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Lista de obras de Scott H Kaufmann

4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.

artículo científico publicado en 2016

6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin ⬇️

artículo científico publicado el 1 de enero de 1998

A One-Step Method for Protein Estimation in Biological Samples: Nitration of Tyrosine in Nitric Acid

artículo científico publicado en 1999

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia

artículo científico publicado en 2016

A Phase I Multicenter Study of Continuous Oral Administration of Lonafarnib (SCH 66336) and Intravenous Gemcitabine in Patients With Advanced Cancer ⬇️

artículo científico publicado el 1 de noviembre de 2011

A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia

artículo científico publicado en 2016

A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer

artículo científico publicado en 2003

A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.

artículo científico publicado en 2000

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer

artículo científico publicado en 2004

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice

artículo científico publicado en 2016

A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines

artículo científico publicado en 2001

A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia

artículo científico publicado en 2006

A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer

artículo científico publicado en 2002

A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer

artículo científico publicado en 2005

A phase I and pharmacological study of topotecan infused over 30 minutes for five days in patients with refractory acute leukemia.

artículo científico publicado en 1996

A phase I study of sequential irinotecan and 5-fluorouracil/leucovorin

artículo científico publicado en 2002

A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors

scientific article published on 31 August 2018

A phase I trial of the novel farnesyl protein transferase inhibitor, BMS-214662, in combination with paclitaxel and carboplatin in patients with advanced cancer.

artículo científico publicado en 2005

A phase II "window" study of topotecan in untreated patients with high risk adult acute lymphoblastic leukemia

artículo científico publicado en 1998

A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma

artículo científico publicado en 2011

A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation

artículo científico publicado en 2008

A subset of non-histone nuclear proteins reversibly stabilized by the sulfhydryl cross-linking reagent tetrathionate

scientific article published on 01 December 1984

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

artículo científico publicado en 2013

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

artículo científico publicado en 2016

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.

artículo científico publicado en 2013

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

artículo científico publicado en 1997

Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.

artículo científico publicado en 2002

Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide

scientific article published on 24 December 2008

Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes

artículo científico publicado en 2006

Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine

artículo científico publicado en 2004

Addition of etoposide to initial therapy of adult acute lymphoblastic leukemia: a combined clinical and laboratory study

artículo científico publicado en 1996

Additional members of the rat liver lamin polypeptide family. Structural and immunological characterization

artículo científico publicado en 1989

Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors

artículo científico publicado en 1996

Alterations in insulin binding accompanying differentiation of 3T3-L1 preadipocytes ⬇️

artículo científico publicado en 1977

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance ⬇️

artículo científico publicado el 20 de octubre de 2003

Altered formation of topotecan-stabilized topoisomerase I-DNA adducts in human leukemia cells

artículo científico publicado en 1997

An Alternative Approach to the Quantitation of Glucocorticoid-Receptor Complexes in the Nuclei of Lymphoid Cells*

artículo científico publicado en 1982

Analysis of Caspase Activation During Apoptosis

article

Analysis of the internal nuclear matrix

article

Anastrozole has an association between degree of estrogen suppression and outcomes in early breast cancer and is a ligand for estrogen receptor α

artículo científico publicado en 2020

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line

artículo científico publicado en 1991

Anticancer therapy: boosting the bang of Bim.

artículo científico publicado en 2008

Apoptosis and the response to anticancer therapy.

artículo científico publicado en 2001

Apoptosis in the treatment of cancer: a promise kept?

artículo científico publicado en 2006

Apoptosis-associated caspase activation assays

scientific article published on March 2008

Apoptosis: an optimization approach

artículo científico publicado en 2004

Apparent cleavage of poly(ADP-ribose) polymerase in non-apoptotic mouse LTA cells: an artifact of cross-reactive secondary antibody

artículo científico publicado en 1998

Assessment of aldehyde dehydrogenase in viable cells.

artículo científico publicado en 1995

Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type

artículo científico publicado en 1991

Association of topoisomerase II with the hepatoma cell nuclear matrix: the role of intermolecular disulfide bond formation

artículo científico publicado en 1991

Ataxia telangiectasia and rad3-related kinase contributes to cell cycle arrest and survival after cisplatin but not oxaliplatin

artículo científico publicado en 2009

Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module

artículo científico publicado en 2014

BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma

artículo científico publicado en 2014

BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis

artículo científico publicado en 2008

BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents

scientific article published on 16 October 2019

Bcl-2 Prevents CD95 (Fas/APO-1)-induced Degradation of Lamin B and Poly(ADP-ribose) Polymerase and Restores the NF-κB Signaling Pathway

artículo científico publicado en 1996

Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line

artículo científico publicado en 2002

Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism

artículo científico publicado en 2002

Bim regulation miRrors microRNA 17∼92 cluster expression in endothelial cells in vivo

artículo científico publicado en 2014

Binding of dexamethasone to rat liver nuclei in vivo and in vitro: Evidence for two distinct binding sites

article

Binding of the glucocorticoid receptor to the rat liver nuclear matrix. The role of disulfide bond formation

artículo científico publicado en 1986

CDK2-mediated upregulation of TNFa as a mechanism of selective cytotoxicity in acute leukemia

scientific article published on 07 January 2021

CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.

artículo científico publicado en 2013

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

artículo científico publicado en 2015

CXCR4 Chemokine Receptor Signaling Induces Apoptosis in Acute Myeloid Leukemia Cells via Regulation of the Bcl-2 Family Members Bcl-XL, Noxa, and Bak ⬇️

artículo científico publicado el 24 de junio de 2013

Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia

artículo científico publicado en 2002

Camptothecin analogues: studies from the Johns Hopkins Oncology Center

artículo científico publicado en 1994

Cancer. Targeting bacteria to improve cancer therapy

artículo científico publicado en 2010

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

artículo científico publicado en 2014

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation.

artículo científico publicado en 2014

Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis

artículo científico publicado en 2003

Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis

artículo científico publicado en 1999

Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons.

artículo científico publicado en 2001

Caspases and caspase inhibitors

artículo científico publicado en 1997

Caspases mediate tumor necrosis factor-alpha-induced neutrophil apoptosis and downregulation of reactive oxygen production

article

Cell death induced by topoisomerase-targeted drugs: more questions than answers

artículo científico publicado en 1998

Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro

artículo científico publicado en 2003

Changes in topoisomerase I levels and localization during myeloid maturation in vitro and in vivo

artículo científico publicado en 1995

Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions

artículo científico publicado en 1999

Characterization of a <i>RAD51C</i>-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance

artículo científico publicado en 2021

Characterization of an alternative BAK-binding site for BH3 peptides

artículo científico publicado en 2020

Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol.

artículo científico publicado en 2000

Characterization of the major polypeptides of the rat liver nuclear envelope

artículo científico publicado en 1983

Chemotherapy-induced apoptosis

artículo científico publicado en 1997

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

artículo científico publicado en 1996

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

artículo científico publicado en 1994

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

artículo científico publicado en 2001

Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions ⬇️

artículo científico publicado el 1 de agosto de 1997

Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis

artículo científico publicado en 1997

Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis

artículo científico publicado en 1999

Comparison of potential markers of farnesyltransferase inhibition

artículo científico publicado en 2000

Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.

artículo científico publicado en 2004

Considerations in the isolation of rat liver nuclear matrix, nuclear envelope, and pore complex lamina

artículo científico publicado en 1981

Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells.

artículo científico publicado en 2015

Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.

scientific article published on 07 April 2009

Context-dependent antagonism between Akt inhibitors and topoisomerase poisons

artículo científico publicado en 2014

Contribution of Bcl-2 phosphorylation to Bak binding and drug resistance.

artículo científico publicado en 2013

Correction: Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

artículo científico publicado en 2018

Current status of clinical trials of farnesyltransferase inhibitors.

artículo científico publicado en 2001

Cyclophosphamide resistance in medulloblastoma.

artículo científico publicado en 1992

Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines

artículo científico publicado en 1996

Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration ⬇️

artículo científico publicado el 15 de agosto de 1997

Cytotoxic synergy between pyrazoloacridine (NSC 366140) and cisplatin in vitro: inhibition of platinum-DNA adduct removal.

artículo científico publicado en 1997

Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation.

artículo científico publicado en 2011

DNA topoisomerases in chemotherapy

artículo científico publicado el 1 de enero de 1991

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis ⬇️

artículo científico publicado el 22 de septiembre de 2011

Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.

artículo científico publicado en 2009

Decreased drug accumulation in a mitoxantrone-resistant gastric carcinoma cell line in the absence of P-glycoprotein.

artículo científico publicado en 1997

Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.

scientific article published on 17 August 2009

Detection of DNA Cleavage in Apoptotic Cells

article

Detection of Poly(ADP-Ribose) Polymerase and Its Apoptosis-Specific Fragment by a Nonisotopic Activity–Western Blot Technique

artículo científico publicado en 1995

Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE)

scientific article published on 17 June 2020

Development of PARP inhibitors: an unfinished story.

artículo científico publicado en 2010

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

artículo científico publicado en 2014

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.

artículo científico publicado en 2014

Differential expression of nuclear envelope lamins A and C in human lung cancer cell lines

artículo científico publicado en 1991

Distribution of nucleolar proteins B23 and nucleolin during mouse spermatogenesis

artículo científico publicado en 1991

Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924

artículo científico publicado en 2011

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

artículo científico publicado en 2011

Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia

artículo científico publicado en 2005

Dynamics of granzyme B-induced apoptosis: mathematical modeling

artículo científico publicado en 2007

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

scientific article published on 05 March 2019

Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

artículo científico publicado en 1992

Effect of P-glycoprotein on flavopiridol sensitivity

artículo científico publicado en 2001

Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity

scientific article published on 01 January 1998

Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II

article

Effect of v-rasH on sensitivity of NCI-H82 human small cell lung cancer cells to cisplatin, etoposide, and camptothecin

scientific article published on 01 December 1995

Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro ⬇️

artículo científico publicado el 6 de agosto de 2012

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

artículo científico publicado en 2002

Effects of the MEK inhibitor CI-1040 (PD 184352) on progenitor growth from normal and myelodysplastic marrow.

artículo científico publicado en 2003

Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro

artículo científico publicado en 2000

Efficient method to optimize antibodies using avian leukosis virus display and eukaryotic cells

artículo científico publicado en 2015

Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.

artículo científico publicado en 1998

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.

artículo científico

Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT(388)-granulocyte-macrophage colony-stimulating factor (GM-CSF), a truncated diphtheria toxin fused to human GM-CSF.

artículo científico publicado en 2001

Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.

artículo científico publicado en 2011

Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells

artículo científico publicado en 1994

Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

artículo científico publicado en 2005

Erasable Western Blots

artículo científico publicado el 1 de enero de 1992

Erasure of Western blots after autoradiography or chemiluminescent detection

artículo científico publicado en 1993

Erasure of western blots after autoradiographic or chemiluminescent detection

artículo científico publicado en 1998

Evaluation of 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl) hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistancein vitro

scientific article published on 01 January 1996

Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia

artículo científico publicado en 2000

Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data

artículo científico publicado en 2008

Evaluation of the BH3-only protein Puma as a direct Bak activator

artículo científico publicado en 2013

Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis

artículo científico publicado en 2006

Evidence that rodent epididymal sperm contain the Mr approximately 94,000 glucocorticoid receptor but lack the Mr approximately 90,000 heat shock protein

artículo científico publicado en 1992

Expression of nuclear envelope lamins A and C in human myeloid leukemias ⬇️

artículo científico publicado el 15 de mayo de 1992

Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias

artículo científico publicado en 1996

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

scientific article published on 12 March 2020

Factors affecting topotecan sensitivity in human leukemia samples

artículo científico publicado en 1996

Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro ⬇️

artículo científico publicado el 30 de enero de 2012

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

artículo científico

Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma

artículo científico publicado en 2004

Fine-structural cytochemical and immunocytochemical observations on nuclear bodies in the bovine 2-cell embryo

artículo científico publicado en 2000

Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

artículo científico publicado en 2006

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells

artículo científico publicado en 1996

Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

artículo científico publicado en 2018

Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.

artículo científico publicado en 2005

Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy

article

Genes associated with bowel metastases in ovarian cancer

scientific article published on 14 June 2019

Genetic analysis of the short splice variant of the inhibitor of caspase-activated DNase (ICAD-S) in chicken DT40 cells.

artículo científico publicado en 2007

HIC1 hypermethylation is a late event in hematopoietic neoplasms

artículo científico publicado en 1997

Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.

artículo científico publicado en 2010

Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines

artículo científico publicado en 2003

High cell surface death receptor expression determines type I versus type II signaling

artículo científico publicado en 2011

Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts

artículo científico publicado en 2015

Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells

artículo científico publicado en 2016

How does doxorubicin work?

artículo científico publicado en 2012

Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

artículo científico publicado en 2001

Imatinib spells BAD news for Bcr/abl-positive leukemias

artículo científico publicado en 2006

Immunodetection of human topoisomerase I-DNA covalent complexes

artículo científico publicado en 2016

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

artículo científico publicado en 2006

In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia ⬇️

artículo científico publicado el 1 de mayo de 2003

In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.

artículo científico publicado en 2016

Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia

article

Increased phosphorylation rate of intermediate filaments during mitotic arrest

artículo científico publicado en 1981

Induction of apoptosis by cancer chemotherapy.

artículo científico publicado en 2000

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

artículo científico publicado en 1989

Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells☆☆☆

article

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

artículo científico publicado en 2009

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.

artículo científico publicado en 2007

Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies.

artículo científico publicado en 2006

Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells

artículo científico publicado en 2005

Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

artículo científico publicado en 2003

Irinotecan in the treatment of glioma patients: current and future studies of the North Central Cancer Treatment Group

artículo científico publicado en 2003

Isolation of a TRAIL antagonist from the serum of HIV-infected patients.

artículo científico publicado en 2011

JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained

artículo científico publicado en 2006

Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia

artículo científico publicado en 2006

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

artículo científico publicado en 2018

Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells

artículo científico publicado en 2001

Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy

artículo científico publicado en 2002

Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer.

artículo científico publicado en 2014

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

artículo científico publicado en 2003

Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer.

artículo científico publicado en 2001

Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group

artículo científico publicado en 2008

MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors.

artículo científico publicado en 2015

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

artículo científico publicado en 1999

Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

artículo científico publicado en 2007

Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

artículo científico publicado en 2004

Methods utilized in the study of apoptosis

artículo científico publicado en 1997

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

artículo científico publicado en 2018

Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I

artículo científico publicado en 2008

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

artículo científico publicado en 2014

Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia

artículo científico publicado en 2011

Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas ⬇️

artículo científico publicado el 3 de noviembre de 2011

Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent

artículo científico publicado en 1999

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.

artículo científico publicado en 2011

Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.

artículo científico publicado en 2010

Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells ⬇️

artículo científico publicado el 22 de marzo de 2011

On the TRAIL of a new therapy for leukemia.

artículo científico publicado en 2005

On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents

artículo científico publicado en 2009

Osteoblasts protect AML cells from SDF-1-induced apoptosis.

artículo científico publicado en 2014

Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines

artículo científico publicado en 2008

Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells

artículo científico publicado en 1996

Phase 1 study of sorafenib in combination with bortezomib in patients with advanced malignancies.

scientific article published on 26 July 2013

Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points.

artículo científico publicado en 2005

Phase 2 trial of imatinib mesylate in myelofibrosis with myeloid metaplasia

artículo científico publicado en 2002

Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia

artículo científico publicado en 1994

Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias

artículo científico publicado en 2005

Phase I and pharmacokinetic study of lonafarnib, SCH 66336, using a 2-week on, 2-week off schedule in patients with advanced solid tumors

article

Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single-dosing and multiple-dosing schedules.

artículo científico publicado en 1995

Phase I and pharmacologic study of high doses of the topoisomerase I inhibitor topotecan with granulocyte colony-stimulating factor in patients with solid tumors.

artículo científico publicado en 1996

Phase I and pharmacologic study of infusional topotecan and Carboplatin in relapsed and refractory acute leukemia

artículo científico publicado en 2005

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor ⬇️

artículo científico publicado el 1 de abril de 1992

Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias.

artículo científico publicado en 2012

Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma.

artículo científico publicado en 2010

Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer

artículo científico publicado en 2003

Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain

artículo científico publicado en 2001

Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm.

artículo científico publicado en 2012

Phosphorylated forms of activated caspases are present in cytosol from HL-60 cells during etoposide-induced apoptosis

artículo científico publicado en 1998

Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.

artículo científico publicado en 2014

Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

artículo científico publicado en 2016

Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.

artículo científico publicado en 2015

Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.

artículo científico publicado en 2011

Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression.

artículo científico publicado en 2014

Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical Outcomes

artículo científico publicado en 2017

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

artículo científico publicado en 2016

Programmed cell death: alive and well in the new millennium ⬇️

artículo científico publicado el 1 de diciembre de 2001

Prospects for the Use of ATR Inhibitors to Treat Cancer.

artículo científico publicado en 2010

Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.

artículo científico publicado en 2009

Proteolytic cleavage during chemotherapy-induced apoptosis

artículo científico publicado en 1996

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

artículo científico publicado en 2021

RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I

scientific article published on 01 April 1996

Rad9 protects cells from topoisomerase poison-induced cell death

artículo científico publicado en 2004

Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer

scientific article published on 10 December 2019

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2

artículo científico publicado en 2020

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

artículo científico publicado en 2020

Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling

artículo científico publicado en 2006

Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

artículo científico publicado en 2002

Resistance to topoisomerase II poisons: Is the answer in the promoter?

artículo científico publicado en 1997

Reutilization of Immunoblots after Chemiluminescent Detection

artículo científico publicado en 2001

Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

artículo científico publicado en 2018

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

artículo científico publicado en 2016

S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

artículo científico publicado en 2001

S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells.

artículo científico publicado en 2004

Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.

scientific article published on December 1996

Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

artículo científico publicado en 2012

Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.

artículo científico publicado en 2007

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

artículo científico publicado en 2006

Severe graft-versus-host disease in a liver-transplant recipient

artículo científico publicado en 1988

Simultaneous immunoelectron microscopic visualization of protein B23 and C23 distribution in the HeLa cell nucleolus

artículo científico publicado en 1989

Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma.

artículo científico publicado en 2016

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

artículo científico publicado en 1993

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

artículo científico publicado en 1995

Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads

artículo científico publicado en 2000

Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines.

artículo científico publicado en 2001

Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.

artículo científico publicado en 2016

Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo

artículo científico publicado en 2006

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

artículo científico publicado en 2002

TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer

artículo científico publicado en 2015

Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells

artículo científico publicado en 1996

The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer

artículo científico publicado en 2020

The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells.

artículo científico publicado en 2013

The current status of camptothecin analogues as antitumor agents

artículo científico publicado en 1993

The erasable Western blot

artículo científico publicado en 1987

The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

artículo científico publicado en 1996

The molecular origin and taxonomy of mucinous ovarian carcinoma

scientific article published on 02 September 2019

The relationship of the nuclear matrix to cellular structure and function ⬇️

artículo científico publicado el 1 de enero de 1978

The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

artículo científico publicado en 2005

The role of proteases during apoptosis.

artículo científico publicado en 1996

The saintly side of Smac/DIABLO: giving anticancer drug-induced apoptosis a boost

artículo científico publicado en 2003

Therapy‐related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy* ⬇️

artículo científico publicado el 17 de noviembre de 2011

Topoisomerase II and the response to antileukemic therapy

artículo científico publicado en 1998

Topoisomerase II as a target for anticancer chemotherapy

artículo científico publicado en 1995

Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

artículo científico publicado en 1994

Topoisomerase II levels during granulocytic maturation in vitro and in vivo

artículo científico publicado en 1991

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions

artículo científico publicado en 2019

Topoisomerases in human leukemia.

artículo científico publicado en 1994

Topotecan in combination chemotherapy.

artículo científico publicado en 1997

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

artículo científico publicado en 2011

Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.

artículo científico publicado en 1998

Tumorgrafts as in vivo surrogates for women with ovarian cancer.

artículo científico publicado en 2014

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

artículo científico publicado en 2018

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

scientific article published on 11 October 2019

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