

Oncogenic protein interfaces: small molecules, big challenges.

artículo científico publicado en 2014

Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase

artículo científico publicado en 2004

PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: in vitro bioactivity, stability and in vivo pharmacokinetics

artículo científico publicado en 2012

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

artículo científico publicado en 2013

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

artículo científico publicado en 2010

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

artículo científico publicado en 2015

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

artículo científico publicado en 2013

Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation

scientific journal article

Pore-forming protein toxins: from structure to function

artículo científico publicado en 2005

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

artículo científico publicado en 2014

Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.

artículo científico publicado en 1998

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

artículo científico publicado en 2020

Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid

artículo científico publicado en 2011

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

artículo científico publicado en 2008

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

artículo científico publicado en 2017

Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1.

artículo científico publicado en 2002

Protein crystallography in Australia.

artículo científico publicado en 1995

Protein structure and computational drug discovery

scientific article published on 20 September 2018

Protein structure from x-ray diffraction

artículo científico publicado en 2003

Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases

artículo científico publicado en 1999

Protonation of histidine-132 promotes oligomerization of the channel-forming toxin aerolysin.

artículo científico publicado en 1995

Purification, crystallisation and preliminary X-ray diffraction characterisation of methanol dehydrogenase from Methylosinus trichosporium OB3b.

artículo científico publicado en 1987

Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.

artículo científico publicado en 2008

Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.

artículo científico publicado en 2011

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins

artículo científico publicado en 2017

Rational design of an organometallic glutathione transferase inhibitor

artículo científico publicado en 2009

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations

scientific article published on 12 November 2018

Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.

artículo científico publicado en 2010

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

artículo científico publicado en 2011

Repurposing of drugs as STAT3 inhibitors for cancer therapy

scientific article published on 08 November 2019

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth

artículo científico publicado en 2019

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

artículo científico publicado en 2021

Role of the β Common (βc) Family of Cytokines in Health and Disease

artículo científico publicado en 2017

Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae

article

Shifting Substrate Specificity of Human Glutathione Transferase (from Class Pi to Class Alpha) by a Single Point Mutation

artículo científico publicado en 1998

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

artículo científico publicado en 2002

Signalling by the βc family of cytokines

artículo científico

Site-directed mutagenesis of theProteus mirabilisglutathione transferase B1-1 G-site

scientific article published on 01 February 1998

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

artículo científico publicado en 2019

Small molecule proprotein convertase inhibitors for inhibition of embryo implantation

artículo científico publicado en 2013

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

article

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

article

Solution Structure of Glutathione Bound to Human Glutathione Transferase P1-1: Comparison of NMR Measurements with the Crystal Structure†

scientific article published on 01 March 1998

Structural Basis for Antibody Discrimination between Two Hormones That Recognize the Parathyroid Hormone Receptor

artículo científico publicado en 2009

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

artículo científico publicado en 2016

Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target

artículo científico publicado en 2016

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

artículo científico publicado en 2018

Structural approaches to probing metal interaction with proteins

artículo científico

Structural basis for glycogen recognition by AMP-activated protein kinase

artículo científico publicado en 2005

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

artículo científico publicado en 2016

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay

artículo científico publicado en 2003

Structural identity between the iron- and manganese-containing superoxide dismutases

artículo científico publicado en 1987

Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration

artículo científico publicado en 2013

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

artículo científico publicado en 2007

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen

artículo científico publicado en 2008

Structure and function of glutathione S-transferases.

artículo científico publicado en 1994

Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution

artículo científico publicado en 2007

Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states

artículo científico publicado en 1994

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

artículo científico publicado en 2003

Structure of the Janus protein human CLIC2

artículo científico publicado en 2007

Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity

artículo científico publicado en 2012

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

artículo científico publicado en 2014

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins

artículo científico publicado en 2007

Structures of thermolabile mutants of human glutathione transferase P1-1

artículo científico publicado en 2000

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

artículo científico publicado en 2011

Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering.

artículo científico publicado en 1999

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

artículo científico publicado en 2018

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

artículo científico publicado en 2010

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

artículo científico publicado en 2014

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

artículo científico publicado en 2012

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription.

artículo científico publicado en 2013

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment.

artículo científico publicado en 2017

Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies.

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The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements

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The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.

artículo científico publicado en 2016

The GM-CSF receptor family: mechanism of activation and implications for disease

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The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

artículo científico publicado en 2012

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

artículo científico publicado en 1999

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

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The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants

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The extended catalysis of glutathione transferase

scientific article published on 14 December 2010

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease

scientific article published on 09 November 2018

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes

artículo científico publicado en 1997

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

artículo científico publicado en 2009

The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin

artículo científico publicado en 2004

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force

artículo científico publicado en 2013

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

artículo científico publicado en 1999

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

artículo científico publicado en 2018

The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.

artículo científico publicado en 1998

The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum

artículo científico publicado en 2008

The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.

artículo científico publicado en 2014

The role of electrostatic charge in the membrane insertion of colicin A. Calculation and mutation.

artículo científico publicado en 1994

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

artículo científico publicado en 2008

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

artículo científico publicado en 2019

The βc receptor family - Structural insights and their functional implications

artículo científico

Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione

artículo científico publicado en 2003

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2

artículo científico publicado en 2011

Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

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Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

artículo científico publicado en 2017

Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition

artículo científico publicado en 2006

Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae.

artículo científico publicado en 1999

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.

artículo científico publicado en 2015

Valine 10 May Act as a Driver for Product Release from the Active Site of Human Glutathione Transferase P1-1

artículo científico publicado en 2000

Vibrio spp. secrete proaerolysin as a folded dimer without the need for disulphide bond formation.

artículo científico publicado en 1995

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