Lista de obras - Ingo Ott - Dominio Público Uruguay

5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells

artículo científico publicado en 2007

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

artículo científico publicado en 2014

A chemical-biological evaluation of rhodium(I) N-heterocyclic carbene complexes as prospective anticancer drugs.

artículo científico publicado en 2013

A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand

artículo científico publicado en 2013

A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.

artículo científico publicado en 2009

A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs

artículo científico publicado en 2019

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

artículo científico publicado en 2016

A ruthenocene-PNA bioconjugate--synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake.

artículo científico publicado en 2012

AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

artículo científico publicado en 2015

Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics

artículo científico publicado en 2013

Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones.

artículo científico publicado en 2015

Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo

artículo científico publicado en 2014

Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes

artículo científico publicado en 2011

Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug action

artículo científico publicado en 2005

Atomic absorption spectrometric determination of the iridium content in tumor cells exposed to an iridium metallodrug

artículo científico publicado en 2008

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

artículo científico publicado en 2010

Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability

scientific article published on 27 June 2017

Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins

artículo científico publicado en 2012

Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl‐Substituted Phenanthroline Ligands ⬇️

artículo científico publicado el 17 de febrero de 2011

Cellular Uptake Quantification of Metalated Peptide and Peptide Nucleic Acid Bioconjugates by Atomic Absorption Spectroscopy

artículo científico publicado en 2008

Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation

artículo científico publicado en 2009

Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes.

artículo científico publicado en 2016

Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.

artículo científico publicado en 2009

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

artículo científico publicado en 2011

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

artículo científico publicado en 2018

Cytotoxic gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors

artículo científico publicado en 2014

Cytotoxic rhodium(III) and iridium(III) polypyridyl complexes: structure-activity relationships, antileukemic activity, and apoptosis induction.

artículo científico publicado en 2009

Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands ⬇️

artículo científico publicado el 14 de marzo de 2012

DNA Intercalating RuIIPolypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

scientific article published on 11 September 2014

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

artículo científico publicado en 2014

Development of a method for the quantification of the molar gold concentration in tumour cells exposed to gold-containing drugs

artículo científico publicado en 2007

Development of cobalt(3,4-diarylsalen) complexes as tumor therapeutics

artículo científico publicado en 2004

Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: synthesis, cytotoxicity and DNA binding.

artículo científico publicado en 2009

Effects of Metal Salophene and Saldach Complexes on Lymphoma and Leukemia Cells ⬇️

artículo científico publicado el 14 de enero de 2011

Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

artículo científico publicado en 2012

Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity ⬇️

artículo científico publicado el 23 de septiembre de 2012

Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs.

artículo científico publicado en 2016

Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophenylnaphthalimides: results of a comparative pilot study.

artículo científico publicado en 2011

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

artículo científico publicado en 2018

From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents

scientific article published on 08 November 2018

From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

artículo científico publicado en 2011

Gold Organometallics with Biological Properties

Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators

artículo científico publicado en 2014

Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.

artículo científico publicado en 2016

Gold(I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents

artículo científico publicado en 2015

Gold(i) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition ⬇️

artículo científico publicado el 9 de agosto de 2011

Highly Electrophilic, Catalytically Active and Redox-Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes.

artículo científico publicado en 2017

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

artículo científico publicado en 2011

Historical and biochemical aspects of a seventeenth century gold-based aurum vitae recipe

artículo científico publicado en 2014

Insights on the mechanism of thioredoxin reductase inhibition by gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation

artículo científico publicado en 2014

Investigations on the effects of cobalt-alkyne complexes on leukemia and lymphoma cells: cytotoxicity and cellular uptake

artículo científico publicado en 2004

Labile Pd-sulphur and Pt-sulphur bonds in organometallic palladium and platinum complexes [(COD)M(alkyl)(S-ligand)]n+-A speciation study.

artículo científico publicado en 2016

Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity

artículo científico publicado en 2014

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents.

artículo científico publicado en 2016

Metal complexes as protein kinase inhibitors.

artículo científico publicado en 2010

Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone: cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase

artículo científico publicado en 2014

Metallo-nucleosides: synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2'-deoxyuridines.

artículo científico publicado en 2007

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid ⬇️

artículo científico publicado el 11 de diciembre de 2012

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors.

artículo científico publicado en 2018

N-Heterocyclic carbene metal complexes in medicinal chemistry

artículo científico publicado en 2012

Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs.

artículo científico publicado en 2009

New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide

artículo científico publicado en 2008

On the biological properties of alkynyl phosphine gold(I) complexes.

artículo científico publicado en 2012

Organometallic anticancer compounds

artículo científico publicado en 2010

Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells

artículo científico publicado en 2014

Phosphine-bridged dinuclear gold(I) alkynyl complexes: Thioredoxin reductase inhibition and cytotoxicity

Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex

artículo científico publicado en 2008

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes

scientific article published on 19 February 2020

Preclinical and clinical studies on the use of platinum complexes for breast cancer treatment.

artículo científico publicado en 2007

Protease-activatable organometal-Peptide bioconjugates with enhanced cytotoxicity on cancer cells

artículo científico publicado en 2010

Special qualities of inorganic cytostatics. Medicinal chemistry of platinum complexes

artículo científico publicado en 2006

Stability, protein binding and thiol interaction studies on [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt

artículo científico publicado en 2005

Structure-activity relationships and DNA binding properties of apoptosis inducing cytotoxic rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS(3).

artículo científico publicado en 2009

Substituted pyridazino[3,4-b][1,5]benzoxazepin-5(6H)ones as multidrug-resistance modulating agents

artículo científico publicado en 2004

Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells.

artículo científico publicado en 2008

Surfactant protein B labelled with [99mTc(CO)3(H2O)3]+ retains biological activity in vitro

artículo científico publicado en 2001

Synthesis and Biological Activities of Transition Metal Complexes Based on Acetylsalicylic Acid as Neo-Anticancer Agents ⬇️

artículo científico publicado el 14 de octubre de 2010

Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes

artículo científico publicado en 2018

Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.

artículo científico publicado en 2006

Synthesis and biological evaluation of chromium bioorganometallics based on the antibiotic platensimycin lead structure

artículo científico publicado en 2009

Synthesis, cellular uptake and structure-activity relationships for potent cytotoxic trichloridoiridium(III) polypyridyl complexes.

artículo científico publicado en 2008

Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals.

artículo científico publicado en 2017

The antioxidant 2,6-di-tert-butylphenol moiety attenuates the pro-oxidant properties of the auranofin analogue

artículo científico publicado en 2018

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

artículo científico publicado en 2014

Total reflection X-ray fluorescence spectrometry as a tool for the quantification of gold and platinum metallodrugs: determination of recovery rates and precision in the ppb concentration range

scientific article published on 25 July 2012

Tuning the electronic properties of dppz-ligands and their palladium(II) complexes.

artículo científico publicado en 2010

[Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents.

artículo científico publicado en 2010

[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties

artículo científico publicado en 2009

Lista de obras de Ingo Ott

5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

A chemical-biological evaluation of rhodium(I) N-heterocyclic carbene complexes as prospective anticancer drugs.

A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand

A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.

A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

A ruthenocene-PNA bioconjugate--synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake.

AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics

Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones.

Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo

Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes

Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug action

Atomic absorption spectrometric determination of the iridium content in tumor cells exposed to an iridium metallodrug

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability

Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins

Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl‐Substituted Phenanthroline Ligands ⬇️

Cellular Uptake Quantification of Metalated Peptide and Peptide Nucleic Acid Bioconjugates by Atomic Absorption Spectroscopy

Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation

Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes.

Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

Cytotoxic gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors

Cytotoxic rhodium(III) and iridium(III) polypyridyl complexes: structure-activity relationships, antileukemic activity, and apoptosis induction.

Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands ⬇️

DNA Intercalating RuIIPolypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

Development of a method for the quantification of the molar gold concentration in tumour cells exposed to gold-containing drugs

Development of cobalt(3,4-diarylsalen) complexes as tumor therapeutics

Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: synthesis, cytotoxicity and DNA binding.

Effects of Metal Salophene and Saldach Complexes on Lymphoma and Leukemia Cells ⬇️

Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity ⬇️

Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs.

Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophenylnaphthalimides: results of a comparative pilot study.

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents

From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

Gold Organometallics with Biological Properties

Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators

Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.

Gold(I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents

Gold(i) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition ⬇️

Highly Electrophilic, Catalytically Active and Redox-Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes.

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

Historical and biochemical aspects of a seventeenth century gold-based aurum vitae recipe

Insights on the mechanism of thioredoxin reductase inhibition by gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation

Investigations on the effects of cobalt-alkyne complexes on leukemia and lymphoma cells: cytotoxicity and cellular uptake

Labile Pd-sulphur and Pt-sulphur bonds in organometallic palladium and platinum complexes [(COD)M(alkyl)(S-ligand)]n+-A speciation study.

Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents.

Metal complexes as protein kinase inhibitors.

Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone: cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase

Metallo-nucleosides: synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2'-deoxyuridines.

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid ⬇️

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors.

N-Heterocyclic carbene metal complexes in medicinal chemistry

Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs.

New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide

On the biological properties of alkynyl phosphine gold(I) complexes.

Organometallic anticancer compounds

Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells

Phosphine-bridged dinuclear gold(I) alkynyl complexes: Thioredoxin reductase inhibition and cytotoxicity

Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes

Preclinical and clinical studies on the use of platinum complexes for breast cancer treatment.

Protease-activatable organometal-Peptide bioconjugates with enhanced cytotoxicity on cancer cells

Special qualities of inorganic cytostatics. Medicinal chemistry of platinum complexes

Stability, protein binding and thiol interaction studies on [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt

Structure-activity relationships and DNA binding properties of apoptosis inducing cytotoxic rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS(3).

Substituted pyridazino[3,4-b][1,5]benzoxazepin-5(6H)ones as multidrug-resistance modulating agents

Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells.

Surfactant protein B labelled with [99mTc(CO)3(H2O)3]+ retains biological activity in vitro

Synthesis and Biological Activities of Transition Metal Complexes Based on Acetylsalicylic Acid as Neo-Anticancer Agents ⬇️

Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes