Lista de obras - Michelle L Halls - Dominio Público Uruguay

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

artículo científico publicado en 2012

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

artículo científico publicado en 2021

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

artículo científico publicado en 2012

Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes

artículo científico publicado en 2006

Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation ⬇️

artículo científico publicado el 1 de marzo de 2012

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

artículo científico publicado en 2012

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

artículo científico publicado en 2020

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

artículo científico publicado en 2017

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

artículo científico publicado en 2014

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

artículo científico publicado en 2015

Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors

artículo científico publicado en 2005

Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse β3-Adrenoceptor ⬇️

artículo científico publicado el 25 de abril de 2012

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.

artículo científico publicado en 2015

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

artículo científico publicado en 2009

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

artículo científico publicado en 2019

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

scientific article published on 31 March 2020

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

artículo científico publicado en 2005

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

scientific article published on 17 July 2018

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

artículo científico publicado en 2017

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

article published in the Proceedings of the National Academy of Sciences of the United States of America

RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail.

artículo científico publicado en 2009

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases ⬇️

artículo científico publicado el 1 de enero de 2011

Relaxin activates multiple cAMP signaling pathway profiles in different target cells

artículo científico publicado en 2009

Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

artículo científico publicado en 2008

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms

artículo científico publicado en 2006

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways

artículo científico publicado en 2007

Relaxin family peptide receptors--from orphans to therapeutic targets.

artículo científico publicado en 2008

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

scientific journal article

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3.

artículo científico publicado en 2009

Signal switching after stimulation of LGR7 receptors by human relaxin 2

artículo científico publicado en 2005

Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes

artículo científico publicado en 2005

Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

scientific article published on 05 April 2019

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

artículo científico publicado en 2010

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells

artículo científico publicado en 2015

Lista de obras de Michelle L Halls

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes

Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation ⬇️

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors

Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse β3-Adrenoceptor ⬇️

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail.

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases ⬇️

Relaxin activates multiple cAMP signaling pathway profiles in different target cells

Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways

Relaxin family peptide receptors--from orphans to therapeutic targets.

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3.

Signal switching after stimulation of LGR7 receptors by human relaxin 2

Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes

Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells