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Lista de obras de Ursula Klingmüller

A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes

artículo científico publicado en 2012

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.

artículo científico publicado en 2016

A functional green fluorescent protein-erythropoietin receptor despite physical separation of JAK2 binding site and tyrosine residues

artículo científico publicado en 2002

A mouse model for visualization and conditional mutations in the erythroid lineage

artículo científico publicado en 2004

A rapidly reversible chemical dimerizer system to study lipid signaling in living cells.

artículo científico publicado en 2014

A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway

artículo científico publicado en 2008

A systems biology approach to unravel the drug-TNFα signaling synergy in idiosyncratic DILI

scholarly article by Bob van de Water et al published September 2014 in Toxicology Letters

Addressing parameter identifiability by model-based experimentation

artículo científico publicado en 2011

An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors

artículo científico publicado en 2017

An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes

artículo científico publicado en 2012

Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue

artículo científico publicado en 2022

BMP-9 interferes with liver regeneration and promotes liver fibrosis.

artículo científico publicado en 2017

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification.

artículo científico publicado en 2018

Cellular ERK phospho-form profiles with conserved preference for a switch-like pattern.

artículo científico publicado en 2012

Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders

artículo científico publicado en 2011

Characterisation of cell-type-specific responses in the liver towards IL-1β by a mathematical model for the p38MAPK/MK2 pathway

article

Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling

artículo científico publicado en 2010

Comprehensive serial biobanking in advanced NSCLC: feasibility, challenges and perspectives

scientific article published on 01 August 2020

Computational processing and error reduction strategies for standardized quantitative data in biological networks

artículo científico publicado en 2005

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice

artículo científico publicado en 2020

Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation

artículo científico publicado en 2016

Correction: Lessons Learned from Quantitative Dynamical Modeling in Systems Biology.

artículo científico publicado en 2013

Correlated receptor transport processes buffer single-cell heterogeneity

artículo científico publicado en 2017

Covering a broad dynamic range: information processing at the erythropoietin receptor

artículo científico publicado en 2010

Cytokine receptor signal transduction and the control of hematopoietic cell development

artículo científico publicado en 1996

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation

artículo científico publicado en 2015

Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems

artículo científico publicado en 2015

Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction

artículo científico publicado en 2020

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling

artículo científico publicado en 2015

Distinct roles of Mdm2 and Mdm4 in red cell production

artículo científico publicado en 2006

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.

artículo científico publicado en 2011

Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

artículo científico publicado en 2016

Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets

artículo científico publicado en 2010

Dynamic pathway modeling: feasibility analysis and optimal experimental design

artículo científico publicado en 2007

Dynamics and feedback loops in the transforming growth factor β signaling pathway

artículo científico publicado en 2012

Dynamics of receptor and protein transducer homodimerisation

artículo científico publicado en 2008

Effects of telomerase modulation in human hematopoietic progenitor cells

artículo científico publicado en 2004

Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors.

artículo científico publicado en 2002

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice

artículo científico publicado en 2013

Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion

artículo científico publicado en 2015

Excemplify: A Flexible Template Based Solution, Parsing and Managing Data in Spreadsheets for Experimentalists

artículo científico publicado en 2013

Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists.

artículo científico publicado en 2013

Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.

artículo científico publicado en 2018

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells

artículo científico publicado en 2006

Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor.

artículo científico publicado en 1993

Hepatocellular carcinoma: a systems biology perspective

artículo científico publicado en 2013

Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment

artículo científico publicado en 2012

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

artículo científico publicado en 2012

High-Content Imaging Platform for Profiling Intracellular Signaling Network Activity in Living Cells.

artículo científico publicado en 2016

High-dimensional Bayesian parameter estimation: case study for a model of JAK2/STAT5 signaling

artículo científico publicado en 2013

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

artículo científico publicado en 2021

IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification

artículo científico publicado en 2017

Identifiability and observability analysis for experimental design in nonlinear dynamical models

artículo científico publicado en 2010

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells

artículo científico publicado en 2016

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

artículo científico publicado en 2020

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

artículo científico publicado en 1997

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling

artículo científico publicado en 2014

Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling

artículo científico publicado en 2003

In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.

artículo científico publicado en 2012

Interaction of the erythropoietin and stem-cell-factor receptors

artículo científico publicado en 1995

Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1

scientific article published on 01 June 1999

Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains

artículo científico publicado en 1994

Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation

artículo científico publicado en 2010

Lessons learned from quantitative dynamical modeling in systems biology

artículo científico publicado en 2013

Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice

artículo científico publicado en 2014

MSPypeline: a python package for streamlined data analysis of mass spectrometry-based proteomics

artículo científico publicado en 2022

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

artículo científico publicado en 2019

Mathematical modeling of hematological malignancies

artículo científico publicado en 2012

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

artículo científico publicado en 2017

Model-based extension of high-throughput to high-content data

artículo científico publicado en 2010

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.

artículo científico publicado en 2018

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

artículo científico publicado en 1996

One-source peptide/phosphopeptide standards for accurate phosphorylation degree determination

artículo científico publicado en 2011

Packing density of the erythropoietin receptor transmembrane domain correlates with amplification of biological responses

artículo científico publicado en 2008

Predictive mathematical models of cancer signalling pathways

artículo científico

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

artículo científico publicado en 2006

Prognostic significance of erythropoietin in pancreatic adenocarcinoma

artículo científico publicado en 2011

Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation

scientific article published on 24 January 2017

Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling

artículo científico publicado en 2004

Quantification of frap experiments in live cell image sequences by combining segmentation and registration

scholarly article published March 2011

Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis

scientific article published on 27 April 2020

Quantitative data generation for systems biology: the impact of randomisation, calibrators and normalisers.

artículo científico publicado en 2005

Quantitative protein microarrays for time-resolved measurements of protein phosphorylation

artículo científico publicado en 2008

Quenched substrates for live-cell labeling of SNAP-tagged fusion proteins with improved fluorescent background

artículo científico publicado en 2010

Receptor dynamics in signaling

artículo científico

Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008)

artículo científico publicado en 2008

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression

artículo científico publicado en 2017

Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

artículo científico publicado en 2001

Short-term information processing, long-term responses: Insights by mathematical modeling of signal transduction. Early activation dynamics of key signaling mediators can be predictive for cell fate decisions

artículo científico publicado en 2012

Simulation Methods for Optimal Experimental Design in Systems Biology

article by D. Faller et al published December 2003 in Simulation

Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development

artículo científico publicado en 2006

Spatial aspects in the SMAD signaling pathway.

artículo científico publicado en 2012

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

artículo científico publicado en 1995

Standardizing experimental protocols

artículo científico publicado en 2008

Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.

artículo científico publicado en 2008

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

artículo científico publicado en 2009

Systems biology of JAK/STAT signalling

artículo científico publicado en 2008

Systems biology of mammalian cells: A report from the Freiburg conference ⬇️

artículo científico publicado el 1 de diciembre de 2010

T160‐phosphorylated CDK2 defines threshold for HGF dependent proliferation in primary hepatocytes

artículo científico publicado en 2015

TTCA: an R package for the identification of differentially expressed genes in time course microarray data

artículo científico publicado en 2017

Targeted near-infrared imaging of the erythropoietin receptor in human lung cancer xenografts

artículo científico publicado en 2012

The ParaHox gene Cdx4 induces acute erythroid leukemia in mice

artículo científico publicado en 2019

The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells

artículo científico publicado en 2002

The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction

artículo científico publicado en 1995

The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.

artículo científico publicado en 2008

The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro

artículo científico publicado en 2020

The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper

artículo científico publicado en 2003

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

artículo científico publicado en 2011

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

artículo científico publicado en 2013

The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells--signals emanating from the erythropoietin receptor

artículo científico publicado en 1997

The virtual liver: state of the art and future perspectives

artículo científico publicado en 2014

Theoretical analysis of time-to-peak responses in biological reaction networks

artículo científico publicado en 2010

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions

artículo científico publicado en 2009

Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding

artículo científico publicado en 2011

Tyrosine Residues within the Intracellular Domain of the Erythropoietin Receptor Mediate Activation of AP-1 Transcription Factors

artículo científico publicado en 1998

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

artículo científico publicado en 2014

Unraveling liver complexity from molecular to organ level: challenges and perspectives

artículo científico publicado en 2014

Vegf regulates embryonic erythroid development through Gata1 modulation

artículo científico publicado en 2010

Whither systems medicine?

artículo científico publicado en 2018

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

scientific article published on 17 September 2020

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