Lista de obras - Timothy B. Niewold - Dominio Público Uruguay

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

artículo científico publicado en 2011

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

scholarly article by Zubin Patel published in April 2018

ABIN1 dysfunction as a genetic basis for lupus nephritis

artículo científico publicado en 2013

Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients

artículo científico publicado en 2013

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

artículo científico publicado en 2013

African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity

artículo científico publicado en 2010

Age- and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic lupus erythematosus.

artículo científico publicado en 2009

Age- and sex-related patterns of serum interferon-alpha activity in lupus families

artículo científico publicado en 2008

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

artículo científico publicado en 2016

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus

artículo científico publicado en 2011

Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis.

artículo científico publicado en 2007

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups

artículo científico publicado en 2011

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

artículo científico publicado en 2011

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility

artículo científico publicado en 2011

Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients

artículo científico publicado en 2008

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus

artículo científico publicado en 2012

Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds

artículo científico publicado en 2018

Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept

scientific article published on December 2007

Autoimmune disease genetics

artículo científico publicado en 2012

Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients

artículo científico publicado en 2011

B lymphocyte stimulator levels in systemic lupus erythematosus: higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels

artículo científico publicado en 2011

Bone health issues in sarcoidosis

artículo científico publicado en 2011

Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus

artículo científico publicado en 2012

CheB is required for behavioural responses to negative stimuli during chemotaxis in Bacillus subtilis

article

Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease

artículo científico publicado en 2013

Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience

artículo científico publicado en 2009

Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM

artículo científico publicado en 2014

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

artículo científico publicado en 2016

Concomitant interferon-alpha therapy and tumor necrosis factor alpha inhibition for rheumatoid arthritis and hepatitis C.

artículo científico publicado en 2006

Cytokines in systemic lupus erythematosus

artículo científico publicado en 2010

Cytokines in systemic lupus erythematosus 2011.

artículo científico publicado en 2011

Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

artículo científico publicado en 2016

Defining biological subsets in systemic lupus erythematosus: progress toward personalized therapy

artículo científico publicado en 2017

Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features.

artículo científico publicado en 2016

Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange

article

Drug-induced granulomatous interstitial nephritis in a patient with ankylosing spondylitis during therapy with adalimumab

artículo científico publicado en 2010

Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy.

artículo científico publicado en 2009

End-stage renal disease in African Americans with lupus nephritis is associated with APOL1

scientific article published on February 2014

Evaluation of TRAF6 in a large multiancestral lupus cohort

artículo científico publicado en 2012

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus

artículo científico publicado en 2012

Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade.

artículo científico publicado en 2008

Familial aggregation of autoimmune disease in juvenile dermatomyositis

artículo científico publicado en 2011

Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus

artículo científico publicado en 2013

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

artículo científico publicado en 2012

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

scientific article published on 17 August 2012

Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus

artículo científico publicado en 2012

Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis

artículo científico publicado en 2010

Genetic ancestry, serum interferon-α activity, and autoantibodies in systemic lupus erythematosus

artículo científico publicado en 2012

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

artículo científico publicado en 2015

Genetic regulation of serum cytokines in systemic lupus erythematosus

artículo científico publicado en 2009

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients

artículo científico publicado en 2010

Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.

artículo científico publicado en 2013

Genetics of the type I interferon pathway in systemic lupus erythematosus

scientific article published on December 2013

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

artículo científico publicado en 2012

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

artículo científico publicado en 2012

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

artículo científico publicado en 2010

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study

artículo científico publicado en 2011

Immunogenetics of systemic lupus erythematosus: A comprehensive review

artículo científico publicado en 2015

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

artículo científico publicado en 2012

Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study

artículo científico publicado en 2017

Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis

artículo científico publicado en 2015

Increased serum type I interferon activity in organ-specific autoimmune disorders: clinical, imaging, and serological associations.

artículo científico publicado en 2013

Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features

artículo científico publicado en 2011

Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins

artículo científico publicado en 2012

Interferon alpha as a primary pathogenic factor in human lupus ⬇️

artículo científico publicado el 16 de septiembre de 2011

Interferon alpha in systemic lupus erythematosus

artículo científico publicado en 2010

Interferon alpha-induced lupus: proof of principle

artículo científico publicado en 2008

Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus

artículo científico publicado en 2012

Interferon regulatory factors in human lupus pathogenesis

artículo científico publicado en 2011

Interferon regulatory factors: critical mediators of human lupus

artículo científico publicado en 2014

Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis

artículo científico publicado en 2013

Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosus

artículo científico publicado en 2012

Lenalidomide for the treatment of cryoglobulinemia and undifferentiated spondyloarthropathy in a patient with multiple myeloma

artículo científico publicado en 2010

Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells

artículo científico publicado en 2010

Lessons from precision medicine in rheumatology

artículo científico publicado en 2020

Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry

artículo científico publicado en 2011

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus

artículo científico publicado en 2013

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

artículo científico publicado en 2011

Novel mutation in the NRLP3 manifesting as an intermediate phenotype of cryopyrinopathies

artículo científico publicado en 2020

Nucleic Acid sensors and type I interferon production in systemic lupus erythematosus

artículo científico publicado en 2013

Ocrelizumab: a step forward in the evolution of B-cell therapy

artículo científico publicado en 2009

Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus

artículo científico publicado en 2011

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes

artículo científico publicado en 2013

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

artículo científico publicado en 2011

Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus

artículo científico publicado en 2013

Post-streptococcal reactive arthritis and glomerulonephritis in an adult

artículo científico publicado en 2003

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.

artículo científico publicado en 2014

Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression

artículo científico publicado en 2013

Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients

artículo científico publicado en 2010

Rheumatologic manifestations of sarcoidosis

artículo científico publicado en 2010

Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus

artículo científico publicado en 2014

Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus

artículo científico publicado en 2008

Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations

artículo científico publicado en 2010

Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes

artículo científico publicado en 2021

Sirukumab : a novel therapy for lupus nephritis?

artículo científico

Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman

artículo científico publicado en 2013

Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C.

artículo científico publicado en 2004

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

artículo científico publicado en 2014

The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus

artículo científico publicado en 2008

The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes

artículo científico publicado en 2011

The clinical and immunologic features of pulmonary fibrosis in sarcoidosis

artículo científico publicado en 2012

The role of genetic variation near interferon-kappa in systemic lupus erythematosus

artículo científico publicado en 2010

The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies

artículo científico publicado en 2011

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.

artículo científico publicado en 2010

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.

artículo científico publicado en 2013

Transancestral mapping and genetic load in systemic lupus erythematosus

artículo científico

Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription

artículo científico publicado en 2014

Type I Interferon Predicts an Alternate Immune System Phenotype in Systemic Lupus Erythematosus

artículo científico publicado en 2019

Type I interferon in human autoimmunity

artículo científico publicado en 2014

Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis

artículo científico publicado en 2012

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry

artículo científico publicado en 2013

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries

artículo científico publicado en 2012

Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus

artículo científico publicado en 2011

Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations

artículo científico publicado en 2015

Lista de obras de Timothy B. Niewold

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

ABIN1 dysfunction as a genetic basis for lupus nephritis

Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity

Age- and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic lupus erythematosus.

Age- and sex-related patterns of serum interferon-alpha activity in lupus families

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus

Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis.

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility

Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus

Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds

Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept

Autoimmune disease genetics

Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients

B lymphocyte stimulator levels in systemic lupus erythematosus: higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels

Bone health issues in sarcoidosis

Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus

CheB is required for behavioural responses to negative stimuli during chemotaxis in Bacillus subtilis

Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease

Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience

Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

Concomitant interferon-alpha therapy and tumor necrosis factor alpha inhibition for rheumatoid arthritis and hepatitis C.

Cytokines in systemic lupus erythematosus

Cytokines in systemic lupus erythematosus 2011.

Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

Defining biological subsets in systemic lupus erythematosus: progress toward personalized therapy

Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features.

Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange

Drug-induced granulomatous interstitial nephritis in a patient with ankylosing spondylitis during therapy with adalimumab

Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy.

End-stage renal disease in African Americans with lupus nephritis is associated with APOL1

Evaluation of TRAF6 in a large multiancestral lupus cohort

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus

Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade.

Familial aggregation of autoimmune disease in juvenile dermatomyositis

Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus

Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis

Genetic ancestry, serum interferon-α activity, and autoantibodies in systemic lupus erythematosus

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

Genetic regulation of serum cytokines in systemic lupus erythematosus

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients

Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.

Genetics of the type I interferon pathway in systemic lupus erythematosus

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study

Immunogenetics of systemic lupus erythematosus: A comprehensive review

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study

Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis

Increased serum type I interferon activity in organ-specific autoimmune disorders: clinical, imaging, and serological associations.

Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features

Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins

Interferon alpha as a primary pathogenic factor in human lupus ⬇️

Interferon alpha in systemic lupus erythematosus

Interferon alpha-induced lupus: proof of principle

Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus

Interferon regulatory factors in human lupus pathogenesis

Interferon regulatory factors: critical mediators of human lupus

Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis

Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosus

Lenalidomide for the treatment of cryoglobulinemia and undifferentiated spondyloarthropathy in a patient with multiple myeloma

Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells

Lessons from precision medicine in rheumatology

Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

Novel mutation in the NRLP3 manifesting as an intermediate phenotype of cryopyrinopathies