Lista de obras - María J. Vicent - Dominio Público Uruguay

A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury

artículo científico publicado en 2009

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells

artículo científico publicado en 2013

Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate

Biocompatibility Reduces Inflammation-Induced Apoptosis in Mesothelial Cells Exposed to Peritoneal Dialysis Fluid

artículo científico publicado en 2015

Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design

artículo científico publicado en 2017

Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression

artículo científico publicado en 2019

Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines

artículo científico publicado en 2009

Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery.

artículo científico publicado en 2016

Demonstrating the importance of polymer-conjugate conformation in solution on its therapeutic output: Diethylstilbestrol (DES)-polyacetals as prostate cancer treatment

artículo científico publicado en 2011

Design of Poly-l -Glutamate-Based Complexes for pDNA Delivery

artículo científico publicado en 2017

Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery

artículo científico publicado en 2017

Discovery of inhibitors of protein-protein interactions from combinatorial libraries

artículo científico publicado en 2007

Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities.

scientific article published on 11 December 2009

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

artículo científico publicado en 2019

Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate

scientific article published on 06 February 2020

Envisioning the future of polymer therapeutics for brain disorders

artículo científico publicado en 2018

Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

scientific article published in 2019

HIF-1α inhibition by diethylstilbestrol and its polyacetal conjugate in hypoxic prostate tumour cells: insights from NMR metabolomics.

artículo científico publicado en 2017

HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines

artículo científico publicado en 2005

Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats.

artículo científico publicado en 2017

Identification of miR-187 and miR-182 as biomarkers of early diagnosis and prognosis in patients with prostate cancer treated with radical prostatectomy.

artículo científico publicado en 2014

Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel

artículo científico publicado en 2011

Integrin-targeted nano-sized polymeric systems for paclitaxel conjugation: a comparative study.

artículo científico publicado en 2017

Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells

artículo científico publicado en 2006

Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models.

artículo científico publicado en 2018

MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer.

artículo científico publicado en 2015

Modulating angiogenesis with integrin-targeted nanomedicines.

artículo científico publicado en 2017

Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors

scientific journal article

Molecular platforms for targeted drug delivery

artículo científico publicado en 2019

Molecules that modulate Apaf-1 activity

artículo científico publicado en 2010

Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.

artículo científico publicado en 2009

Near-Infrared Activatable Phthalocyanine–Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy

artículo científico publicado en 2018

Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light-dark toxicity ratio toward an effective photodynamic cancer therapy.

artículo científico publicado en 2017

New CSPs based on peptidomimetics: efficient chiral selectors in enantioselective separations

New supported beta-amino alcohols as efficient catalysts for the enantioselective addition of diethylzinc to benzaldehyde under flow conditions.

artículo científico publicado en 2002

P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency

artículo científico publicado en 2012

Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.

artículo científico publicado en 2006

Polyacetal-Based Combination Therapy for the Treatment of Prostate Cancer

article

Polyacetal-stilbene conjugates — The first examples of polymer therapeutics for the inhibition of HIF-1 in the treatment of solid tumours

article

Polymer Therapeutics as Nano-Sized Medicines for Tissue Regeneration and Repair

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment.

artículo científico publicado en 2018

Polymer conjugates as therapeutics: future trends, challenges and opportunities

artículo científico publicado en 2008

Polymer masked-unmasked protein therapy. 1. Bioresponsive dextrin-trypsin and -melanocyte stimulating hormone conjugates designed for alpha-amylase activation

artículo científico publicado en 2008

Polymer therapeutics designed for a combination therapy of hormone-dependent cancer

artículo científico publicado en 2005

Polymer therapeutics: Clinical applications and challenges for development

article

Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease.

artículo científico publicado en 2014

Polymer-drug conjugates: current status and future trends

artículo científico publicado en 2008

Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer.

artículo científico publicado en 2005

Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges.

artículo científico publicado en 2016

Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis

scientific article published on 14 December 2019

Preclinical safety assessments of nano-sized constructs on cardiovascular system toxicity: A case for telemetry.

artículo científico publicado en 2017

Professor Ruth Duncan: a pioneer in the field of polymer therapeutics

artículo científico publicado en 2017

Reduction sensitive Poly(l-glutamic acid) (PGA)-protein conjugates designed for polymer masked-unmasked protein therapy

artículo científico publicado en 2014

Relevance of folic acid/polymer ratio in targeted PEG-epirubicin conjugates

artículo científico publicado en 2010

Relevant Physicochemical Descriptors of "Soft Nanomedicines" to Bypass Biological Barriers.

artículo científico

Smart branched polymer drug conjugates as nano-sized drug delivery systems

artículo científico

Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake

artículo científico publicado en 2010

Synthesis, Characterization and Preliminary Biological Evaluation of P(HPMA)-b-P(LLA) Copolymers: A New Type of Functional Biocompatible Block Copolymer

artículo científico publicado en 2010

Targeting a rare amyloidotic disease through rationally designed polymer conjugates.

artículo científico publicado en 2014

Total synthesis and preliminary biological evaluation of cis-solamin isomers

artículo científico publicado en 2004

Triblock Copolymer Nanovesicles for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer Cells.

artículo científico publicado en 2015

Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

artículo científico publicado en 2018

Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I.

artículo científico publicado en 2016

Using small-angle neutron scattering to study the solution conformation of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates

artículo científico publicado en 2007

Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications.

artículo científico publicado en 2015

pH-Responsive Polyacetal-Protein Conjugates Designed for Polymer Masked-Unmasked Protein Therapy (PUMPT).

artículo científico publicado en 2017

Lista de obras de María J. Vicent

A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells

Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate

Biocompatibility Reduces Inflammation-Induced Apoptosis in Mesothelial Cells Exposed to Peritoneal Dialysis Fluid

Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design

Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression

Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines

Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery.

Demonstrating the importance of polymer-conjugate conformation in solution on its therapeutic output: Diethylstilbestrol (DES)-polyacetals as prostate cancer treatment

Design of Poly-l -Glutamate-Based Complexes for pDNA Delivery

Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery

Discovery of inhibitors of protein-protein interactions from combinatorial libraries

Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities.

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate

Envisioning the future of polymer therapeutics for brain disorders

Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

HIF-1α inhibition by diethylstilbestrol and its polyacetal conjugate in hypoxic prostate tumour cells: insights from NMR metabolomics.

HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines

Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats.

Identification of miR-187 and miR-182 as biomarkers of early diagnosis and prognosis in patients with prostate cancer treated with radical prostatectomy.

Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel

Integrin-targeted nano-sized polymeric systems for paclitaxel conjugation: a comparative study.

Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells

Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models.

MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer.

Modulating angiogenesis with integrin-targeted nanomedicines.

Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors

Molecular platforms for targeted drug delivery

Molecules that modulate Apaf-1 activity

Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.

Near-Infrared Activatable Phthalocyanine–Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy

Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light-dark toxicity ratio toward an effective photodynamic cancer therapy.

New CSPs based on peptidomimetics: efficient chiral selectors in enantioselective separations

New supported beta-amino alcohols as efficient catalysts for the enantioselective addition of diethylzinc to benzaldehyde under flow conditions.

P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency

Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.

Polyacetal-Based Combination Therapy for the Treatment of Prostate Cancer

Polyacetal-stilbene conjugates — The first examples of polymer therapeutics for the inhibition of HIF-1 in the treatment of solid tumours

Polymer Therapeutics as Nano-Sized Medicines for Tissue Regeneration and Repair

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment.

Polymer conjugates as therapeutics: future trends, challenges and opportunities

Polymer masked-unmasked protein therapy. 1. Bioresponsive dextrin-trypsin and -melanocyte stimulating hormone conjugates designed for alpha-amylase activation

Polymer therapeutics designed for a combination therapy of hormone-dependent cancer

Polymer therapeutics: Clinical applications and challenges for development

Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease.

Polymer-drug conjugates: current status and future trends

Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer.

Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges.

Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis

Preclinical safety assessments of nano-sized constructs on cardiovascular system toxicity: A case for telemetry.

Professor Ruth Duncan: a pioneer in the field of polymer therapeutics

Reduction sensitive Poly(l-glutamic acid) (PGA)-protein conjugates designed for polymer masked-unmasked protein therapy

Relevance of folic acid/polymer ratio in targeted PEG-epirubicin conjugates

Relevant Physicochemical Descriptors of "Soft Nanomedicines" to Bypass Biological Barriers.

Smart branched polymer drug conjugates as nano-sized drug delivery systems

Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake

Synthesis, Characterization and Preliminary Biological Evaluation of P(HPMA)-b-P(LLA) Copolymers: A New Type of Functional Biocompatible Block Copolymer

Targeting a rare amyloidotic disease through rationally designed polymer conjugates.

Total synthesis and preliminary biological evaluation of cis-solamin isomers

Triblock Copolymer Nanovesicles for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer Cells.

Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I.

Using small-angle neutron scattering to study the solution conformation of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates

Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications.

pH-Responsive Polyacetal-Protein Conjugates Designed for Polymer Masked-Unmasked Protein Therapy (PUMPT).