Lista de obras - Ana Perez-Castillo - Dominio Público Uruguay

15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest.

artículo científico publicado en 2009

15-deoxy-Delta-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism

artículo científico publicado en 2004

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

artículo científico publicado en 2015

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

artículo científico publicado en 2012

Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.

artículo científico publicado en 2009

CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease

artículo científico publicado en 2017

CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury

artículo científico publicado en 2008

CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor.

artículo científico publicado en 2015

CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells

scientific journal article

Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.

scientific article published on 21 October 2016

Control by thyroid hormone of NGFI-A gene expression in lung: regulation of NGFI-A promoter activity

artículo científico publicado en 1998

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

artículo científico publicado en 2014

Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells

artículo científico publicado en 2010

Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat.

artículo científico publicado en 2010

Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning.

artículo científico publicado en 2012

Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain.

artículo científico publicado en 1994

Effect of perinatal hypothyroidism on the developmental regulation of rat pituitary growth hormone and thyrotropin genes

artículo científico publicado en 1995

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

artículo científico publicado en 2012

Effects of neonatal hypothyroidism on rat brain gene expression

artículo científico publicado en 1991

Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line

artículo científico publicado en 2003

Evidence of glucagon biosynthesis involving protein intermediates in rat salivary glands

artículo científico publicado en 1984

Familial reciprocal translocation t(1;4)(q31;p15) traced through five generations

artículo científico publicado en 1985

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

artículo científico publicado en 2012

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

artículo científico publicado en 2012

Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats.

artículo científico publicado en 2009

Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism

artículo científico publicado en 2008

Infertility associated with two accessory bisatellited chromosomes

artículo científico publicado en 1986

Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8

artículo científico publicado en 2010

Interaction of Dietary Carbohydrate and Glucagon in Regulation of Rat Hepatic Messenger Ribonucleic Acid S14 Expression: Role of Circadian Factors and 3′,5′-Cyclic Adenosine Monophosphate

artículo científico publicado en 1987

Is a gene for microcephaly located on chromosome 1?

artículo científico publicado en 1984

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

artículo científico publicado en 2012

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

artículo científico publicado en 2014

Multiple regulation of S14 gene expression during brown fat differentiation

artículo científico publicado en 1993

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

artículo científico publicado en 2014

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

artículo científico publicado en 2020

NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders

artículo científico publicado en 2007

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

artículo científico publicado en 2015

Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development.

artículo científico publicado en 1997

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

artículo científico publicado en 2011

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

artículo científico publicado en 2016

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

artículo científico publicado en 2019

New insights into the effects of extra nucleolus organizer regions

artículo científico publicado en 1986

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

artículo científico publicado en 2014

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

artículo científico publicado en 2016

Normal level of thyroglobulin messenger ribonucleic acid in a human congenital goiter with thyroglobulin deficiency

artículo científico publicado en 1986

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

artículo científico publicado en 2015

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

artículo científico publicado en 2015

Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo

scientific article published on 01 February 2011

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

artículo científico

Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease

scientific article published on 31 August 2019

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

artículo científico publicado en 2015

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

artículo científico publicado en 2011

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

artículo científico publicado en 2016

Regulation by Thyroid Hormone and Retinoic Acid of the CCAAT/Enhancer Binding Protein α and β Genes during Liver Development

artículo científico publicado en 1997

Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation

artículo científico publicado en 2005

Role of C/EBPβ transcription factor in adult hippocampal neurogenesis

artículo científico publicado en 2011

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

artículo científico publicado en 2014

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

artículo científico

Synthesis and release of glucagon by human salivary glands

artículo científico publicado en 1980

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

artículo científico publicado en 2009

The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice.

artículo científico publicado en 2016

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

artículo científico publicado en 2017

The early ontogenesis of thyroid hormone receptor in the rat fetus

artículo científico publicado en 1985

The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action

artículo científico publicado en 2005

The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells.

artículo científico publicado en 2005

Thyroid hormone controls the expression of insulin-like growth factor I receptor gene at different levels in lung and heart of developing and adult rats

scientific article published on 01 March 1997

Thyroid hormone regulates Galphai1 gene expression in the rat cerebellar cortex during post-natal development.

artículo científico publicado en 2005

Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats.

artículo científico publicado en 2001

Lista de obras de Ana Perez-Castillo

15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest.

15-deoxy-Delta-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.

CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease

CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury

CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor.

CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells

Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.

Control by thyroid hormone of NGFI-A gene expression in lung: regulation of NGFI-A promoter activity

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells

Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat.

Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning.

Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain.

Effect of perinatal hypothyroidism on the developmental regulation of rat pituitary growth hormone and thyrotropin genes

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

Effects of neonatal hypothyroidism on rat brain gene expression

Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line

Evidence of glucagon biosynthesis involving protein intermediates in rat salivary glands

Familial reciprocal translocation t(1;4)(q31;p15) traced through five generations

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats.

Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism

Infertility associated with two accessory bisatellited chromosomes

Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8

Interaction of Dietary Carbohydrate and Glucagon in Regulation of Rat Hepatic Messenger Ribonucleic Acid S14 Expression: Role of Circadian Factors and 3′,5′-Cyclic Adenosine Monophosphate

Is a gene for microcephaly located on chromosome 1?

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

Multiple regulation of S14 gene expression during brown fat differentiation

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development.

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

New insights into the effects of extra nucleolus organizer regions

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

Normal level of thyroglobulin messenger ribonucleic acid in a human congenital goiter with thyroglobulin deficiency

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

Regulation by Thyroid Hormone and Retinoic Acid of the CCAAT/Enhancer Binding Protein α and β Genes during Liver Development

Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation

Role of C/EBPβ transcription factor in adult hippocampal neurogenesis

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

Synthesis and release of glucagon by human salivary glands

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice.

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

The early ontogenesis of thyroid hormone receptor in the rat fetus

The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action

The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells.

Thyroid hormone controls the expression of insulin-like growth factor I receptor gene at different levels in lung and heart of developing and adult rats

Thyroid hormone regulates Galphai1 gene expression in the rat cerebellar cortex during post-natal development.

Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats.