Lista de obras - Manuel Medarde - Dominio Público Uruguay

A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species

artículo científico publicado en 2001

A new family of quinoline and quinoxaline analogues of combretastatins.

artículo científico publicado en 2004

Anti-HIV activity of some synthetic lignanolides and intermediates.

artículo científico publicado en 2004

Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers

scientific article published on 01 February 2000

Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

scientific article published on 25 October 2018

Biosynthesis of podophyllotoxin in Linum album cell cultures.

artículo científico publicado en 2002

Conformationally restricted macrocyclic analogues of combretastatins

artículo científico publicado en 2007

Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization

artículo científico publicado en 2008

Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes

artículo científico publicado en 2000

Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.

artículo científico publicado en 2013

Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins

artículo científico publicado en 2009

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.

artículo científico publicado en 2015

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

artículo científico publicado en 2005

Heterolignanolides: antitumor activity of furyl-, thienyl-, and pyridyl analogs of lignanolides

artículo científico publicado en 1995

Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions.

artículo científico publicado en 2006

Inotropic activity of hydroindene amidinohydrazones.

artículo científico publicado en 2002

Intrinsically fluorescent cytotoxic cisplatin analogues as DNA marker molecules.

artículo científico publicado en 2005

Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

artículo científico publicado en 2009

Leishmanicidal activity of combretastatin analogues and heteroanalogues

artículo científico publicado en 1999

N-substituted pyrrolinones from enamines and α-dicarbonyls

Naphthalene analogues of lignans

artículo científico publicado en 2003

Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.

artículo científico publicado en 2008

New naphthylcombretastatins. Modifications on the ethylene bridge.

artículo científico publicado en 2005

New para–para Stilbenophanes: Synthesis by McMurry Coupling, Conformational Analysis and Inhibition of Tubulin Polymerisation ⬇️

artículo científico publicado el 23 de febrero de 2011

Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases

artículo científico publicado en 2006

Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.

artículo científico publicado en 2007

Open analogues of arcyriaflavin A. Synthesis through Diels-Alder reaction between maleimides and 1-aryl-3-tert-butyldimethylsiloxy-1, 3-butadienes

scientific article published on 01 June 2000

Physiological characteristics of allo-cholic acid

artículo científico publicado en 2003

Pyridine Based Antitumour Compounds Acting at the Colchicine Site.

artículo científico publicado en 2016

Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.

artículo científico publicado en 2006

Sesquiterpene Lactones from Leucanthemopsis pectinata

artículo científico publicado en 1988

Structural characterization, kinetic studies, and in vitro biological activity of new cis-diamminebis-cholylglycinate(O,O') Pt(II) and cis-diamminebis-ursodeoxycholate(O,O') Pt(II) complexes.

artículo científico publicado en 2000

Synthesis and Characterization of the New Cytostatic Complexcis-Diammineplatinum(II)−Chlorocholylglycinate

artículo científico publicado en 1997

Synthesis and biological activity of bromolignans and cyclolignans

scientific article published on 01 July 1993

Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins

artículo científico publicado en 2007

Synthesis and cytotoxic activities of analogues of thuriferic acid

artículo científico publicado en 2002

Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues

artículo científico publicado en 2003

Synthesis and inotropic activity of hydroindene derivatives

scientific article published on 01 December 1999

Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins

scientific article published on 01 August 1999

Synthesis of Enantiopure 2,3,8,8a- Tetrahydro-7H-oxazolo[3,2-a]pyridine Derivatives†

artículo científico publicado en 1996

Synthesis, antitumoral and antiviral evaluation of halo- and demethyl-yatein derivatives

artículo científico publicado en 1995

Trypanosoma cruzi: Inhibition of Parasite Growth and Respiration by Oxazolo(thiazolo)pyridine Derivatives and Its Relationship to Redox Potential and Lipophilicity

scientific article published on 01 September 2001

p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition

artículo científico publicado en 2014

Lista de obras de Manuel Medarde

A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species

A new family of quinoline and quinoxaline analogues of combretastatins.

Anti-HIV activity of some synthetic lignanolides and intermediates.

Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers

Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

Biosynthesis of podophyllotoxin in Linum album cell cultures.

Conformationally restricted macrocyclic analogues of combretastatins

Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization

Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes

Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.

Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

Heterolignanolides: antitumor activity of furyl-, thienyl-, and pyridyl analogs of lignanolides

Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions.

Inotropic activity of hydroindene amidinohydrazones.

Intrinsically fluorescent cytotoxic cisplatin analogues as DNA marker molecules.

Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

Leishmanicidal activity of combretastatin analogues and heteroanalogues

N-substituted pyrrolinones from enamines and α-dicarbonyls

Naphthalene analogues of lignans

Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.

New naphthylcombretastatins. Modifications on the ethylene bridge.

New para–para Stilbenophanes: Synthesis by McMurry Coupling, Conformational Analysis and Inhibition of Tubulin Polymerisation ⬇️

Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases

Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.

Open analogues of arcyriaflavin A. Synthesis through Diels-Alder reaction between maleimides and 1-aryl-3-tert-butyldimethylsiloxy-1, 3-butadienes

Physiological characteristics of allo-cholic acid

Pyridine Based Antitumour Compounds Acting at the Colchicine Site.

Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.

Sesquiterpene Lactones from Leucanthemopsis pectinata

Structural characterization, kinetic studies, and in vitro biological activity of new cis-diamminebis-cholylglycinate(O,O') Pt(II) and cis-diamminebis-ursodeoxycholate(O,O') Pt(II) complexes.

Synthesis and Characterization of the New Cytostatic Complexcis-Diammineplatinum(II)−Chlorocholylglycinate

Synthesis and biological activity of bromolignans and cyclolignans

Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins

Synthesis and cytotoxic activities of analogues of thuriferic acid

Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues

Synthesis and inotropic activity of hydroindene derivatives

Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins

Synthesis of Enantiopure 2,3,8,8a- Tetrahydro-7H-oxazolo[3,2-a]pyridine Derivatives†

Synthesis, antitumoral and antiviral evaluation of halo- and demethyl-yatein derivatives

Trypanosoma cruzi: Inhibition of Parasite Growth and Respiration by Oxazolo(thiazolo)pyridine Derivatives and Its Relationship to Redox Potential and Lipophilicity

p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition