Lista de obras - Melanie Boerries - Dominio Público Uruguay

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

artículo científico publicado en 2018

A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS

artículo científico publicado en 2021

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes

artículo científico publicado en 2016

Absence of the Integrin α3 Subunit Induces an Activated Phenotype in Human Keratinocytes

artículo científico publicado en 2017

Alteration of Proteotranscriptomic Landscape Reveals the Transcriptional Regulatory Circuits Controlling Key-Signaling Pathways and Metabolic Reprogramming During Tumor Evolution

artículo científico publicado en 2020

Annotation of Human Exome Gene Variants with Consensus Pathogenicity

scientific article published on 14 September 2020

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells

artículo científico publicado en 2014

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

artículo científico publicado en 2018

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

artículo científico publicado en 2020

Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development.

artículo científico publicado en 2018

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

artículo científico publicado en 2017

Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect

scientific article published on 16 July 2020

Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

artículo científico publicado en 2016

Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration

artículo científico publicado en 2012

CCL5 mediates target-kinase independent resistance to FLT3 inhibitors in FLT3-ITD-positive AML

scientific article published on 13 February 2020

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

artículo científico publicado en 2016

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury

artículo científico publicado en 2018

Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes

artículo científico publicado en 2007

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1

scientific article published on 21 April 2020

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT

artículo científico publicado en 2022

Cardiac Regeneration and Tumor Growth-What Do They Have in Common?

artículo científico publicado en 2020

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium

artículo científico publicado en 2004

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

scientific article published on 12 October 2020

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

artículo científico publicado en 2018

Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications

artículo científico publicado en 2010

Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization

artículo científico publicado en 2013

Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7.

artículo científico publicado en 2017

Constitutional absence of epithelial integrin α3 impacts the composition of the cellular microenvironment of ILNEB keratinocytes

article

Copper-induced cell death and the protective role of glutathione: the implication of impaired protein folding rather than oxidative stress

scientific article published on 01 December 2018

Cover Image, Volume 9, Issue 4

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

scientific article published on 05 December 2018

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

artículo científico publicado en 2012

Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration

scientific article published on 28 December 2018

Development and clinical validation of discriminatory multi-target digital droplet PCR assays for the detection of hot spot KRAS and NRAS mutations in cell-free DNA

scientific article published on 03 May 2020

Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals

artículo científico publicado en 2018

Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes

artículo científico publicado en 2005

Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts

artículo científico publicado en 2021

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer

artículo científico publicado en 2016

Epithelioid hemangioendotheliomas of the liver and lung in children and adolescents.

artículo científico publicado en 2017

Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

artículo científico publicado en 2020

Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)

artículo científico publicado en 2003

From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

artículo científico publicado en 2014

Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cells

scientific article published on 07 August 2019

Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines

artículo científico publicado en 2015

Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans

artículo científico publicado en 2020

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

scientific article published on 01 March 2020

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

artículo científico publicado en 2020

HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration

artículo científico publicado en 2016

Harnessing the tissue and plasma lncRNA-peptidome to discover peptide-based cancer biomarkers

scientific article published on 23 August 2019

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

article

Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma.

artículo científico publicado en 2018

Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

artículo científico publicado en 2020

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

artículo científico publicado en 2018

Image-derived models of cell organization changes during differentiation and drug treatments

artículo científico publicado en 2019

Implementing Pharmacogenomic Clinical Decision Support into German Hospitals

In silico approaches and the role of ontologies in aging research

artículo científico publicado en 2013

Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

artículo científico publicado en 2014

Induction of phenotype modifying cytokines by FERMT1 mutations.

artículo científico publicado en 2011

Information Theoretic Concepts to Unravel Cell–Cell Communication

KDM4 inhibition targets breast cancer stem-like cells

artículo científico publicado en 2017

Label-free detection of neuronal differentiation in cell populations using high-throughput live-cell imaging of PC12 cells

artículo científico publicado en 2013

Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure

artículo científico publicado en 2020

Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells

artículo científico publicado en 2020

MIRACUM: Medical Informatics in Research and Care in University Medicine

artículo científico publicado en 2018

MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions

artículo científico publicado en 2018

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

artículo científico publicado en 2020

MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors

artículo científico publicado en 2020

Molecular characterization and natural history of linear porokeratosis: a case series

artículo científico publicado en 2020

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks

article

Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility

scientific journal article

Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development

artículo científico publicado en 2013

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

scientific article published on 12 December 2019

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

artículo científico publicado en 2018

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

scientific article published on 03 April 2020

Personalized Clinical Decision Making Through Implementation of a Molecular Tumor Board: A German Single-Center Experience

scientific article published on 16 August 2018

Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation

scientific article published on 24 January 2017

Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer

scientific article published on 16 August 2016

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

artículo científico publicado en 2014

RARβ regulates neuronal cell death and differentiation in the avian ciliary ganglion

artículo científico publicado en 2015

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

artículo científico publicado en 2017

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

artículo científico publicado en 2024

Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal

scientific article published on 10 February 2020

Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles.

artículo científico publicado en 2018

S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy

artículo científico publicado en 2009

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4

artículo científico publicado en 2014

S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling

artículo científico publicado en 2016

SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer

artículo científico publicado en 2021

SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation

artículo científico publicado en 2019

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells.

artículo científico publicado en 2017

Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine

artículo científico publicado en 2015

Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling

artículo científico publicado en 2018

Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study

artículo científico publicado en 2017

Specific role of RhoC in tumor invasion and metastasis

artículo científico publicado en 2017

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

artículo científico publicado en 2015

Supporting Molecular Tumor Boards in Molecular-Guided Decision-Making - The Current Status of Five German University Hospitals

artículo científico publicado en 2017

Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency

scientific article published on 18 June 2020

Systems Biology

TGFβ-induced cytoskeletal remodeling mediates elevation of cell stiffness and invasiveness in NSCLC

artículo científico publicado en 2019

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

artículo científico publicado en 2017

The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints

artículo científico publicado en 2013

Understanding the mTOR signaling pathway via mathematical modeling

artículo científico publicado en 2017

Variant classification in precision oncology

artículo científico publicado en 2019

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

artículo científico publicado en 2014

miR-146a Controls Immune Response in the Melanoma Microenvironment

artículo científico publicado en 2018

miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages

artículo científico publicado en 2020

miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.

artículo científico publicado en 2017

miR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion

artículo científico publicado en 2014

Lista de obras de Melanie Boerries

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes

Absence of the Integrin α3 Subunit Induces an Activated Phenotype in Human Keratinocytes

Alteration of Proteotranscriptomic Landscape Reveals the Transcriptional Regulatory Circuits Controlling Key-Signaling Pathways and Metabolic Reprogramming During Tumor Evolution

Annotation of Human Exome Gene Variants with Consensus Pathogenicity

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development.

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect

Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration

CCL5 mediates target-kinase independent resistance to FLT3 inhibitors in FLT3-ITD-positive AML

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury

Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT

Cardiac Regeneration and Tumor Growth-What Do They Have in Common?

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications

Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization

Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7.

Constitutional absence of epithelial integrin α3 impacts the composition of the cellular microenvironment of ILNEB keratinocytes

Copper-induced cell death and the protective role of glutathione: the implication of impaired protein folding rather than oxidative stress

Cover Image, Volume 9, Issue 4

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration

Development and clinical validation of discriminatory multi-target digital droplet PCR assays for the detection of hot spot KRAS and NRAS mutations in cell-free DNA

Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals

Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes

Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer

Epithelioid hemangioendotheliomas of the liver and lung in children and adolescents.

Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)

From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cells

Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines

Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration

Harnessing the tissue and plasma lncRNA-peptidome to discover peptide-based cancer biomarkers

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma.

Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

Image-derived models of cell organization changes during differentiation and drug treatments

Implementing Pharmacogenomic Clinical Decision Support into German Hospitals

In silico approaches and the role of ontologies in aging research

Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

Induction of phenotype modifying cytokines by FERMT1 mutations.

Information Theoretic Concepts to Unravel Cell–Cell Communication

KDM4 inhibition targets breast cancer stem-like cells

Label-free detection of neuronal differentiation in cell populations using high-throughput live-cell imaging of PC12 cells

Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure

Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells

MIRACUM: Medical Informatics in Research and Care in University Medicine

MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors

Molecular characterization and natural history of linear porokeratosis: a case series

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks

Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility

Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

Personalized Clinical Decision Making Through Implementation of a Molecular Tumor Board: A German Single-Center Experience

Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation

Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

RARβ regulates neuronal cell death and differentiation in the avian ciliary ganglion