Lista de obras - Bibek Gooptu - Dominio Público Uruguay

1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin

artículo científico publicado en 2011

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

artículo científico publicado en 2010

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

artículo científico publicado en 2015

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

artículo científico publicado en 2015

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

artículo científico publicado en 2014

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Conformational changes and disease--serpins, prions and Alzheimer's.

artículo científico publicado en 1998

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

artículo científico publicado en 2009

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

artículo científico publicado en 2015

Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis

artículo científico publicado en 2024

Defining the mechanism of polymerization in the serpinopathies

artículo científico publicado en 2010

Familial dementia caused by polymerization of mutant neuroserpin

artículo científico publicado en 1999

In silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformers

artículo científico publicado en 2012

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

artículo científico publicado en 2015

Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study.

artículo científico publicado en 2016

Nucleation of alpha 1-antichymotrypsin polymerization

artículo científico publicado en 2003

Polymers and inflammation: disease mechanisms of the serpinopathies

artículo científico publicado en 2008

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

artículo científico publicado en 2013

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

artículo científico publicado en 2013

Real-world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha-1-antitrypsin deficiency

artículo científico publicado en 2018

Spontaneous pneumothorax can be associated with TGFBR2 mutation.

artículo científico publicado en 2015

Structural dynamics associated with intermediate formation in an archetypal conformational disease.

artículo científico publicado en 2012

Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders

artículo científico publicado en 2014

Targeting serpins in high-throughput and structure-based drug design

artículo científico publicado en 2011

The molecular and cellular pathology of α₁-antitrypsin deficiency.

artículo científico publicado en 2013

The serpinopathies studying serpin polymerization in vivo

artículo científico publicado en 2011

The structural basis for Z α1-antitrypsin polymerization in the liver

scientific article published on 21 October 2020

Therapeutic target-site variability in α1-antitrypsin characterized at high resolution

artículo científico publicado en 2011

Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency

artículo científico publicado en 2014

Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization.

artículo científico publicado en 2012

Update on alpha-1 antitrypsin deficiency: New therapies

artículo científico publicado en 2016

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

artículo científico publicado en 2009

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.

artículo científico publicado en 2018

Lista de obras de Bibek Gooptu

1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Conformational changes and disease--serpins, prions and Alzheimer's.

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis

Defining the mechanism of polymerization in the serpinopathies

Familial dementia caused by polymerization of mutant neuroserpin

In silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformers

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study.

Nucleation of alpha 1-antichymotrypsin polymerization

Polymers and inflammation: disease mechanisms of the serpinopathies

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Real-world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha-1-antitrypsin deficiency

Spontaneous pneumothorax can be associated with TGFBR2 mutation.

Structural dynamics associated with intermediate formation in an archetypal conformational disease.

Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders

Targeting serpins in high-throughput and structure-based drug design

The molecular and cellular pathology of α₁-antitrypsin deficiency.

The serpinopathies studying serpin polymerization in vivo

The structural basis for Z α1-antitrypsin polymerization in the liver

Therapeutic target-site variability in α1-antitrypsin characterized at high resolution

Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency

Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization.

Update on alpha-1 antitrypsin deficiency: New therapies

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.