Lista de obras - Germaine Escames - Dominio Público Uruguay

1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence

artículo científico publicado en 2012

4,5-dihydro-1H-pyrazole derivatives with inhibitory nNOS activity in rat brain: synthesis and structure-activity relationships

artículo científico publicado en 2004

A review of the melatonin functions in zebrafish physiology

artículo científico publicado en 2014

Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: Effects of melatonin treatment

scientific article published on 17 October 2006

Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans.

artículo científico publicado en 2018

Analysis of the daily changes of melatonin receptors in the rat liver

artículo científico publicado en 2012

Antioxidant defence and inflammatory response in professional road cyclists during a 4-day competition.

artículo científico publicado en 2010

Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice

artículo científico publicado en 2007

Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model

artículo científico publicado en 2011

Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum

artículo científico publicado en 2001

Cardiological aging in SAM model: effect of chronic treatment with growth hormone

scientific article published on 01 June 2010

Cell protective role of melatonin in the brain

artículo científico publicado en 1995

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

artículo científico publicado en 2007

Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures

artículo científico publicado en 2003

Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine

artículo científico publicado en 2004

Changes in the redox status and inflammatory response in handball players during one-year of competition and training

artículo científico publicado en 2013

Characterization of melatonin high-affinity binding sites in purified cell nuclei of the hamster (Mesocricetus auratus) harderian gland

artículo científico publicado en 2003

Characterization of nocturnal ultradian rhythms of melatonin in children with growth hormone-dependent and independent growth delay.

artículo científico publicado en 2001

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice.

artículo científico publicado en 2007

Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice

artículo científico publicado en 2007

Circadian rhythms of dopamine and dihydroxyphenyl acetic acid in the mouse striatum: effects of pinealectomy and of melatonin treatment

artículo científico publicado en 2002

Clinical trial to test the efficacy of melatonin in COVID-19

artículo científico publicado en 2020

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

artículo científico publicado en 2016

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

artículo científico publicado en 2017

Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice

artículo científico publicado en 2017

Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?

artículo científico publicado en 2020

Determination of Coenzyme Q10, Coenzyme Q9, and Melatonin Contents in Virgin Argan Oils: Comparison with Other Edible Vegetable Oils

scientific article published on 31 October 2011

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

artículo científico publicado en 2015

Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency

scientific journal article

Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

artículo científico publicado en 2013

Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes.

artículo científico publicado en 2017

Effect of a Combined Treatment With Growth Hormone and Melatonin in the Cardiological Aging on Male SAMP8 Mice

scientific article published on 10 June 2011

Effect of clonidine on plasma ACTH, cortisol and melatonin in children

scientific article published on 01 August 2000

Effect of propranolol plus exercise on melatonin and growth hormone levels in children with growth delay.

artículo científico publicado en 2001

Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats

artículo científico publicado en 2004

Envejecimiento del sistema circadiano

artículo científico publicado en 2011

Exercise and melatonin in humans: reciprocal benefits.

artículo científico

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

artículo científico publicado en 2011

Extrapineal melatonin: sources, regulation, and potential functions.

artículo científico

Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation

artículo científico publicado en 2009

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin.

artículo científico publicado en 2005

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.

artículo científico publicado en 2014

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

artículo científico publicado en 2016

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.

artículo científico publicado en 2008

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

artículo científico publicado en 2017

Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.

artículo científico publicado en 2002

Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

artículo científico publicado en 2006

Kynurenamines as neural nitric oxide synthase inhibitors

artículo científico publicado en 2005

Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin

scientific article published on 01 October 2019

Local application of melatonin into alveolar sockets of beagle dogs reduces tooth removal-induced oxidative stress

artículo científico publicado en 2007

Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum

artículo científico publicado en 2004

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

artículo científico publicado en 2019

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

artículo científico publicado en 2017

Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome

scientific article published on 16 September 2020

Melatonin and beta-endorphin changes in children sensitized to olive and grass pollen after treatment with specific immunotherapy

artículo científico publicado en 2001

Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.

artículo científico publicado en 2009

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

artículo científico publicado en 2014

Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.

artículo científico publicado en 2006

Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model.

artículo científico publicado en 2015

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

artículo científico publicado en 2017

Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8) ⬇️

artículo científico publicado el 9 de septiembre de 2010

Melatonin in the oral cavity: physiological and pathological implications.

artículo científico publicado en 2014

Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

artículo científico publicado en 2002

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

artículo científico publicado en 2011

Melatonin protects lung mitochondria from aging ⬇️

artículo científico publicado el 26 de mayo de 2011

Melatonin protects rats from radiotherapy-induced small intestine toxicity

artículo científico publicado en 2017

Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice.

artículo científico publicado en 2010

Melatonin reduces oxidative stress because of tooth removal

artículo científico publicado en 2007

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

artículo científico publicado en 2016

Melatonin role in the mitochondrial function.

artículo científico publicado en 2007

Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy

artículo científico publicado en 2011

Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

artículo científico publicado en 2010

Melatonin, clock genes and mitochondria in sepsis.

artículo científico

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

artículo científico publicado en 2020

Mitochondrial DNA and inflammatory diseases.

artículo científico publicado en 2011

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

artículo científico publicado en 2017

Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.

artículo científico publicado en 2010

Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients

artículo científico publicado en 2006

Participation of ACTH1–10 and ACTH4–10 on the melatonin modulation of benzodiazepine receptors in rat cerebral cortex

artículo científico publicado en 1995

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network

artículo científico publicado en 2015

Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.

artículo científico publicado en 2008

Protective Effects of Melatonin on the Skin: Future Perspectives

scientific article published on 08 October 2019

Protective actions of melatonin and growth hormone on the aged cardiovascular system.

artículo científico publicado en 2014

Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats

artículo científico publicado en 2014

Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

artículo científico publicado en 2011

Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III).

artículo científico publicado en 2008

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease

artículo científico publicado en 2019

Redox status and antioxidant response in professional cyclists during training

artículo científico publicado en 2014

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

artículo científico publicado en 2018

Relationship between salivary melatonin levels and periodontal status in diabetic patients

artículo científico publicado en 2003

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

artículo científico publicado en 2015

Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin

artículo científico publicado en 2005

Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide

artículo científico publicado en 2011

Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion

artículo científico publicado en 2003

Synthesis and biological evaluation of indazole derivatives

scientific article published on 28 January 2011

The Protective Effect of Melatonin Against Age-Associated Sarcopenia-Dependent Tubular Aggregates Formation, Lactate Depletion and Mitochondrial Changes.

artículo científico publicado en 2018

The Role of Mitochondria in Brain Aging and the Effects of Melatonin ⬇️

artículo científico publicado el 1 de septiembre de 2010

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.

artículo científico publicado en 2013

The benefits of four weeks of melatonin treatment on circadian patterns in resistance-trained athletes.

artículo científico publicado en 2015

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

artículo científico publicado en 2015

Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency

artículo científico publicado en 2014

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in mice

artículo científico publicado en 2019

β-globin gene cluster haplotypes in sickle cell patients from Panamá.

artículo científico publicado en 2011

Lista de obras de Germaine Escames

1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence

4,5-dihydro-1H-pyrazole derivatives with inhibitory nNOS activity in rat brain: synthesis and structure-activity relationships

A review of the melatonin functions in zebrafish physiology

Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: Effects of melatonin treatment

Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans.

Analysis of the daily changes of melatonin receptors in the rat liver

Antioxidant defence and inflammatory response in professional road cyclists during a 4-day competition.

Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice

Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model

Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum

Cardiological aging in SAM model: effect of chronic treatment with growth hormone

Cell protective role of melatonin in the brain

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures

Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine

Changes in the redox status and inflammatory response in handball players during one-year of competition and training

Characterization of melatonin high-affinity binding sites in purified cell nuclei of the hamster (Mesocricetus auratus) harderian gland

Characterization of nocturnal ultradian rhythms of melatonin in children with growth hormone-dependent and independent growth delay.

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice.

Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice

Circadian rhythms of dopamine and dihydroxyphenyl acetic acid in the mouse striatum: effects of pinealectomy and of melatonin treatment

Clinical trial to test the efficacy of melatonin in COVID-19

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice

Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?

Determination of Coenzyme Q10, Coenzyme Q9, and Melatonin Contents in Virgin Argan Oils: Comparison with Other Edible Vegetable Oils

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency

Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes.

Effect of a Combined Treatment With Growth Hormone and Melatonin in the Cardiological Aging on Male SAMP8 Mice

Effect of clonidine on plasma ACTH, cortisol and melatonin in children

Effect of propranolol plus exercise on melatonin and growth hormone levels in children with growth delay.

Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats

Envejecimiento del sistema circadiano

Exercise and melatonin in humans: reciprocal benefits.

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

Extrapineal melatonin: sources, regulation, and potential functions.

Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin.

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.

Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

Kynurenamines as neural nitric oxide synthase inhibitors

Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin

Local application of melatonin into alveolar sockets of beagle dogs reduces tooth removal-induced oxidative stress

Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome

Melatonin and beta-endorphin changes in children sensitized to olive and grass pollen after treatment with specific immunotherapy

Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.

Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model.

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8) ⬇️

Melatonin in the oral cavity: physiological and pathological implications.

Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

Melatonin protects lung mitochondria from aging ⬇️

Melatonin protects rats from radiotherapy-induced small intestine toxicity

Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice.

Melatonin reduces oxidative stress because of tooth removal

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

Melatonin role in the mitochondrial function.

Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy

Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

Melatonin, clock genes and mitochondria in sepsis.

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

Mitochondrial DNA and inflammatory diseases.

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.

Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients

Participation of ACTH1–10 and ACTH4–10 on the melatonin modulation of benzodiazepine receptors in rat cerebral cortex