Lista de obras - Claus J Loland - Dominio Público Uruguay

A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study

artículo científico publicado en 2015

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability

artículo científico publicado en 2018

A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter

artículo científico publicado en 2014

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins

artículo científico publicado en 2012

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

artículo científico publicado en 2012

Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation

artículo científico publicado en 2016

An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability

artículo científico publicado en 2018

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

artículo científico publicado en 2008

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability

scientific article published on 05 November 2018

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.

artículo científico publicado en 2016

Conformational dynamics of the human serotonin transporter during substrate and drug binding

artículo científico publicado en 2019

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site

artículo científico publicado en 1999

Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites

artículo científico publicado en 2001

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study

artículo científico publicado en 2017

Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation

artículo científico publicado en 2015

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.

artículo científico publicado en 2013

Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study

artículo científico publicado en 2020

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

artículo científico publicado en 2017

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues

artículo científico publicado en 2014

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

artículo científico publicado en 2001

Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

artículo científico publicado en 2003

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

artículo científico publicado en 2013

Grafted biomembranes containing membrane proteins--the case of the leucine transporter

artículo científico publicado en 2015

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies

artículo científico publicado en 2016

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

artículo científico publicado en 2003

Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length.

artículo científico publicado en 2016

Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study

artículo científico publicado en 2015

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

artículo científico publicado en 2010

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

artículo científico publicado en 2015

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.

artículo científico publicado en 2016

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

artículo científico publicado en 2014

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.

artículo científico publicado en 2002

Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

artículo científico publicado en 2021

Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

artículo científico publicado en 2020

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

artículo científico publicado en 2012

New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability

artículo científico publicado en 2020

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies

artículo científico publicado en 2017

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation

artículo científico publicado en 2015

Novel tripod amphiphiles for membrane protein analysis

artículo científico publicado en 2013

Probing dopamine transporter structure and function by Zn2+-site engineering ⬇️

artículo científico publicado el 31 de octubre de 2003

R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

artículo científico publicado en 2012

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

artículo científico publicado en 2018

Regulation of dopamine transporter trafficking by intracellular amphetamine

artículo científico publicado en 2006

Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors

artículo científico publicado en 2007

Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability.

artículo científico publicado en 2017

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

artículo científico publicado en 2005

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study

artículo científico publicado en 2019

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter ⬇️

artículo científico publicado el 24 de septiembre de 2012

Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability.

artículo científico publicado en 2018

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

scientific article published on 01 December 2000

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

artículo científico publicado en 2017

Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

scientific article published on 14 November 2019

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter

artículo científico

Substrate-induced conformational dynamics of the dopamine transporter.

artículo científico publicado en 2019

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

artículo científico publicado en 2015

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

artículo científico publicado en 2018

Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions.

artículo científico publicado en 2004

Tandem facial amphiphiles for membrane protein stabilization

artículo científico publicado en 2010

The Environment Shapes the Inner Vestibule of LeuT.

artículo científico publicado en 2016

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

artículo científico publicado en 2021

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

artículo científico publicado en 2010

The dopamine transporter antiports potassium to increase the uptake of dopamine

artículo científico publicado en 2022

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

artículo científico publicado en 2020

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters.

artículo científico publicado en 2014

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.

scientific article published on 28 September 2016

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

artículo científico publicado en 2019

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

artículo científico publicado en 2018

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

scientific article published on 21 February 2020

Lista de obras de Claus J Loland

A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability

A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation

An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.

Conformational dynamics of the human serotonin transporter during substrate and drug binding

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site

Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study

Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.

Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

Grafted biomembranes containing membrane proteins--the case of the leucine transporter

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length.

Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.

Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation

Novel tripod amphiphiles for membrane protein analysis

Probing dopamine transporter structure and function by Zn2+-site engineering ⬇️

R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

Regulation of dopamine transporter trafficking by intracellular amphetamine

Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors

Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability.

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter ⬇️

Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability.

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter

Substrate-induced conformational dynamics of the dopamine transporter.

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions.

Tandem facial amphiphiles for membrane protein stabilization

The Environment Shapes the Inner Vestibule of LeuT.

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

The dopamine transporter antiports potassium to increase the uptake of dopamine

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters.

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release