Lista de obras - Joao Goncalves - Dominio Público Uruguay

A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia

artículo científico publicado en 2014

A novel reactive epitope-based antigen targeted by serum autoantibodies in oligoarticular and polyarticular juvenile idiopathic arthritis and development of an electrochemical biosensor.

artículo científico publicado en 2016

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins

artículo científico

Analysis of Immunogenicity Data in the Product Information of Biological Drugs: A Need to Report Immunogenicity Data Systematically

scientific article published on 01 December 2019

Anti-TNF biosimilars in psoriasis: from scientific evidence to real-world experience

artículo científico publicado en 2019

Anti-type II collagen antibodies detection and avidity in patients with oligoarticular and polyarticular forms of juvenile idiopathic arthritis.

artículo científico publicado en 2015

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.

artículo científico publicado en 2018

Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition

artículo científico publicado en 2018

Assessing combinatorial strategies to multimerize libraries of single-domain antibodies

artículo científico publicado en 2012

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

artículo científico publicado en 2004

Biodistribution of a (67)Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag).

artículo científico publicado en 2014

Biosimilar DMARDs: What Does the Future Hold?

artículo científico publicado en 2016

Biosimilars in rheumatology

artículo científico publicado en 2019

Biosimilars: An Opportunity to Update the Product Information of Biological Drugs Regarding their Immunogenicity

scientific article published on 01 December 2019

CIB1 and CIB2 are HIV-1 helper factors involved in viral entry.

artículo científico publicado en 2016

Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity

artículo científico publicado en 2004

Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies

artículo científico publicado en 2005

Characterization of plasma labile heme in hemolytic conditions

artículo científico publicado en 2017

Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads.

artículo científico publicado en 2018

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

artículo científico publicado en 2016

Editorial: antigenic response to CT-P13 and infliximab originator in IBD shows similar epitope recognition-evidence from basic science supports safe switching to biosimilars. Authors’ reply

artículo científico publicado en 2018

Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center

artículo científico publicado en 2019

Establishment of a bioluminescent canine B-cell lymphoma xenograft model for monitoring tumor progression and treatment response in preclinical studies

artículo científico publicado en 2018

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

artículo científico publicado en 2005

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

artículo científico publicado en 2002

HIV-1 Vif and APOBEC3G: multiple roads to one goal

artículo científico publicado en 2004

HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation

artículo científico publicado en 2004

HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay

scientific article published on 29 January 2011

HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action.

artículo científico publicado en 2006

Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches

scientific article published on 24 October 2013

Human mtDNA haplogroups and reduced male fertility: real association or hidden population substructuring

article

Identification of SOX3 as an XX male sex reversal gene in mice and humans

artículo científico publicado en 2011

Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents

scientific article published on 01 February 2020

Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display.

artículo científico publicado en 2015

Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody

scientific article published on 22 October 2019

Insights on the Formulation of Recombinant Proteins

artículo científico publicado en 2020

Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims

artículo científico publicado en 2016

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

artículo científico publicado en 2005

Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.

artículo científico publicado en 2012

M13 bacteriophage purification using poly(ionic liquids) as alternative separation matrices.

artículo científico publicado en 2017

Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

artículo científico publicado en 2014

Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates

artículo científico publicado en 2017

Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells.

artículo científico publicado en 2005

Molecular construction of bionanoparticles: chimaeric SIV p17-HIV I p6 nanoparticles with minimal viral protein content.

artículo científico publicado en 2007

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.

artículo científico publicado en 2012

Next-generation sequencing of hereditary hemochromatosis-related genes: Novel likely pathogenic variants found in the Portuguese population

scientific article published on 22 July 2016

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells

artículo científico publicado en 2010

Novel promoter and splice junction defects add to the genetic, clinical or geographic heterogeneity of ?-thalassaemia in the Portuguese population ⬇️

artículo científico publicado el 1 de julio de 1992

Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands

scientific article published on 02 July 2019

Pharmacoeconomics of Biosimilars: What Is There to Gain from Them?

artículo científico publicado en 2016

Phosphorylation of Vif and its role in HIV-1 replication

artículo científico publicado en 1996

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation

artículo científico publicado en 2004

Piezoelectric biosensors for biorecognition analysis: Application to the kinetic study of HIV-1 Vif protein binding to recombinant antibodies

artículo científico publicado en 2007

Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies.

artículo científico publicado en 2016

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

artículo científico publicado en 2017

Rare double sex and mab-3-related transcription factor 1 regulatory variants in severe spermatogenic failure

artículo científico publicado en 2015

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

artículo científico publicado en 2016

Recombinant antibodies as therapeutic agents: pathways for modeling new biodrugs

artículo científico publicado en 2008

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

artículo científico publicado en 2012

Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor.

artículo científico publicado en 2007

SB5 shows cross-immunogenicity to adalimumab but not infliximab: results in patients with inflammatory bowel disease or rheumatoid arthritis

scientific article published on 04 December 2019

Synthetic antibody discovery against native antigens by CRISPR/Cas9-library generation and endoplasmic reticulum screening

artículo científico publicado en 2020

The hepcidin gene promoter nc.-1010C > T; -582A > G haplotype modulates serum ferritin in individuals carrying the common H63D mutation in HFE gene.

artículo científico publicado en 2014

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma.

artículo científico publicado en 2018

The mutational spectrum of WT1 in male infertility.

artículo científico publicado en 2014

Therapeutic Antibody Engineering and Selection Strategies

artículo científico publicado en 2020

Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?

artículo científico publicado en 2010

Ultrastructure of HIV-1 genomic RNA

scientific article published on 01 July 1997

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.

artículo científico publicado en 2016

Lista de obras de Joao Goncalves

A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia

A novel reactive epitope-based antigen targeted by serum autoantibodies in oligoarticular and polyarticular juvenile idiopathic arthritis and development of an electrochemical biosensor.

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins

Analysis of Immunogenicity Data in the Product Information of Biological Drugs: A Need to Report Immunogenicity Data Systematically

Anti-TNF biosimilars in psoriasis: from scientific evidence to real-world experience

Anti-type II collagen antibodies detection and avidity in patients with oligoarticular and polyarticular forms of juvenile idiopathic arthritis.

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.

Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition

Assessing combinatorial strategies to multimerize libraries of single-domain antibodies

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

Biodistribution of a (67)Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag).

Biosimilar DMARDs: What Does the Future Hold?

Biosimilars in rheumatology

Biosimilars: An Opportunity to Update the Product Information of Biological Drugs Regarding their Immunogenicity

CIB1 and CIB2 are HIV-1 helper factors involved in viral entry.

Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity

Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies

Characterization of plasma labile heme in hemolytic conditions

Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads.

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

Editorial: antigenic response to CT-P13 and infliximab originator in IBD shows similar epitope recognition-evidence from basic science supports safe switching to biosimilars. Authors’ reply

Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center

Establishment of a bioluminescent canine B-cell lymphoma xenograft model for monitoring tumor progression and treatment response in preclinical studies

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

HIV-1 Vif and APOBEC3G: multiple roads to one goal

HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation

HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay

HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action.

Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches

Human mtDNA haplogroups and reduced male fertility: real association or hidden population substructuring

Identification of SOX3 as an XX male sex reversal gene in mice and humans

Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents

Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display.

Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody

Insights on the Formulation of Recombinant Proteins

Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.

M13 bacteriophage purification using poly(ionic liquids) as alternative separation matrices.

Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates

Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells.

Molecular construction of bionanoparticles: chimaeric SIV p17-HIV I p6 nanoparticles with minimal viral protein content.

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.

Next-generation sequencing of hereditary hemochromatosis-related genes: Novel likely pathogenic variants found in the Portuguese population

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells

Novel promoter and splice junction defects add to the genetic, clinical or geographic heterogeneity of ?-thalassaemia in the Portuguese population ⬇️

Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands

Pharmacoeconomics of Biosimilars: What Is There to Gain from Them?

Phosphorylation of Vif and its role in HIV-1 replication

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation

Piezoelectric biosensors for biorecognition analysis: Application to the kinetic study of HIV-1 Vif protein binding to recombinant antibodies

Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies.

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

Rare double sex and mab-3-related transcription factor 1 regulatory variants in severe spermatogenic failure

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

Recombinant antibodies as therapeutic agents: pathways for modeling new biodrugs

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor.

SB5 shows cross-immunogenicity to adalimumab but not infliximab: results in patients with inflammatory bowel disease or rheumatoid arthritis

Synthetic antibody discovery against native antigens by CRISPR/Cas9-library generation and endoplasmic reticulum screening

The hepcidin gene promoter nc.-1010C > T; -582A > G haplotype modulates serum ferritin in individuals carrying the common H63D mutation in HFE gene.

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma.

The mutational spectrum of WT1 in male infertility.

Therapeutic Antibody Engineering and Selection Strategies

Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?

Ultrastructure of HIV-1 genomic RNA

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.