Lista de obras - Donald M O'Rourke - Dominio Público Uruguay

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

artículo científico publicado en 2017

Actinomycotic brain infection: registered diffusion, perfusion MR imaging and MR spectroscopy

artículo científico publicado en 2006

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells

artículo científico publicado en 2009

Anticancer effects of fenretinide in human medulloblastoma

artículo científico publicado en 2006

Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma

scientific article published on 19 June 2019

Arterial spin-labeling and MR spectroscopy in the differentiation of gliomas

artículo científico publicado en 2007

Assignment Confidence in Localization of the Hand Motor Cortex: Comparison of Structural Imaging With Functional MRI.

artículo científico publicado en 2016

Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy

artículo científico publicado en 2017

Automated tumor volumetry using computer-aided image segmentation

artículo científico publicado en 2015

Clinically silent somatotroph adenomas are common.

artículo científico publicado en 2011

Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells

artículo científico publicado en 1998

Diagnostic utility of diffusion tensor imaging in differentiating glioblastomas from brain metastases

artículo científico publicado en 2014

Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging.

artículo científico publicado en 2008

Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging

artículo científico publicado en 2011

Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy.

artículo científico publicado en 2013

Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells

artículo científico publicado en 2004

Domain-specific Interactions between the p185neuand Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

artículo científico publicado en 1999

Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.

artículo científico publicado en 2002

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

artículo científico publicado en 2018

Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells.

artículo científico publicado en 2005

Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression

artículo científico publicado en 2000

Factors associated with increased survival after surgical resection of glioblastoma in octogenarians

artículo científico publicado en 2015

Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity

artículo científico publicado en 2008

Go, no-go decision making for phase 3 clinical trials: ACT IV revisited - Authors' reply

artículo científico publicado en 2017

Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla

artículo científico publicado en 2005

Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma

scientific article published on 04 March 2020

IDH mutation impairs histone demethylation and results in a block to cell differentiation

artículo científico publicado en 2012

Identification of a 140 kDa protein of rat presynaptic terminal membranes encompassing the active zones

scientific article published on 01 November 1995

Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques.

artículo científico publicado en 2015

In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index.

artículo científico publicado en 2017

In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.

artículo científico publicado en 2018

Intraaxial brain masses: MR imaging-based diagnostic strategy--initial experience.

artículo científico publicado en 2007

Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases.

artículo científico publicado en 2015

Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes.

artículo científico publicado en 2014

Magnetic resonance perfusion-weighted imaging defines angiogenic subtypes of oligodendroglioma according to 1p19q and EGFR status

artículo científico publicado en 2009

Neural stem cell biology may be well suited for improving brain tumor therapies.

artículo científico publicado en 2003

Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases

artículo científico publicado en 2015

Pattern analysis of dynamic susceptibility contrast-enhanced MR imaging demonstrates peritumoral tissue heterogeneity

artículo científico publicado en 2014

Population-based MRI atlases of spatial distribution are specific to patient and tumor characteristics in glioblastoma.

artículo científico publicado en 2016

Posttreatment recurrence of malignant brain neoplasm: accuracy of relative cerebral blood volume fraction in discriminating low from high malignant histologic volume fraction

artículo científico publicado en 2009

Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging.

artículo científico publicado en 2007

Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics

artículo científico publicado en 2017

Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas.

artículo científico publicado en 2015

Proton magnetic resonance spectroscopy in differentiating glioblastomas from primary cerebral lymphomas and brain metastases.

artículo científico publicado en 2010

Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1.

artículo científico publicado en 2018

Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo

artículo científico publicado en 2000

Receptor tyrosine kinase signaling in gliomagenesis: pathobiology and therapeutic approaches.

artículo científico publicado en 2003

Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells

artículo científico publicado en 1997

Resident training in neurosurgical oncology: results of the survey of North American training programs by the AANS/CNS Section on Tumors

artículo científico publicado en 2006

Reversion of the ErbB malignant phenotype and the DNA damage response.

artículo científico publicado en 2012

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

artículo científico publicado en 2017

Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors.

artículo científico publicado en 2009

Role of proton magnetic resonance spectroscopy in differentiating oligodendrogliomas from astrocytomas.

artículo científico publicado en 2010

SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival

artículo científico publicado en 2004

SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.

artículo científico publicado en 2010

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

artículo científico publicado en 2004

Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma.

artículo científico publicado en 2015

Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes

artículo científico publicado en 1999

The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha.

artículo científico publicado en 2004

The application of 5-bromodeoxyuridine in the management of CNS tumors

artículo científico publicado en 1994

The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells.

artículo científico publicado en 2009

The role of distinct p185neu extracellular subdomains for dimerization with the epidermal growth factor (EGF) receptor and EGF-mediated signaling.

artículo científico publicado en 2001

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

artículo científico publicado en 2001

Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.

artículo científico publicado en 1997

Transcriptional regulation of signal regulatory protein alpha1 inhibitory receptors by epidermal growth factor receptor signaling

artículo científico publicado en 2004

Treatment of steroid refractory, Gamma Knife related radiation necrosis with bevacizumab: Case report and review of the literature ⬇️

artículo científico publicado el 8 de septiembre de 2011

Use of magnetic perfusion-weighted imaging to determine epidermal growth factor receptor variant III expression in glioblastoma ⬇️

artículo científico publicado el 4 de abril de 2012

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

artículo científico publicado en 2020

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

artículo científico publicado en 2016

Lista de obras de Donald M O'Rourke

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

Actinomycotic brain infection: registered diffusion, perfusion MR imaging and MR spectroscopy

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells

Anticancer effects of fenretinide in human medulloblastoma

Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma

Arterial spin-labeling and MR spectroscopy in the differentiation of gliomas

Assignment Confidence in Localization of the Hand Motor Cortex: Comparison of Structural Imaging With Functional MRI.

Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy

Automated tumor volumetry using computer-aided image segmentation

Clinically silent somatotroph adenomas are common.

Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells

Diagnostic utility of diffusion tensor imaging in differentiating glioblastomas from brain metastases

Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging.

Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging

Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy.

Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells

Domain-specific Interactions between the p185neuand Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells.

Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression

Factors associated with increased survival after surgical resection of glioblastoma in octogenarians

Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity

Go, no-go decision making for phase 3 clinical trials: ACT IV revisited - Authors' reply

Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla

Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Identification of a 140 kDa protein of rat presynaptic terminal membranes encompassing the active zones

Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques.

In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index.

In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.

Intraaxial brain masses: MR imaging-based diagnostic strategy--initial experience.

Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases.

Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes.

Magnetic resonance perfusion-weighted imaging defines angiogenic subtypes of oligodendroglioma according to 1p19q and EGFR status

Neural stem cell biology may be well suited for improving brain tumor therapies.

Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases

Pattern analysis of dynamic susceptibility contrast-enhanced MR imaging demonstrates peritumoral tissue heterogeneity

Population-based MRI atlases of spatial distribution are specific to patient and tumor characteristics in glioblastoma.

Posttreatment recurrence of malignant brain neoplasm: accuracy of relative cerebral blood volume fraction in discriminating low from high malignant histologic volume fraction

Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging.

Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics

Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas.

Proton magnetic resonance spectroscopy in differentiating glioblastomas from primary cerebral lymphomas and brain metastases.

Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1.

Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo

Receptor tyrosine kinase signaling in gliomagenesis: pathobiology and therapeutic approaches.

Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells

Resident training in neurosurgical oncology: results of the survey of North American training programs by the AANS/CNS Section on Tumors

Reversion of the ErbB malignant phenotype and the DNA damage response.

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors.

Role of proton magnetic resonance spectroscopy in differentiating oligodendrogliomas from astrocytomas.

SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival

SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma.

Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes

The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha.

The application of 5-bromodeoxyuridine in the management of CNS tumors

The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells.

The role of distinct p185neu extracellular subdomains for dimerization with the epidermal growth factor (EGF) receptor and EGF-mediated signaling.

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.

Transcriptional regulation of signal regulatory protein alpha1 inhibitory receptors by epidermal growth factor receptor signaling

Treatment of steroid refractory, Gamma Knife related radiation necrosis with bevacizumab: Case report and review of the literature ⬇️

Use of magnetic perfusion-weighted imaging to determine epidermal growth factor receptor variant III expression in glioblastoma ⬇️

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma