Lista de obras - Jack W. Singer - Dominio Público Uruguay

A phase I and pharmacokinetic study of paclitaxel poliglumex and cisplatin in patients with advanced solid tumors

artículo científico publicado en 2008

An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome

artículo científico publicado en 1996

Anthracycline cardiotoxicity: clinical and pathologic outcomes assessed by radionuclide ejection fraction

artículo científico publicado en 1980

Antileukemic activity of lysophosphatidic acid acyltransferase-beta inhibitor CT32228 in chronic myelogenous leukemia sensitive and resistant to imatinib

artículo científico publicado en 2006

Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma

artículo científico publicado en 2003

Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high pre-therapy EVI1 expression.

artículo científico publicado en 2004

Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis

artículo científico publicado en 1987

Chronic lymphocytic leukaemia: Clonal origin in a committed B-lymphocyte progenitor ⬇️

artículo científico publicado el 26 de agosto de 1978

Chronic lymphocytosis with neutropenia: evidence for a novel, abnormal T-cell population associated with antibody-mediated neutrophil destruction

scientific article published on 01 April 1983

Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures

scientific article published on 27 September 2019

Comparison of pixantrone-based regimen (CPOP-R) with doxorubicin-based therapy (CHOP-R) for treatment of diffuse large B-cell lymphoma

artículo científico publicado en 2013

Correlation between cytogenetic and molecular findings in human chronic myelogenous leukemia lines EM-2 and EM-3.

artículo científico publicado en 1987

Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta

artículo científico publicado en 2005

Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man.

artículo científico publicado en 1982

Effect of GM-CSF on circulating granulocyte-monocyte progenitors in autologous bone marrow transplantation

artículo científico publicado en 1989

Evidence for a stem cell common to hematopoiesis and its in vitro microenvironment: studies of patients with clonal hematopoietic neoplasia

artículo científico publicado en 1984

Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis

artículo científico publicado en 2005

Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomas.

artículo científico publicado en 2005

Lisofylline suppresses ex vivo release by murine spleen cells of hematopoietic inhibitors induced by cancer chemotherapeutic agents

artículo científico publicado en 2000

Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is highly expressed in advanced ovarian cancer and is associated with aggressive histology and poor survival

scientific article published on 01 October 2006

Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.

artículo científico publicado en 2005

Non-small cell lung cancer: does estrogen affect outcome?

artículo científico publicado en 2007

Paclitaxel poliglumex (XYOTAX, CT-2103): a macromolecular taxane.

artículo científico publicado en 2005

Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxane.

artículo científico publicado en 2005

Phase I/II study of pixantrone in combination with cyclophosphamide, vincristine, and prednisone in patients with relapsed aggressive non-Hodgkin lymphoma

artículo científico publicado en 2011

Phase III trial comparing paclitaxel poliglumex (CT-2103, PPX) in combination with carboplatin versus standard paclitaxel and carboplatin in the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer.

artículo científico publicado en 2008

Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice.

artículo científico publicado en 1995

Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells

artículo científico publicado en 2004

Pixantrone dimaleate in combination with fludarabine, dexamethasone, and rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: phase 1 study with a dose-expansion cohort

scientific article published on 16 June 2011

Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial

artículo científico publicado en 2012

Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines

artículo científico publicado en 1996

Prevalence of clinically relevant bacteremia after upper gastrointestinal endoscopy in bone marrow transplant recipients

artículo científico publicado en 1990

Procoagulant inhibitory properties of paclitaxel poliglumex.

artículo científico publicado en 2010

Radiopharmaceutical reimbursement rates

scientific article published on 01 June 2008

Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer

artículo científico publicado en 2008

Responsiveness of the in vitro hematopoietic microenvironment to platelet-derived growth factor

artículo científico publicado en 1985

Single-agent versus combination chemotherapy in patients with advanced non-small cell lung cancer and a performance status of 2: prognostic factors and treatment selection based on two large randomized clinical trials

artículo científico publicado en 2009

Substrate specificity of lysophosphatidic acid acyltransferase beta -- evidence from membrane and whole cell assays

scientific article published on 20 December 2005

Synthesis and in vivo antitumor activity of poly(l-glutamic acid) conjugates of 20S-camptothecin

artículo científico publicado en 2003

Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta

artículo científico publicado en 2004

The Use of Genetic Markers in Studies of Myeloid Neoplasia

artículo científico publicado en 1990

The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients.

artículo científico publicado en 2012

The use of recombinant human granulocyte macrophage colony-stimulating factor in autologous and allogeneic bone marrow transplantation

artículo científico publicado en 1993

Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin

artículo científico publicado en 2014

Treatment of chronic granulocytic leukaemia in chronic phase by allogeneic marrow transplantation

artículo científico publicado en 1982

Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo

artículo científico publicado en 2001

rhGM-CSF after allogeneic bone marrow transplantation from unrelated donors: a pilot study of cyclosporine and prednisone as graft-versus-host disease prophylaxis

artículo científico publicado en 1993

Lista de obras de Jack W. Singer

A phase I and pharmacokinetic study of paclitaxel poliglumex and cisplatin in patients with advanced solid tumors

An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome

Anthracycline cardiotoxicity: clinical and pathologic outcomes assessed by radionuclide ejection fraction

Antileukemic activity of lysophosphatidic acid acyltransferase-beta inhibitor CT32228 in chronic myelogenous leukemia sensitive and resistant to imatinib

Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma

Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high pre-therapy EVI1 expression.

Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis

Chronic lymphocytic leukaemia: Clonal origin in a committed B-lymphocyte progenitor ⬇️

Chronic lymphocytosis with neutropenia: evidence for a novel, abnormal T-cell population associated with antibody-mediated neutrophil destruction

Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures

Comparison of pixantrone-based regimen (CPOP-R) with doxorubicin-based therapy (CHOP-R) for treatment of diffuse large B-cell lymphoma

Correlation between cytogenetic and molecular findings in human chronic myelogenous leukemia lines EM-2 and EM-3.

Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta

Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man.

Effect of GM-CSF on circulating granulocyte-monocyte progenitors in autologous bone marrow transplantation

Evidence for a stem cell common to hematopoiesis and its in vitro microenvironment: studies of patients with clonal hematopoietic neoplasia

Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis

Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomas.

Lisofylline suppresses ex vivo release by murine spleen cells of hematopoietic inhibitors induced by cancer chemotherapeutic agents

Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is highly expressed in advanced ovarian cancer and is associated with aggressive histology and poor survival

Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.

Non-small cell lung cancer: does estrogen affect outcome?

Paclitaxel poliglumex (XYOTAX, CT-2103): a macromolecular taxane.

Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxane.

Phase I/II study of pixantrone in combination with cyclophosphamide, vincristine, and prednisone in patients with relapsed aggressive non-Hodgkin lymphoma

Phase III trial comparing paclitaxel poliglumex (CT-2103, PPX) in combination with carboplatin versus standard paclitaxel and carboplatin in the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer.

Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice.

Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells

Pixantrone dimaleate in combination with fludarabine, dexamethasone, and rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: phase 1 study with a dose-expansion cohort

Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial

Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines

Prevalence of clinically relevant bacteremia after upper gastrointestinal endoscopy in bone marrow transplant recipients

Procoagulant inhibitory properties of paclitaxel poliglumex.

Radiopharmaceutical reimbursement rates

Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer

Responsiveness of the in vitro hematopoietic microenvironment to platelet-derived growth factor

Single-agent versus combination chemotherapy in patients with advanced non-small cell lung cancer and a performance status of 2: prognostic factors and treatment selection based on two large randomized clinical trials

Substrate specificity of lysophosphatidic acid acyltransferase beta -- evidence from membrane and whole cell assays

Synthesis and in vivo antitumor activity of poly(l-glutamic acid) conjugates of 20S-camptothecin

Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta

The Use of Genetic Markers in Studies of Myeloid Neoplasia

The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients.

The use of recombinant human granulocyte macrophage colony-stimulating factor in autologous and allogeneic bone marrow transplantation

Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin

Treatment of chronic granulocytic leukaemia in chronic phase by allogeneic marrow transplantation

Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo

rhGM-CSF after allogeneic bone marrow transplantation from unrelated donors: a pilot study of cyclosporine and prednisone as graft-versus-host disease prophylaxis