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Lista de obras de Jih-Hwa Guh

(-)-Discretamine, a selective alpha 1D-adrenoceptor antagonist, isolated from Fissistigma glaucescens ⬇️

artículo científico publicado en 1994

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis

artículo científico publicado en 2002

2-(1H-Imidazol-1-yl)-4-[3-(trifluoro-meth-yl)phen-yl]-1,3-thia-zole.

artículo científico publicado en 2013

A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides.

artículo científico publicado en 2014

A novel hydroxysuberamide derivative potentiates MG132-mediated anticancer activity against human hormone refractory prostate cancers--the role of histone deacetylase and endoplasmic reticulum stress.

artículo científico publicado en 2013

A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.

artículo científico publicado en 2014

A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models

scientific article published on 01 May 2005

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways ⬇️

artículo científico publicado el 1 de mayo de 2011

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway

artículo científico publicado en 2014

Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells

artículo científico publicado en 2006

An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia

artículo científico publicado en 2018

Anti-angiogenic effects and mechanism of prazosin.

artículo científico publicado en 2010

Antiplatelet effect of gingerol isolated from Zingiber officinale

scientific article published on 01 April 1995

Antiproliferative Effect in Human Prostatic Smooth Muscle Cells by Nitric Oxide Donor ⬇️

artículo científico publicado el 1 de marzo de 1998

Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens

artículo científico publicado en 1996

Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo

artículo científico publicado en 2005

Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.

artículo científico publicado en 2009

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.

artículo científico publicado en 2011

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.

artículo científico publicado en 2012

Ascleposide, a natural cardenolide, induces anticancer signaling in human castration-resistant prostatic cancer through Na+ /K+ -ATPase internalization and tubulin acetylation

scientific article published on 06 January 2020

Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells.

artículo científico publicado en 2008

Bioactive diterpenes from Callicarpa longissima.

artículo científico publicado en 2012

CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.

artículo científico publicado en 2007

CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.

artículo científico publicado en 2008

CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.

artículo científico publicado en 2004

Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation

artículo científico publicado en 2014

Catalytic transfer hydrogenation and anticancer activity of arene-ruthenium compounds incorporating bi-dentate precursors

artículo científico publicado en 2015

Cell proliferation in human prostatic smooth muscle cells involves the modulation of protein kinase C isozymes

scientific article published on 01 October 1998

Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption

artículo científico publicado en 2014

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies

artículo científico publicado en 2020

Characterization of alpha 1-adrenoceptor subtypes in tension response of human prostate to electrical field stimulation.

artículo científico publicado en 1995

Characterization of some novel alpha 1-adrenoceptor antagonists in human hyperplastic prostate

artículo científico publicado en 2002

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis.

artículo científico publicado en 2011

Combined treatment with denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells.

artículo científico publicado en 2009

Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.

artículo científico publicado en 2011

Cryptocaryone, a natural dihydrochalcone, induces apoptosis in human androgen independent prostate cancer cells by death receptor clustering in lipid raft and nonraft compartments.

artículo científico publicado en 2010

Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells.

artículo científico publicado en 2008

Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity.

artículo científico publicado en 2005

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.

artículo científico publicado en 2013

Design, synthesis and cytotoxic activity of N-Modified oleanolic saponins bearing A glucosamine

artículo científico publicado en 2017

Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death Against Human Non-Small Cell Lung Cancers

artículo científico publicado en 2020

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

artículo científico publicado en 2017

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

artículo científico publicado en 2016

Effect of a potent cyclooxygenase inhibitor, 5-ethyl-4-methoxy-2-phenylquinoline (KTC-5), on human platelets.

artículo científico publicado en 2002

Effects of ouabain on tension response and [3H]noradrenaline release in human prostate

scientific article published on 01 January 2000

Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma.

artículo científico publicado en 2008

Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways

artículo científico publicado en 2017

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

artículo científico publicado en 2015

Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats.

artículo científico publicado en 2003

Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7.

artículo científico publicado en 2009

Functional identification of alpha 1-adrenoceptor subtypes in human prostate: comparison with those in rat vas deferens and spleen

artículo científico publicado en 1994

Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.

artículo científico publicado en 2006

Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells

artículo científico publicado en 2004

Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth

artículo científico publicado en 2016

ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers

artículo científico publicado en 2011

Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells

artículo científico publicado en 2003

Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.

artículo científico publicado en 2005

Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes

artículo científico publicado en 2004

Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine

artículo científico publicado en 2005

Inhibition by tamsulosin of tension responses of human hyperplastic prostate to electrical field stimulation

scientific article published on 01 June 1996

Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: involvement of IkappaB-alpha stabilization.

artículo científico publicado en 2001

Inhibitory effect of DCDC on lipopolysaccharide-induced nitric oxide synthesis in RAW 264.7 cells.

artículo científico publicado en 2001

Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia.

artículo científico publicado en 2005

Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells

artículo científico publicado en 2003

Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells.

artículo científico publicado en 2004

Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.

artículo científico publicado en 2004

KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.

artículo científico publicado en 2015

Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.

artículo científico publicado en 1995

Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells

artículo científico publicado en 1996

Menthols as Chiral Auxiliaries for Asymmetric Cycloadditive Oligomerization: Syntheses and Studies of β-Proline Hexamers

artículo científico publicado en 2015

Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways

artículo científico publicado en 2010

Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells

artículo científico publicado en 2004

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer

artículo científico publicado en 2013

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

artículo científico publicado en 2009

New bioactive clerodane diterpenoids from the roots of Casearia membranacea.

artículo científico publicado en 2008

New cytotoxic clerodane diterpenoids from the leaves and twigs of Casearia membranacea

artículo científico publicado en 2004

New prostanoids with cytotoxic activity from Taiwanese octocoral Clavularia viridis

artículo científico publicado en 2004

Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways

scientific article published on 19 October 2016

Ouabain-induced increases in resting tone of human hyperplastic prostate following repeated noradrenaline and electrical field stimulation.

artículo científico publicado en 1996

Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer

artículo científico publicado en 2011

Pharmacological evaluation of N-methyl-actinodaphnine, a new vascular alpha-adrenoceptor antagonist, isolated from Illigera luzonensis.

artículo científico publicado en 1995

Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells.

artículo científico publicado en 2003

Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair ⬇️

artículo científico publicado el 17 de enero de 2012

Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway

artículo científico publicado en 2003

Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines

artículo científico publicado en 2011

Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells.

artículo científico publicado en 2012

Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways

artículo científico publicado en 2007

Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle.

artículo científico publicado en 2014

Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades

artículo científico publicado en 2013

Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer: a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

artículo científico publicado en 2015

Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway

artículo científico publicado en 2015

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.

artículo científico publicado en 2015

Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents.

artículo científico publicado en 2014

Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway ⬇️

artículo científico publicado el 2 de abril de 2012

Structural studies and anticancer activity of a novel class of β-peptides

artículo científico publicado en 2014

Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.

artículo científico publicado en 2012

Synthesis and anti-cancer activity of a glycosyl library of N-acetylglucosamine-bearing oleanolic acid.

artículo científico publicado en 2013

Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors

scientific article published on 12 June 2011

Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy ⬇️

artículo científico publicado el 28 de abril de 2013

Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates

artículo científico publicado en 2007

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.

artículo científico publicado en 2011

Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator

artículo científico publicado en 2011

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

artículo científico publicado en 2013

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

artículo científico publicado en 2020

The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells

artículo científico publicado en 2014

The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo.

artículo científico publicado en 2010

The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion

scientific article published on 01 November 2008

Three new taxane diterpenoids from Taxus sumatrana.

artículo científico publicado en 2005

Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – a critical role of Cdk1 in mitotic entry.

artículo científico publicado en 2015

Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78.

artículo científico publicado en 2009

Two new cytotoxic clerodane diterpenoids from Casearia membranacea ⬇️

artículo científico publicado en 2004

WJ9708012 exerts anticancer activity through PKC-α related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells

artículo científico publicado en 2010

WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.

artículo científico publicado en 2007

YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G0-G1 in Human Hepatocellular Carcinoma Cells

artículo científico publicado en 2004

YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models.

artículo científico publicado en 2005

YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.

artículo científico publicado en 2005

YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells.

artículo científico publicado en 2008

YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells

artículo científico publicado en 2004

YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.

artículo científico publicado en 2005

Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.

artículo científico publicado en 2015

abeo-taxane diterpenoids from the Taiwanese Yew Taxus sumatrana.

artículo científico publicado en 2009

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