Lista de obras - Joseph A. Marsh - Dominio Público Uruguay

A Graph-Based Approach for Detecting Sequence Homology in Highly Diverged Repeat Protein Families

artículo científico publicado en 2019

A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect

artículo científico publicado en 2016

Alpha Helices Are More Robust to Mutations than Beta Strands

artículo científico publicado en 2016

Biallelic variants in DNA2 cause microcephalic primordial dwarfism

artículo científico publicado en 2019

Buried and accessible surface area control intrinsic protein flexibility

artículo científico publicado en 2013

Calculation of residual dipolar couplings from disordered state ensembles using local alignment

artículo científico publicado en 2008

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodeling

artículo científico publicado en 2018

Characterization of disordered proteins with ENSEMBLE.

artículo científico publicado en 2012

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

artículo científico publicado en 2024

Co-translational assembly of protein complexes

artículo científico publicado en 2015

Computational Modelling of Protein Complex Structure and Assembly

artículo científico publicado en 2018

Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

artículo científico publicado en 2018

ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity

artículo científico publicado en 2017

Editorial overview: Sequences and topology: Dynamic sequences and topologies of proteins

artículo científico publicado en 2018

Ensemble modeling of protein disordered states: Experimental restraint contributions and validation ⬇️

artículo científico publicado el 17 de noviembre de 2011

Evolution of condensin and cohesin complexes driven by replacement of Kite by Hawk proteins

artículo científico publicado en 2017

Evolution of protein interfaces in multimers and fibrils.

artículo científico publicado en 2019

Experimental Characterization of Protein Complex Structure, Dynamics, and Assembly

artículo científico publicado en 2018

Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

artículo científico publicado en 2015

Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data

artículo científico publicado en 2019

Functional determinants of protein assembly into homomeric complexes

artículo científico publicado en 2017

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

artículo científico publicado en 2018

How do proteins gain new domains?

artículo científico publicado en 2010

Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

artículo científico publicado en 2007

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

article published in 2018

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

artículo científico publicado en 2019

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

artículo científico publicado en 2016

Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology

artículo científico publicado en 2018

Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes

artículo científico publicado en 2019

Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes

artículo científico publicado en 2019

Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective

artículo científico publicado en 2019

Mouse mutations cause retinal degeneration and reduced mitochondrial function

artículo científico publicado en 2018

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

artículo científico publicado en 2020

Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration

artículo científico publicado en 2017

Operon Gene Order Is Optimized for Ordered Protein Complex Assembly

artículo científico publicado en 2016

Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain

artículo científico publicado en 2007

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.

artículo científico publicado en 2013

Principles of assembly reveal a periodic table of protein complexes

artículo científico publicado en 2015

Probing the diverse landscape of protein flexibility and binding

artículo científico publicado en 2012

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

artículo científico publicado en 2019

Protein complexes are under evolutionary selection to assemble via ordered pathways

artículo científico publicado en 2013

Protein flexibility facilitates quaternary structure assembly and evolution

artículo científico publicado en 2014

Proteome-scale prediction of molecular mechanisms underlying dominant genetic diseases

artículo científico publicado en 2024

Recurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA-protein interaction

artículo científico publicado en 2019

Regulation, evolution and consequences of cotranslational protein complex assembly

artículo científico publicado en 2016

Relative solvent accessible surface area predicts protein conformational changes upon binding

artículo científico publicado en 2011

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

artículo científico publicado en 2017

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

artículo científico publicado en 2006

Signalling assemblies: the odds of symmetry

artículo científico publicado en 2017

Structural Determinants of Sleeping Beauty Transposase Activity

artículo científico publicado en 2016

Structural and evolutionary versatility in protein complexes with uneven stoichiometry

artículo científico publicado en 2015

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

artículo científico publicado en 2010

Structural signature of the MYPT1-PP1 interaction.

artículo científico publicado en 2010

Structure and disorder in an unfolded state under nondenaturing conditions from ensemble models consistent with a large number of experimental restraints

artículo científico publicado en 2009

Structure, dynamics, assembly, and evolution of protein complexes

artículo científico publicado en 2014

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

artículo científico publicado en 2010

Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs

artículo científico publicado en 2007

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture

artículo científico publicado en 2012

The genetic basis and evolution of red blood cell sickling in deer.

artículo científico publicado en 2017

The properties of human disease mutations at protein interfaces

artículo científico publicado en 2022

The role of protein complexes in human genetic disease

scientific article published on 01 July 2019

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.

artículo científico publicado en 2013

Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR.

artículo científico publicado en 2006

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

artículo científico publicado en 2022

Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations

artículo científico publicado en 2020

Whole genome sequencing reveals novel mutations causing autosomal dominant inherited macular degeneration

scientific article published on 19 November 2018

Lista de obras de Joseph A. Marsh

A Graph-Based Approach for Detecting Sequence Homology in Highly Diverged Repeat Protein Families

A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect

Alpha Helices Are More Robust to Mutations than Beta Strands

Biallelic variants in DNA2 cause microcephalic primordial dwarfism

Buried and accessible surface area control intrinsic protein flexibility

Calculation of residual dipolar couplings from disordered state ensembles using local alignment

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodeling

Characterization of disordered proteins with ENSEMBLE.

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

Co-translational assembly of protein complexes

Computational Modelling of Protein Complex Structure and Assembly

Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity

Editorial overview: Sequences and topology: Dynamic sequences and topologies of proteins

Ensemble modeling of protein disordered states: Experimental restraint contributions and validation ⬇️

Evolution of condensin and cohesin complexes driven by replacement of Kite by Hawk proteins

Evolution of protein interfaces in multimers and fibrils.

Experimental Characterization of Protein Complex Structure, Dynamics, and Assembly

Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data

Functional determinants of protein assembly into homomeric complexes

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

How do proteins gain new domains?

Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology

Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes

Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes

Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective

Mouse mutations cause retinal degeneration and reduced mitochondrial function

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration

Operon Gene Order Is Optimized for Ordered Protein Complex Assembly

Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.

Principles of assembly reveal a periodic table of protein complexes

Probing the diverse landscape of protein flexibility and binding

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

Protein complexes are under evolutionary selection to assemble via ordered pathways

Protein flexibility facilitates quaternary structure assembly and evolution

Proteome-scale prediction of molecular mechanisms underlying dominant genetic diseases

Recurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA-protein interaction

Regulation, evolution and consequences of cotranslational protein complex assembly

Relative solvent accessible surface area predicts protein conformational changes upon binding

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

Signalling assemblies: the odds of symmetry

Structural Determinants of Sleeping Beauty Transposase Activity

Structural and evolutionary versatility in protein complexes with uneven stoichiometry

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

Structural signature of the MYPT1-PP1 interaction.

Structure and disorder in an unfolded state under nondenaturing conditions from ensemble models consistent with a large number of experimental restraints

Structure, dynamics, assembly, and evolution of protein complexes

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture

The genetic basis and evolution of red blood cell sickling in deer.

The properties of human disease mutations at protein interfaces

The role of protein complexes in human genetic disease

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.

Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR.

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations

Whole genome sequencing reveals novel mutations causing autosomal dominant inherited macular degeneration