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Lista de obras de Brian A. Walker

A Rapid and Robust Protocol for Reduced Representation Bisulfite Sequencing in Multiple Myeloma

artículo científico publicado en 2018

A TC classification-based predictor for multiple myeloma using multiplexed real-time quantitative PCR.

artículo científico publicado en 2013

A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value

artículo científico publicado en 2010

A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue.

artículo científico publicado en 2014

A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment.

artículo científico publicado en 2011

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms

artículo científico publicado en 2004

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis

artículo científico publicado en 2019

A modified method for whole exome resequencing from minimal amounts of starting DNA

artículo científico publicado en 2012

A molecular diagnostic approach able to detect the recurrent genetic prognostic factors typical of presenting myeloma

artículo científico publicado en 2014

A multiple myeloma classification system that associates normal B-cell subset phenotypes with prognosis

scientific article published on 01 September 2018

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex

artículo científico publicado en 2014

A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial.

artículo científico publicado en 2011

A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations

scientific article published on 19 September 2019

APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma ⬇️

artículo científico publicado en 2015

Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma

artículo científico publicado en 2010

Aminopeptidase inhibition as a targeted treatment strategy in myeloma.

artículo científico publicado en 2009

An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome

scientific article published on 09 August 2019

Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach.

artículo científico publicado en 2017

BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma

scientific article published on 27 January 2020

Bi-allelic inactivation is more prevalent at relapse in multiple myeloma, identifying RB1 as an independent prognostic marker

scientific article published on 24 February 2017

Biology and treatment of myeloma

artículo científico

Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials

artículo científico publicado en 2020

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

artículo científico publicado en 2014

Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors

artículo científico publicado en 2014

Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells.

artículo científico publicado en 2013

Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism

artículo científico publicado en 2005

Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients

scientific article published on 07 February 2019

Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma.

artículo científico publicado en 2016

Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations

artículo científico publicado en 2014

Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma.

artículo científico publicado en 2018

Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

scientific journal article

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

scientific journal article

Comprehensive translocation and clonality detection in lymphoproliferative disorders by next-generation sequencing

artículo científico publicado en 2016

Correction to: A Rapid and Robust Protocol for Reduced Representation Bisulfite Sequencing in Multiple Myeloma

artículo científico publicado en 2018

Could DNA methylation become a useful measure for multiple myeloma prognoses?

artículo científico publicado en 2011

Daratumumab and dexamethasone is safe and effective for triple refractory myeloma patients: final results of the IFM 2014-04 (Etoile du Nord) trial

scientific article published on 19 June 2019

Deletions of CDKN2C in multiple myeloma: biological and clinical implications

artículo científico publicado en 2008

Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours

artículo científico publicado en 2017

Draft Genome Sequences of 48 Vancomycin-Resistant Enterococcus faecium Strains Isolated from Inpatients with Bacteremia and Urinary Tract Infection

artículo científico publicado en 2019

Gender disparities in the tumor genetics and clinical outcome of multiple myeloma

artículo científico publicado en 2011

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

article

Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma.

artículo científico publicado en 2011

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma ⬇️

artículo científico publicado en 2016

Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance

artículo científico publicado en 2016

Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns

scientific article published on 19 June 2020

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma.

artículo científico publicado en 2013

High expression levels of the mammalian target of rapamycin inhibitor DEPTOR are predictive of response to thalidomide in myeloma.

artículo científico publicado en 2010

High-resolution genomic profiling in hairy cell leukemia-variant compared with typical hairy cell leukemia

artículo científico publicado en 2011

Identification of a novel t(7;14) translocation in multiple myeloma resulting in overexpression of EGFR.

artículo científico publicado en 2013

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

scientific article published in Nature Communications

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

scientific article published on 08 June 2018

Impact of genes highly correlated with MMSET myeloma on the survival of non-MMSET myeloma patients

artículo científico publicado en 2016

Improved risk stratification in myeloma using a microRNA-based classifier.

artículo científico publicado en 2013

Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance

artículo científico publicado en 2019

Inherited genetic susceptibility to monoclonal gammopathy of unknown significance

artículo científico publicado en 2014

Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma

artículo científico publicado en 2006

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma.

artículo científico publicado en 2012

Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms

scientific article published on 02 July 2013

Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma

artículo científico publicado en 2021

Investigating the feasibility of tumour molecular profiling in gastrointestinal malignancies in routine clinical practice

artículo científico publicado en 2018

Kinase domain activation through gene rearrangement in multiple myeloma.

artículo científico publicado en 2018

Knick-knack PADIMAC

scientific article published on 01 November 2018

Long-term outcomes after autologous stem cell transplantation for multiple myeloma

artículo científico publicado en 2020

Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition?

artículo científico publicado en 2018

Low expression of hexokinase-2 is associated with false-negative FDG-positron emission tomography in multiple myeloma

artículo científico publicado en 2017

MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma.

artículo científico publicado en 2018

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.

artículo científico publicado en 2008

MMSET is the key molecular target in t(4;14) myeloma

artículo científico publicado en 2013

Mapping of chromosome 1p deletions in myeloma identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as being genes in regions associated with adverse survival.

artículo científico publicado en 2011

Monitoring Treatment Response and Disease Progression in Myeloma with Circulating Cell-Free DNA

artículo científico publicado en 2020

Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease

artículo científico publicado en 2020

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.

artículo científico publicado en 2015

Neutral tumor evolution in myeloma is associated with poor prognosis. ⬇️

artículo científico publicado en 2017

Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control.

artículo científico publicado en 2017

Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of

scientific article published on 22 January 2019

Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients. ⬇️

artículo científico publicado en 2017

Search for rare protein altering variants influencing susceptibility to multiple myeloma

artículo científico publicado en 2017

Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma

article

Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

artículo científico publicado en 2017

The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells

artículo científico publicado en 2014

The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

artículo científico publicado en 2013

The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma. ⬇️

artículo científico publicado en 2016

The chicken B locus is a minimal essential major histocompatibility complex.

artículo científico publicado en 1999

The clinical impact and molecular biology of del(17p) in multiple myeloma treated with conventional or thalidomide-based therapy

artículo científico publicado en 2011

The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes.

artículo científico publicado en 2011

The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma

artículo científico publicado en 2020

The genetic architecture of multiple myeloma.

artículo científico publicado en 2012

The genomic landscape of plasma cells in systemic light chain amyloidosis

scientific article published on 16 November 2018

The level of deletion 17p and bi-allelic inactivation of TP53 has a significant impact on clinical outcome in multiple myeloma.

artículo científico publicado en 2017

The prognostic value of the depth of response in multiple myeloma depends on the time of assessment, risk status and molecular subtype

artículo científico publicado en 2017

The reconstruction of transcriptional networks reveals critical genes with implications for clinical outcome of multiple myeloma

artículo científico publicado en 2011

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma

artículo científico publicado en 2017

The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myeloma

artículo científico publicado en 2017

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

scientific article published on 20 August 2019

Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients

artículo científico publicado en 2014

Understanding next generation sequencing in oncology: A guide for oncologists.

artículo científico

Use of single nucleotide polymorphism-based mapping arrays to detect copy number changes and loss of heterozygosity in multiple myeloma.

artículo científico publicado en 2006

Whole Exome Sequencing in Multiple Myeloma to Identify Somatic Single Nucleotide Variants and Key Translocations Involving Immunoglobulin Loci and MYC

artículo científico publicado en 2018

Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

artículo científico publicado en 2021

XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments

artículo científico publicado en 2010

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