Filtros de búsqueda

Lista de obras de Matthew A Perugini

A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway

artículo científico publicado en 2004

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

artículo científico publicado en 2011

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

artículo científico publicado en 2012

A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.

artículo científico publicado en 2006

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

artículo científico publicado en 2015

A new robust kinetic assay for DAP epimerase activity

artículo científico publicado en 2013

A partially structured region of a largely unstructured protein, Plasmodium falciparum merozoite surface protein 2 (MSP2), forms amyloid-like fibrils

artículo científico publicado en 2007

A synthetic peptide that inhibits lipoprotein(a) assembly.

artículo científico publicado en 2003

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.

artículo científico publicado en 2011

Age-related differences in plasma proteins: how plasma proteins change from neonates to adults

artículo científico publicado en 2011

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

artículo científico publicado en 2016

An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization

artículo científico publicado en 2020

An optimized coupled assay for quantifying diaminopimelate decarboxylase activity

artículo científico publicado en 2015

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

artículo científico publicado en 2009

Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology.

artículo científico publicado en 2008

Bicarbonate-mediated stimulation of RegA, the global virulence regulator from Citrobacter rodentium

artículo científico publicado en 2009

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13

artículo científico publicado en 2006

Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria

artículo científico publicado en 2012

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

artículo científico publicado en 2011

Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.

artículo científico publicado en 2009

Characterisation of the First Enzymes Committed to Lysine Biosynthesis in Arabidopsis thaliana

artículo científico publicado en 2012

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

artículo científico publicado en 2011

Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization

artículo científico publicado en 2011

Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum

artículo científico publicado en 2018

Cloning to crystallization of dihydrodipicolinate synthase from the intracellular pathogen Legionella pneumophila

artículo científico publicado en 2013

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

artículo científico publicado en 2009

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens

artículo científico publicado en 2012

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera

artículo científico publicado en 2011

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica

artículo científico publicado en 2010

Comparative structure and function analyses of native and his-tagged forms of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

artículo científico publicado en 2012

Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae

artículo científico publicado en 2018

Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase

artículo científico publicado en 2008

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

artículo científico publicado en 2001

Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis

artículo científico publicado en 2008

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

artículo científico publicado en 2011

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins.

artículo científico publicado en 2018

Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species

artículo científico publicado en 2008

Crystal structure of theLeishmania majorMIX protein: A scaffold protein that mediates protein-protein interactions

artículo científico publicado en 2011

Crystal, Solution and In silico Structural Studies of Dihydrodipicolinate Synthase from the Common Grapevine

artículo científico publicado en 2012

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate

artículo científico publicado en 2009

Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli

artículo científico publicado en 2009

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae

artículo científico publicado en 2009

Defining the interaction of perforin with calcium and the phospholipid membrane

artículo científico publicado en 2013

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.

artículo científico publicado en 2010

Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions

artículo científico publicado en 2002

Dihydrodipicolinate synthase from Thermotoga maritima.

artículo científico publicado en 2006

Dihydrodipicolinate synthase is absent in fungi

artículo científico publicado en 2018

Dimerization of Bacterial Diaminopimelate Decarboxylase Is Essential for Catalysis

artículo científico publicado en 2016

Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis

artículo científico publicado en 2013

Dimerization of Plant Defensin NaD1 Enhances Its Antifungal Activity

artículo científico publicado en 2012

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

artículo científico publicado en 2013

Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.

artículo científico publicado en 2010

Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus

artículo científico publicado en 2013

Dynamic Modelling Reveals 'Hotspots' on the Pathway to Enzyme-Substrate Complex Formation

artículo científico publicado en 2016

Electron capture dissociation of complexes of diacylglycerophosphocholine and divalent metal ions: competition between charge reduction and radical induced phospholipid fragmentation.

artículo científico publicado en 2008

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

artículo científico publicado en 2016

Evolution of quaternary structure in a homotetrameric enzyme

artículo científico publicado en 2008

Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?

artículo científico publicado en 2009

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate

artículo científico publicado en 2009

Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin

artículo científico publicado en 2005

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

artículo científico publicado en 2013

High density lipoproteins bind Aβ and apolipoprotein C-II amyloid fibrils

article

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

artículo científico publicado en 2017

Identification of a dimeric KDG aldolase from Agrobacterium tumefaciens

artículo científico publicado en 2017

Identification of the bona fide DHDPS from a common plant pathogen

scientific journal article

Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation

scientific article published on 05 August 2019

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

scientific journal article

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

artículo científico publicado en 2007

Inhibition of lysine biosynthesis: an evolving antibiotic strategy

artículo científico publicado en 2007

Insight into the self-association of key enzymes from pathogenic species.

artículo científico publicado en 2005

Integrated activities of two alternative sigma factors coordinate iron acquisition and uptake by Pseudomonas aeruginosa

artículo científico publicado en 2017

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues

artículo científico publicado en 2008

Letter: collision-induced dissociation of [metal(L)(2)](2+) complexes (metal = Cu, Ca and Mg) of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine allows distinction of the acyl groups at the sn1 and sn2 positions

artículo científico publicado en 2007

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.

artículo científico publicado en 2016

Methods for sample labeling and meniscus determination in the fluorescence-detected analytical ultracentrifuge

artículo científico publicado en 2009

Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1

artículo científico publicado en 2011

Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens

artículo científico publicado en 2020

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

scientific article published on 17 January 2020

Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis

artículo científico publicado en 2017

Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme

artículo científico publicado en 2008

New method for purifying histidine-rich glycoprotein from human plasma redefines its functional properties

artículo científico publicado en 2013

Non-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils

artículo científico publicado en 2004

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

artículo científico publicado en 2009

Phospholipid interaction induces molecular-level polymorphism in apolipoprotein C-II amyloid fibrils via alternative assembly pathways.

artículo científico publicado en 2007

Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP

artículo científico publicado en 2020

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

artículo científico publicado en 2004

Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.

artículo científico publicado en 2008

Quaternary Structure Analyses of an Essential Oligomeric Enzyme

artículo científico

Review: Amino Acid Biosynthesis as a Target for Herbicide Development

artículo científico publicado en 2020

Ribosome-inactivating proteins: current status and biomedical applications

artículo científico

Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity

artículo científico publicado en 2017

Self-assembly of peptides into spherical nanoparticles for delivery of hydrophilic moieties to the cytosol

artículo científico publicado en 2010

Self-association of Human Apolipoprotein E3 and E4 in the Presence and Absence of Phospholipid

artículo científico publicado en 2000

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications

Size matters! Fragmentation chemistry of [Cu(L)n]2+ complexes of diacylglycerophosphocholines as a function of coordination number (n = 2-7).

artículo científico publicado en 2007

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

artículo científico publicado en 2002

Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2.

artículo científico publicado en 2008

Sources of artefacts in the electrospray ionization mass spectra of saturated diacylglycerophosphocholines: from condensed phase hydrolysis reactions through to gas phase intercluster reactions

artículo científico publicado en 2006

Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis

artículo científico publicado en 2009

Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target

artículo científico publicado en 2016

Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase

artículo científico publicado el 7 de junio de 2012

Structural and functional characterization of TesB from Yersinia pestis reveals a unique octameric arrangement of hotdog domains

artículo científico publicado en 2015

Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E

artículo científico publicado en 2007

Structural features of apolipoprotein B synthetic peptides that inhibit lipoprotein(a) assembly

artículo científico publicado en 2004

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

artículo científico publicado en 2019

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition

artículo científico publicado en 2013

Structure and Function of Cyanobacterial DHDPS and DHDPR

artículo científico publicado en 2016

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen

artículo científico publicado en 2008

Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms

artículo científico publicado en 2006

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

artículo científico publicado en 2018

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

artículo científico publicado en 2010

Targeting of a natural killer cell receptor family by a viral immunoevasin

artículo científico publicado en 2013

The 2.1A crystal structure of the far-red fluorescent protein HcRed: inherent conformational flexibility of the chromophore

artículo científico publicado en 2005

The BECN1 N-terminal domain is intrinsically disordered

artículo científico publicado en 2016

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity.

artículo científico publicado en 2018

The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping

artículo científico publicado en 2014

The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis

artículo científico publicado en 2003

The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum

artículo científico publicado en 2014

The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)

scientific article published on 21 August 2020

The purification of the σFpvI/FpvR20 and σPvdS/FpvR20 protein complexes is facilitated at room temperature

artículo científico publicado en 2019

The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum

artículo científico publicado en 2008

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

artículo científico publicado en 2010

The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4.

artículo científico publicado en 2015

The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers

artículo científico publicado en 2005

Trifluoroethanol induces the self-association of specific amphipathic peptides

article

Ultramarine, a chromoprotein acceptor for Förster resonance energy transfer

artículo científico publicado en 2012

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

artículo científico publicado en 2008

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP

artículo científico publicado en 2012

i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.

artículo científico publicado en 2016