Lista de obras - Linda Z Penn - Dominio Público Uruguay

A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants

artículo científico publicado en 2005

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

artículo científico publicado en 2015

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

artículo científico publicado en 2009

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

scientific article published on 10 April 2019

Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

artículo científico publicado en 2003

Apoptosis modulators as cancer therapeutics.

artículo científico publicado en 2001

Association between depression, glycaemic control and the prevalence of diabetic retinopathy in a diabetic population in Cameroon

scientific article published on 01 June 2017

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

artículo científico publicado en 2005

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

artículo científico publicado en 1996

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

artículo científico publicado en 1999

Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

artículo científico publicado en 2003

BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors

artículo científico publicado en 2014

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

artículo científico publicado en 2015

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

artículo científico publicado en 2001

Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

artículo científico publicado en 2004

CUL7 is a novel antiapoptotic oncogene

artículo científico publicado en 2007

Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation

artículo científico publicado en 1997

Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.

artículo científico publicado en 2001

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

artículo científico publicado en 2010

ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data

artículo científico publicado en 2016

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome

artículo científico publicado en 2005

Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death

artículo científico publicado en 2020

Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma

artículo científico publicado en 2007

Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents

artículo científico publicado en 2010

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

artículo científico publicado en 2021

Dysregulation of the mevalonate pathway promotes transformation

artículo científico publicado en 2010

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

artículo científico publicado en 2001

Erratum: Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

scholarly article published in Laboratory Investigation

Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma

artículo científico publicado en 2010

Functional analysis of the N-terminal domain of the Myc oncoprotein

artículo científico publicado en 2003

Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity

artículo científico

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

artículo científico publicado en 2015

Guiding principles for a successful multidisciplinary research collaboration

artículo científico publicado en 2015

Identification of c-MYC SUMOylation by mass spectrometry

artículo científico publicado en 2014

Identifying Myc interactors

artículo científico publicado en 2013

Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP.

artículo científico publicado en 2013

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells

artículo científico publicado en 2013

Image-Based Analysis of Protein Stability

scientific article published on 27 November 2019

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

artículo científico publicado en 2014

Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach

artículo científico publicado en 1999

Induction of apoptosis in fibroblasts by c-myc protein

artículo científico publicado en 1992

Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth

artículo científico publicado en 2017

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

artículo científico publicado en 2008

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung

artículo científico

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

artículo científico publicado en 2007

Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation

artículo científico publicado en 1996

Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia

artículo científico publicado en 2001

Lovastatin induces a pronounced differentiation response in acute myeloid leukemias

artículo científico publicado en 2000

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

artículo científico publicado en 2010

Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase

artículo científico publicado en 2000

MYC Deregulation in Primary Human Cancers.

artículo científico publicado en 2017

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

article

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

scientific article published on 08 November 2018

MYC activity is negatively regulated by a C-terminal lysine cluster

artículo científico publicado en 2013

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

scientific article published in Nature Communications

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation

artículo científico publicado en 2016

MYC phosphorylation at novel regulatory regions suppresses transforming activity

artículo científico publicado en 2013

Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor

artículo científico publicado en 2001

Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas

artículo científico publicado en 2002

Modelling the MYC-driven normal-to-tumour switch in breast cancer

artículo científico publicado en 2019

More than MAX: Discovering the Myc interactome

artículo científico publicado en 2011

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

artículo científico publicado en 2013

Multiple direct interactions of TBP with the MYC oncoprotein

scientific article published on 04 November 2019

Myc and its interactors take shape.

artículo científico publicado en 2014

Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.

artículo científico publicado en 2000

Myc represses the growth arrest gene gadd45

article

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

scientific journal article

Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells

scientific article published on 01 May 2000

OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner.

artículo científico publicado en 1998

Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies

artículo científico publicado en 2008

Oxygen regulation of arterial smooth muscle cell proliferation and survival

artículo científico publicado en 2007

Prognostic gene signatures for non-small-cell lung cancer

artículo científico publicado en 2009

Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

artículo científico publicado en 2000

Quantitation of enteroviral RNA by competitive polymerase chain reaction.

artículo científico publicado en 1993

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning

artículo científico publicado en 2021

Repression of the human immunodeficiency virus type-1 long terminal repeat by the c-Myc oncoprotein

artículo científico publicado en 2004

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

artículo científico publicado en 2009

Role of Pirh2 in mediating the regulation of p53 and c-Myc

artículo científico publicado en 2011

Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins

artículo científico publicado en 2017

Statins as anti-cancer agents in the era of precision medicine

scientific article published on 04 September 2020

TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.

artículo científico publicado en 2005

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

artículo científico publicado en 2021

Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one

artículo científico publicado en 2014

Targeting tumor cell metabolism with statins.

artículo científico

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

artículo científico publicado en 2022

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis

artículo científico publicado en 2006

The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53

artículo científico publicado en 2007

The interplay between cell signalling and the mevalonate pathway in cancer

artículo científico publicado en 2016

The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

artículo científico publicado en 2020

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

artículo científico publicado en 1998

The role of ligand density and size in mediating quantum dot nuclear transport

artículo científico publicado en 2014

Three-Gene Prognostic Classifier for Early-Stage Non–Small-Cell Lung Cancer

article

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

artículo científico publicado en 2012

Tumor cell kill by c-MYC depletion: role of MYC-regulated genes that control DNA double-strand break repair.

artículo científico publicado en 2010

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

artículo científico publicado en 2004

Lista de obras de Linda Z Penn

A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

Apoptosis modulators as cancer therapeutics.

Association between depression, glycaemic control and the prevalence of diabetic retinopathy in a diabetic population in Cameroon

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

CUL7 is a novel antiapoptotic oncogene

Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation

Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome

Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death

Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma

Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Dysregulation of the mevalonate pathway promotes transformation

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

Erratum: Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma

Functional analysis of the N-terminal domain of the Myc oncoprotein

Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Guiding principles for a successful multidisciplinary research collaboration

Identification of c-MYC SUMOylation by mass spectrometry

Identifying Myc interactors

Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP.

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells

Image-Based Analysis of Protein Stability

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach

Induction of apoptosis in fibroblasts by c-myc protein

Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation

Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia

Lovastatin induces a pronounced differentiation response in acute myeloid leukemias

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase

MYC Deregulation in Primary Human Cancers.

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

MYC activity is negatively regulated by a C-terminal lysine cluster

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation

MYC phosphorylation at novel regulatory regions suppresses transforming activity

Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor

Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas

Modelling the MYC-driven normal-to-tumour switch in breast cancer

More than MAX: Discovering the Myc interactome

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Multiple direct interactions of TBP with the MYC oncoprotein

Myc and its interactors take shape.

Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.

Myc represses the growth arrest gene gadd45

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells

OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner.

Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies

Oxygen regulation of arterial smooth muscle cell proliferation and survival

Prognostic gene signatures for non-small-cell lung cancer

Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

Quantitation of enteroviral RNA by competitive polymerase chain reaction.

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning

Repression of the human immunodeficiency virus type-1 long terminal repeat by the c-Myc oncoprotein

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

Role of Pirh2 in mediating the regulation of p53 and c-Myc

Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins